2,836 results on '"Zhi, He"'
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2. Robust single divacancy defects near stacking faults in 4H-SiC under resonant excitation
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He, Zhen-Xuan, Zhou, Ji-Yang, Lin, Wu-Xi, Li, Qiang, Liang, Rui-Jian, Wang, Jun-Feng, Wen, Xiao-Lei, Hao, Zhi-He, Liu, Wei, Ren, Shuo, Li, Hao, You, Li-Xing, Tang, Jian-Shun, Xu, Jin-Shi, Li, Chuan-Feng, and Guo, Guang-Can
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Quantum Physics - Abstract
Color centers in silicon carbide (SiC) have demonstrated significant promise for quantum information processing. However, the undesirable ionization process that occurs during optical manipulation frequently causes fluctuations in the charge state and performance of these defects, thereby restricting the effectiveness of spin-photon interfaces. Recent predictions indicate that divacancy defects near stacking faults possess the capability to stabilize their neutral charge states, thereby providing robustness against photoionization effects. In this work, we present a comprehensive protocol for the scalable and targeted fabrication of single divacancy arrays in 4H-SiC using a high-resolution focused helium ion beam. Through photoluminescence emission (PLE) experiments, we demonstrate long-term emission stability with minimal linewidth shift ($\sim$ 50 MHz over 3 hours) for the single c-axis divacancies within stacking faults. By measuring the ionization rate for different polytypes of divacancies, we found that the divacancies within stacking faults are more robust against resonant excitation. Additionally, angle-resolved PLE spectra reveal their two resonant-transition lines with mutually orthogonal polarizations. Notably, the PLE linewidths are approximately 7 times narrower and the spin-coherent times are 6 times longer compared to divacancies generated via carbon-ion implantation. These findings highlight the immense potential of SiC divacancies for on-chip quantum photonics and the construction of efficient spin-to-photon interfaces, indicating a significant step forward in the development of quantum technologies., Comment: 11 pages, 4 figures
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- 2024
3. Process mechanism research on direct vortex melting reduction of vanadium–titanium magnetite
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Han, Yong-chao, Dou, Zhi-he, Yang, Zhan-ning, Xie, Wei, and Zhang, Ting-an
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- 2024
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4. Enrichment and reconfiguration of titanium-bearing phase in vortex smelting reduction process of vanadium–titanium magnetite
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Han, Yong-chao, Dou, Zhi-he, Zhang, Rui, Zhang, Ting-an, and Fang, Shuai
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- 2024
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5. Measuring the radiation hardness of terahertz devices for space applications
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Yuan-Zhi He, Chen-Sheng Ma, and Hao Yin
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Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Abstract The application of terahertz technology in space is frontier for the development of 6G technologies. Terahertz transceiver devices based on gallium arsenide Schottky barrier diodes (GaAs SBDs) have the characteristics of small size, light weight and low power consumption, making them suitable for application on spacecraft. However, there is currently a lack of experimental assessments on their space adaptability. Here, we study the radiation hardness of terahertz devices to determine their adaptability in complex space environments. We exposed GaAs SBDs and terahertz multipliers as typical terahertz devices to gamma rays and protons. The experimental results showed that the terahertz devices exhibited good tolerance to protons, but prolonged exposure to gamma rays could significantly increase the leakage current of the GaAs SBDs and alter its C-V characteristics, leading to the failure of the terahertz multiplier. Nevertheless, the terahertz devices maintained a good level of radiation hardness, making them highly suitable for use in Low Earth Orbit (LEO) satellites. The comparison between the results of proton and gamma ray tests indicated that the terahertz devices exhibited high inherent radiation hardness against displacement damage but were more sensitive to ionization damage, requiring higher shielding requirements.
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- 2024
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6. Robust single modified divacancy color centers in 4H-SiC under resonant excitation
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He, Zhen-Xuan, Zhou, Ji-Yang, Li, Qiang, Lin, Wu-Xi, Liang, Rui-Jian, Wang, Jun-Feng, Wen, Xiao-Lei, Hao, Zhi-He, Liu, Wei, Ren, Shuo, Li, Hao, You, Li-Xing, Zhang, Rui-Jun, Zhang, Feng, Tang, Jian-Shun, Xu, Jin-Shi, Li, Chuan-Feng, and Guo, Guang-Can
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- 2024
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7. Plasmonic-enhanced bright single spin defects in silicon carbide membranes
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Zhou, Ji-Yang, Li, Qiang, Hao, Zhi-He, Lin, Wu-Xi, He, Zhen-Xuan, Liang, Rui-Jian, Guo, Liping, Li, Hao, You, Lixing, Tang, Jian-Shun, Xu, Jin-Shi, Li, Chuan-Feng, and Guo, Guang-Can
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Physics - Optics ,Quantum Physics - Abstract
Optically addressable spin defects in silicon carbide (SiC) have emerged as attractable platforms for various quantum technologies. However, the low photon count rate significantly limits their applications. We strongly enhanced the brightness by 7 times and spin-control strength by 14 times of single divacancy defects in 4H-SiC membranes using surface plasmon generated by gold film coplanar waveguides. The mechanism of the plasmonic-enhanced effect is further studied by tuning the distance between single defects and the surface of the gold film. A three-energy-level model is used to determine the corresponding transition rates consistent with the enhanced brightness of single defects. Lifetime measurements also verified the coupling between defects and surface plasmons. Our scheme is low-cost, without complicated microfabrication and delicate structures, which is applicable for other spin defects in different materials. This work would promote developing spin defect-based quantum applications in mature SiC materials.
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- 2023
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8. Effect of different working periods on missed diagnosis of colorectal polyps in colonoscopy
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Qing Xu and Zhi He
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Colorectal polyps ,Missed diagnosis ,Working time ,Artificial intelligence ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background To investigate the effect of different working periods on missed diagnoses in patients with colorectal polyps in colonoscopy. Methods We conducted a retrospective analysis of patients who were diagnosed with colorectal polyps during colonoscopy in an outpatient department between July and December 2022. These patients were subsequently hospitalized for resection during this period. Patients with missed diagnoses were those who had newly discovered polyps in a second colonoscopy. The working periods were categorized as work, near the end of work, and delayed work, respectively, in the morning and afternoon. Results A total of 482 patients were included, and the miss rate of diagnosis was 48.1% (232/482), mainly in the transverse colon (25%), and the ascending colon (23%). Patient age was a risk factor for the miss rate of diagnosis (OR = 1.025, 95%CI: 1.009–1.042, P = 0.003) and was also associated with the number of polyps detected for the first colonoscopy (χ2 = 18.196, P = 0.001). The different working periods had no statistical effect on the missed rate of diagnosis (χ2 = 1.998, P = 0.849). However, there was an increasing trend in miss rates towards the end of work and delayed work periods, both in the morning and afternoon. The highest miss rate (60.0%) was observed during delayed work in the afternoon. Additionally, poor bowel preparation was significantly more common during delayed work in the afternoon. Conclusions The increasing trend in miss rates towards the end of work and delayed work periods deserves clinical attention. Endoscopists cannot always stay in good condition under heavy workloads.
