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278 results on '"Zheng Xiaolan"'

14. Sensemaking, institutions and crises of legitimacy : the case of Nike's sweatshop

Author

Zheng, Xiaolan

Subjects
338.0068, HD Industries. Land use. Labor
Abstract

The aim of this study is to explore the phenomenon of the legitimacy crisis. This is a variant of organizational crises which, although increasingly common and managerially relevant, is still under-explored. A legitimacy crisis signals a problematic relationship between the focal organization and its socio-institutional environment which calls for repairing of meaning. Having considered this, the study has developed a theoretical framework that integrates the sensemaking and institutional perspectives to investigate this phenomenon. To operationalize this theoretical framework, I have conducted a single longitudinal case study featuring Nike in the 1990s' sweatshop controversy, using a narrative approach and documenting the narrative unfolding of the crisis as the unit of analysis. An extensive collection of publicly accessible archival data constituted the bulk of the data base. By means of this framework, the research provides rounded understanding of the causes of legitimacy crises, their unfolding patterns, and organizations' responses to them. Moreover, this theoretical integration also contributes to narrowing the gap between the sensemaking and institutional theories. The findings highlight that rational myths serve as sensegiving mechanisms for social actors, and that their effects penetrate the interplay between frameworks and meanings in sensemaking processes, as well as operating throughout the process of organizational restructuring in the context of a legitimacy crisis. Moreover, this study identifies that improving the efficiency of sensemaking, and thereby improving meaning management, is the key to resolving a legitimacy crisis. This should be achieved through the modification and elaboration of interpretation frameworks. In particular, this study highlights the effects of organizational structuring in facilitating both internal and external communication during a legitimacy crisis, thereby contributing to the improved management of the unfolding crisis and to resolution of the crisis.

Published
2010

19. Construction of a risk prediction model for non-variceal upper gastrointestinal bleeding and rebleeding based on multi-dimensional indicators and its application research

Author

Li, Xiaoxia, Zheng, Xiaolan, Wang, Yuanyuan, Shao, Lihua, Xiao, Yan, and Lv, Xiaohong

Subjects
Original Article
Abstract

Objective: To construct a predictive model for the risk of rebleeding in non-variceal upper gastrointestinal bleeding (NVUGIB) based on multidimensional indicators to provide an assessment tool for early screening of rebleeding in NVUGIB. Methods: Retrospective analysis of the 3-month follow-up data of 85 patients with NVUGIB diagnosed at the Fifth Hospital of Wuhan from January 2019 to December 2021 who were discharged from the hospital after medical treatment. Patients were divided into a rebleeding group (n=45) and a non-rebleeding group (n=95) based on whether they rebleed during follow-up. The demographic characteristics, clinical characteristics and biochemical indicators of the two groups were compared. A multivariate logistic regression was used to analyze the influencing factors of NVUGIB rebleeding. A nomograph model was built using the screening results. The area under the working characteristic curve of the subject (AUC) was used to analyze the model differentiation, evaluate the model specificity and sensitivity, and verify the prediction performance of the model with the validation set. Results: There were significant differences in age, hematemesis, red blood cell count (RBC), platelet (PLT), albumin (Alb), prothrombin time (PT), TT, fibrinogen (Fib), plasma D-dimer (D-D), and blood lactate (LAC) levels between the two groups (all P0.5 mg/L were associated with greater risk of rebleeding. The nomogram model was constructed based on the above four indicators. The AUC of the training set (n=98) for predicting the risk of NVUGIB rebleeding was 0.887 (95% CI: 0.812-0.962), the specificity was 0.882, and the sensitivity was 0.833. The AUC of the validation set (n=42) was 0.881 (95% CI: 0.777-0.986), the specificity was 0.815, and the sensitivity was 0.867. After 500 times of sampling by bootstrap method, the mean absolute error of the calibration curve of the validation set model was 0.031, indicating that the calibration curve and the ideal curve fit well, and the predicted value of the model was in good agreement with the actual value. Conclusion: Age ≥75, hematemesis >5 times, lower PLT, and higher D-D levels rise the risk of rebleeding in NVUGIB patients and have some reference value in clinical diagnosis and disease assessment.

Published
2023

24. Board Reforms and Dividend Policy: International Evidence.

Author

Bae, Kee-Hong, El Ghoul, Sadok, Guedhami, Omrane, and Zheng, Xiaolan

Subjects
DIVIDEND policy, CORPORATE reform, BOARDS of directors, DIVIDENDS, STOCKHOLDERS
Abstract

We study the impact of board reforms implemented in 40 countries worldwide on corporate dividend policy. Using a difference-in-differences analysis, we find that firms pay higher dividends following the reforms. The increase in dividend payouts is more pronounced for firms with weak board governance in the pre-reform period and those in countries with strong external governance mechanisms. Our findings corroborate the dividend outcome model, which postulates that board reforms strengthen the monitoring role of the board and empower outside shareholders to force management to disgorge dividends. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Optimization of a Series of Novel, Potent and Selective Macrocyclic SYK Inhibitors

