94 results on '"Zhi-Wei, He"'
Search Results
2. Application status and optimization suggestions of tumor organoids and CAR-T cell co-culture models
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Rong-Xuan Ning, Cun-Yu Liu, Shi-Qi Wang, Wen-Kai Li, Xia Kong, and Zhi-Wei He
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Tumor organoid ,CAR-T therapy ,Co-culture models ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Tumor organoids, especially patient-derived organoids (PDOs) exhibit marked similarities in histopathological morphology, genomic alterations, and specific marker expression profiles to those of primary tumour tissues. They are applied in various fields including drug screening, gene editing, and identification of oncogenes. However, CAR-T therapy in the treatment of solid tumours is still at an exploratory stage. Tumour organoids offer unique advantages over other preclinical models commonly used for CAR-T therapy research, which the preservation of the biological characteristics of primary tumour tissue is critical for the study of early-stage solid tumour CAR-T therapies. Although some investigators have used this co-culture model to validate newly targeted CAR-T cells, optimise existing CAR-T cells and explore combination therapy strategies, there is still untapped potential in the co-culture models used today. This review introduces the current status of the application of tumour organoid and CAR-T cell co-culture models in recent years and commented on the limitations of the current co-cultivation model. Meanwhile, we compared the tumour organoid model with two pre-clinical models commonly used in CAR-T therapy research. Eventually, combined with the new progress of organoid technologies, optimization suggestions were proposed for the co-culture model from five perspectives: preserving or reconstructing the tumor microenvironment, systematization, vascularization, standardized culture procedures, and expanding the tumor organoids resource library, aimed at assisting related researchers to better utilize co-culture models.
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- 2024
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3. Identifying the risk factors of ICU-acquired fungal infections: clinical evidence from using machine learning
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Yi-si Zhao, Qing-pei Lai, Hong Tang, Ren-jie Luo, Zhi-wei He, Wei Huang, Liu-yang Wang, Zheng-tao Zhang, Shi-hui Lin, Wen-jian Qin, and Fang Xu
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fungal infection ,ICU-acquired fungi ,machine learning ,empiric antifungal therapy ,risk factors ,Medicine (General) ,R5-920 - Abstract
BackgroundFungal infections are associated with high morbidity and mortality in the intensive care unit (ICU), but their diagnosis is difficult. In this study, machine learning was applied to design and define the predictive model of ICU-acquired fungi (ICU-AF) in the early stage of fungal infections using Random Forest.ObjectivesThis study aimed to provide evidence for the early warning and management of fungal infections.MethodsWe analyzed the data of patients with culture-positive fungi during their admission to seven ICUs of the First Affiliated Hospital of Chongqing Medical University from January 1, 2015, to December 31, 2019. Patients whose first culture was positive for fungi longer than 48 h after ICU admission were included in the ICU-AF cohort. A predictive model of ICU-AF was obtained using the Least Absolute Shrinkage and Selection Operator and machine learning, and the relationship between the features within the model and the disease severity and mortality of patients was analyzed. Finally, the relationships between the ICU-AF model, antifungal therapy and empirical antifungal therapy were analyzed.ResultsA total of 1,434 cases were included finally. We used lasso dimensionality reduction for all features and selected six features with importance ≥0.05 in the optimal model, namely, times of arterial catheter, enteral nutrition, corticosteroids, broadspectrum antibiotics, urinary catheter, and invasive mechanical ventilation. The area under the curve of the model for predicting ICU-AF was 0.981 in the test set, with a sensitivity of 0.960 and specificity of 0.990. The times of arterial catheter (p = 0.011, OR = 1.057, 95% CI = 1.053–1.104) and invasive mechanical ventilation (p = 0.007, OR = 1.056, 95%CI = 1.015–1.098) were independent risk factors for antifungal therapy in ICU-AF. The times of arterial catheter (p = 0.004, OR = 1.098, 95%CI = 0.855–0.970) were an independent risk factor for empirical antifungal therapy.ConclusionThe most important risk factors for ICU-AF are the six time-related features of clinical parameters (arterial catheter, enteral nutrition, corticosteroids, broadspectrum antibiotics, urinary catheter, and invasive mechanical ventilation), which provide early warning for the occurrence of fungal infection. Furthermore, this model can help ICU physicians to assess whether empiric antifungal therapy should be administered to ICU patients who are susceptible to fungal infections.
