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We developed a novel strategy whereby Hg2+ induces a supramolecular polymer network to form fluorescent nanoparticles (NPs) in situ. This strategy was successfully applied in efficiently sensing Hg2+ in living cells and separating Hg2+ from water.

The direct C(sp3)–H functionalization is one of the major research topics in synthetic chemistry since C(sp3)–H bonds are ubiquitous in every aspect of chemistry. Despite impressive advances in transition-metal-catalyzed C(sp3)–H activation, the radical-initiated process via hydrogen atom abstraction (HAA) of C(sp3)–H bonds represents a more appealing strategy owing to the mild reaction conditions and good regioselectivity. Given the importance of alkynes as versatile synthons in organic synthesis and key structural motifs in drug discovery, great efforts have been made toward their synthesis via the combination of HAA and alkynylation process in recent years. This review summarizes the recent progress in radical-initiated C(sp3)–H alkynylation reactions with emphasis on the alkynylating reagents and mechanistic discussion.1 Introduction2 Alkynylation of C(sp3)–H via Intermolecular Hydrogen Atom Abstraction3 Alkynylation of C(sp3)–H via Intramolecular Hydrogen Atom Abstraction4 Conclusion

Paramesotriton aurantius (Caudata: Salamandridae) is a new species that found in southeastern China. Its complete mitochondrial genome (mitogenome) sequence was 16,313 bp in length with with A + T contents of 60.9%, and contained 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, one control region (D-loop), and one non-coding region. Our molecular tree showed that P. aurantius was positioned near P. hongkongensis, and formed a clade with other Paramesotriton species. The first complete mitogenome sequence of P. aurantius could provided fundamental data for resolving phylogenetic and genetic problems related to genus Paramesotriton.

We constructed the evaluation index system of the transport scheme based on the influencing factors of large-scale highway transport to save cost and improve the decision-making process of a large-scale transport scheme. The scheme considered safety, technical, economic, and timeliness factors. Moreover, we used the analytic hierarchy process-grey (AHP-grey) correlation degree method to optimize the transport scheme. The method adopted AHP to determine index weight, used benefit and cost index normalization to change the decision-making matrix into a relative membership degree matrix, and chose the scheme according to grey correlation degree between the best scheme and alternatives. The methods provided an effective solution for multi-index quantitative analysis of the transport scheme. The objectivity and effectiveness of the method was validated using an example.

The detection and treatment of cancer is a very important and challenging subject. Herein, the conception of aggregation-induced emission (AIE) is introduced into the design of anticancer drugs. A novel nitrogen mustard functionalized tripodal AIE anticancer prodrug (TM) was designed and synthesized. Interestingly, the TM had strong fluorescent in DMSO/H2O (water fraction 50%) binary solution. The fluorescence experiments showed that TM could enter the nucleus and cytoplasm of HepG2 cells. The TM could be used for both fluorescent imaging and killing cancer cells. The in vitro cytotoxicity of TM was about 3.2 fold than that of the free nitrogen mustard against HepG2 cells. This related to the unique design improved the effective content of nitrogen mustard drugs. The design that introduced AIE into anticancer drugs provides a effective approach to the detection and treatment of cancer.

This paper mainly describes an iot gateway which has broad access capability of making the integrated communications among heterogeneous networks to be possible.The capability described above can set up multi-threaded execution,so that it can read,segment,extract,recombine,establish Socket and transmit the data which are collected by heterogeneous WSN to the serve through the way of the UDP transport protocol.And then realizing the perception of heterogeneous sensor network data terminal broad access, integration, processing, transmission, and finally realizing the perception network and transmission network connectivity.This paper will use this experimental method to show the final fusion of Intelligent transportation project in the induction system and the parking system.

As China's major grain producing areas of Jiangxi Province, in recent years, food production has stabilized at about 400 billion pounds since 2004 to maintain grain quality in the redeployment of more than 100 billion kilograms. Team depth of grain production counties in Jiangxi Province (district), the organization of agricultural cooperatives, agricultural enterprises, grain cooperatives, grassroots cadres and ordinary FAO held a forum to listen to the opinions and suggestions, and to gain first-hand information on the household survey. Through research benefiting the agriculture policy Jiangxi grain cooperatives affect the costs and benefits to help pinpoint stabilize grain production, increase grain production capacity to ensure food security direction.