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- 2024
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9. Smad4 and FoxH1 potentially interact to regulate cyp19a1a promoter in the ovary of ricefield eel (Monopterus albus)
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Qiqi Chen, Deying Yang, Mingqiang Chen, Jinxin Xiong, Junjie Huang, Wenxiang Ding, Kuo Gao, Bolin Lai, Li Zheng, Ziting Tang, Mingwang Zhang, Taiming Yan, and Zhi He
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Smad4 ,FoxH1 ,Ovary development ,Cyp19a1a promoter ,Monopterus albus ,Medicine ,Physiology ,QP1-981 - Abstract
Abstract Background Cyp19a1a is a key enzyme in the pathway that converts androgens into estrogen and is regulated by TGF-β signaling. Smad4 and FoxH1 are downstream effectors of TGF-β signaling and may play important roles in ovarian development in M. albus. Methods We investigated the expression pattern of the Smad4 and FoxH1 using qRT‒PCR and immunofluorescence, then tested the changes of smad4 and foxh1 by qRT‒PCR after ovary incubation with FSH in vitro, and analysed the regulation of cyp19a1a transcription by Smad4 and FoxH1 by dual-luciferase reporter assays. Results We found that Smad4 encoded a putative protein of 449 amino acids and harbored the three conserved domains typical of this protein family. Smad4 and foxh1 exhibited similar expression patterns during ovarian development and after FSH incubation, with Pearson’s coefficients of 0.873 and 0.63–0.81, respectively. Furthermore, Smad4, FoxH1 and Cyp19a1a colocalized in the granulosa cells and theca cells of ovaries during the mid-to-late vitellogenic stage. Smad4 repressed cyp19a1a activity via SBE1 (− 1372/−1364) and SBE2 (− 415/−407) in the cyp19a1a promoter, whereas mutating SBE1 or SBE2 restored cyp19a1a promoter activity. Co-overexpression of Smad4 and FoxH1 significantly reduced cyp19a1a promoter activity. Conclusions This study provides new insights into the potential functions of transcription factors Smad4 and FoxH1 in ovarian development and the transcriptional regulation mechanism of cyp19a1a in M. albus, which will reveal Smad4/FoxH1-mediated TGF-β signaling in reproduction and the regulation of the cyp19a1a. Plain English summary Aromatase, encoded by cyp19a1a, is involved in ovarian development and plays an important role in the quality of eggs, as well the sex ratio, of the teleost fish, M. albus. The research on the transcriptional regulation of cyp19a1a has contributed to the understanding of its role in ovarian development. In previous study, it was shown that FoxH1 inhibits cyp19a1a transcription. In the present study, Smad4 was confirmed as a cyp19a1a transcriptional repressor and Smad4 may also coordinate with FoxH1 to repress cyp19a1a transcription. At present, we provide a new perspective for the transcriptional regulation of cyp19a1a by transcription factors Smad4 and FoxH1 in teleost fish ovary. In the future, the regulatory networks of Smad4 and FoxH1 will be further studied and the gene editing technology will be applied to screen specific regulatory factors of cyp191a1a gene, so as to alter the female cycle and modulate the sex ratio of the eggs production.
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- 2024
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10. Morphological and phylogenetic analyses reveal two new Alternaria species (Pleosporales, Pleosporaceae) in Alternaria section from Cucurbitaceae plants in China
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Sein Lai Lai Aung, Feng-Yin Liu, Ya-Nan Gou, Zin Mar Nwe, Zhi-He Yu, and Jian-Xin Deng
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Botany ,QK1-989 - Abstract
Alternaria species are commonly found as saprophytes, endophytes and plant pathogens. During a survey of small-spored Alternaria in China, two new species were discovered from Cucurbitaceae plants collected in Hubei and Sichuan provinces. This study identified two new species of Alternaria using seven genes (ITS, GAPDH, TEF1, RPB2, Alt a 1, EndoPG, and OPA10-2) for phylogenetic analyses and morphological characteristics. The two new species A. jingzhouensis and A. momordicae were described and illustrated. Alternaria jingzhouensis sp. nov., associated with Citrullus lanatus, is characterized by producing muriform, ellipsoidal, flask-shaped, rostrate, and beaked conidia. It differs from A. koreana, A. ovoidea, and A. baoshanensis by bearing conidia in a simple conidiogenous locus with occasionally longer beaks in a chain, and from A. momordicae sp. nov. by having shorter beaks. Alternaria momordicae sp. nov. from Momordica charantia was distinct from A. koreana, A. ovoidea, and A. baoshanensis by producing muriform, long ellipsoid or ovoid to obclavate, sometimes inverted club-shaped conidia on a single conidiogenous locus with a wider body and longer beak in a chain, and distinct from A. jingzhouensis sp. nov. by a longer beak conidia. These two species were clearly distinguished from other species in the section Alternaria based on DNA based phylogeny and morphological characteristics. The morphological features were discussed and compared to relevant species in the present paper.
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- 2024
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11. A distinctive HPHT platform with different types of large-volume press subsystems at SECUF
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Yufei Ge, Shuailing Ma, Cun You, Kuo Hu, Chuang Liu, Yixuan Wang, Xinglin Wang, Xinyang Li, Hongyu Li, Qiang Tao, Shuqing Jiang, Lu Wang, Hu Tang, Di Yao, Zhi He, Xinyi Yang, Zhaodong Liu, Qiang Zhou, Pinwen Zhu, Bo Zou, Bingbing Liu, and Tian Cui
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Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Large-volume presses (LVPs) providing large volumes, liquid media, deformation capability, jump compression, and in situ measurements are in great demand for high-pressure research, particularly in the fields of geoscience, condensed matter physics, material science, chemistry, and biology. A high-pressure and high-temperature (HPHT) platform with different LVP subsystems, both solid-state and liquid environments, and nonequilibrium subsystems, has been constructed at the Synergetic Extreme Condition User Facility, Jilin University. This article describes the construction of the different subsystems and provides an overview of the capabilities and characteristics of the different HPHT subsystems. A large sample volume (1000 mm3) at 20 GPa is achieved through the use of a belt-type apparatus in the solid-state subsystem. HPHT conditions (1.8 GPa and 1000 K) are realized in the liquid subsystem through the use of a piston–cylinder-type LVP with optical diamond windows for in situ spectroscopic measurements. A maximum pressure jump to 10.2 GPa can be reached within 20 ms in the nonequilibrium subsystem with the use of an improved bladder-pressurization jump press. Some typical results obtained with different LVPs are briefly reviewed to illustrate the applications and advantages of these presses. In summary, the platform described here has the potential to contribute greatly to high-pressure research and to innovations in high-pressure technology.
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- 2024
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12. LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway
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Jiamei Li, Feng Xiao, Siqi Wang, Xiaolan Fan, Zhi He, Taiming Yan, Jia Zhang, Mingyao Yang, and Deying Yang
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Age-related diseases ,Ageing ,AMPK signalling pathway ,Long noncoding RNA ,microRNA ,Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
A long noncoding RNA (lncRNA) is longer than 200 bp. It regulates various biological processes mainly by interacting with DNA, RNA, or protein in multiple kinds of biological processes. Adenosine monophosphate-activated protein kinase (AMPK) is activated during nutrient starvation, especially glucose starvation and oxygen deficiency (hypoxia), and exposure to toxins that inhibit mitochondrial respiratory chain complex function. AMPK is an energy switch in organisms that controls cell growth and multiple cellular processes, including lipid and glucose metabolism, thereby maintaining intracellular energy homeostasis by activating catabolism and inhibiting anabolism. The AMPK signalling pathway consists of AMPK and its upstream and downstream targets. AMPK upstream targets include proteins such as the transforming growth factor β-activated kinase 1 (TAK1), liver kinase B1 (LKB1), and calcium/calmodulin-dependent protein kinase β (CaMKKβ), and its downstream targets include proteins such as the mechanistic/mammalian target of rapamycin (mTOR) complex 1 (mTORC1), hepatocyte nuclear factor 4α (HNF4α), and silencing information regulatory 1 (SIRT1). In general, proteins function relatively independently and cooperate. In this article, a review of the currently known lncRNAs involved in the AMPK signalling pathway is presented and insights into the regulatory mechanisms involved in human ageing and age-related diseases are provided.
