110 results on '"Zheng HG"'
Search Results
2. Ruthenium complexes with N(SPR2)(2)(-) (R = Ph or Pr-i)
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Leung, Wa Hung, Zheng, HG, Chim, JLC, Chan, J., Wong, WT, Williams, Ian Duncan, Leung, Wa Hung, Zheng, HG, Chim, JLC, Chan, J., Wong, WT, and Williams, Ian Duncan
- Abstract
Reactions of [Ru(PPh3)(3)Cl-2], [Ru(CO)(2)Cl-2](x), or [Ru(dmso)(4)Cl-2] (dmso=dimethyl sulfoxide) with KLR [L-R=N(SPR2)(2), R=Ph or Pr-i] afforded [Ru(L-R)(2)(PPh3)] (R=Ph 1 or Pr-i 2), cis-[Ru(L-R)(2)(CO)(2)] (L=Ph 3 or Pr-i 4), or cis-[Ru(L-Ph)(2)(dmso)(2)] 5, respectively. The crystal structures of complexes 1 and 2 have been determined. They show weak agostic interaction between Ru and L-R with calculated Ru ... H-C separations of 3.37 and 2.91 Angstrom, respectively. The Ru-P and average Ru-S distances in 1 are 2.218(1) and 2.400 Angstrom, respectively. The corresponding bond lengths for 2 are 2.210(2) and 2.404 Angstrom. Treatment of 2 with (BuNC)-N-t afforded trans-[Ru(L-Pr)(2)((BuNC)-N-t)(2)] 6, the average Ru-S and Ru-C distances of which are 2.453 and 1.990(3) Angstrom, respectively. Reaction of RuCl3 with KLR in methanol gave the homoleptic complexes [Ru(L-R)(3)] (L=Ph 7 or Pr-i 8). The average Ru-S distance and S-Ru-S angle in 7 are 2.414 Angstrom and 97.41 degrees, respectively. While complex 1 reacts with pyridine (py) to give [Ru(L-Ph)(2)(PPh3)(py)] 9, reaction of 2 with py led to isolation of structurally characterised [Ru(L-Pr)(2)(SO)] 10. The Ru-S(O) and S-O bond lengths in 10 are 2.0563(11) and 1.447(3) Angstrom, respectively, the Ru-S-O angle being 125.5(2)degrees. Treatment of 1 with SO2 afforded structurally characterised cis-[Ru(L-Ph)(2)(PPh3)(SO2)] 11. The SO2 ligand binds to Ru in 11 in a eta(1)-S mode and the Ru-S(O) distance is 2.140(4) Angstrom. Complex 2 reacted with SO2 to give the mu-sulfato-bridged ruthenium(III) dimer [{Ru(L-Pr)(PPh3)}(2)(mu-SO4)(2)] 12, which has been characterised by X-ray crystallography. The Ru-P and average Ru-S and Ru-O distances in 12 are 2.294(2), 2.321 and 2.133 Angstrom, respectively. Complex 1 is capable of catalysing hydrogenation of styrene in the presence of Et3N presumably via a ruthenium hydride intermediate.
- Published
- 2000
3. Heterobimetallic mu-nitrido complexes containing ruthenium(II) dithiocarbamate
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Zheng, HG, Leung, Wa Hung, Chim, JLC, Lai, W., Lam, CH, Williams, Ian Duncan, Wong, WT, Zheng, HG, Leung, Wa Hung, Chim, JLC, Lai, W., Lam, CH, Williams, Ian Duncan, and Wong, WT
- Abstract
Interaction of [Ru(Co)H(Et(2)dtc) with triflic acid (HOTf) afforded [Ru(Co)H(Et(2)dtc)(PPh3)(2)(OTf) (1), which has been characterized by X-ray crystallography. The Ru-C, Ru-O, average Ru-S and average Ru-P distances in 1 an 1.811(5), 2.216(3), 2.433 and 2.423 Angstrom, respectively. Reaction of 1 with amines L results in the formation of adducts trans-[Ru(CO)(Et(2)dtc)(PPh3)(2)L](OTf) (L = N2H4 (2) and NH2OH (3)). The Ru-C, Ru-N, average Ru-S and average Ru-P distance in 3 are 1.85(1), 2.179(8), 2.433 and 2.393, respectively; the Ru-N-O angle being 119.7(5)degrees. Treatment of 1 with [(NBu4)-Bu-n][OsN(C7H6S2)(2)] ([C7H6S2](2-) =3,4-toluenedithiolate(2-)), and [ReN(Et(2)dtc)(2)] (Et(2)dtc = N,N-diethyldithiocarbamate) gave the corresponding mu-nitrido complexes [Ru(CO)(Et(2)dtc)(PPh3)(2)(NOsO3)] (4), [Ru(CO)(Et(2)dtc)(PPh3)(2){NOs(C7H6S2)(2)}] (5) and [Ru(CO)(Et(2)dtc)(PPh3)(2){NRe(Et(2)dtc)(2)}] (6). The structures of complexes 4-6 have been established by X-ray crystallography. The Os-N and Ru-N distances, and Os-N-Ru angle in 4 are 1.719(7) and 2.075(7) Angstrom, and 155.1(4)degrees, respectively. The Os-N and Ru-N distances and Os-N-Ru angle in 5 are 1.680(6) and 2.068(6) Angstrom, and 166.2(3)degrees, respectively. The Re-N and Ru-N distances, and Re-N-Ru angle for 6 are 1.670(3) and 2.108(3) Angstrom, and 170.9(2)degrees, respectively. The bond lengths and angles for these mu-nitrido complexes are indicative of asymmetric bridging mode of nitride, i.e. M=N --> Ru(II) (M = Os(VIII), Os(VI), Re(V)). (C) 2000 Elsevier Science S.A. All rights reserved.
- Published
- 2000
4. Syntheses, crystal structures and non-linear optical properties of two novel windmill-shaped clusters: [M2Pd4S8(dppm)(2)]center dot 4DMF (M = W or Mo)
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Zheng, HG, Leung, Wa Hung, Tan, WL, Long, DL, Ji, W., Chen, JT, Xin, FB, Xin, XQ, Zheng, HG, Leung, Wa Hung, Tan, WL, Long, DL, Ji, W., Chen, JT, Xin, FB, and Xin, XQ
- Abstract
Novel cluster compounds [M2Pd4S8(dppm)(2)]. 4DMF (M=W 1 or Mo 2) were synthesized by the reaction of [NEt4](2)[MS4] and [Pd(dppm)Cl-2] (dppm=Ph2PCH2PPh2) in CH2Cl2 and CH3CN, and their crystal structures have been characterized by X-ray diffraction. Both clusters have novel new skeletal structures with eight atoms in a plane. The non-linear optical properties of 1 were studied with a 7 ns pulsed laser at 532 nm. The effective third-order non-linearities were determined yielding alpha(2)=1.2x10(-6) cm W-1 M-1 and n(2)=-1.5x10(-10) cm(2) W-1 M-1. Compound 1 exhibits a considerably large self-defocusing property.
- Published
- 2000
5. Ruthenium(II) ammine and hydrazine complexes with [N(Ph(2)PQ)(2)](-) (Q = S, Se) ligands
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Zhang, Qianfeng, Zheng, HG, Wong, WY, Wong, WT, Leung, Wa Hung, Zhang, Qianfeng, Zheng, HG, Wong, WY, Wong, WT, and Leung, Wa Hung
- Abstract
Reactions of coordinatively unsaturated Ru[N(Ph(2)PQ)(2)](2)(PPh3) (Q = S (1), Se (2)) with pyridine (py), SO2, and NH3 afford the corresponding 18e adducts Ru[N(Ph(2)PQ)(2)](2)(PPh3)(L) (Q = S, L = NH3 (5); Q = Se, L = py (3), SO2 (4), NH3 (6)). The molecular structures of complexes 2 and 6 are determined. The geometry around Ru in 2 is pseudo square pyramidal with PPh3 occupying the apical position, while that in 6 is pseudooctahedral with PPh3 and NH3 mutually cis. The Ru-P distances in 2 and 6 are 2.2025(11) and 2.2778(11) Angstrom, respectively. The Ru-N bond length in 6 is 2.185(3) Angstrom. Treatment of 1 or 2 with substituted hydrazines L or NH2OH yields the respective adducts Ru[N(Ph(2)PQ)(2)](2)(PPh3)(L) (Q = S, L = NH2NH2 (12), t-BuNHNH2 (14), l-aminopiperidine (C5H10NNH2) (15); Q = Se, L = PhCONHNH2 (7), PhNHNH2 (8), NH2OH (9), t-BuNHNH2 (10), C5H10NNH2 (11), NH2NH2 (13)), which are isolated as mixtures of their trans and cis isomers. The structures of cis-14 and cis-15 are characterized by X-ray crystallography. In both molecular structures, the ruthenium adopts a pseudooctahedral arrangement with PPh3 and hydrazine mutually cis. The Ru-N bond lengths in cis-14 . CH2Cl2 and cis-15 are 2.152(3) and 2.101(3) Angstrom, respectively. The Ru-N-N bond angles in cis-14 . CH2Cl2 and cis-15 are 120.5(4) and 129.0(2)degrees, respectively. Treatment of 1 with hydrazine monohydrate leads to the isolation of yellow 5 and red trans-Ru[N(Ph2PS)(2)](2)(NH3)(H2O) (16), which are characterized by mass spectrometry, H-1 NMR spectroscopy, and elemental analyses. The geometry around ruthenium in 16 is pseudooctahedral with the NH3 and H2O ligands mutually trans. The Ru-O and Ru-N bond distances are 2.118(4) and 2.142(6) Angstrom, respectively. Oxidation reactions of the above ruthenium hydrazine complexes are also studied.