In recent years, new personal and home hold Consumer Electronic Devices (CEDs) areemerging rapidly, such as smart phones, panel computers, and electronic vehicles. All of these CEDsare surely convenient for our daily lives, but users usually have a common feeling on the CEDs: thebattery cannot support the CEDS for long time working, which require charging the batteries withinonly several hours. Considering this urgent issue, this paper presented a solar battery structure with abigger capacity for consumer electronic devices. This battery consisted of four parts: solar panel part,energy management part, energy storage part and DC/DC converter part. Especially, a super-capacitorwas performed as the energy storage part, which was based on transmission line model. A simplesimulation was done for evaluating the performances of the proposed structure. The simulation resultsindicated that, the proposed battery structure had a bigger capacity and higher output power, whichwas more suitable for CEDs.

Totally 96 elderly patients with spleen-kidney Yang deficiency type hypertension were selected in this study. Patients were randomly divided into study and control group. It was treated with the Jingui Shenqi pill combined nifedipine sustained-release tablets in the study group and only nifedipine sustained-release tablets for the control group. Meanwhile, the clinical features including reducing blood pressure, blood lipid and traditional Chinese medicine (TCM) syndromes of the two groups were observed pre and post treatment. Finally, the results showed that it could significantly reduce the hypertensive, hyperlipidemia and TCM syndromes in the study group compared with the control group (P0.05), which indicated that the combination of the Jingui Shenqi pill with nifedipine sustained-release tablets was effective for the patients with hypertension with spleen-kidney Yang deficiency type, especially for decreasing TCM syndromes and the blood lipid.

Because of the situation that the disc cutter bearing seriously damaged in the cutting process, disc cutter structural parameters is optimized which mainly affect the force on the bearing. The disc cutter cutting edge angle, cutting edge width, transition arc radius and caulking ring width between the bearings are taken as design variables, and the minimum equivalent load on the bearing as the target, the optimization model is established. Genetic Algorithm (GA) is used in the mathematical model.Finally, the optimized results indicate that the equivalent load on the bearing reduces 21% compared with the actual structural parameters. So the optimization results effectively reduce the force on the bearing and extend the life cycle of disc cutter.

The clinical significance of palliative interventional therapy in the management of patients with advanced hilar cholangiocarcinoma (HCCA; stages III–IV) has yet to be studied. The present work was aimed to compare the clinical outcomes of the patients treated with surgery or interventional

Two novel interpenetrated coordination polymers, [Zn(IBA)2]n (1) and {[Cd(IBA)2(H2O)]·4H2O}n (2), have been synthesized by using 4-imidazole-benzoic acid (HIBA) as ligand under hydrothermal conditions. Complex 1 crystallizes in a chiral space group and has a two-fold interpenetrated 2D network structure with (4,4) topology, while complex 2 is a 3D porous dia network with four nets interpenetrating each other. The SHG activity of 1 and the photoluminescent property of 2 have been investigated.

Seven new metal−organic frameworks (MOFs) [Cu(bib)2(H2O)2](Cl3CCOO)2·2MeOH·2H2O (1), [Cu(bib)2]Cl2·H2O (2), [Cu(bib)2(SO4)(H2O)]·4H2O (3), [Cu(bib)(SO4)(H2O)2] (4), [Cu(bib)(N3)(OAc)]·DMF (5) (OAc = acetate), [Cu(bib)(ox)]·MeOH·2H2O (6) (ox = oxalate), and [Cu(bib)(mal)]·MeOH (7) (mal = malonate) were obtained by reactions of flexible bidentate ligand 1-bromo-3,5-bis(imidazol-1-ylmethyl)benzene (bib) with corresponding copper(II) salts. The structures of these MOFs were established by single-crystal X-ray diffraction analysis. Complexes 1 and 2 have similar one-dimensional (1D) hinged chain structure. Complex 3 has a 2D network structure with (4,4) topology. Complex 4 has M2L2 metallocyclic ring structure and the rings are further linked by the sulfate anions to form a 1D tube-like chain. Complex 5 is also a dinuclear M2L2 metallocyclic ring, which is further connected by Br···Br interactions to form 1D chain. While in the cases of complexes 6 and 7, both have 2D network structure in which the oxalate and...