Author

Grimster, Neil Patrick, primary, Gingipalli, Lakshmaiah, additional, Balazs, Amber, additional, Barlaam, Bernard, additional, Boiko, Scott, additional, Boyd, Scott, additional, Dry, Hannah, additional, Goldberg, Frederick W., additional, Ikeda, Tim, additional, Johnson, Tony, additional, Kawatkar, Sameer, additional, Kemmitt, Paul, additional, Lamont, Scott, additional, Lorthioir, Olivier, additional, Mfuh, Adelphe, additional, Patel, Joe, additional, Pike, Andy, additional, Read, Jon, additional, Romero, Romulo, additional, Sarkar, Ujjal, additional, Sha, Li, additional, Simpson, Iain, additional, Song, Kun, additional, Su, Qibin, additional, Wang, Haixia, additional, Watson, David, additional, Wu, Allan, additional, Zehnder, Troy E., additional, Zheng, XiaoLan, additional, Li, Shaolu, additional, Dong, Zhiqiang, additional, Yang, Dejian, additional, Song, Yanwei, additional, Wang, Peng, additional, Liu, Xuemei, additional, Dowling, James E., additional, and Edmondson, Scott D., additional

Published
2023
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29. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Author

Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., and Hird, Alexander W.

Published
2018
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31. Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors

Author

Grimster, Neil P., Gingipalli, Lakshmaiah, Balazs, Amber, Barlaam, Bernard, Boiko, Scott, Boyd, Scott, Dry, Hannah, Goldberg, Frederick W., Ikeda, Tim, Johnson, Tony, Kawatkar, Sameer, Kemmitt, Paul, Lamont, Scott, Lorthioir, Olivier, Mfuh, Adelphe, Patel, Joe, Pike, Andy, Read, Jon, Romero, Romulo, Sarkar, Ujjal, Sha, Li, Simpson, Iain, Song, Kun, Su, Qibin, Wang, Haixia, Watson, David, Wu, Allan, Zehnder, Troy E., Zheng, XiaoLan, Li, Shaolu, Dong, Zhiqiang, Yang, Dejian, Song, Yanwei, Wang, Peng, Liu, Xuemei, Dowling, James E., and Edmondson, Scott D.

Published
2023
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33. AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

Author

Keeton, Erika K., McEachern, Kristen, Dillman, Keith S., Palakurthi, Sangeetha, Cao, Yichen, Grondine, Michael R., Kaur, Surinder, Wang, Suping, Chen, Yuching, Wu, Allan, Shen, Minhui, Gibbons, Francis D., Lamb, Michelle L., Zheng, Xiaolan, Stone, Richard M., DeAngelo, Daniel J., Platanias, Leonidas C., Dakin, Les A., Chen, Huawei, Lyne, Paul D., and Huszar, Dennis

Published
2014
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34. Abstract 5076: Evaluation of the CNS penetration of a next generation PARP inhibitor, AZD9574, in cynomolgus monkey using positron emission tomography

Author

Pike, Andy, primary, Balazs, Amber, additional, Cselényi, Zsolt, additional, Degorce, Sébastien L., additional, Ghosh, Avipsa, additional, Hande, Sudhir M., additional, Johannes, Jeffrey, additional, Johnström, Peter, additional, Packer, Martin J., additional, Schou, Magnus, additional, and Zheng, XiaoLan, additional

Published
2022
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41. Protective efficient comparisons among all kinds of respirators and masks for health-care workers against respiratory viruses

Author

Li, Jiawen, Qiu, Yu, Zhang, Yulin, Gong, Xue, He, Yunru, Yue, Peng, Zheng, Xiaolan, Liu, Lei, Liao, Hongyu, Zhou, Kaiyu, Hua, Yimin, and Li, Yifei

Subjects
medical mask, Infection Control, N95 Respirators, Health Personnel, Network Meta-Analysis, Masks, N95 respirator, betacoronavirus, health care workers, Betacoronavirus, Influenza A Virus, H1N1 Subtype, Virus Diseases, Influenza, Human, Humans, Coronavirus Infections, Respiratory Tract Infections, Systematic Review and Meta-Analysis, Research Article
Abstract