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- 2024
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13. Resource Utilization of Copper Slag with a Focus on Impoverishment and Reduction: A Review
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Hao, Jun, Dou, Zhi-he, Zhang, Ting-an, and The Minerals, Metals & Materials Society
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- 2024
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14. The Synergistic Extraction Kinetics of Aluminum and Silicon from High-Alumina Fly Ash by Carbochlorination
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Wang, Long, Zhang, Zi-mu, Zhang, Ting-An, Lv, Guo-Zhi, Dou, Zhi-He, Zhang, Xi-yu, Iloeje, Chukwunwike, editor, Alam, Shafiq, editor, Guillen, Donna Post, editor, Tesfaye, Fiseha, editor, Zhang, Lei, editor, Hockaday, Susanna A. C., editor, Neelameggham, Neale R., editor, Peng, Hong, editor, Haque, Nawshad, editor, Yücel, Onuralp, editor, and Baba, Alafara Abdullahi, editor
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- 2024
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15. In-Situ Observation of Melting and Solidification Process of CuCr Alloy by High Temperature Confocal Microscope
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Han, Jin-Ru, Dou, Zhi-He, Zhang, Ting-An, Wagstaff, Samuel, editor, Anderson, Alexandra, editor, Sabau, Adrian S., editor, and Iloeje, Chukwunwike, editor
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- 2024
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16. Maskless Generation of Single Silicon Vacancy Arrays in Silicon Carbide by a Focused He+ Ion Beam
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He, Zhen-Xuan, Li, Qiang, Wen, Xiao-Lei, Zhou, Ji-Yang, Lin, Wu-Xi, Hao, Zhi-He, Xu, Jin-Shi, Li, Chuan-Feng, and Guo, Guang-Can
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Quantum Physics - Abstract
Precise generation of spin defects in solid-state systems is essential for nanostructure fluorescence enhancement. We investigated a method for creating single silicon vacancy defect arrays in silicon carbide using a helium-ion microscope. Maskless and targeted generation can be realized by precisely controlling the focused He+ ion beam with an implantation uncertainty of 60 nm. The generated silicon vacancies were identified by measuring the optically detected magnetic resonance spectrum and room temperature photoluminescence spectrum. We systematically studied the effects of the implantation ion dose on the generated silicon vacancies. After optimization, a conversion yield of ~ 6.95 % and a generation rate for a single silicon vacancy of ~ 35 % were realized. This work paves the way for the integration and engineering of color centers to photonic structures and the application of quantum sensing based on spin defects in silicon carbide.
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- 2022
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17. Protein expression patterns and metal metabolites in a protogynous hermaphrodite fish, the ricefield eel (Monopterus albus)
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Zhi He, Feng Xiao, Deying Yang, Faqiang Deng, Wenxiang Ding, Zhide He, Siqi Wang, Qiqi Chen, Haochen Wang, Mingqiang Chen, Kuo Gao, Jinxing Xiong, Ziting Tang, Mingwang Zhang, and Taiming Yan
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Monopterus albus ,Proteomic analysis ,Sex change ,Metal metabolites ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background The ricefield eel Monopterus albus undergoes a natural sex change from female to male during its life cycle, and previous studies have shown the potential mechanisms of this transition at the transcriptional and protein levels. However, the changes in protein levels have not been fully explored, especially in the intersexual stage. Results In the present study, the protein expression patterns in the gonadal tissues from five different periods, the ovary (OV), early intersexual stage gonad (IE), middle intersexual stage gonad (IM), late intersexual stage gonad (IL), and testis (TE), were determined by untargeted proteomics sequencing. A total of 5125 proteins and 394 differentially expressed proteins (DEPs) were detected in the gonadal tissues. Of the 394 DEPs, there were 136 between the OV and IE groups, 20 between the IM and IE groups, 179 between the IL and IM groups, and 59 between the TE and IL groups. Three candidate proteins, insulin-like growth factor 2 mRNA-binding protein 3 isoform X1 (Igf2bp3), triosephosphate isomerase (Tpi), and Cu-Zn superoxide dismutase isoform X1 [(Cu-Zn) Sod1], were validated by western blotting to verify the reliability of the data. Furthermore, metal metabolite-related proteins were enriched in the IL vs. IM groups and TE vs. IL groups, which had close relationships with sex change, including Cu2+-, Ca2+-, Zn2+- and Fe2+/Fe3+-related proteins. Analysis of the combined transcriptome data revealed consistent protein/mRNA expression trends for two metal metabolite-related proteins/genes [LOC109953912 and calcium Binding Protein 39 Like (cab39l)]. Notably, we detected significantly higher levels of Cu2+ during the sex change process, suggesting that Cu2+ is a male-related metal metabolite that may have an important function in male reproductive development. Conclusions In summary, we analyzed the protein profiles of ricefield eel gonadal tissues in five sexual stages (OV, IE, IM, IL, and TE) and verified the plausibility of the data. After preforming the functional enrichment of metal metabolite-related DEPs, we detected the contents of the metal metabolites Zn2+, Cu2+, Ca2+, and Fe2+/Fe3+ at these five stages and screened for (Cu-Zn) Sod1 and Mmp-9 as possible key proteins in the sex reversal process.
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- 2024
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18. Magnetic detection under high pressures using designed silicon vacancy centers in silicon carbide
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Wang, Jun-Feng, Liu, Lin, Liu, Xiao-Di, Li, Qiang, Cui, Jin-Ming, Zhou, Di-Fan, Zhou, Ji-Yang, Wei, Yu, Xu, Hai-An, Xu, Wan, Lin, Wu-Xi, Yan, Jin-Wei, He, Zhen-Xuan, Liu, Zheng-Hao, Hao, Zhi-He, Li, Hai-Ou, Liu, Wen, Xu, Jin-Shi, Gregoryanz, Eugene, Li, Chuan-Feng, and Guo, Guang-Can
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Physics - Applied Physics ,Condensed Matter - Materials Science ,Quantum Physics - Abstract
Pressure-induced magnetic phase transition is attracting interest due to its ability to detect superconducting behaviour at high pressures in diamond anvil cells. However, detection of the local sample magnetic properties is a great challenge due to the small sample chamber volume. Recently, optically detected magnetic resonance (ODMR) of nitrogen vacancy (NV) centers in diamond have been used for in-situ pressure-induced phase transition detection. However, owing to their four orientation axes and temperature-dependent zero-field-splitting, interpreting the observed ODMR spectra of NV centers remain challenging. Here, we study the optical and spin properties of implanted silicon vacancy defects in 4H-SiC, which is single-axis and temperature-independent zero-field-splitting. Using this technique, we observe the magnetic phase transition of Nd2Fe14B at about 7 GPa and map the critical temperature-pressure phase diagram of the superconductor YBa2Cu3O6.6. These results highlight the potential of silicon vacancy-based quantum sensors for in-situ magnetic detection at high pressures.