Three complexes [Co(L4)(DMF)(H2O)(NO3)]NO3· DMF·0.5H2O (1), [Co(L4)2(SCN)2]·4CH3OH·H2O (2) and [Cd(L4)(bipy)(H2O)2](ClO4)2·4H2O (3) (DMF = N, N-dimethylformamide, bipy = 4,4′-bipyridine) were synthesized by reactions of ligand 1,3,5-tris(4-pyridylmethoxyl)benzene (L4) with the corresponding metal salts and their structures were determined by X-ray single-crystal structure analysis. Complex 1 crystallizes in monoclinic space group C2/c with cell parameters a = 26.200(9) A, b = 17.465(5) A, c = 17.275(5) A, β = 118.183(10)°, V = 6968(4) A3, Z = 8, while complexes 2 and 3 crystallize in triclinic space group with different cell parameters, complex 2:a = 9.3077(7) A, b = 14.7251(7) A, c = 21.4745(13) A, α = 70.380(4)°, β = 83.161(4)°, γ = 82.350(4)°, V = 2738.9(3) A3, Z = 2; complex 3: a = 9.797(6) A, b = 11.807(6) A, c = 13.970(11) A, α = 88.03(6)°, β = 88.77(6)°, γ = 74.53(5)°, V = 1556.4(17) A3, Z = 1. In complexes 1, 2 and 3, all the metal atoms adopt distorted octahedral coordination, however, the ligand L4 have different coordination modes. In complex 1, the ligand acts as a three-connected node to coordinate with three CoII atoms, and generate a doubly interpenetrated (10, 3)-b three-dimensional framework. In complex 2, each ligand L4 uses two of three arms to link two CoII atoms to form an infinite one-dimensional hinged chain structure, while in complex 3, the L4 only serves as a terminal monodentate ligand.

Three metal-organic frameworks (MOFs) [La(bta)(H2O)]n (1), [La(bta)(H2O)2·H2O]n (2) and [Er(bta)(H2O)2·H2O]n (3) with different structures were synthesized by reactions of 1,3,5-benzenetriacetic acid (H3bta) with the corresponding lanthanide salts under different conditions. X-ray diffraction analyses reveal that complexes 1 and 2 have the same metal atom and ligand but different structures. In 1, each bta3 − adopts cis, cis, cis conformation and acts as a μ6-bridge linking six lanthanum atoms to form a 2D framework; while in 2, the bta3 − has cis, trans, trans conformation and serves as a μ5-bridging ligand, which results in a 3D channel-like structure. In the case of 3, each bta3 − also adopts cis, trans, trans conformation but acts as a μ4-bridge linking four erbium atoms to form a 3D channel-like framework. The results imply that the reaction conditions have great impact on the structure of MOFs, and the flexible triacid ligand H3bta is versatile and can adopt different conformations in the formati...

Three novel metal-organic architectures, [Ag3(bta)].1.5H2O (1), [Cd3(bta)2(H2O)7].5H2O (2), and [Cu11(bta)6(Hbta)2(H2O)10].29H2O (3), were obtained by reactions of the corresponding metal salts with a flexible tripodal ligand, benzene-1,3,5-triacetic acid (H3bta), and their structures were determined by single-crystal X-ray diffraction studies. The results revealed that, in complexes 1 and 2, the carboxylate groups of the bta3- ligand adopted varied coordination modes to link metal atoms and further to form three-dimensional structures with open channels occupied by water molecules, while in complex 3, for the first time, the flexible H3bta acted as a secondary building unit to generate a novel nanometer-sized metallocage, which is composed of a Cu(II) paddle wheel (square secondary building units) and bta3-/Hbta2- organic links (triangular secondary building units). The photoluminescence properties of complexes 1 and 2 were investigated, and the results showed that 2 exhibited photoluminescence in the solid state at room temperature.