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- 2024
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4. Retrieval of Rugged Mountainous Areas Land Surface Temperature From High-Spatial-Resolution Thermal Infrared Remote Sensing Data.
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Zhi-Wei He 0004 and Bo-Hui Tang
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- 2023
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5. Retrieval of Plateau Lake Water Surface Temperature from UAV Thermal Infrared Data
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Ouyang Sima, Bo-Hui Tang, Zhi-Wei He, Dong Wang, and Jun-Li Zhao
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unmanned aerial vehicle (UAV) ,plateau lakes ,lake water surface temperature (LWST) ,lake water surface emissivity (LWSE) ,radiative transfer model ,Meteorology. Climatology ,QC851-999 - Abstract
The lake water surface temperature (LWST) is a critical parameter influencing lake ecosystem dynamics and addressing challenges posed by climate change. Traditional point measurement techniques exhibit limitations in providing comprehensive LWST data. However, the emergence of satellite remote sensing and unmanned aerial vehicle (UAV) Thermal Infrared (TIR) technology has opened new possibilities. This study presents an approach for retrieving plateau lake LWST (p-LWST) from UAV TIR data. The UAV TIR dataset, obtained from the DJI Zenmuse H20T sensor, was stitched together to form an image of brightness temperature (BT). Atmospheric parameters for atmospheric correction were acquired by combining the UAV dataset with the ERA5 reanalysis data and MODTRAN5.2. Lake Water Surface Emissivity (LWSE) spectral curves were derived using 102 hand-portable FT-IR spectrometer (102F) measurements, along with the sensor’s spectral response function, to obtain the corresponding LWSE. Using estimated atmospheric parameters, LWSE, and UAV BT, the un-calibrated LWST was calculated through the TIR radiative transfer model. To validate the LWST retrieval accuracy, the FLIR Infrared Thermal Imager T610 and the Fluke 51-II contact thermometer were utilized to estimate on-point LWST. This on-point data was employed for cross-calibration and verification. In the study area, the p-LWST method retrieved LWST ranging from 288 K to 295 K over Erhai Lake in the plateau region, with a final retrieval accuracy of 0.89 K. Results demonstrate that the proposed p-LWST method is effective for LWST retrieval, offering technical and theoretical support for monitoring climate change in plateau lakes.
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- 2024
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6. Case report: Endoscopic Hemoclip treatment for massive hematemesis caused by a Dieulafoy’s lesion on duodenal papilla caused acute pancreatitis
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Zhi-wei He, Hui Xu, Hua Shi, Yang-mei Wang, Han Zhong, and Xiao-cong Liu
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Dieulafoy’s lesion ,duodenal papilla ,hematemesis ,endoscopic hemoclips ,pancreatitis ,Medicine (General) ,R5-920 - Abstract
BackgroundDieulafoy’s lesion is an uncommon cause of hemorrhage of the digestive tract. It often presents with urgent and massive bleeding usually leading to shock, even death. Dieulafoy’s lesions have been reported throughout the digestive tract but which occurred on duodenal papilla were particularly rare and presented challenges in the choice of hemostasis.Case presentationA 66-year-old man with melena for 2 days was admitted. Gastrointestinal endoscopy revealed blood clots covering the duodenal papilla with oozing blood. During the procedure of trying to place a plastic stent into the duodenal papilla first, the hemorrhage began to present pulsating bleeding. The patient went into shock. With consent, two titanium clips were inserted to clamp the bleeding site to stop the bleeding. The patient complained of epigastric pain 14 h after the endoscopy. An abdominal CT scan showed signs of acute pancreatitis. Endoscopy was performed to remove the titanium clips and showed a vessel stump on the duodenal papilla. The patient was discharged from the hospital on the 14th day and followed for 6 months with no recurrence.ConclusionThis case was diagnosed with a Dieulafoy’s lesion on the duodenal papilla, which has rarely been reported. Hematemesis was stopped by clamping the vessel stump with titanium clips but caused acute pancreatitis. Reviewing the treatment, electrocoagulation might be a better choice, and life support treatment, including central vena catheterization and an adequate supply of blood products, should be prepared in advance to provide extra time for the stent placement or vascular intervention treatment.