- Published
- 2000
6. Synthesis and crystal structures of two nest-shaped cluster compounds, [MoOS3Cu3(SCN)py(5)] and [WOS3Cu3(SCN)py(5)]
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Zheng, HG, Chen, JX, Xin, XQ, Leung, WH, Hong, MC, Zheng, HG, Chen, JX, Xin, XQ, Leung, WH, and Hong, MC
- Abstract
The compounds [MOS3Cu3(SCN)X-5] (M = Mo, W; X = py, 4-CH(3)py, 4-tert-Bupy) have been prepared by the reaction of(NH4)(2)MO2S2 (M = MO, W), CuSCN and the appropriate ligand X under mild conditions and were characterized by elemental analyses, LR and UV-Vis spectra. Single-crystal X-ray analyses of both compounds reveal that they have a nest-shaped structure and the average M-Cu distances are 2.684(3) Angstrom for M = Mo and 2.693(2) Angstrom for M = W.
- Published
- 2000
7. Synthesis and characterization of oxidized products of CuX (X = Cl, Br) and N,N-dimethylbenzeneethanethioamide
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Zheng, HG, Chen, TN, Ye, XR, Xin, XQ, Wong, WT, Leung, Wa Hung, Zheng, HG, Chen, TN, Ye, XR, Xin, XQ, Wong, WT, and Leung, Wa Hung
- Abstract
The binuclear complexes Cu-2(C10H12ONS)(2)X-2, where X = Cl, Br, have been synthesized and characterized and the X-ray structure determination of Cu-2(C10H12ONS)(2)Br-2 is reported. The ligand originally prepared has been oxidized (along with the metal ion) and changed into a bidentate ligand. Copper(II) has a distorted square planar coordination with Cu-S 2.242(2) Angstrom and Cu-Br 2.318(1) Angstrom. In the structure, two Cu atoms are linked by bridging oxygen atoms with Cu-O 1.908(4) Angstrom and Cu-Cu 3.042 Angstrom.
- Published
- 1999
8. Syntheses, crystal structures and nonlinear optical properties of heteronuclear clusters [MS4Cu4(SCN)(2)(NC5H5)(6)] (M = W, Mo)
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Zheng, HG, Tan, WL, Ji, W., Leung, Wa Hung, Williams, Ian Duncan, Long, DL, Huang, JS, Xin, XQ, Zheng, HG, Tan, WL, Ji, W., Leung, Wa Hung, Williams, Ian Duncan, Long, DL, Huang, JS, and Xin, XQ
- Abstract
The title compounds [MS4Cu4(SCN)(2)(NC5H5)(6)] (M = W (1); M = Mo (2); NC5H5 = pyridine) were obtained by the reaction of (NH4)(2)MS4, CuSCN, KSCN and pyridine. The X-ray analyses of 1 and 2 show that four edges of the tetrahedral MS42- core are coordinated by four copper atoms, giving an MS4Cu4 aggregate of approximate D-2h symmetry. The nonlinear optical properties of 1 and 2 were investigated by a Z-scan technique with 7 ns laser pulses of 532 nm. The third-order nonlinearities were determined with alpha(2) = 4.3 x 10(-5) and 4.1 x 10(-5) cm W-1 M-1; and n(2) = -4.3 x 10(-10) and - 4.1 x 10(-10) cm(2) W-1 M-1, respectively, for compounds 1 and 2. (C) 1999 Elsevier Science S.A. All rights reserved.
- Published
- 1999
9. Synthesis and crystal structures of two nest-shaped cluster compounds, [MoOS3Cu3(SCN)py(5)] and [WOS3Cu3(SCN)py(5)]
- Author
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Zheng, Hg, Jinxi Chen, Xin, Xq, Leung, Wh, and Hong, Mc
10. [Simultaneous determination of eight organic amines in desulfurization solution by ion chromatography].
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Gao LH, Jiang ZB, Zheng HG, and Li WH
- Abstract
The applications of organic-amine desulfurization have steadily increased owing to its high efficiency, low cost, and low energy consumption. Different proportions of organic amines exert different effects on sulfur dioxide removal. Therefore, the accurate determination of different organic amines in the desulfurization solution is of great importance. The ion-chromatographic method for the detection of organic amines does not require a derivatization step, has simple pretreatment procedures, and allows for the simultaneous determination of many types of organic amines. In this study, a method based on ion chromatography was developed for the simultaneous determination of ethanolamine (MEA), diethylethanolamine (DEEA), n -methyldiethanolamine (MDEA), 2-amino-2-methyl-1-propanol (AMP), hydroxyethylethylenediamine (AEEA), piperazine (PZ), n -hydroxyethylpiperazine (HEPZ), and diethylenetriamine (DETA). The separation efficiency of the eight organic amines in different types of columns, leaching solutions, and column temperatures were compared. The determination was performed using an IonPac CS17 column with column temperature of 35 ℃ and gradient leaching with methyl sulfonic acid (MSA) solution via the inhibition conductance method. Samples of the desulfurization solution were analyzed using ultrapure water filtered through a 0.22 μm nylon microporous filter membrane and an OnGuard Ⅱ RP column; thus, the pretreatment steps are simple. The eight organic amines showed a good linear relationship within a certain concentration range, and the coefficient of determinations ( R
2 ) were greater than 0.998. The limits of detection (LODs) and quantification (LOQs) were determined from the mass concentrations of the organic amines corresponding to signal-to-noise ratios ( S/N ) of 3 and 10, respectively. LODs of 0.02-0.08 mg/L and LOQs of 0.07-0.27 mg/L were determined from a 1.0 μL sample injection. The actual recoveries ranged from 93.0% to 111%, and the relative standard deviations (RSDs, n =5) ranged from 0.31% to 1.2%. The results indicated that the proposed method has good accuracy and precision; thus, it is suitable for the determination of various organic amines in desulfurization solution.- Published
- 2024
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11. [Determination of fluoroacetic acid in human blood and urine by accelerated solvent extraction-ion chromatography-mass spectrometry].
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Wang YH, Zhang JW, Zheng HG, Lu SJ, Yu SH, Yang RQ, and Wang Y
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- Humans, Spectrum Analysis, Gas Chromatography-Mass Spectrometry, Chromatography, High Pressure Liquid, Tandem Mass Spectrometry, Fluoroacetates
- Abstract
Fluoroacetic acid is a highly polar poison used for rodent control. When ingested by the human body, it seriously damages nerve cells and heart tissues and even causes death by cardiac arrest or respiratory failure. Common detection methods for fluoroacetic acid include gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry, both of which require complex pretreatment methods, such as derivatization. In this study, a method to determine fluoroacetic acid in human blood and urine based on accelerated solvent extraction-ion chromatography-mass spectrometry (ASE-IC-MS) was established. Two pretreatment methods, namely, acetonitrile precipitation and accelerated solvent extraction, were compared. Furthermore, the effects of different extraction conditions, such as the extraction time, extraction temperature, and number of cycles, were investigated. The most suitable chromatographic separation conditions, such as the chromatographic column, column temperature, and elution procedure, were determined, and the MS conditions, such as the collision energy (CE) and declustering potential (DP) of the ion pairs of the target compound, were investigated. Based on the experimental results, the optimal pretreatment methods and detection conditions were obtained, and reliable data were collected. Deionized water was used as the extraction solvent, and blood and urine samples were processed by accelerated solvent extractor. The supernatant was sequentially collected via centrifugal ultrafiltration and 0.22 μm membrane filtration, diluted 50 times, and then injected into the chromatographic column for detection. An Ion Pac AS20 IC column was used for isocratic elution with 15.0 mmol/L KOH solution as the eluent. The effluent was passed through a suppressor and into a triple quadrupole mass spectrometer, which was used to perform MS/MS (ESI
- ) in multiple reaction monitoring (MRM) mode. The quantitative ion was m/z 77.0>57.0 when the CE and DP were -15.0 eV and -20.0 V, respectively. An external standard method was used for quantitative analysis. The results showed a good linear relationship for fluoroacetic acid in the range of 0.5-500.0 μg/L ( r >0.999), with limits of detection (LOD) and quantification (LOQ) of 0.14 and 0.47 μg/L, respectively. The recoveries of fluoroacetic acid in blood and urine were 93.4%-95.8% and 96.2%-98.4%, respectively. The intra-day RSDs for blood and urine were 0.8%-1.6% and 0.2%-1.0%, respectively, while the inter-day RSDs were 2.3%-3.8% and 3.9%-6.9%, respectively. Further investigation revealed that the matrix effects of this method in blood and urine, at -7.4% and -3.0%, respectively, were fairly weak. The established method was successfully applied to detect fluoroacetic acid in human blood and urine obtained from a poisoning case, and the results obtained provided crucial clues that led to swift case resolution. The efficiency of the method was significantly higher than that of conventional detection methods. In conclusion, the developed method has high sensitivity and good repeatability and is suitable for the rapid detection of fluoroacetic acid in human blood and urine. Moreover, because this method does not require derivatization, it is simple and efficient.- Published
- 2023
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12. Evaluation of efficacy and safety for compound kushen injection combined with intraperitoneal chemotherapy for patients with malignant ascites: A systematic review and meta-analysis.