Two novel lanthanide coordination polymers, [La(tpaa)3(H2O)2] (1) and [Eu2(BDC)3(DMF)2(H2O)2] (2) (Htpaa = terephthalamic acid, H2BDC = 1,4-benzenedicarboxylic acid, DMF = N,N-dimethylformamide), were hydro(solvo)thermally synthesized by reactions of the corresponding lanthanide nitrate salts with 1,3,5-triazine-2,4,6-tri(4-benzenecarboxylate) (L), in which a simultaneous hydrolysis of the ligand L occurred. Single-crystal X-ray analysis revealed that complex 1 comprises one-dimensional chains that are further interlinked via hydrogen bonds, resulting in a two-dimensional network; while complex 2 is a three-dimensional interpenetrated coordination architecture.

Three new coordination polymers with formula [Gd(bta)(H2O)·1.39H2O] n (1), [Dy(bta)(H2O)·1.35H2O] n (2) and [Y(bta)(H2O)2·0.5H2O] n (3) were synthesized by using corresponding rare earth nitrates and 1,3,5-benzenetriacetic acid (H3bta) under hydrothermal/solvothermal reaction conditions, and characterized by single-crystal X-ray diffraction. In these complexes, the carboxylate groups of bta3− adopt different coordination modes, namely one carboxylate group adopts μ2-η1:η1-bridging and each of the other two carboxylate groups adopts μ2-η2:η1-bridging coordination modes in 1 and 2, and one carboxylate group adopts a μ2-η2:η1-bridging coordination mode and each of the other two carboxylate groups adopts a μ2-η1:η1-bridging mode for the major component and one carboxylate group adopts a μ2-η2:η1-bridging coordination mode, one has a μ2-η1:η1-bridging mode and the third has a monodentate mode for the minor component in 3. The magnetic properties of the complexes 1 and 2 were investigated in the temperature range of 1.8–300 K.

A new complex [Pr(bib)2(NO3)3] (1) was synthesized by reaction of bidentate imidazole-containing ligand 1-bromo-3,5-bis(imidazol-1-ylmethyl)benzene (bib) with Pr(NO3)·6H2O and characterized by X-ray crystallography. Complex 1 has a two-dimensional herringbone-like structure with the ligand bib serving as a bridging ligand using its two imidazolyl nitrogen atoms. Ligand bib adopts cis and trans two different conformations, and the Pr(III) atoms are bridged by bib in two different ways. Thermogravimetric analysis for complex 1 was carried out and the result shows that the complex is stable up to 180 °C. Variable-temperature magnetic susceptibility of complex 1 was measured between 1.8 and 300 K and the result shows that the χMT value decreases continuously over the whole temperature range. Copyright © 2005 John Wiley & Sons, Ltd.

The effect of storage temperature, storage time and total soluble solid (TSS) on the total sugar (TS), sucrose, glucose, fructose, total amino acid (TAA), pH, 5-hydroxymethylfurfural (HMF) and browning degree (BD) in carrot juice concentrate (CJC) stored at −18, 0, 25 and 37 °C was studied and the relationship between HMF and BD was established. Higher temperature at 25 and 37 °C had a significant effect (p

A novel two-dimensional coordination polymer [Ag(µ3-hexamethylenetetramine)(H2O)](BF4) was synthesized and characterized by X-ray crystallography. It crystallized in the orthorhombic space group Pnnm with a = 15.561(7) A, b = 10.754(5) A, c = 6.514(3) A, and Z = 4. Each Ag center is four-coordinated in a slightly distorted tetrahedral geometry. The structure consists of 2D wavy layers of hexagonal units; these 2D layers are further connected to form a 3D network by O-H⋯F, C-H⋯F hydrogen bonds with counter anions BF 4 − in the layers.