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- 2023
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7. Interleaved hybrid control with an upper optimizer of parallel three‐level LLC converters for battery charging applications
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Hui‐Pin Lin, Xiao‐Guang Jin, Zhe‐Yu Miao, Zhi‐Wei He, and Ming‐Yu Gao
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Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Abstract This letter proposes an interleaved hybrid control for parallel three‐level (TL) LLC converters in battery charging applications. The duty cycle and the switching frequency are used to adjust the voltage gain; the phase shift control is adopted to realize voltage sharing of the divided capacitors. A virtual equivalent frequency‐gain control is adopted to coordinate multiple control variables. And the current ripples are reduced for the interleaved structure. Based on the performance analysis, an upper optimizer is proposed to update the upper limit frequency and interleaving arrangement in real time. Accordingly, it achieves a wide range of output voltage, and it further improves the system efficiency under light load and low output voltage conditions. A prototype is presented to verify the effectiveness of the proposed method.
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- 2022
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8. Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats
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Tao Wang, Li-Ni Zeng, Zhe Zhu, Yu-Hui Wang, Lu Ding, Wei-Bin Luo, Xiao-Min Zhang, Zhi-Wei He, and Hong-Fu Wu
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nerve regeneration ,peripheral nerve injury ,brachial plexus avulsion ,hypoxia ,ischemia ,hypoxia-inducible factor 1α overexpression ,pluronic F-127 ,motor neurons ,axonal regeneration ,angiogenesis ,neural regeneration ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available. Hypoxia-inducible factor 1α is a critical molecule targeting several genes associated with ischemia-hypoxia damage and angiogenesis. In this study, a rat model of brachial plexus avulsion-reimplantation was established, in which C5–7 ventral nerve roots were avulsed and only the C6 root reimplanted. Different implants were immediately injected using a microsyringe into the avulsion-reimplantation site of the C6 root post-brachial plexus avulsion. Rats were randomly divided into five groups: phosphate-buffered saline, negative control of lentivirus, hypoxia-inducible factor 1α (hypoxia-inducible factor 1α overexpression lentivirus), gel (pluronic F-127 hydrogel), and gel + hypoxia-inducible factor 1α (pluronic F-127 hydrogel + hypoxia-inducible factor 1α overexpression lentivirus). The Terzis grooming test was performed to assess recovery of motor function. Scores were higher in the hypoxia-inducible factor 1α and gel + hypoxia-inducible factor 1α groups (in particular the gel + hypoxia-inducible factor 1α group) compared with the phosphate-buffered saline group. Electrophysiology, fluorogold retrograde tracing, and immunofluorescent staining were further performed to investigate neural pathway reconstruction and changes of neurons, motor endplates, and angiogenesis. Compared with the phosphate-buffered saline group, action potential latency of musculocutaneous nerves was markedly shortened in the hypoxia-inducible factor 1α and gel + hypoxia-inducible factor 1α groups. Meanwhile, the number of fluorogold-positive cells and ChAT-positive neurons, neovascular area (labeled by CD31 around avulsed sites in ipsilateral spinal cord segments), and the number of motor endplates in biceps brachii (identified by α-bungarotoxin) were all visibly increased, as well as the morphology of motor endplate in biceps brachil was clear in the hypoxia-inducible factor 1α and gel + hypoxia-inducible factor 1α groups. Taken together, delivery of hypoxia-inducible factor 1α overexpression lentiviral vectors mediated by pluronic F-127 effectively promotes spinal root regeneration and functional recovery post-brachial plexus avulsion. All animal procedures were approved by the Institutional Animal Care and Use Committee of Guangdong Medical University, China.