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- 2022
19. Possible involvement of Jun, Foxo1, Nobox in the regulation of smad2/3 transcription in the protogynous hermaphroditic ricefield eel (Monopterus albus)
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Zhi He, Haochen Wang, Li Zheng, Qiqi Chen, Jinxin Xiong, Mingqiang Chen, Wenxiang Ding, Junjie Huang, Kuo Gao, Bolin Lai, Zhijun Ma, Ziting Tang, Mingwang Zhang, Deying Yang, and Taiming Yan
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Smad2 ,Smad3 ,Immunoreactivity ,Promoter characteristics ,Monopterus albus ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
Small mothers against decapentaplegic2/3 (Smad2/3) are two signalling intermediates in the transforming growth factor beta (TGF-β) signalling pathway, which plays a critical role in gonad development. However, a systemic analysis of Smad2/3 in Monopterus albus (M. albus) has not been performed. The smad2 sequence in M. albus was characterized in our previous publication. In this study, we characterized the nucleotide sequence of smad3 and reported that smad3 is widely expressed in different tissues of M. albus. Importantly, the expression of smad3 significantly increased at the early vitellogenic stage in the ovary and decreased with oocyte maturation. Next, we aimed to identify the upstream factors that regulate Smad2/3 transcription. The 5′ flanking sequences of smad2/3 were cloned, and their core promoter regions were determined to be between −447 bp and −100 bp and between −1520 bp and −927 bp, respectively. The Jun and Foxo1 binding sites were conserved in the smad2 promoter region, and the Sp1, Bcl-6, and Nobox binding sites were conserved in the smad3 promoter region. Through dual-luciferase reporter gene experiments, we showed that Jun and Foxo1 binding sites may be involved in the regulation of smad2 transcription, whereas the Nobox binding site may be involved in the activation of the smad3 promoter.
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- 2024
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20. Multi-class multi-label classification of social media texts for typhoon damage assessment: a two-stage model fully integrating the outputs of the hidden layers of BERT
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Liwei Zou, Zhi He, Chengle Zhou, and Wenbing Zhu
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Social media ,typhoon damage assessment ,multi-class multi-label classification ,BERT ,hidden layers ,Mathematical geography. Cartography ,GA1-1776 - Abstract
ABSTRACTWith the development of social media, it has become increasingly important to quickly and accurately identify social media texts related to disasters (e.g. typhoon) to aid in rescue and recovery efforts. Currently, multi-class classification and pre-trained language model Bidirectional Encoder Representations from Transformers (BERT) are widely used for text classification. However, most studies on typhoon damage classification are multi-class single-label, which contradicts to the reality that a social media text may correspond to multiple types of damage. Moreover, the outputs of the hidden layers of BERT are not fully utilized. This paper proposes a two-stage multi-class multi-label classification method for typhoon damage assessment by fully integrating the outputs of the hidden layers of BERT. In the first stage, sentence vectors are adopted to identify typhoon damage-related texts. In the second stage, word matrices are applied for multi-class multi-label classification to further classify the texts into five damage categories (i.e. transportation, public, electricity, forestry, and waterlogging). The two stages are trained end-to-end to identify typhoon damage from social media texts. Experiments on [Formula: see text] texts during typhoon landfall in Chinese coastal regions demonstrate that the proposed method can effectively improve the accuracy of text classification and comprehensively assess typhoon damage.
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- 2024
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21. Serum chemokine IL-8 acts as a biomarker for identifying COVID-19-associated persistent severe acute kidney injury
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Zhi He, Jing-jing Liu, and Shao-lei Ma
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covid-19 ,acute kidney injury ,IL-8 ,IP-10 ,biomarker ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objectives Persistent severe acute kidney injury (PS-AKI) is associated with poor clinical outcomes. Our study attempted to evaluate the diagnostic value of chemokines for early-stage PS-AKI prediction.Methods According to the KDIGO criteria, 115 COVID-19 patients diagnosed with stage 2/3 AKI were recruited from the intensive care unit between December 2022 and February 2023. Primary clinical outcomes included detecting PS-AKI in the first week (≥ KDIGO stage 2 ≥ 72 h). Cytometric Bead Array was used to detect patient plasma levels (interleukin-8 (IL-8), C-C chemokine ligand 5 (CCL5), chemokine (C-X-C Motif) ligand 9 (CXCL9), and interferon-inducible protein 10 (IP-10)) of chemokines within 24 h of enrollment.Results Of the 115 COVID-19 patients with stage 2/3 AKI, 27 were diagnosed with PS-AKI. Among the four measured chemokines, only the IL-8 level was significantly elevated in the PS-AKI group than in the Non-PS-AKI group. IL-8 was more effective as a biomarker while predicting PS-AKI with an area under the curve of 0.769 (0.675-0.863). This was superior to other biomarkers related to AKI, including serum creatinine. Moreover, plasma IL-8 levels of >32.2 pg/ml on admission could predict PS-AKI risk (sensitivity = 92.6%, specificity = 51.1%). Additionally, the IL-8 level was associated with total protein and IL-6 levels.Conclusion Plasma IL-8 is a promising marker for the early identification of PS-AKI among COVID-19 patients. These findings should be validated in further studies with a larger sample size.
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- 2024
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22. Identification and functional prediction of new triterpenoids from Alismatis Rhizoma using HPLC-HRMS and in-silico analysis
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Tao Gao, Sheng-lin Hu, Rui Yan, Ling-zhi He, Nan Fang, Zhong-hao Zhang, Zhi-hao Duan, Zi-zhong Tang, Yang-er Chen, Shu Yuan, Lin Ye, Xiao-rong Yan, and Ming Yuan
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Alismatis Rhizoma ,HPLC-HRMS ,In-silico analysis ,Molecular docking ,ADMET prediction ,Chemistry ,QD1-999 - Abstract
Alismatis Rhizoma (AR) is a crucial substance for discovering new triterpenoids to address hyperlipidemia and obesity. Currently, approximately 120 triterpenoids have been identified in AR, making the discovery of new triterpenoids increasingly challenging. Thus, based on the advantages of HPLC-HRMS, it was utilized to identify both reported and new triterpenoids, and then in-silico analysis was employed to predict the functions of these new triterpenoids. Twenty reported triterpenoids and four new triterpenoids (25-methoxy-16-oxo-11-anhydroalisol A, 25-methoxy-16-oxo-alisol A, 25-methoxy-16-oxo-alisol A 23-acetate, and 25-methoxy-16-oxo-alisol A 24-acetate) from AR were identified using HPLC-HRMS, and then KEGG analysis suggested four new triterpenoids might be activated the PPAR signaling pathway to relieve hyperlipemia. The results of PPI and molecular docking indicated PPARA might be the key targets for anti-hyperlipidemia of four new triterpenoids, of which 25-methoxy-16-oxo-11-anhydroalisol A has better binding activity with PPARA. Additionally, 25-methoxy-16-oxo-11-anhydroalisol A has more potential as a candidate drug because of its better absorption, distribution, metabolism, excretion, and lower toxicity. Hence, our findings proved there are new triterpenoids with anti-hyperlipidemia medicinal potential in AR, thereby guiding the direction of future works and reducing the consumption of time and financial resources.