Two novel series of coordination frameworks [Ln(bta)(H2O)2]·nH2O·mEtOH (Ln = La 1a, n = 4.5, m = 0; Ln = Ce 1b, n = 4, m = 0; Ln = Pr 1c, n = 2.88, m = 0.35) and [Ln2(bta)2(H2O)3]·nH2O (Ln = La 2a, n = 2.14; Ln = Ce 2b, Pr 2c, n = 2) were synthesized by the reaction of 1,3,5-benzenetriacetic acid (H3bta) with the corresponding lanthanide salts using different methods. X-ray diffraction analyses reveal that all six complexes have 3D channel structures, but in the first series of complexes, each bta3- ligand adopts a cis, trans, trans conformation and acts as a μ5-bridge linking five lanthanide atoms, while in the second series, the bta3- ligands adopt cis, trans, trans and cis, cis, cis conformations and act as μ6- and μ5-bridges, respectively. Thus two series of complexes have the same metal atoms and ligands but different structures. The results show that the flexible triacid ligand is versatile and can adopt different conformations according to different reaction conditions. The variable-temperature mag...

Two new coordination polymers [Ca3(bta)2(H2O)8]·3H2O (1) and Ba3(bta)2(H2O)8 (2) were obtained by self-assembly of the corresponding metal carbonate with a flexible tripodal ligand, benzene-1,3,5-triacetic acid (H3bta), and their structures were determined by single-crystal X-ray diffraction studies. The results revealed that complex 1 crystallizes in the triclinic space group P1 with a = 8.3045(10) A, b = 10.4883(10) A, c = 11.0184(16) A, α = 102.703(3)°, β = 100.001(4)°, γ = 108.842(7)°, V = 854.36(18) A3, and Z = 1; compound 2 is in the monoclinic space group C2/c with a = 23.4363(8) A, b = 6.9782(3) A, c = 21.7150(8) A, β = 111.4480(10)°, V = 3305.4(2) A3, and Z = 4. Complexes 1 and 2 have two-dimensional network structures, and each bta3- ligand coordinates to Ca(II) or Ba(II) atoms using two of three carboxylate groups adopting different coordination modes: μ3-η2:η2-bridging and μ2-η2:η1-bridging coordination modes in 1 or μ3-η2:η2-bridging and μ3-η2:η1-bridging coordination modes in 2. The noncoo...

This study was purposed to detect the alloantibodies against Factor VIII (FVIII) by ELISA for estimating the incidence of the alloantibodies against Factor VIII (FVIII) in patients with hemophilia A, and to investigate the relationship between factor VIIIC domain and alloantibodies. Total of 140 patients with hemophilia A and 80 normal controls were enrolled in this study, among them plasma FVIII level of 84 patients was less than 1%, plasma FVIII level of 34 patients was between 1% and 5%, and plasma FVIII level of 22 patients was more than 5%. All patients were treated with plasma-derived FVIII concentrate or plasma before. The ELISA plate was coated with McAb (SZ-132) against FVIII prepared in our laboratory, then human recombinant FVIII concentrates were applied. After incubation in room temperature for 2 hours, diluted plasma samples and HRP-conjugated goat anti-human IgG were added successively, finally A490 was recorded. The threshold of alloantibody of patient plasma was set as mean value3 SD more than control. The plate was coated with antibody against His, then human recombinant FVIII-C1C2 prepared in our laboratory was added. After incubation in room temperature for 2 hours, diluted plasma samples and HRP-conjugated goat anti-human IgG were added successively, finally A490 were recorded. The threshold was set as the mean value3 SD more than control. The results showed that the alloantibodies against FVIII were found in 56 patients (40%) by ELISA, and 82.1% (46/56) of this kind of alloantibody could interact with the C domain of FVIII. It is concluded that C domain of FVIII is one of the primary binding sites for the alloantibodies against FVIII in Chinese patients with hemophilia A.