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Yu HB, Hu JQ, Han BJ, Cao HJ, Chen ST, Chen X, Xiong HT, Gao J, Du YY, and Zheng HG
- Abstract
Objectives: Compound Kushen injection (CKI) combined with intraperitoneal chemotherapy (IPC) is widely used in the treatment of malignant ascites (MA). However, evidence about its efficacy and safety remains limited. This review aimed to evaluate the efficacy and safety of CKI combined with IPC for the treatment of MA. Methods: Protocol of this review was registered in PROSPERO (CRD42022304259). Randomized controlled trials (RCTs) on the efficacy and safety of IPC with CKI for the treatment of patients with MA were searched through 12 electronic databases and 2 clinical trials registration platforms from inception until 20 January 2023. The Cochrane risk-of-bias tool was used to assess the quality of the included trials through the risk of bias assessment. We included RCTs that compared IPC single used or CKI combined with IPC for patients with MA schedule to start IPC. The primary outcome was identified as an objective response rate (ORR), while the secondary outcomes were identified as the quality of life (QoL), survival time, immune functions, and adverse drug reactions (ADRs). The Revman5.4 and Stata17 software were used to calculate the risk ratio (RR) at 95% confidence intervals (CI) for binary outcomes and the mean difference (MD) at 95% CI for continuous outcomes. The certainty of the evidence was assessed according to the GRADE criteria. Results: A total of 17 RCTs were assessed, which included 1200 patients. The risk of bias assessment of the Cochrane risk-of-bias tool revealed that one study was rated high risk and the remaining as unclear or low risk. Meta-analysis revealed that CKI combined with IPC had an advantage in increasing ORR (RR = 1.31, 95% CI 1.20 to 1.43, p < 0.00001) and QoL (RR = 1.50, 95% CI 1.23 to 1.83, p < 0.0001) when compared with IPC alone. Moreover, the combined treatment group showed a lower incidence of myelosuppression (RR = 0.51, 95%CI 0.40-0.64, p < 0.00001), liver dysfunction (RR = 0.33, 95%CI 0.16 to 0.70, p = 0.004), renal dysfunction (RR = 0.39, 95%CI 0.17 to 0.89, p = 0.02), and fever (RR = 0.51, 95%CI 0.35 to 0.75, p = 0.0007) compared to those of the control group. The quality of evidence assessment through GRADE criteria showed that ORR, myelosuppression, and fever were rated moderate, renal dysfunction and liver dysfunction were rated low, and QoL and abdominal pain were rated very low. Conclusion: The efficacy and safety of CKI combined with IPC were superior to that with IPC alone for the treatment of MA, which indicates the potentiality of the treatment. However, more high-quality RCTs are required to validate this conclusion. Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022304259], identifier [PROSPERO 2022 CRD42022304259]., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer NL declared a shared parent affiliation with the authors HY, JH, BH, XC, HX, JG, YD, and HZ to the handling editor at the time of review., (Copyright © 2023 Yu, Hu, Han, Cao, Chen, Chen, Xiong, Gao, Du and Zheng.)
- Published
- 2023
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13. Regulation of Chirality in Metal-Organic Frameworks (MOFs) Based on Achiral Precursors through Substituent Modification.
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Gao XJ, Wu TT, Ge FY, Lei MY, and Zheng HG
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- Metal-Organic Frameworks
- Abstract
The generation and regulation of chirality are closely related to the origin of life. Using achiral precursors to spontaneously build chiral MOFs remains a major challenge. Here, a method to synthesize chiral MOFs from achiral precursors by utilizing chiral fragments was achieved. The transformation from chiral fragments of 1 to chiral frameworks of 2 and 3 was realized by modifying the substituents, and the enantiomer resolution of 3 - P 4
1 21 2 and 3 - P 43 21 2 was achieved by d/l camphoric acid. 3 was then further studied in applications.- Published
- 2022
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14. Association of Fear of Falling With Cognition and Physical Function in Community-Dwelling Older Adults.
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Wang QX, Ye ZM, Wu WJ, Zhang Y, Wang CL, and Zheng HG
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- Aged, Cognition, Hand Strength, Humans, Middle Aged, Fear psychology, Independent Living
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Background: Fear of falling (FOF) might be associated with physical and cognitive function, but there is a lack of understanding of the specific relationship between the three variables., Objectives: The aim of this study was to accurately investigate the association of FOF with cognitive and physical function in community-dwelling older adults., Methods: Six hundred sixty-nine older adults (>60 years old) participated in this study. A self-report questionnaire collected information about demographic characteristics, lifestyle, and behavioral habits. FOF was evaluated through the Shortened Version of the Falls Efficacy Scale International. Global cognitive function and the subdomains of cognitive function (including memory, visual-spatial, language, attention, and executive function) were assessed using the Montreal Cognitive Assessment scale, the Auditory Verbal Learning Test, the Clock Drawing Test (CDT), the Verbal Fluency Test, and the Trail Making Test. Subjective memory complaints were assessed using the Subjective Memory Complaints Questionnaire. Physical function was evaluated by measuring muscle strength and balance ability, and muscle strength was indicated by hand grip strength. In contrast, balance was assessed using the Timed Up and Go (TUG) Test., Results: After adjustment for potential confounding factors, the linear or ordinal regression analysis showed that the values of hand grip strength, Montreal Cognitive Assessment, Auditory Verbal Learning Test, and CDT were significantly and negatively correlated with the score of FOF. On the other hand, Subjective Memory Complaints Questionnaire and TUG Test values showed significant positive correlations with FOF scores. Moreover, compared with other cognitive or physical measures, the CDT and TUG Test values showed a greater association with the FOF scores., Discussion: Low subjective or objective cognitive ability and low physical function, especially low visuospatial and balance ability, were positively associated with the risk of FOF in a community-dwelling older population., Competing Interests: The authors have no conflicts of interest to report., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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15. From Hydrogen Bond to van der Waals Force: Molecular Scalpel Strategy to Exfoliate a Two-Dimensional Metal-Organic Nanosheet.
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Ge FY, Yan Q, Liang S, Duan XD, and Zheng HG
- Abstract
The facile exfoliation of a two-dimensional metal-organic nanosheet of {[Co(HL)(H
2 O)(Py)3/4 ]·1 /2 H2 O·DMF}n [ 1-Py ; H3 L = 5-(1 H -pyrazol-4-yl)isophthalic acid and Py = pyridine] was achieved, via a molecular scalpel strategy, by weakening intermolecular forces between adjacent layers. The resulting 1-Py/KB40 (KB = Ketjen black) shows an increased oxygen evolution reaction (OER) performance with an overpotential of 370 mV at a current density of 10 mA cm-2 and a Tafel slope of 58 mV dec-1 . This work sheds light on the structure-morphology-reactivity relationship of such materials in OER.- Published
- 2022
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16. Response to the Temperature and Solvent Stimulation of MOF Material in a Single-Crystal to Single-Crystal Manner.
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Qian JL, Zhou T, Lu X, Xu H, Sun JY, Zhang CL, and Zheng HG
- Abstract
Under solvothermal conditions, a three-dimensional mononuclear crystal AQNU-1, {[Co(H
2 L)(DPD)(H2 O)2 ]·2DMA}n (H2 L = 5-(bis(4-carboxybenzyl)amino)isophthalic acid, DPD = 4,4'-(2,5-diethoxy-1,4-phenylene)dipyridine) has been synthesized. The transformations of AQNU-1 to binuclear {[Co2 (L)(DPD)1.5 (H2 O)3 ]·DMA·H2 O}n (AQNU-2) and pentanuclear {[Co5 (L)2 (DPD)2 (OH)2 ]·2H2 O}n (AQNU-3) were realized by double stimulation of temperature and solvent, which were accomplished by single-crystal to single-crystal (SC-SC) reaction.- Published
- 2022
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17. Ultra-Performance Liquid Chromatography/Mass Spectrometry-Based Metabolomics for Discovering Potential Biomarkers and Metabolic Pathways of Colorectal Cancer in Mouse Model (ApcMin/+) and Revealing the Effect of Honokiol .