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- 2024
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23. Microstructure and property evolution of CuCr50 alloy prepared by aluminum thermal reduction-electromagnetic casting during hot forging process
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An, Wang, Dou, Zhi-he, Zhang, Ting-an, and Han, Jin-ru
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- 2024
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24. High-value terminal treatment: Utilizing copper slag heat in the manufacture of copper-containing weathering steel
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Hao, Jun, Dou, Zhi-he, Wan, Xing-yuan, Qi, Song, Wang, Kun, and Zhang, Ting-an
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- 2024
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25. Population structure and adaptability analysis of Schizothorax o’connori based on whole-genome resequencing
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Kuo Gao, Zhi He, Jinxin Xiong, Qiqi Chen, Bolin Lai, Fei Liu, Ping Chen, Mingqiang Chen, Wenjie Luo, Junjie Huang, Wenxiang Ding, Haochen Wang, Yong Pu, Li Zheng, Yuanyuan Jiao, Mingwang Zhang, Ziting Tang, Qingsong Yue, Deying Yang, and Taiming Yan
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Schizothorax o’connori ,Genetic diversity ,Environmental adaptation ,Whole genome resequencing ,Yarlung Zangbo River ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background Schizothorax o’connori is an endemic fish distributed in the upper and lower reaches of the Yarlung Zangbo River in China. It has experienced a fourth round of whole gene replication events and is a good model for exploring the genetic differentiation and environmental adaptability of fish in the Qinghai-Tibet Plateau. The uplift of the Qinghai-Tibet Plateau has led to changes in the river system, thereby affecting gene exchange and population differentiation between fish populations. With the release of fish whole genome data, whole genome resequencing has been widely used in genetic evolutionary analysis and screening of selected genes in fish, which can better elucidate the genetic basis and molecular environmental adaptation mechanisms of fish. Therefore, our purpose of this study was to understand the population structure and adaptive characteristics of S. o’connori using the whole-genome resequencing method. Results The results showed that 23,602,746 SNPs were identified from seven populations, mostly distributed on chromosomes 2 and 23. There was no significant genetic differentiation between the populations, and the genetic diversity was relatively low. However, the Zangga population could be separated from the Bomi, Linzhi, and Milin populations in the cluster analysis. Based on historical dynamics analysis of the population, the size of the ancestral population of S. o’connori was affected by the late accelerated uplift of the Qinghai Tibet Plateau and the Fourth Glacial Age. The selected sites were mostly enriched in pathways related to DNA repair and energy metabolism. Conclusion Overall, the whole-genome resequencing analysis provides valuable insights into the population structure and adaptive characteristics of S. o’connori. There was no obvious genetic differentiation at the genome level between the S. o’connori populations upstream and downstream of the Yarlung Zangbo River. The current distribution pattern and genetic diversity are influenced by the late accelerated uplift of the Qinghai Tibet Plateau and the Fourth Ice Age. The selected sites of S. o’connori are enriched in the energy metabolism and DNA repair pathways to adapt to the low temperature and strong ultraviolet radiation environment at high altitude.
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- 2024
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26. Reduced representative methylome profiling of cell-free DNA for breast cancer detection
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Qingmo Yang, Xingqiang Zhu, Yulu Liu, Zhi He, Huan Xu, Hailing Zheng, Zhiming Huang, Dan Wang, Xiaofang Lin, Ping Guo, and Hongliang Chen
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Medicine ,Genetics ,QH426-470 - Abstract
Abstract Background Whole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced representative methylome profiling (RRMP), which employs restriction enzyme for depletion of AT-rich sequence to achieve enrichment and deep sequencing of CG-rich sequences. Methods We first verified the ability of RRMP to enrich CG-rich sequences using tumor cell genomic DNA and analyzed differential methylation regions between tumor cells and normal whole blood cells. We then analyzed cfDNA from 29 breast cancer patients and 27 non-breast cancer individuals to detect breast cancer by building machine learning models. Results RRMP captured 81.9% CpG islands and 75.2% gene promoters when sequenced to 10 billion base pairs, with an enrichment efficiency being comparable to RRBS. RRMP allowed us to assess DNA methylation changes between tumor cells and whole blood cells. Applying our approach to cfDNA from 29 breast cancer patients and 27 non-breast cancer individuals, we developed machine learning models that could discriminate between breast cancer and non-breast cancer controls (AUC = 0.85), suggesting possibilities for truly non-invasive cancer detection. Conclusions We developed a new method to achieve reduced representative methylome profiling of cell-free DNA for tumor detection.
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- 2024
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27. Self-poled piezoelectric polymer composites via melt-state energy implantation
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Zhao-Xia Huang, Lan-Wei Li, Yun-Zhi Huang, Wen-Xu Rao, Hao-Wei Jiang, Jin Wang, Huan-Huan Zhang, He-Zhi He, and Jin-Ping Qu
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Science - Abstract
Abstract Lightweight flexible piezoelectric polymers are demanded for various applications. However, the low instinctively piezoelectric coefficient (i.e. d33) and complex poling process greatly resist their applications. Herein, we show that introducing dynamic pressure during fabrication is capable for poling polyvinylidene difluoride/barium titanate (PVDF/BTO) composites with d33 of ~51.20 pC/N at low density of ~0.64 g/cm3. The melt-state dynamic pressure driven energy implantation induces structure evolutions of both PVDF and BTO are demonstrated as reasons for self-poling. Then, the porous material is employed as pressure sensor with a high output of ~20.0 V and sensitivity of ~132.87 mV/kPa. Besides, the energy harvesting experiment suggests power density of ~58.7 mW/m2 can be achieved for 10 N pressure with a long-term durability. In summary, we not only provide a high performance lightweight, flexible piezoelectric polymer composite towards sustainable self-powered sensing and energy harvesting, but also pave an avenue for electrical-free fabrication of piezoelectric polymers.
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- 2024
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28. The effect of Ti and Zr content on the structure, mechanics and energy-release characteristics of Ti–Zr–Ta alloys
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Jia-yu Meng, Jing-zhi He, Bin Zhang, Jin Chen, Shun Li, Dun Niu, and Yu Tang
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Energetic structural materials ,Ti–Zr–Ta ,Multi-element alloy ,Energy release characteristics ,Military Science - Abstract
Energetic structural materials (ESMs) are a new type of structural materials with bearing and damage characteristics. In this work the microstructure, mechanical properties and energy release characteristics of multi-element Ti–Zr–Ta alloys with good casting performance were studied. The microstructure of the TixZrTa alloys gradually change from BCC + HCP to single BCC structure with the increase of Ti. While the Ti2ZryTa alloys was still uniform and single BCC structure with the increase of Zr. The evolution of microstructure and composition then greatly affect the mechanical properties and energy-release characteristics of Ti–Zr–Ta alloys. The synergistic effect of dual phase structure increases the fracture strain of TixZrTa (x = 0.2, 0.5) with the Ti content decreases, while the fracture strain of TixZrTa (x = 2.0, 3.0, 4.0) gradually increase with the Ti content increases caused by the annihilation of the obstacles for dislocation movement. And as Zr content increases, the fracture strain of Ti2ZryTa alloys decrease, then the oxidation reaction rate and fragmentation degree gradually increase. The higher oxidation rate and the lager exposed oxidation area jointly leads the higher releasing energy efficiency of TixZrTa alloys with low Ti content and Ti2ZryTa alloys with high Zr content.
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- 2024
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29. Thermodynamic Insight into the Equilibrium Component Prediction in the Al-Ti-Ca-Oxide System
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Yu-lai Song, Zhi-he Dou, Ting-an Zhang, Chu Cheng, Hui Fang, and Chao-Lei Ban
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metallurgy ,ion and molecule coexistence theory ,thermodynamics ,equilibrium ,slag ,Mining engineering. Metallurgy ,TN1-997 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The prediction of equilibrium components for chemical reactions is a considerable section in the metallurgical industry. According to the ion and molecule coexistence theory (IMCT), a modified mass action concentration model based on a thermodynamic database is proposed in this paper, which complys with the law of mass conservation and can be applied in the batching process for Al-Ti-Ca-oxide system that originates from SHS (Self-propagating High-temperature Synthesis) metallurgy. The trend for slag and alloy component under different batching conditions are in good agreement with experiment, while the difference between the theoretical calculation and experiment can be attributed to the deviation from the thermodynamic equilibrium. The modified mass action concentration model with melts and slag can be used to predict the composition and content of the system when equilibrium is achieved at a certain temperature under a specific material ratio, which is conducive to reducing the cost of the experiment and predicting the operability of the actual process. Moreover, it is believed that this thermodynamic insight may has certain application prospects in these metallurgical procedure based on the equilibrium process.