To investigate the feasibility and safety of video-assisted thoracoscopic esophagectomy for esophageal carcinoma and gastro-esophageal anastomosis in right thoracic cavity.The clinical data of 120 patients who underwent esophagectomy for esophageal carcinoma and gastro-esophageal anastomosis in right thoracic cavity from March to December 2011 was analyzed retrospectively. In the video-assisted thoracoscopic surgery group, there were 60 patients [41 male and 19 female patients with aver age of (62 ± 7) years old] who underwent video-assisted thoracoscopic esophagectomy for esophageal carcinoma and gastro-esophageal anastomosis in right thoracic cavity. In the routine thoracotomy group, there were 60 patients [39 male and 21 female patients with aver age of (62 ± 9) years old] who underwent routine thoracotomy esophagectomy for esophageal carcinoma and gastro-esophageal anastomosis in right thoracic cavity. Operation time, intra-operative blood loss, postoperative total thoracic drainage in 3 days, total number of harvested lymph nodes, hospitalization, cost of hospitalization and complications were compared between the two groups.The operations were carried out successfully in two groups. There was no perioperative death in all patients. There was no statistical difference in intra-operative blood loss, postoperative total thoracic drainage and cost of hospitalization between the two groups. Operation time of rideo-assisted thoracoscopic surgery group was significantly longer than that of thoracotomy group ((188 ± 38) minutes vs. (138 ± 50) minutes, t = 6.171, P = 0.000), but postoperative hospitalization was significantly lower ((14 ± 3) d vs. (18 ± 6) d, t = -4.093, P = 0.000) and total number of harvested lymph nodes was lower (17 ± 9 vs. 21 ± 11, t = -2.058, P = 0.042). There was significantly statistical difference in total postoperative main complication (25.0% vs. 48.3%, χ(2) = 7.033, P = 0.008). And postoperative incisional infection of VATE group patients was significantly lower than that of thoracotomy group patients (6.7% vs. 25.0%, χ(2) = 7.566, P = 0.006).Video-assisted thoracoscopic esophagectomy for esophageal carcinoma and gastro-esophageal anastomosis in right thoracic cavity is technically feasible and safe, with minimized trauma and quick recovery. The recent result is satisfactory.

To investigate the keratin 17 gene (KRT17) mutation in a pedigree with pachyonychia congenita type 2 (PC-II).DNA was extracted from the blood samples of the patients, unaffected members of the pedigree, and 100 unrelated healthy controls. PCR was performed to amplify the hot spots in KRT17 gene. PCR products were directly sequenced to detect mutation.A heterozygous 296T--C mutation was found in all the affected members of this family, which resulted in the substitution of leucine by proline in codon 99 (L99P) in the 1A domain of the KRT17, but not in the healthy individuals from the family and the 100 unrelated controls.The mutation of KRT17 may play a major role in the pathogenesis of this pedigree with pachyonychia congenita type 2.

Background: Porokeratosis (PK) is a heterogeneous group of keratinization disorders that exhibit similarities with psoriasis at both the clinical and molecular levels. Methods: The transcript levels of keratin (KRT) 6A, 16, 17, S100A7, A8, A9, p53 and three candidate genes (i.e. SART3, SSH1 and ARPC3) were reassessed in pairwise lesional and uninvolved skin from nine patients with PK by real-time quantitative polymerase chain reaction (RTQ–PCR). Results: The results of RTQ–PCR confirmed that KRT6A, 16, S100A7, A8 and A9 (p = 0.008) were mostly up-regulated in the lesional skin when compared with uninvolved skin. Different from the microarray data, there was no significant difference observed in KRT17 expression patterns between lesional and normal-appearing skin (p = 0.066). No statistical difference was observed in p53 and three candidate genes' expression patterns between lesional and uninvolved skin. Conclusions: In the present study, 9 of the 10 gene expression measured by RTQ–PCR in PK were statistically comparable to microarray data. KRT6A was identified as specific biomarker for porokeratotic keratinocytes, as it was the most significantly up-regulated gene in the nine patient samples. Zhang Z-H, Wang Z-M, Crosby ME, Kang KF, Luan J, Huang W, Xiang L-H, Zheng Z-Z. Reassessment of microarray expression data of porokeratosis by quantitative real-time polymerase chain reaction.