Background: There is no definite conclusion about comparison of better effectiveness between N95 respirators and medical masks in preventing health-care workers (HCWs) from respiratory infectious diseases, so that conflicting results and recommendations regarding the protective effects may cause difficulties for selection and compliance of respiratory personal protective equipment use for HCWs, especially facing with pandemics of corona virus disease 2019. Methods: We systematically searched MEDLINE, Embase, PubMed, China National Knowledge Infrastructure, Wanfang, medRxiv, and Google Scholar from initiation to November 10, 2020 for randomized controlled trials, case-control studies, cohort studies, and cross-sectional studies that reported protective effects of masks or respirators for HCWs against respiratory infectious diseases. We gathered data and pooled differences in protective effects according to different types of masks, pathogens, occupations, concurrent measures, and clinical settings. The study protocol is registered with PROSPERO (registration number: 42020173279). Results: We identified 4165 articles, reviewed the full text of 66 articles selected by abstracts. Six randomized clinical trials and 26 observational studies were included finally. By 2 separate conventional meta-analyses of randomized clinical trials of common respiratory viruses and observational studies of pandemic H1N1, pooled effects show no significant difference between N95 respirators and medical masks against common respiratory viruses for laboratory-confirmed respiratory virus infection (risk ratio 0.99, 95% confidence interval [CI] 0.86–1.13, I2 = 0.0%), clinical respiratory illness (risk ratio 0.89, 95% CI 0.45–1.09, I2 = 83.7%, P = .002), influenza-like illness (risk ratio 0.75, 95% CI 0.54–1.05, I2 = 0.0%), and pandemic H1N1 for laboratory-confirmed respiratory virus infection (odds ratio 0.92, 95% CI 0.49–1.70, I2 = 0.0%, P = .967). But by network meta-analysis, N95 respirators has a significantly stronger protection for HCWs from betacoronaviruses of severe acute respiratory syndrome, middle east respiratory syndrome, and corona virus disease 2019 (odds ratio 0.43, 95% CI 0.20–0.94). Conclusions: Our results provide moderate and very-low quality evidence of no significant difference between N95 respirators and medical masks for common respiratory viruses and pandemic H1N1, respectively. And we found low quality evidence that N95 respirators had a stronger protective effectiveness for HCWs against betacoronaviruses causative diseases compared to medical masks. The evidence of comparison between N95 respirators and medical masks for corona virus disease 2019 is open to question and needs further study.

Published
2021

42. Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Author

Johannes, Jeffrey W., primary, Balazs, Amber, additional, Barratt, Derek, additional, Bista, Michal, additional, Chuba, Matthew D., additional, Cosulich, Sabina, additional, Critchlow, Susan E., additional, Degorce, Sébastien L., additional, Di Fruscia, Paolo, additional, Edmondson, Scott D., additional, Embrey, Kevin, additional, Fawell, Stephen, additional, Ghosh, Avipsa, additional, Gill, Sonja J., additional, Gunnarsson, Anders, additional, Hande, Sudhir M., additional, Heightman, Tom D., additional, Hemsley, Paul, additional, Illuzzi, Giuditta, additional, Lane, Jordan, additional, Larner, Carrie, additional, Leo, Elisabetta, additional, Liu, Lina, additional, Madin, Andrew, additional, Martin, Scott, additional, McWilliams, Lisa, additional, O’Connor, Mark J., additional, Orme, Jonathan P., additional, Pachl, Fiona, additional, Packer, Martin J., additional, Pei, Xiaohui, additional, Pike, Andrew, additional, Schimpl, Marianne, additional, She, Hongyao, additional, Staniszewska, Anna D., additional, Talbot, Verity, additional, Underwood, Elizabeth, additional, Varnes, Jeffrey G., additional, Xue, Lin, additional, Yao, Tieguang, additional, Zhang, Ke, additional, Zhang, Andrew X., additional, and Zheng, Xiaolan, additional

Published
2021
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43. Abstract 296: Structure-based and property-based drug design of AZD5305, a highly selective PARP1 inhibitor and trapper

Author

Hande, Sudhir, primary, Balazs, Amber, additional, Degorce, Sébastien L., additional, Embrey, Kevin, additional, Ghosh, Avipsa, additional, Gill, Sonja J., additional, Gunnarsson, Anders, additional, Illuzzi, Giuditta, additional, Lane, Jordan, additional, Larner, Carrie, additional, Leo, Elisabetta, additional, Madin, Andrew, additional, McWilliams, Lisa, additional, O'Connor, Mark J., additional, Orme, Jonathan, additional, Pachl, Fiona, additional, Packer, Martin, additional, Pike, Andy, additional, Rawlins, Philip, additional, Schimpl, Marianne, additional, Staniszewska, Anna D., additional, Zhang, Andrew, additional, Zheng, Xiaolan, additional, and Johannes, Jeffrey W., additional

Published
2021
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44. Optimization of a series of potent, selective and orally bioavailable SYK inhibitors

Author

Grimster, Neil P., Gingipalli, Lakshmaiah, Barlaam, Bernard, Su, Qibin, Zheng, XiaoLan, Watson, David, Wang, Haixia, Simpson, Iain, Pike, Andy, Balazs, Amber, Boiko, Scott, Ikeda, Timothy P., Impastato, Anna C., Jones, Natalie H., Kawatkar, Sameer, Kemmitt, Paul, Lamont, Scott, Patel, Joe, Read, Jon, Sarkar, Ujjal, Sha, Li, Tomlinson, Ronald C., Wang, Haiyun, Wilson, David M., Zehnder, Troy E., Wang, Lianghe, Wang, Peng, Goldberg, Frederick W., Shao, Wenlin, Fawell, Stephen, Dry, Hannah, Dowling, James E., and Edmondson, Scott D.

Published
2020
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