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- 2023
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30. Fruit and vegetable intake and the risk of arterial hypertension in China: A prospective cohort study
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Zhi He, Yanhui Jia, Jianxin Li, Jie Cao, Fangchao Liu, Hongfan Li, Jichun Chen, Dongsheng Hu, Chong Shen, Yingxin Zhao, Xiaoqing Liu, Ling Yu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu, and Shufeng Chen
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fruit and vegetable ,hypertension ,prospective study ,Medicine (General) ,R5-920 - Abstract
Abstract Background Population‐based epidemiological evidence regarding the association between fruit and vegetable intake and the incidence of hypertension is inconsistent. This prospective cohort study aimed to investigate the association between fruit and vegetable intake and the risk of new‐onset hypertension. Methods Based on the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China‐PAR), 58,981 Chinese adults without hypertension at baseline were included. Information on fruit and vegetable intake was collected using a food‐frequency questionnaire. Cox proportional hazards models were performed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of incident hypertension. Results During 640,795 person‐years of follow‐up, 21,008 new cases of hypertension were recorded. Compared with participants in the lowest quintile (Q1) of total fruit and vegetable (TFV) intake, the HRs (95% CIs) of incident hypertension were 0.90 (0.86–0.95), 0.85 (0.81–0.90), 0.82 (0.78–0.86), and 0.83 (0.78–0.88) for the Q2 to Q5 group (ptrend
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- 2023
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31. Gut‐lung axis and asthma: A historical review on mechanism and future perspective
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Xiu‐Ling Song, Juan Liang, Shao‐Zhu Lin, Yu‐Wei Xie, Chuang‐Hong Ke, Dang Ao, Jun Lu, Xue‐Mei Chen, Ying‐Zhi He, Xiao‐Hua Liu, and Wen Li
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asthma ,gut microbiota ,gut‐lung axis ,host immune system ,metabolites ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background Gut microbiota are closely related to the development and regulation of the host immune system by regulating the maturation of immune cells and the resistance to pathogens, which affects the host immunity. Early use of antibiotics disrupts the homeostasis of gut microbiota and increases the risk of asthma. Gut microbiota actively interact with the host immune system via the gut‐lung axis, a bidirectional communication pathway between the gut and lung. The manipulation of gut microbiota through probiotics, helminth therapy, and fecal microbiota transplantation (FMT) to combat asthma has become a hot research topic. Body This review mainly describes the current immune pathogenesis of asthma, gut microbiota and the role of the gut‐lung axis in asthma. Moreover, the potential of manipulating the gut microbiota and its metabolites as a treatment strategy for asthma has been discussed. Conclusion The gut‐lung axis has a bidirectional effect on asthma. Gut microecology imbalance contributes to asthma through bacterial structural components and metabolites. Asthma, in turn, can also cause intestinal damage through inflammation throughout the body. The manipulation of gut microbiota through probiotics, helminth therapy, and FMT can inform the treatment strategies for asthma by regulating the maturation of immune cells and the resistance to pathogens.
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- 2024
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32. Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance
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Yanhui Jia, Zhi He, Fangchao Liu, Jianxin Li, Fengchao Liang, Keyong Huang, Jichun Chen, Jie Cao, Hongfan Li, Chong Shen, Ling Yu, Xiaoqing Liu, Dongsheng Hu, Jianfeng Huang, Yingxin Zhao, Yang Liu, Xiangfeng Lu, Dongfeng Gu, and Shufeng Chen
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Fine particulate matter ,Healthy diet ,Insulin resistance ,Triglyceride-glucose index ,Metabolic score for insulin resistance ,Effect modification ,Environmental sciences ,GE1-350 - Abstract
The relationship of fine particulate matter (PM2.5) exposure and insulin resistance remains inclusive. Our study aimed to investigate this association in the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). Specifically, we examined the associations between long-term PM2.5 exposure and three surrogate indicators of insulin resistance: the triglyceride-glucose index (TyG), TyG with waist circumference (TyG-WC) and metabolic score for insulin resistance (METS-IR). Additionally, we explored potential effect modification of dietary intake and components. Generalized estimating equations were used to evaluate the associations between PM2.5 and the indicators with an unbalanced repeated measurement design. Our analysis incorporated a total of 162,060 observations from 99,329 participants. Each 10 μg/m3 increment of PM2.5 was associated with an increase of 0.22 % [95 % confidence interval (CI): 0.20 %, 0.25 %], 1.60 % (95 % CI: 1.53 %, 1.67 %), and 2.05 % (95 % CI: 1.96 %, 2.14 %) in TyG, TyG-WC, and METS-IR, respectively. These associations were attenuated among participants with a healthy diet, particularly those with sufficient intake of fruit and vegetable, fish or tea (pinteraction
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- 2024
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33. Long-term series wetland classification of Guangdong-Hong Kong-Macao Greater Bay Area based on APSMnet
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Anjun Lou, Zhi He, Chengle Zhou, and Guanglin Lai
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Wetland classification ,Google earth engine ,Deep learning ,Landsat ,Physical geography ,GB3-5030 ,Environmental sciences ,GE1-350 - Abstract
Wetlands play a crucial role in achieving carbon peak and carbon neutrality goals. Exploring spatiotemporal distribution is one of the fundamental task in wetland research. However, existing large-scale and long-term series wetland mapping methods have challenges related to classification accuracy and obtaining inter-annual wetland samples. Therefore, a rapid sample collection and precise classification method are needed to support wetland resource assessment, conservation, and ecological restoration. In this paper, we propose a novel deep learning method suitable for large-scale and long-term series wetland classification. First, we acquire and preprocess the long-term series remote sensing data on the Google Earth Engine (GEE) platform. Second, the maximum wetland extent is extracted using decision trees and the Otsu algorithm (OTSU). Third, the attention and pyramid structure-based multidimensional feature extraction network (APSMnet) and the inter-annual sample migration algorithm (ISM) are proposed for realizing inter-annual wetland classification and wetland change analysis. Experiments conducted on Landsat 7 data of the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) from 2000 to 2022 demonstrate that the overall accuracy (OA), average accuracy (AA), and kappa coefficient (Kappa) achieved by the proposed wetland classification method are 0.9664, 0.9396, and 0.9570, respectively. Long-term series trend analysis reveals that mangrove/swamp areas experience fluctuations influenced by urbanization and ecological policies, ultimately undergoing restoration and becoming stable. The codes and datasets are made available publicly at https://github.com/louanjun/APSMnet.