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Chen X, Shi BL, Qi RZ, Chang X, and Zheng HG
- Abstract
Endogenous metabolites are a class of molecules playing diverse and significant roles in many metabolic pathways for disease. Honokiol (HNK), an active poly-phenolic compound, has shown potent anticancer activities. However, the detailed crucial mechanism regulated by HNK in colorectal cancer remains unclear. In the present study, we investigated the therapeutic effects and the underlying molecular mechanisms of HNK on colorectal cancer in a mouse model (ApcMin/+) by analyzing the urine metabolic profile based on metabolomics, which is a powerful tool for characterizing metabolic disturbances. We found that potential urine biomarkers were involved in the metabolism of compounds such as purines, tyrosines, tryptophans, etc. Moreover, we showed that a total of 27 metabolites were the most contribution biomarkers for intestinal tumors, and we found that the citrate cycle (TCA cycle) was regulated by HNK. In addition, it was suggested that the efficacy of HNK was achieved by affecting the multi-pathway system via influencing relevant metabolic pathways and regulating metabolic function. Our work also showed that high-throughput metabolomics can characterize the regulation of metabolic disorders as a therapeutic strategy to prevent colorectal cancer., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Chen, Shi, Qi, Chang and Zheng.)
- Published
- 2021
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18. The difference in the CO 2 adsorption capacities of different functionalized pillar-layered metal-organic frameworks (MOFs).
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Gao XJ and Zheng HG
- Abstract
The excessive use of fossil energy has caused the CO2 concentration in the atmosphere to increase year by year. MOFs are ideal CO2 adsorbents that can be used in CO2 capture due to their excellent characteristics. Studies of the structure-activity relationship between the small structural differences in MOFs and the CO2 adsorption capacities are helpful for the development of efficient MOF-based CO2 adsorbents. Therefore, a series of pillar-layered MOFs with similar structural and different functional groups were designed and synthesized. The CO2 adsorption tests were carried out at 273 K to explore the relationship between the small structural differences in MOFs caused by different functional groups and the CO2 adsorption capacities. Significantly, compound 6 which contains a pyridazinyl group has a 30.9% increase in CO2 adsorption capacity compared to compound 1 with no functionalized group.
- Published
- 2021
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19. Mixed matrix membranes containing fluorescent coordination polymers for detecting Cr 2 O 7 2- with high sensitivity, stability and recyclability.
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Xu YK, Meng MM, Xi JM, Wang LF, Zhu R, Liu XG, Zhang R, Dong W, Lu ZZ, Zheng HG, and Huang W
- Abstract
Three coordination polymers (CPs) were synthesized by using CdII, fluorescent 9,10-di(4-pyridyl)anthracene (dpa), and cyclohexane-1,4-dicarboxylic acid (H2cda), and they are [Cd2(dpa)2(cda)Cl2]n (1), [Cd(dpa)2(cda)]n (2) and [Cd(dpa)(cda)(H2O)]n (3). Both 1 and 2 are fluorescent and contain nonporous layers. 3 is an isomer of 2 and contains a porous diamondoid network. Fluorescent mixed matrix membranes were prepared by dispersing the particles of 1 or 2 within the matrix of polymethyl methacrylate, and showed high sensitivity and selectivity for detecting Cr2O72- in water. Both stability and recyclability of the MMMs were remarkably higher than those of the CP powders.
- Published
- 2021
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20. Molecular engineering in a family of pillared-layered metal-organic frameworks for tuning gas adsorption behavior.
- Author
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Liang S, Ge FY, Ren SS, Lei MY, Gao XJ, and Zheng HG
- Abstract
In this work, inspired by a water-assisted three-dimensional supramolecular structure 1, we use a mixed-ligand strategy to form a 3D pillared-layered matrix by the introduction of linear ligands to compete against the water molecules. The resulting analogue microporous MOFs of 2-H, 2-F and 2-N, decorated with different functional groups, similarly show the CO2 uptake. Thanks to the negligible N2 adsorption capacity, enhanced selective adsorption towards CO2 is achieved in compound 2-N. That is, we present here an alternative plan for the high CO2 selective adsorption performance. In addition, the structure stability and moderate affinity for CO2 of these microporous MOFs endow them with excellent reusability.
- Published
- 2021
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21. [Application effects of fertilizer recommendation by Nutrient Expert System on radish].
- Author
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Shan N, Chuan LM, Liu JP, Zheng HG, and Zhao TK
- Subjects
- Expert Systems, Nutrients, Soil, Fertilizers, Raphanus
- Abstract
A field experiment was conducted for two seasons to evaluate the application effects of a decision support system named Nutrient Expert on radish based on yield response and agronomic efficiency, to provide theoretical and technical support for convenient and quick recommendation on fertilization management. There were seven treatments: farmer's practice treatment (FP), recommended fertilization treatment based on Nutrient Expert (TE), recommended fertilization treatment based on soil testing (TS), treatment of replacing 30% nitrogen fertilizer with organic fertilizer based on TE (TE+OM), and corresponding nitrogen omission treatment (TE-N), phosphorus omission treatment (TE-P), and potassium omission treatment (TE-K). We measured and compared the effects of different fertilization managements on radish yield, nutrient uptake, fertilizer utilization and fertilization benefit. The results showed that the N, P
2 O5 and K2 O fertilizer applications based on Nutrient Expert were 200, 132 and 215 kg·hm-2 in the first half of the year, and 171, 204 and 251 kg·hm-2 in the second half of the year, respectively. The Nutrient Expert recommended fertilization adjusted the application amount of nitrogen, phosphorus, and potassium fertilizer. Compared with FP treatment, the economic yield of radish in the two-season experiments increased by 14.8% and 18.4%, and the profit of fertilization increased by 20115 and 14905 yuan·hm-2 , respectively. Compared with the TS treatment, the economic yield of radish over the two seasons increased by 9.8% and 16.8%, and the profit of fertilization increased by 9076 and 9987 yuan·hm-2 , respectively. The Nutrient Expert recommended fertilization improved the agronomic efficiency and nutrient recovery efficiency of radish, and promoted the efficient utilization of nutrients. The reasonable proportion of organic fertilizer in radish production could promote the transfer of plant nutrients to roots to a certain extent. In general, the application of Nutrient Expert on radish was feasible. This method could make full use of the indigenous nutrients of soil, consider the balance and sustainable supply, and reasonably regulate the supply of nitrogen, phosphorus and potassium, and finally result in high yield, high efficiency and sustainable development of radish production.- Published
- 2020
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22. A Europium-based MOF Fluorescent Probe for Efficiently Detecting Malachite Green and Uric Acid.
- Author
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Han LJ, Kong YJ, Hou GZ, Chen HC, Zhang XM, and Zheng HG
- Abstract
Lanthanide (such as Tb and Eu) metal-organic frameworks (MOFs) have been widely used in fluorescent probes because of their multiple coordination modes and brilliant fluorescence characteristic. Many lanthanide MOFs were applied in detecting metal ions, inorganic anions, and small molecules. However, it's rarely reported that Ln-MOF was devoted to detecting malachite green (MG) and uric acid (UA). We prepared a europium-based metal-organic framework (Eu-TDA) (TDA = 2,5-thiophenedicarboxylic acid group). Luminescence studies demonstrated that Eu-TDA can rapidly detect MG and UA with excellent selectivity and sensitivity, where individual quenching efficiency K
sv (MG: 5.8 × 105 M-1 ; UA: 4.15 × 104 M-1 ) and detection limit (MG: 0.0221 μM; UA: 0.689 μM) were regarded as the excellent MOF sensors for detecting MG and UA. The quenching of Eu-TDA's fluorescence emission by MG and UA was likely due to the spectral overlap, energy transfer, and competition. Among 11 metal cations and 14 anions, Eu-TDA can quickly and effectively recognize MG and UA with highly selective and sensitive properties. Our method possesses potential application in detecting UA in human blood and MG in the fishpond.- Published
- 2020
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23. Three metal-organic framework isomers of different pore sizes for selective CO 2 adsorption and isomerization studies.
- Author
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Zhang R, Huang JH, Meng DX, Ge FY, Wang LF, Xu YK, Liu XG, Meng MM, Lu ZZ, Zheng HG, and Huang W
- Abstract
Metal-organic frameworks (MOFs) or porous coordination polymers (PCPs) with tunable pore sizes, shapes and functionalities have excellent prospects in many applications, such as carbon capture. Molecular sieving can usually enable very high CO
2 adsorption selectivity but has rarely been achieved, because it is difficult to precisely control the pore size in the range of 3-4 Å. We report here three MOF isomers built from CdII , terephthalic acid and 3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine with the same stoichiometric ratio, among which 1 and 2 are framework-catenation isomers and 2 and 3 are framework-topological isomers. 1 contains 2-fold interpenetrated networks (topology of pcu) and 1D ultra-micropores and shows highly selective adsorption of CO2 over N2 and CH4 , which is mainly ascribed to the molecular sieving effect of the framework. 2 contains a pcu network with 3D interconnected micropores, and 3 contains a kag network with much larger pores of 15 Å. Framework isomerization, in this case, was shown to be a feasible way of tuning the pore size of a MOF for selective CO2 adsorption. The effects of hydrothermal reaction conditions and additives on the structures and the formation of the MOF isomers were also studied.- Published
- 2020
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24. Tetrazole-based porous metal-organic frameworks for selective CO 2 adsorption and isomerization studies.