Reactions of tripodal ligand 1,3,5-tris(imidazole-1-ylmethyl)-2,4,6-trimethylbenzene (L) with lanthanide metal salts and triethyl orthoformate led to the formation of six bowl-like dinuclear compounds [Ln2(L)(HL)(NO3)6(HCOO)].3CH3OH (Ln = Gd 1, Tb 2, Dy 3, Er 4, Yb 5, and Eu 6). The single-crystal X-ray diffraction analysis revealed that six complexes are isomorphous and isostructural and that the dinuclear molecules are further connected by hydrogen bonds and pi-pi interactions, resulting in 3D channel-like structures. The luminescence properties have been studied, and the results showed that the Tb(III) (2) and Eu(III) (6) complexes exhibited sensitized luminescence in the visible region and their luminescence lifetimes in powder and DMSO-d6 solution are in the range of milliseconds. The Yb(III) complex (5) emits typical near-infrared luminescence in DMSO-d6 solution. Variable-temperature magnetic susceptibility measurements of 1-6 showed that complex 1 (Gd) is nearly a paramagnet and complexes 2 (Tb), 3 (Dy), and 4 (Er) show the ferromagnetic coupling between magnetic centers, whereas the depopulation of the Stark levels in complexes 5 (Yb) and 6 (Eu) leads to a continuous decrease in (chi M)T when the sample is cooled from 300 to 1.8 K.

Five novel lanthanide complexes with the formulas [Nd(bta)(H2O)2.4.35H2O]n(1), [Sm(bta)(H2O)2.4.5H2O]n (2), [Eu(bta)(H2O).1.48H2O]n (3), [Tb(bta)(H2O).1.31H2O]n (4), and [Yb(bta)(H2O).H2O]n (5) (H3bta = 1,3,5-benzenetriacetic acid) have been prepared by using the corresponding lanthanide salt and H3bta. The results of an X-ray crystallographic analysis revealed that all the complexes have three-dimensional channel-like structures, in which the bta3- ligands adopt different coordination modes: monodentate and mu2-eta2:eta1-bridging coordination modes in 1, 2, and 5 and mu2-eta1:eta1-bridging and mu2-eta2:eta1-bridging coordination modes in 3 and 4, respectively. Complexes 1 and 2, as well as 3 and 4, are isostructural, respectively, in which all the Ln(III) (Ln = Nd, Sm, Eu, and Tb) atoms are nine-coordinated, while the Yb(III) atoms in complex 5 are eight-coordinated. Both complexes 3 and 4 showed strong luminescence upon excitation, and their luminescence decay curves fit well with single exponential decays of which the lifetime is 0.45 ms for 3 and 1.0 ms for 4. The magnetic properties of the complexes were investigated in the temperature range of 1.8-300 K.

Two novel metal-organic frameworks with different structures were obtained by reactions of PbI2 with N,N′-bis(3-pyridylmethyl)-1,4-biphenylenedimethyleneimine (L) under different M/L ratios. When t...

Disseminated superficial actinic porokeratosis (DSAP) is an uncommon autosomal dominant chronic keratinization disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border. Thus far, although two loci for DSAP have been identified, the genetic basis and pathogenesis of this disorder have not been elucidated yet. In this study, we performed a genome-wide linkage analysis in three Chinese affected families and localized the gene in an 8.0 cM interval defined by D12S330 and D12S354 on chromosome 12. Upon screening 30 candidate genes, we identified a missense mutation, p.Ser63Asn in SSH1 in one family, a frameshift mutation, p.Ser19CysfsX24 in an alternative variant (isoform f) of SSH1 in another family, and a frameshift mutation, p.Pro27ProfsX54 in the same alternative variant in one non-familial case with DSAP. SSH1 encodes a phosphatase that plays a pivotal role in actin dynamics. Our data suggested that cytoskeleton disorganization in epidermal cells is likely associated with the pathogenesis of DSAP.