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- 2024
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34. LncRNA-NEF suppressed oxaliplatin resistance and epithelial-mesenchymal transition in colorectal cancer through epigenetically inactivating MEK/ERK signaling
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Shi, Chuan-Jian, Xue, Zhi-He, Zeng, Wei-Qiang, Deng, Li-Qiang, Pang, Feng-Xiang, Zhang, Feng-Wei, Fu, Wei-Ming, and Zhang, Jin-Fang
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- 2023
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35. Process strengthening for electrochemical reduction of solid TiO2 to Ti in situ
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Guan, Chang-Long, Zhang, Ting-An, Chen, Jian-She, and Dou, Zhi-He
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- 2023
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36. Evolution and regulation of microstructure and properties of CuCr alloys prepared by self-propagating metallurgy
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Han, Jin-ru, Dou, Zhi-he, Zhang, Ting-an, and An, Wang
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- 2024
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37. Dynamic biomechanical changes of clear aligners during extraction space closure: Finite element analysis
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Wang, Yi-gan, Zhu, Guan-yin, Liu, Jun-qi, Wang, Yi-fan, and Zhao, Zhi-he
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- 2024
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38. Temperature dependence of divacancy spin coherence in implanted silicon carbide
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Lin, Wu-Xi, Yan, Fei-Fei, Li, Qiang, Wang, Jun-feng, Hao, Zhi-He, Zhou, Ji-Yang, Li, Hao, You, Li-Xing, Xu, Jin-Shi, Li, Chuan-Feng, and Guo, Guang-Can
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Quantum Physics - Abstract
Spin defects in silicon carbide (SiC) have attracted increasing interest due to their excellent optical and spin properties, which are useful in quantum information processing. In this paper, we systematically investigate the temperature dependence of the spin properties of divacancy defects in implanted 4\emph{H}-SiC. The zero-field splitting parameter $D$, the inhomogeneous dephasing time $T_2^{*}$, the coherence time $T_2$, and the depolarization time $T_1$ are extensively explored in a temperature range from 5 to 300 K. Two samples implanted with different nitrogen molecule ion fluences ($\rm {N_2}^{+}$, $1\times 10^{14}/\rm cm^{2}$ and $1\times 10^{13}/\rm cm^{2}$) are investigated, whose spin properties are shown to have similar temperature-dependent behaviors. Still, the sample implanted with a lower ion fluence has longer $T_{2}$ and $T_{1}$. We provide possible theoretical explanations for the observed temperature-dependent dynamics. Our work promotes the understanding of the temperature dependence of spin properties in solid-state systems, which can be helpful for constructing wide temperature-range thermometers based on the mature semiconductor material., Comment: 7 pages, 5 figures, 46 references
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- 2021
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39. Research on High-Quality Carbon Reduction Pathways for Green Buildings under the Dual Carbon Background
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Xing Wei, Zhi He, Yitong Li, and Xiaoping Li
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carbon peaking and carbon neutrality ,green buildings ,high-quality development ,high-quality carbon reduction ,pathways ,Building construction ,TH1-9745 - Abstract
Carbon peaking and carbon neutrality strategies bring both opportunities and challenges to the development of green buildings. In this context, the development of high-quality green buildings requires a focus on improving carbon reduction effects throughout their entire lifespan. Based on a systematic review of the achievements and existing problems in the development of green buildings in China over the past thirty years, this article benchmarks the new trends in green building standards in developed countries abroad, dissects the new requirements for the development of green buildings in China under the new situation, and proposes a high-quality carbon reduction pathways from four aspects: theoretical research, policy systems, technical systems, and software platforms. Finally, it proposes implementation suggestions for collaborative development from four dimensions: theoretical methods for calculating carbon emissions, green finance policies, a full-process carbon reduction technology system, and carbon emission accounting tools.
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- 2024
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40. Energy conservation and emission reduction through utilization of latent heat of copper slag for iron and copper recovery
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Hao, Jun, Dou, Zhi-he, Zhang, Ting-an, Wan, Xing-yuan, and Wang, Kun
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- 2024
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41. Oxygen removal and subsequent morphology transformation of TiOx<1 powders in electrodeoxidation process
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Zhou, Xin-yu, Dou, Zhi-he, Zhang, Ting-an, Zhang, Chen, and Du, Dao-guang
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- 2023
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42. Magnetic detection under high pressures using designed silicon vacancy centres in silicon carbide
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Wang, Jun-Feng, Liu, Lin, Liu, Xiao-Di, Li, Qiang, Cui, Jin-Ming, Zhou, Di-Fan, Zhou, Ji-Yang, Wei, Yu, Xu, Hai-An, Xu, Wan, Lin, Wu-Xi, Yan, Jin-Wei, He, Zhen-Xuan, Liu, Zheng-Hao, Hao, Zhi-He, Li, Hai-Ou, Liu, Wen, Xu, Jin-Shi, Gregoryanz, Eugene, Li, Chuan-Feng, and Guo, Guang-Can
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- 2023
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43. Influence of kinetic factors on preparation of boron carbide by magnesiothermic self-propagation synthesis
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Shi, Hao, Dou, Zhi-he, Meng, Yang, and Zhang, Ting-an
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- 2023
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44. Adipose-derived mesenchymal stem cell exosomes ameliorate spinal cord injury in rats by activating the Nrf2/HO-1 pathway and regulating microglial polarization
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Yi Luo, You-zhi He, Yong-fu Wang, Yu-xia Xu, and Li Yang
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spinal cord injury ,adipose-derived mesenchymal stem cells ,exosomes ,microglial polarization ,nrf2/ho-1 pathway ,Medicine - Abstract
As of now, there are no satisfactory treatments for spinal cord injury (SCI), so new therapeutic approaches are necessary to be explored. Adipose-derived mesenchymal stem cell exosomes (ADMSC-Exo), delightfully, show remarkable therapeutic effects. Therefore, we try to investigate the effects and mechanisms of ADMSC-Exo on SCI, as well as to provide novel approaches for the treatment of SCI. Adipose-derived mesenchymal stem cells (ADMSC) were isolated from rats and then exosomes (Exo) were extracted from the cells. The extracted Exo were identified by flow cytometry, transmission electron microscopy and nanoparticle tracking analysis (NTA). Then, the SCI rat model was established by the spinal cord impactor and injected with 200 µl PBS or Exo into their tail veins at 30 min, 24 h, and 48 h after surgery. The rats in the Control group and Exo group only exposed the spine. Motor function recovery was assessed on days 0, 7, 14, 21, and 28; histopathological changes and apoptosis levels in spinal cord tissues were observed by HE staining and TUNEL staining; the levels of inflammatory cytokines TNF-a, IL-6, and MCP-1 in spinal cord tissues were measured by ELISA; the expression levels of iNOS, IL-12, Arg1, and Mrc1 in spinal cord tissues were detected by qRT-PCR; and Nrf2, HO-1, and NQO1 protein expression in spinal cord tissues were detected by Western blot. ADMSC-Exo were successfully isolated and identified. ADMSC-Exo significantly relieved SCI and promoted motor function recovery in SCI rats. Moreover, ADMSC-Exo inhibited the expression of both inflammatory factors in the spinal cord tissues and M1 microglia, promoted the expression of M2 microglia, and activated the Nrf2/HO-1 pathway. Altogether, ADMSC-Exo can not only ameliorate SCI, but also promote the motor function recovery of rats. And the mechanism of ADMSC-Exo improving SCI may be achieved by activating Nrf2/HO-1 pathway and microglial polarization.
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- 2023
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45. A day-to-day management model improves patient compliance to treatment for Helicobacter pylori infection: a prospective, randomized controlled study
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Zhen Yang, Wenjie Xiong, Ruoyun Yang, Haisheng Qian, Zhi He, Meihong Chen, Jiajia Yang, Huaiming Sang, Jin Yan, Xiaobing Xu, Yun Wang, Guoxin Zhang, and Feng Ye
- Subjects
Helicobacter pylori infection ,Day-to-day ,Conventional outpatient education ,Habit formation ,Compliance ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background The day-to-day (DTD) management model encourages patients to actively participate in their healthcare by setting goals. We determined the effectiveness of the DTD model in the treatment of Helicobacter pylori (H. pylori) infection, as compared with conventional outpatient education (OE). Methods We randomized 254 H. pylori-positive patients into a DTD group (127 patients) and an OE group (127 patients) prior to primary treatment with 14-day bismuth-containing quadruple therapy, including esomeprazole, amoxicillin, and clarithromycin. Both groups received consistent medication instructions. Patients in the DTD group recorded daily attendance after completing their daily medication plan from day 1 to day 14. The medication compliance, follow-up compliance, H. pylori eradication rates, and adverse events (AEs) were evaluated. Results In the modified intention-to-treat (MITT) and per-protocol (PP) analyses, the DTD group showed significantly higher medication compliance than the OE group (P = 0.001 and P = 0.031, respectively). Both the MITT and PP analyses showed significant differences in follow-up compliance (P
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- 2023
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46. Review of the recent Chinese research on the electrical properties of CuCr contacts for vacuum interrupters
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Jin-ru Han, Zhi-he Dou, Ting-an Zhang, and Wang An
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Vacuum interrupters ,CuCr contact Materials ,Self-propagating metallurgy ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Vacuum interrupters are important components to ensure the safety of medium and high-voltage power transmission, and contact material is an important factor affecting the performance of vacuum interrupters. CuCr contact materials have been used in most commercial vacuum interrupters. This paper summarizes the research status of the electrical properties of CuCr contacts used in vacuum interrupters, analyses the factors influencing the electrical properties of CuCr contacts, and summarizes the relevant mechanisms, which point out the direction for improving the properties of CuCr alloys and promotes the development of subsequent research on the electrical properties of CuCr contacts. Finally, the electrical properties of CuCr contacts prepared by self-propagating metallurgy based on the Al–CuO–Cr2O3 reaction system are summarized.