- Author
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Zhang R, Meng DX, Ge FY, Huang JH, Wang LF, Xv YK, Liu XG, Meng MM, Yan H, Lu ZZ, Zheng HG, and Huang W
- Abstract
Tetrazole-based molecules have numerous bridging coordination modes which afford great synthetic possibilities for the preparation of porous metal-tetrazolate architectures for many applications, such as carbon capture. We reported here three tetrazole-based MOFs: 1, {[Cu
12 (ttz)8/3 Cl5 (H2 O)16 ]11+ ·11Cl- }n (H3 ttz = N2 ,N4 ,N6 -tris(4-(1H-tetrazol-5-yl)phenyl)-1,3,5-triazine-2,4,6-triamine), contains highly positively charged Cu12 clusters and the largest mesopores (32 Å) among the reported MOFs based on a tri-topic tetrazole ligand. 2 and 3 are two MOF isomers built by using CuII and 2-(1H-tetrazol-5-yl)pyrimidine. 3 contains nonporous layers, while 2 contains 1D channels and showed high selectivity for adsorbing CO2 , which should be attributed to the high density of free nucleophilic tetrazole N atoms on the pore surfaces. We found that the isomerization between 2 and 3 was caused by the diverse coordination modes of tetrazole-based ligands and can be controlled in synthesis processes.- Published
- 2020
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25. Effective adsorption of Congo red by a MOF-based magnetic material.
- Author
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Han LJ, Ge FY, Sun GH, Gao XJ, and Zheng HG
- Abstract
Metal-organic frameworks (MOFs) are an exciting class of porous crystallized materials, which have attracted great interest in sustainable energy and environmental remediation. Magnetite (Fe3O4) is one of the best-known magnetic materials and has been extensively studied with respect to properties involving high saturation magnetization, biocompatibility and low toxicity. The combination of MOFs and Fe3O4 has shown its potential applications in drug delivery, catalysis and wastewater treatment. However, only classical porous MOFs are used to encapsulate magnetic nanoparticles, such as MIL-100(Fe), ZIF-8, UiO-66 and so on. Herein, we firstly synthesized a new MOF ZTB-1 and surveyed its applications in magnetic materials. As a result, a highly water-stable MOF-based magnetic material Fe3O4@ZTB-1 has been obtained, and it was for the first time used as an excellent adsorbent for the fast adsorption of Congo red (CR) from aqueous solutions, exhibiting an adsorption capacity of 458 mg CR per gram. The electrostatic interactions and hydrogen bond are responsible for binding of CR with Fe3O4@ZTB-1. The magnetic material Fe3O4@ZTB-1 shows a potential application in dyeing wastewater treatment.
- Published
- 2019
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26. An excellent example illustrating the fluorescence sensing property of cobalt-organic frameworks.
- Author
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Zhang CL, Liu ZT, Xu H, Zheng HG, Ma J, and Zhao J
- Abstract
A novel luminescent cobalt-organic framework was assembled and employed as a chemosensor for the detection of metal ions via fluorescence enhancement and quenching. The sensing mechanism was based on the exposed pyridyl and carboxyl functional sites in the MOF structure, which interacted with metal ions via Lewis acid-base interactions and electrostatic interactions.
- Published
- 2019
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27. Safety, Effectiveness, and Manipulability of Peritoneal Dialysis Machines Made in China: A Randomized, Crossover, Multicenter Clinical Study.
- Author
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Cao XY, He YN, Zhou JH, Sun SR, Miao LN, Chen W, Fang JA, Wang M, Wang NS, Lin HL, Liu J, Ni ZH, Liu WH, Na Y, Zhao JY, Guo ZY, Zheng HG, Shi W, Jiang GR, Cai GY, and Chen XM
- Subjects
- Adult, China, Cross-Over Studies, Female, Humans, Male, Middle Aged, Multicenter Studies as Topic, Peritoneal Dialysis methods, Quality of Life, Temperature, Peritoneal Dialysis adverse effects, Peritoneal Dialysis instrumentation
- Abstract
Background: Automated peritoneal dialysis (APD) can cater to individual needs, provide treatment while asleep, take into account the adequacy of dialysis, and improve the quality of life. Currently, independent research and development of APD machines made in China are more conducive to patients. A randomized, multicenter, crossover study was conducted by comparing an APD machine made in China with an imported machine. The safety, effectiveness, and manipulability of the two machines were compared., Methods: Two hundred and sixty patients who underwent peritoneal dialysis (PD) on a regular basis in 18 centers between August 2015 and February 2016 were included. The inclusion criteria include age ≥18 years and PD ≥30 days. The exclusion criteria were as follows: hemodialysis; exit site or tunnel infection; and peritonitis ≤30 days. The patients were randomly divided into Group A, who were first treated with a FM machine made in China, then changed to an imported machine; and Group B, who were treated using the reverse sequence. APD treatment was performed with 10 L/10 h and 5 cycles of exchange. After 72 h, the daily peritoneal Kt/V, the accuracy of the injection rate, accuracy of the injection temperature, safety, and manipulability of the machine were assessed. Noninferiority test was conducted between the two groups., Results: The daily peritoneal Kt/V in the APD machine made in China and the imported APD machine were 0.17 (0.14, 0.25) and 0.16 (0.13, 0.23), respectively. There was no significant difference between the groups (Z = 0.15, P = 0.703). The lower limit of the daily Kt/V difference between the two groups was 0.0069, which was greater than the noninferiority value of -0.07 in this study. The accuracy of the injection rate and injection temperature was 89.7% and 91.5%, respectively, in the domestic APD machine, which were both slightly better than the accuracy rates of 84.0% and 86.8% in the imported APD machine (89.7% vs. 84.0%, P = 0.2466; 91.5% vs. 86.8%, P = 0.0954). Therefore, the APD machine made in China was not inferior to the imported APD machine. The fuselage of the imported APD machine was space-saving, while the APD machine made in China was superior with respect to body mobility, man-machine dialog operation, alarm control, and patient information recognition., Conclusions: The FM machine made in China was not inferior to the imported APD machine. In addition, the FM machine made in China had better operability., Trial Registration: Clinicaltrials.gov, NCT02525497; https://clinicaltrials.gov/ct2/results?cond=&term=NCT02525497&cntry=& state=&city=&dist=., Competing Interests: Morestep and Baxter Inc. support data collection for this research
- Published
- 2018
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28. [Research of Feiliuping Gao and its combination with different types of drugs intervention on expression of PI3K/AKT/NF-κB in lung metastatic microenvironment].
- Author
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Liu R, Zheng HG, Li WD, Hua BJ, Yao B, Qi X, Pei YX, and Zhang Y
- Subjects
- Animals, Lung, Mice, NF-kappa B metabolism, Phosphatidylinositol 3-Kinases metabolism, Proto-Oncogene Proteins c-akt metabolism, Carcinoma, Lewis Lung pathology, Drugs, Chinese Herbal pharmacology, Neoplasm Metastasis, Signal Transduction
- Abstract
The aim of this paper was to observe the effect of Feiliuping Gao and its combination with different types of drugs intervention on the expression of PI3K/AKT/NF-κB in lung metastatic microenvironment, and to reveal the advantage of Chinese medicine intervention time on the key molecule in lung metastatic microenvironment. The mouse model of Lewis lung carcinoma was established, and lung tissues were collected at 14 days, 21 days and 28 days after the intervention of Feiliuping Gao, and the expressions of PI3K, AKT and NF-κB were detected by immunohistochemistry and Western blot. At 14 days, there was no significant difference in PI3K expression between each group and the control group. The expression of AKT protein was significantly inhibited in the celecoxib (CLB) group, the Feiliuping Gao (FLP) combination with cyclophosphamide (FLP+CTX) group, and the Feiliuping Gao combination with celecoxib (FLP+CLB) group ( P <0.05). The inhibition of AKT protein expression in FLP+CLB group was superior. The FLP+CLB group can inhibit the expression of NF-κB protein ( P <0.05). At 21 days, compared with the control group, the expression of PI3K was inhibited in FLP group and the FLP+CTX group ( P <0.05), while the expression of PI3K was best inhibited in the FLP+CLB group ( P <0.001). Only the FLP+CLB group could significantly inhibit the expression of AKT protein ( P <0.01). The FLP+CTX group had the best effect in inhibiting the expression of NF-κB protein ( P <0.001). At 28 days, compared with the control group, the expression of PI3K and AKT was inhibited in the FLP+CLB group ( P <0.001). Feiliuping ointment combination with celecoxib has an advantage in regulating the expression of PI3K/AKT/NF-κB molecules in lung metastatic microenvironment., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)
- Published
- 2018
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29. Elevated miR-21 is associated with poor prognosis in non-small cell lung cancer: a systematic review and meta-analysis.