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- 2019
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9. ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells
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Xia Kong, Pin Xu, Wei-Jie Cai, Huai-Gao Wang, Bin-Bin Li, Guo-Liang Huang, Zhi-Wei He, George Chen, and Cai-Guo Ye
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Sp1 ,Sp3 ,ZBP-89 ,Bak ,Hepatocellular carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism of Bak expression regulation by ZBP-89 and Sp proteins, based on in vitro experiment and The Cancer Genome Atlas (TCGA) hepatocellular carcinoma (HCC) data cohort. Methods We downloaded TCGA hepatocellular carcinoma (HCC) cohort data to analysis the association of Bak transcription level with ZBP-89 and Sp proteins transcription level. HCC cell lines and liver immortal non-tumour cell lines were used for mechanism study, including western blotting analysis, expression vector mediated gene expression and siRNA interference. Results Results showed that cancer tissues have higher Bak transcription level compared with adjacent non-cancer tissues. Bak transcription level was correlated with Sp1 and Sp3 expression level, while no correlation was found in ZBP-89 and Bak, neither Sp2 nor Sp4. Mithramycin A (MMA) induced Bak expression in a dose-dependent manner. Western blotting results showed Sp1 overexpression increased Bak expression both in liver immortal non-tumour cells and HCC cells. Interference Sp1 expression could inhibit Bak expression alone. ZBP-89 siRNA suppressed Bak expression even in the presence of MMA treatment and S1 overexpression. Additionally, Bak and Sp1 level were associated with HCC patient survival. Conclusions Bak expression required ZBP-89 and Sp1 cooperative regulation simultaneously.
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- 2018
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10. GUI Test Case Prioritization by State-Coverage Criterion.
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Zhi-Wei He 0007 and Cheng-Gang Bai
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- 2015
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11. Epigallocatechin-3-gallate Modulates MicroRNA Expression Profiles in Human Nasopharyngeal Carcinoma CNE2 Cells
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Bin-Bin Li, Guo-Liang Huang, Hua-Hui Li, Xia Kong, and Zhi-Wei He
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Antitumor Agents ,Epigallocatechin-3-gallate ,MicroRNAs ,Nasopharyngeal Carcinoma ,Medicine - Abstract
Background: Epigallocatechin-3-gallate (EGCG) has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma (NPC), but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the expression of microRNAs (miRNAs) in NPC cells. Methods: Using microarray analysis, the alterations of miRNA expression profiles were investigated in EGCG-treated CNE2 cells. Furthermore, the target genes and signaling pathways regulated by EGCG-specific miRNAs were identified using target prediction program and gene ontology analysis. Results: A total of 14 miRNAs exhibited >2-fold expression changes in a dose-dependent manner after treatment with 20 μmol/L and 40 μmol/L EGCG. Totally 43, 49, and 52 target genes from these differentially expressed miRNAs were associated with the apoptosis, cell cycle regulation, and cell proliferation, respectively. A total of 66 signaling pathways, primarily involved in cancer development and lipid and glucose metabolism, were shown to be regulated by EGCG-specific miRNAs. Conclusion: EGCG induces considerable alterations of miRNA expression profiles in CNE2 cells, which provides mechanistic insights into cellular responses and antitumor activity mediated by EGCG.
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- 2017
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12. Investigation on Effects of Vertical Degree of Freedom on Gap Resonance Between Two Side-by-Side Boxes Under Wave Actions
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Zhi-wei He, Jun-liang Gao, Hua-bin Shi, Jun Zang, Hong-zhou Chen, and Qian Liu
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Renewable Energy, Sustainability and the Environment ,Mechanical Engineering ,Ocean Engineering ,Oceanography - Published
- 2022
13. Efficiently enhanced photoelectrochemical performance of TiO2 photoanode by facile drop-coating and calcination decoration of Bi4Ti3O12
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Meng-Jie Chang, Cong-Miao Zhang, Jun Liu, Hui Wang, Zhi-Wei He, Jia-Liang Chen, Zhi-Ye Tang, Wen-Yao Zhu, Hui-Ling Du, Jie Yang, and Ying Li
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Biomaterials ,Materials Chemistry ,Ceramics and Composites ,General Chemistry ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2022