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- 2023
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47. Fe microalloying during the in-situ synthesis of homogeneous CuCrFe alloys by aluminothermic self-propagating
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Jin-ru Han, Zhi-he Dou, Ting-an Zhang, and Wang An
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CuCr alloy ,Fe microalloying ,Self-propagation reduction ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Microalloying is an effective approach to improve the performance of CuCr alloys. This paper presents a new idea for the preparation of CuCrFe alloys by self-propagation reduction in-situ microalloying. It is found that the addition of Fe alloying components reduces the Gm and ΔGm of the CuCr melt, which inhibits the occurrence of the liquid phase decomposition process. When the Fe content of CuCrFe alloy is 1.5%, compared with the Cr-rich phase of CuCr alloy, the second phase undergoes significant refinement, the average particle size refined from 21.7 μm to 19.3 μm and the standard deviation reduced from 10.59 to 8.73, and the addition of Fe is beneficial to the spheroidization and refinement of the Cr-rich phase. Fe is mainly combined with Cr, and CuCrFe alloy still exists in the form of two phases. After solution + aging treatment, the average particle size of the second phase in CuCr alloy decreases from 21.8 μm to 17.9 μm, and that in CuCrFe alloy decreases from 19.6 μm to 18.6 μm. The conductivity of CuCrFe alloy increases from 10.5 MS m−1 to 15.9 MS m−1, and the hardness increases from 95.0 HB to 117.0 HB. After heat treatment, the nano-spherical are present in the Cr-rich phase of the CuCrFe alloy, while Fe is completely solid-soluble in the Cr-rich phase; the Cu-rich matrix shows a diffuse distribution of fine second phases, which play a role in strengthening the second phase in the matrix.
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- 2023
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48. The necessity for popularizing varicella-zoster virus vaccine programs worldwide: An age-period-cohort analysis for the Global Burden of Disease study 2019
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Wei Zhang, Zhi He, Pinhao Li, Wen Zeng, Jianglong Feng, Xian Dong, and Hongguang Lu
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Varicella-zoster virus ,Varicella ,Herpes zoster ,Incidence ,Disability-adjusted life years (DALYs) ,Global burden of disease ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Varicella-zoster virus (VZV) causes varicella and herpes zoster (VHZ), which is endemic worldwide. Although infection with VZV represents a considerable health threat, the global, regional and national burden of VZV infection, especially the probable relationship between VZV vaccines and the epidemiology of VZV infection, is poorly known. We sought to estimate the global spatial patterns and temporal trends of VHZ burden in 204 countries and territories from 1990 to 2019. Methods: Numbers and age-standardized rates (ASR) of VHZ incidence, and disability-adjusted life years (DALYs) were estimated using data from the Global Burden of Diseases Study (GBD) 2019. Spatiotemporal trends in ASR were evaluated by estimated annual percentage change (EAPC). Results: Worldwide, in 2019, there were approximately 84.0 million incidence and 0.9 million DALYs due to VHZ. The corresponding ASIR (age-standardized incidence rate) and ASDR (age-standardized DALY rate) drastically decreased in children (aged 50 years old), with highest ASIR and ASDR in the High-income Asia Pacific and Western Sub-Saharan Africa, respectively. From 1990–2019, the corresponding EAPC in ASIR were 0.03 (95% uncertainty interval [UI]: 0.02–0.04). Whereas the global EAPC in ASDR decreased in all regions (−1.59, 95% UI: −1.64 to −1.55), expect for Australasia (0.46, [0.05, 0.88]). Notably, in 2019, age-specific rates of VHZ DALYs presented a rapid growth trend after 70 years old. Conclusion: The spatiotemporal trends of VHZ were heterogeneous across countries from 1990 to 2019. The spatiotemporal trend in ASIR is highest in the High sociodemographic index (SDI) region, however the EAPC in ASDR is lowest, in part probably due to VHZ vaccination. Therefore, reducing morbidity and burden strategies such as vaccines programs for the prevention of VHZ should be promoted in those regions with high growth incidence and/or burden, especially for the population after 70 years old.
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- 2023
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49. Simultaneous Pretreatment with Ultraviolet Light and Alkaline H2O2 to Promote Enzymatic Hydrolysis of Corn Stover
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Jianjun Hu, Zhi He, Quanguo Zhang, Jiatao Dang, Shuheng Zhao, Shaoqi Yang, Panbo Yang, and Xiaoyu Yan
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pretreatment ,enzymatic saccharification ,basic hydrogen peroxide ,uv-catalyzed hydrogen peroxide ,corn stover ,Biotechnology ,TP248.13-248.65 - Abstract
Pretreatment processes are essential for the preparation of biofuels from lignocellulosic feedstocks. Based on alkaline H2O2 pretreatment, photocatalytic alkaline H2O2 pretreatment (U-AHP) was investigated to examine the effects of reaction time, alkali concentration, and H2O2 concentration on the enzymatic digestion of corn stover. The optimum process conditions were determined by orthogonal tests: 1% NaOH, 2% H2O2, and reaction time of 8 h. Under these conditions, the lignin removal efficiency of UH-AHP was 90.2% and the saccharification yield was 94.7%. Furthermore, FT-IR, XRD, and SEM analyses showed that U-AHP pretreatment caused structural damage to the maize straw and increased the crystallinity of the cellulose, and it was speculated that the U-AHP pretreatment reaction was a complex mechanism, which might be a multiple synergistic reaction. This study shows that U-AHP pretreatment is a simple, green and effective method to promote lignin removal.
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- 2023
50. Large-scale epidemiological analysis of common skin diseases to identify shared and unique comorbidities and demographic factors
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Qinmengge Li, Matthew T. Patrick, Sutharzan Sreeskandarajan, Jian Kang, J. Michelle Kahlenberg, Johann E. Gudjonsson, Zhi He, and Lam C. Tsoi
- Subjects
epidemiology ,claims ,skin disease ,comorbidity ,Optum ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionThe utilization of large-scale claims databases has greatly improved the management, accessibility, and integration of extensive medical data. However, its potential for systematically identifying comorbidities in the context of skin diseases remains unexplored.MethodsThis study aims to assess the capability of a comprehensive claims database in identifying comorbidities linked to 14 specific skin and skin-related conditions and examining temporal changes in their association patterns. This study employed a retrospective case-control cohort design utilizing 13 million skin/skin-related patients and 2 million randomly sampled controls from Optum’s de-identified Clinformatics® Data Mart Database spanning the period from 2001 to 2018. A broad spectrum of comorbidities encompassing cancer, diabetes, respiratory, mental, immunity, gastrointestinal, and cardiovascular conditions were examined for each of the 14 skin and skin-related disorders in the study.ResultsUsing the established type-2 diabetes (T2D) and psoriasis comorbidity as example, we demonstrated the association is significant (P-values
- Published
- 2024
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