- Author
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Yuan Y, Xu XY, Zheng HG, and Hua BJ
- Subjects
- Carcinoma, Non-Small-Cell Lung genetics, Disease-Free Survival, Humans, Lung Neoplasms genetics, Neoplasm Recurrence, Local, Prognosis, Carcinoma, Non-Small-Cell Lung pathology, Lung Neoplasms pathology, MicroRNAs genetics
- Abstract
Objective: Increasing studies have investigated the prognostic value of high miR-21 expression in non-small cell lung cancer (NSCLC) with inconsistent results. We conducted this meta-analysis to explore whether the expression of miR-21 was associated with prognosis in NSCLC patients., Materials and Methods: We systematically searched Medline, EMBASE, Web of Science and Cochrane Library for relevant studies. Studies exploring the relationship between miR-21 expression and NSCLC prognosis and clinical pathology, and reporting enough data to get the hazard ratio (HR) and 95% confidence intervals (CIs), were included. Random- or fixed-effect models were employed to calculated pooled hazard ratios (HRs) or risk ratio and 95% confidence intervals (95% CIs)., Results: A total of 28 eligible studies, including 24 for prognosis, 16 for clinicopathological features were identified. Our results revealed that elevated miR-21 was related to unfavorable overall survival (OS) in NSCLC (HR = 1.960, 95% CI = 1.510-2.554, p = 0.000). Similar results were found in disease-free survival, relapse-free survival, and cancer-special death. In a meta-analysis of clinical pathology, overexpressed miR-21 was significantly related to lung adenocarcinoma, larger tumor size, and advanced clinical stage., Conclusions: Our meta-analysis suggested that miR-21 may function as an unfavorable biomarker of prognosis in NSCLC patients.
- Published
- 2018
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30. Two MOFs as dual-responsive photoluminescence sensors for metal and inorganic ion detection.
- Author
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Wang ZJ, Ge FY, Sun GH, and Zheng HG
- Abstract
Two metal-organic frameworks (MOFs), [Zn(BIPA)(tfbdc)]n (1) and {[Cd(BIPA)(tfbdc)(H2O)]·DMF}n (2), were hydrothermally synthesized using the self-assembly of the "V-shape" BIPA ligand (bis(4-(1H-imidazol-1-yl)phenyl)amine) and the H2tfbdc ligand (2,3,5,6-tetrafluorobenzene-1,4-dicarboxylic acid) with Zn/Cd metal salts. 1 is a 2D hcb framework and 2 is a 2D sql network. Their applications in detecting metal and inorganic ions were also explored. The results indicate that 1 exhibits dual-responsive photoluminescence sensing for Fe3+ and Cr2O72- ions while 2 can detect Hg2+ and Cr2O72- ions.
- Published
- 2018
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31. A triphenylamine-functionalized luminescent sensor for efficient p-nitroaniline detection.
- Author
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Ji NN, Shi ZQ, Hu HL, and Zheng HG
- Abstract
The combination of π-conjugated fluorophores within a hybrid system gives rise to a triphenylamine-functionalized material [Zn(bpba)(NO3)] (1) (Hbpba = 4-(bis(4-(pyridin-4-yl)phenyl)amino)benzoic acid). Compound 1 features a 2D + 2D → 2D parallel polycatenation structure with 63-hcb net. Photophysical studies revealed that the title phase showed superior sensitivity towards p-nitroaniline (p-NA) with a low detection limit (down to ∼0.10 ppm). Specifically, following a new detection route, vapor-sensing experiments using a saturated ethanol solution of nitroaromatic isomers have been established for the first time. Highly sensitive and selective detection of p-NA by the proposed material with a rapid response time (t = 30 s, QE > 90.0%) as compared to that via the control isomers (t = 60s, QE < 6.0%) demonstrates an attractive feasible route and a promising luminescent sensor for nitroaromatic detection.
- Published
- 2018
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32. Three Cd(II) MOFs with Different Functional Groups: Selective CO 2 Capture and Metal Ions Detection.
- Author
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Wang ZJ, Han LJ, Gao XJ, and Zheng HG
- Abstract
Three Cd(II) iso-frameworks {[Cd(BIPA)(IPA)]·DMF}
n (1), {[Cd(BIPA)(HIPA)]·DMF}n (2), and {[Cd(BIPA)(NIPA)]·2H2 O}n (3) were synthesized from the self-assembly of the BIPA ligand (BIPA = bis(4-(1 H-imidazol-1-yl)phenyl)amine) and different carboxylic ligands (H2 IPA = isophthalic acid, H2 HIPA = 5-hydroxyisophthalic acid, H2 NIPA = 5-nitroisophthalic acid) with Cd(II), which have amino groups, amino and phenolic hydroxyl groups, and amino and nitro groups, respectively. Both 1 and 2 exhibit CO2 uptakes of more than 20 wt %, indicating that amino and phenolic hydroxyl functionalized groups are beneficial to CO2 adsorption. Their applications and mechanisms in detecting metal ions were researched. The results exhibit that 1 and 2 are dual-responsive photoluminescent sensors for Hg2+ and Pb2+ ions with low detection concentration and high quenching constant. Besides, like most MOFs, 3 can detect a trace quantity of Fe3+ and Cu2+ .- Published
- 2018
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33. A Highly Solvent-Stable Metal-Organic Framework Nanosheet: Morphology Control, Exfoliation, and Luminescent Property.
- Author
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Han LJ, Zheng D, Chen SG, Zheng HG, and Ma J
- Abstract
Compared to bulk metal-organic framework (MOF), 2D MOF nanosheets have gained intensive research attention due to their ultrathin thickness and large surface area with highly accessible active sites. However, structural deterioration and morphological damage have impeded producing high-quality MOF nanosheets during exfoliation. Here, first a new layered bulk MOF ZSB-1 is synthesized and several solvents such as isopropanol, methanol, n-hexyl alcohol, and N,N-dimethylformamide are surveyed to examine their performance for the exfoliation of layered ZSB-1. As a result, a highly solvent-stable metal-organic framework rectangular nanosheet retaining undamaged morphology is obtained by the soft-physical method in n-hexyl alcohol. Theoretical simulations reveal that the strong interaction energy between n-hexyl alcohol and MOF layers is responsible for the best exfoliation performance of making the bulk MOF into nanosheets. In addition, ZSB-1 shows a tunable fluorescence peak position, fluorescent lifetime, and quantum yield by simply changing the solvent and morphology. Besides, the ZSB-1 was selected as a fluorescence sensor to detect metal ions, and ZSB-1 nanosheet exhibits excellent sensing ability for Fe
3+ . It is worth noting that the ZSB-1 nanosheet has better detection limit performance of 0.054 × 10-6 m than that of its bulk counterpart., (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)- Published
- 2018
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34. Three Zn(ii)-based MOFs for luminescence sensing of Fe 3+ and Cr 2 O 7 2- ions.
- Author
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Xiao ZZ, Han LJ, Wang ZJ, and Zheng HG
- Abstract
Three zinc metal-organic frameworks (MOFs), {ZnL(chd)}
n (1), {[Zn(L)0.5 (oba)]·DMF·H2 O}n (2) and {[Zn(L)0.5 (sdb)]·H2 O}n (3) [L = E,E-2,5-dihexyloxy-1,4-bis-(2-pyridin-vinyl)-benzene; H2 chd = 1,4-cyclohexanedicarboxylic acid, H2 oba = 4,4'-oxybisbenzoic acid, H2 sdb = 4,4'-sulfonyldibenzoic acid], have been hydrothermally synthesized. We explored their applications in detecting ions, and the result shows that they all show highly selective sensing for Fe3+ and Cr2 O7 2- ions.- Published
- 2018
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35. A pair of 3D enantiotopic zinc(ii) complexes based on two asymmetric achiral ligands.
- Author
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Zhang MD, Li YL, Shi ZZ, Zheng HG, and Ma J
- Abstract
Enantiomorphism and enantioselectivity are critical in biology and many other applications. Herein, we report two 3D chiral MOFs {[Zn
6 (MIDPPA)3 (1,2,4-btc)3 (NO2 )3 (H2 O)3 ](H2 O)7 }n (1L and 1R) based on achiral ligands with high enantiomeric excess and a novel topological type. The internal mechanism of spontaneous chiral symmetry breaking, during the crystallization of chiral MOFs based on achiral ligands, is elucidated for the first time from both structural and theoretical aspects. Hydrogen bonds are found to play a key role in the spontaneous symmetry breaking of chiral MOFs. Also, DFT calculations support our findings from the aspects of total energies and HOMO-LUMO energy gaps. Both 1L and 1R, exhibiting green fluorescence, present a non-centrosymmetric polar packing arrangement, resulting in good ferroelectric behaviors and second-order nonlinear optical effects.- Published
- 2017
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36. Exploring the Detection of Metal Ions by Tailoring the Coordination Mode of V-Shaped Thienylpyridyl Ligand in Three MOFs.
- Author
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Han LJ, Yan W, Chen SG, Shi ZZ, and Zheng HG
- Abstract
By employing a rational design approach, we synthesized three luminescent metal-organic frameworks (MOFs) 1-3 affording different coordination modes of V-shaped thienylpyridyl ligand. Their application in detecting metal ions was explored, and the mechanism was inferred. And the result exhibits that MOF 3 is a dual-responsive luminescent probe for Fe
3+ and Al3+ ions.- Published
- 2017
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37. Cd-Based metal-organic frameworks from solvothermal reactions involving in situ aldimine condensation and the highly sensitive detection of Fe 3+ ions.
- Author
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Zhang X, Wang ZJ, Chen SG, Shi ZZ, Chen JX, and Zheng HG
- Abstract
Four Cd(ii)-based compounds (1-4) were synthesized from solvothermal reactions involving the in situ aldimine condensation of an o-diamino-functionalized precursor 3,6-di(4H-imidazol-4-yl)benzene-1,2-diamine (L), Cd(NO
3 )2 ·4H2 O and aldehyde. Two modes of cycloaddition ([4 + 1] cycloaddition and [4 + 2] cycloaddition) occurred during condensation, causing the in situ generation of two benzimidazole derivative ligands (L1 and L3) and a quinoxaline derivative ligand (L2). Furthermore, the chemical selectivity of the condensation was studied, where the condensation of o-diamino and the aldehyde is more stable and easy to operate. This strategy enriches the synthesis method of MOFs. Additionally, compound 2 containing uncoordinated quinoxaline N atoms showed excellent luminescent sensitivity for Fe3+ detection.- Published
- 2017
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38. A new five-coordinated copper compound for efficient degradation of methyl orange and Congo red in the absence of UV-visible radiation.
- Author
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Han LJ, Kong YJ, Yan TJ, Fan LT, Zhang Q, Zhao HJ, and Zheng HG
- Abstract
A new copper-based coordination compound Cu
2 (2,2'-bipy)2 (pfbz)4 (1) (where 2,2'-bipy = 2,2'-bipyridine; pfbz = pentafluorobenzoate), was hydrothermally synthesized and structurally characterized. Compound 1 having a binuclear structure consists of two copper cations and two oxygen atoms alternately in a plane square arrangement. In the presence of very small amounts of H2 O2 , the catalytic properties of compound 1 for the degradation of methyl orange (MO) are excellent in the absence of UV-visible radiation. Moreover, compound 1 presents suitable properties for degradation of Congo red (CR). Our results indicated that the five-coordinated copper compound, 1, will be a promising candidate for efficient degradation of organic dyes.- Published
- 2016
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39. H-Bonding Interactions Induced Two Isostructural Cd(II) Metal-Organic Frameworks Showing Different Selective Detection of Nitroaromatic Explosives.
- Author
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Wang ZJ, Qin L, Chen JX, and Zheng HG
- Abstract
Two luminescent Cd(II) metal-organic frameworks (MOFs) were prepared from electron-rich π-conjugated fluorescent ligands. They are isostructural with sql nets. Their strong luminescences can be quenched by a series of nitroaromatic explosives. Notably, MOF 1 shows highly selective and sensitive detection of 4-nitrophenol (4-NP), while MOF 2 exhibits good responses toward picric acid (PA) compared with other nitroaromatic explosives. This different order of quenching efficiency is because there are H-bonding interactions between MOF 1 and 4-NP, while MOF 2 lacks these H-bonding interactions. MOF 1 displays highly selective and sensitive detection of 4-NP with the high quenching constant (6.74× 10
4 M-1 ) and low detection limit (34.48 ppb), which is better than those of known MOFs. MOF 1 and MOF 2 have highly sensitive and selective detection of 4-NP and PA in the practical application, respectively.- Published
- 2016
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40. Diverse structures of metal-organic frameworks via a side chain adjustment: interpenetration and gas adsorption.
- Author
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Shen K, Qin L, and Zheng HG
- Abstract
Three new coordination polymers have been synthesized based on three linear pyridine ligands with different side chains and one flexible V-shaped dicarboxylate co-ligand: {[Co(L1)
0.5 (sdb)]}n (1), {[Co(L2)0.5 (sdb)]·1.5H2 O}n (2) and {[Co(L3)0.5 (sdb)]·2DMF}n (3) (L1 = E,E-2,5-dioctyloxy-1,4-bis-[2-pyridin-vinyl]-benzene; L2 = E,E-2,5-dibutoxy-1,4-bis-[2-pyridin-vinyl]-benzene; L3 = E,E-2,5-dimethoxy-1,4-bis-[2-pyridin-vinyl]-benzene; H2 sdb = 4,4'-sulfonyldibenzoic acid). Complexes 1-3 are 4-connected sql nets with a point symbol of {44 ·62 }. The interpenetration forms and porosity of frameworks have been well controlled by side chain prolongation. A larger steric hindrance for the pendant -On Oct and -On But groups leads to a larger repulsive force between the layers and effective construction of inclined polycatenations. A smaller steric hindrance for the pendant -Me group leads to the formation of a parallel stacked network. Therefore, compounds 1 and 2 feature 3D structures with inclined polycatenation (2D + 2D → 3D); compound 3 exhibits a non-interpenetrated 2D + 2D → 2D parallel stacked network. These complexes have been characterized by single crystal X-ray diffraction, infrared spectroscopy, thermogravimetry, elemental analysis, and powder X-ray diffraction measurements. In addition, the gas adsorption properties of the compounds have also been explored.- Published
- 2016
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41. Three Highly Stable Cobalt MOFs Based on "Y"-Shaped Carboxylic Acid: Synthesis and Absorption of Anionic Dyes.
- Author
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Yan W, Han LJ, Jia HL, Shen K, Wang T, and Zheng HG
- Abstract
Three Co(II) metal-organic frameworks (MOFs) were synthesized employing a rational design approach. On the basis of the different structures of three complexes, we tested their absorption properties toward two anionic dyes. The absorption results indicate that not only uncoordinated functional groups in the structure play an important role in adsorbing capacity but also physical forces can affect absorbing ability. Water stability testing shows that three crystals display high stability in aqueous solutions with different pH values. To our delight, the framework integrity of three complexes can be well-retained even after absorbing dyes.
- Published
- 2016
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42. An elderly patient with advanced lung cancer achieved long-term survival using Chinese medicine: An alternative treatment strategy for cancer patients aged 80 or older without a tissue confirmed diagnosis.
- Author
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Liu R, He SL, Hirasaki Y, Zheng HG, and Hua BJ
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Lung Neoplasms diagnostic imaging, Neoplasm Staging, Radiography, Thoracic, Survival Analysis, Tumor Burden, Complementary Therapies, Drugs, Chinese Herbal therapeutic use, Lung Neoplasms diagnosis, Lung Neoplasms drug therapy
- Published
- 2016
- Full Text
- View/download PDF
43. Heterogeneity of Monosymptomatic Resting Tremor in a Prospective Study: Clinical Features, Electrophysiological Test, and Dopamine Transporter Positron Emission Tomography.
- Author
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Zheng HG, Zhang R, Li X, Li FF, Wang YC, Wang XM, Lu LL, and Feng T
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Parkinson Disease diagnosis, Prospective Studies, Dopamine Plasma Membrane Transport Proteins, Positron-Emission Tomography methods, Tremor diagnosis
- Abstract
Background: The relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD) remains controversial. In this study, we aimed to assess the function of presynaptic dopaminergic neurons in patients with mRT by dopamine transporter positron emission tomography (DAT-PET) and to evaluate the utility of clinical features or electrophysiological studies in differential diagnosis., Methods: Thirty-three consecutive patients with mRT were enrolled prospectively. The Unified Parkinson's Disease Rating Scale and electromyography were tested before DAT-PET. Striatal asymmetry index (SAI) was calculated, and a normal DAT-PET was defined as a SAI of <15%. Scans without evidence of dopaminergic deficits (SWEDDs) were diagnosed in patients with a subsequent normal DAT-PET and structural magnetic resonance imaging., Results: Twenty-eight mRT patients with a significant reduction in uptake of DAT binding in the striatum were diagnosed with PD, while the remained 5 with a normal DAT-PET scan were SWEDDs. As for UPRDS, the dressing and hygiene score, walking in motor experiences of daily living (Part II) and motor examination (Part III) were significant different between two groups (P < 0.05 and P < 0.01, respectively). Bilateral tremor was more frequent in the SWEDDs group (P < 0.05). The frequency of resting tremor and the amplitude of postural tremor tend to be higher in the SWEDDs group (P = 0.08 and P = 0.05, respectively)., Conclusions: mRT is heterogeneous in presynaptic nigrostriatal dopaminergic degeneration, which can be determined by DAT-PET brain imaging. Clinical and electrophysiological features may provide clues to distinguish PD from SWEDDs.
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- 2015
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44. REPAIR EFFECTS OF UMBILICAL CORD MESENCHYMAL STEM CELLS ON PODOCYTE DAMAGE OF IgA NEPHROPATHY.
- Author
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Zhang DW, Qiu H, Mei YM, Fu H, and Zheng HG
- Subjects
- Allografts, Animals, Cattle, Mesenchymal Stem Cells cytology, Mice, Umbilical Cord cytology, Glomerulonephritis, IGA metabolism, Glomerulonephritis, IGA therapy, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells metabolism, Podocytes metabolism, Umbilical Cord metabolism
- Abstract
This study aimed to explore the influence of umbilical cord mesenchymal stem cells (UMSC) on stem cell homing and glomerular mesangial cell (GMC) after intravenous injection performed on mice tails with IgA nephropathy (IgAN) and its possible mechanism, which provide a new way and theoretical basis for the application of stem cell transplantation (SCT) in kidney disease treatment. Specific pathogen free (SPF) male Kunming mice were randomly divided into groups. A complex method applying bovine serum albumin (BSA) gavage, hypodermic injection of CCl4 and lipopolysaccharide (LPS) was used for building IgAN mice model. In addition, vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF) and cluster of differentiation (CD) 44 were observed by Masson staining and detected with immunohistochemistry (IHC) to confirm homing and location of mesenchymal stem cells (MSCs). Moreover, Western Blot was used for detecting VEGF and CTGF so as to explore the possible mechanism of applying UMSC in treating IgAN. Masson staining indicated that fibrosis degree of MSCs in treatment group was significantly lower than in negative control group after stem cell treatment. Routine urine test explained that proteinuria in treatment group were (7.15±0.31), (4.87±0.22), (2.95±0.16) g/24 h and (12.00±1.38) g/24 h in model group (P less than 0.05). MSCs were observed to be located in glomerulus and renal interstitium by IHC detection of CD44 and IHC qualitative observation of VEGF and CTGF had different positive expressions in three groups. Furthermore, different expressions of VEGF and CTGF were observed quantitatively by Western Blot. Fibrosis degree of renal tissue relieves, hematuresis and proteinuria eases and IgAN symptoms obviously improve after UMSC treatment, which hints that the treatment of HUMSC has protective effect on IgAN mice model.
- Published
- 2015
45. Three different metal-organic frameworks derived from a one-pot crystallization and their controllable synthesis.
- Author
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Zhang CL, Li YL, Wang T, Ju ZM, Zheng HG, and Ma J
- Abstract
Three different Co-MOFs, [Co3(L)2(DPDP)]n (1), [Co(HL)(DPDP)]n (2) and {[Co(HL)(1/2DPDP)3(H2O)]·H2O}n (3) (H3L = 4,4',4''-(nitrilotris(methylene))tribenzoic acid, DPDP = 4,4'-(2,5-dibutoxy-1,4-phenylene)dipyridine) have been co-crystallized in a one-pot reaction. Based on the significant differences between the three structures, we adopt solvents to ultimately regulate acquisition of pure crystals of the three compounds.
- Published
- 2015
- Full Text
- View/download PDF
46. Two luminescent Zn(II) metal-organic frameworks for exceptionally selective detection of picric acid explosives.
- Author
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Shi ZQ, Guo ZJ, and Zheng HG
- Abstract
Two luminescent Zn(II) metal-organic frameworks were prepared from a π-conjugated thiophene-containing carboxylic acid ligand. These two MOFs show strong luminescene and their luminescence could be quenched by a series of nitroaromatic explosives. Importantly, they exhibit very highly sensitive and selective detection of picric acid compared to other nitroaromatic explosives.
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- 2015
- Full Text
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47. Chiral crystallization and optical properties of three metal complexes based on two non-centrosymmetric tripodal ligands.
- Author
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Zhang MD, Shi ZQ, Chen MD, and Zheng HG
- Abstract
Chiral coordination polymers have attracted much attention due to their special properties and significant applications. In this work, we synthesized two non-centrosymmetric ligands, N,N-bis(4-(1H-imidazol-1-yl)phenyl)-4-(pyridin-4-yl)aniline (DIMPPA) and N-(4-(1H-imidazol-1-yl)phenyl)-4-(pyridin-4-yl)-N-(4-(pyridin-4-yl)phenyl)aniline (MIDPPA), via structural modification of two reported centrosymmetric ligands; after that achiral → chiral induction occurred in the construction of three coordination polymers namely {[Cd(DIMPPA)(5-OH-bdc)](H2O)}n (1), {[Co(DIMPPA)(5-OH-bdc)](H2O)}n (2) and {[Cd2(MIDPPA)2(D-ca)2(H2O)2](H2O)5}n (3), when replacing the reported centrosymmetric ligands with non-centrosymmetric ligands (5-OH-H2bdc = 5-hydroxyisophthalic acid, D-H2ca = D-camphoric acid). Isostructural complexes 1 and 2 exhibit chiral 2D → 3D frameworks with the coexistence of polyrotaxane and parallel polycatenation features. Complex 3 shows two-fold interpenetrating 3D chiral architecture with cds-type topology. The luminescence emissions of both complexes 1 and 3 are mostly assignable to the internal π→π* electron transition in DIMPPA and MIDPPA, respectively. Complex 3 can satisfy the fundamental requirement of second-order nonlinear optical materials.
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- 2015
- Full Text
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48. Assembly of various degrees of interpenetration of Co-MOFs based on mononuclear or dinuclear cluster units: magnetic properties and gas adsorption.
- Author
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Zheng MX, Gao XJ, Zhang CL, Qin L, and Zheng HG
- Abstract
Three new Co-based MOFs with a nanosized tetradentate pyridine ligand, N,N,N′,N′-tetrakis(4-(4-pyridine)-phenyl) biphenyl-4,4′-diamine (TPPBDA) and carboxylate co-ligands, [Co(TPPBDA)(NO3)2]n·2H2O (1), [Co2(TPPBDA)(bpdc)2 (H2O)]n·2DMA (2) and [Co(TPPBDA)0.5(hfipbb)(H2O)]n·3.5H2O (3) (H2bpdc = biphenyldicarboxylic acid, H2hfipbb = 4,4′-(hexafluoroisopropylidene)bis-(benzoic acid), DMA = N,N-dimethylacetamide) have been synthesized under hydrothermal conditions. For complex 1, a large cavity causes a 4-fold interpenetration of the network, which can be classified as a type IIIa mode of interpenetration. Complex 2 reveals a non-interpenetrating three-dimensional (3D) framework based on the [Co2(μ2-H2O)(CO2)2] unit. Complex 3 is also a 2-fold interpenetrating 3D net based on the [Co2(CO2)2] cluster. These mononuclear or dinuclear cluster units are interconnected by TPPBDA and carboxylate co-ligands, resulting in interesting structural diversities and various degrees of interpenetration.
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- 2015
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49. Diverse structures of metal-organic frameworks based on different metal ions: luminescence and gas adsorption properties.
- Author
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Zhang CL, Qin L, Shi ZZ, and Zheng HG
- Abstract
Four coordination polymers with different metal ions have been synthesized based on a rigid linear pyridine and a flexible V-shaped dicarboxylate ligand (L = 4,4'-(2,5-dimethoxy-1,4-phenylene)dipyridine; H2OBA = 4,4'-oxydibenzoic acid): {[Co(L)(OBA)]·2H2O}n (1), [Zn(L)(OBA)·2H2O]n (2), {[Ni(L)(OBA)]·DMF·H2O}n (3), [Cd(L)(OBA)]·DMF·H2O}n (4). The reaction conditions are similar except for the metal ions for complexes 1-4. Complexes 1 and 2 present a 3D unprecedented hxg-d-4-Cccm net, but 3 and 4 are 4-connected sql nets with a point symbol {4(4)·6(2)}. These complexes were characterized by single crystal X-ray diffraction, infrared spectroscopy, thermogravimetry, elemental analysis, and powder X-ray diffraction measurements. The UV-visible spectra, fluorescence, and gas adsorption properties of the compounds were also explored.
- Published
- 2015
- Full Text
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50. A rare three-coordinated zinc cluster-organic framework with two types of secondary building units.
- Author
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Hu JS, Zhang L, Qin L, Zheng HG, and Zhang XB
- Abstract
A rare chiral 3D cluster-organic framework {[Zn17O5(NTB)6(NDB)3]·41H2O}n () (H3NTB = 4,4',4''-nitrilotrisbenzoic acid and H2NDB = 4,4'-nitrilodibenzoic acid) was prepared and structurally characterized. Complex contains two types of [Zn4(μ4-O)(COO)6] and unreported [Zn9(μ3-O)3(COO)12] SBUs, which link bi- and tri-carboxylic acids and extend to an unprecedented (3,6,12)-connected framework. In addition, electronic structure calculations were performed to scrutinize the features of embedded clusters.
- Published
- 2015
- Full Text
- View/download PDF
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