14. Facile fabrication of compressive aerogels with novel core/shell fibrous skeleton for oil sorption and thermal evaporation
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Jun Liu, Bin Yuan, Ge Bai, Hui Wang, Zhi-Wei He, Wen-Yao Zhu, and Meng-Jie Chang
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Filtration and Separation ,Analytical Chemistry - Published
- 2023
15. Spatiotemporal Change Patterns and Driving Factors of Land Surface Temperature in the Yunnan-Kweichow Plateau from 2000 to 2020
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Zhi-Wei He and Bo-Hui Tang
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- 2023
16. Fabrication of novel water glass-based monolithic aerogels with fibrous skeleton under alkaline for oil sorption and thermal evaporation
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Jun Liu, Zhi-Wei He, Ge Bai, Wen-Yao Zhu, Xin Li, Heng-Xue Xie, Hui Wang, Meng-Jie Chang, Jie Yang, Yu-Qing Wang, and Zhen-Min Luo
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Materials Chemistry ,Ceramics and Composites ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2023
17. Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway
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Zheng-tao Zhang, Ke Xie, Ren-jie Luo, Dan-ying Zhang, Zhi-wei He, Ke-feng Li, Shi-hui Lin, and Fang Xu
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Pharmacology ,Immunology ,Pharmacology (medical) - Abstract
To explore the anti-inflammatory effect and the potential mechanism of dexmedetomidine in ARDS/ALI.C57BL/6 mice and EL-4 cells were used in this research. The ALI model was established by CLP. The level of inflammatory cytokines in the lung and blood, the severity of lung injury, the expression of Foxp3, and the proportion of Tregs were detected before and after dexmedetomidine treatment. The expression of the AMPK/SIRT1 after dexmedetomidine treatment was detected in vivo and in vitro. After blocking the AMPK/SIRT1 pathway or depleting Tregs in vivo, the level of the inflammatory response, tissue injury, and Tregs differentiation were detected again to clarify the effect of dexmedetomidine.Dexmedetomidine significantly reduced systemic inflammation and lung injury in CLP mice. Dexmedetomidine enhanced the Foxp3 expression in the lungs and the frequency of Tregs in the spleen. Dexmedetomidine up-regulated the protein expression of p-AMPK and SIRT1 in lungs and EL-4 cells and facilitated the differentiation of naïve CD4DEX could improve ARDS/ALI by facilitating the differentiation of Tregs from naïve CD4
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- 2022
18. Massive gastrointestinal bleeding caused by a Dieulafoy’s lesion in a duodenal diverticulum: A case report
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Xiao-Cong Liu, Ling Zhong, Zhi-Wei He, Yang-Mei Wang, Hui Xu, and Hua Shi
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Duodenal diverticulum ,Gastrointestinal bleeding ,medicine.medical_specialty ,digestive system ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Case report ,otorhinolaryngologic diseases ,medicine ,medicine.diagnostic_test ,business.industry ,Endoscopy ,General Medicine ,Dieulafoy's lesion ,medicine.disease ,digestive system diseases ,Dieulafoy’s lesion ,surgical procedures, operative ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Hemostatic clip ,Radiology ,medicine.symptom ,business - Abstract
BACKGROUND Dieulafoy’s lesion is a rare vascular abnormality characterized by a small abnormally dilated artery that runs a tortuous course in the submucosa. There is usually no ulcer present in Dieulafoy’s lesions and the overlying mucosa is most often normal. Bleeding caused by a Dieulafoy’s lesion is usually urgent, massive, life-threatening and prone to recurrence. Dieulafoy’s lesions have been reported throughout the digestive tract although the majority of them have been found in the upper digestive tract especially the stomach and duodenum. However, a Dieulafoy’s lesion occurring inside a duodenal diverticulum is very rare. CASE SUMMARY A 74-year-old Asian male with epigastric pain, hematemesis and melena was admitted to our clinic. Before admission, the patient had vomited 500 mL of dark red blood, and passed 200 g of black tarry stool. Conservative management was first undertaken as the patient had not been fasting. However, hemorrhage recurred and the patient went into shock. Urgent endoscopy was performed and a diverticulum of 1.8 cm × 1.2 cm × 0.8 cm was found on the anterior wall of the descending duodenum. The diverticulum was covered with a blood clot. After the clot was removed, an artery stump was observed in the diverticulum with a diameter of 2-3 mm. Two titanium hemostatic clips were inserted to clamp the vessel stump. The patient was discharged 7 d post-endoscopy and followed for 6 mo with no recurrence. CONCLUSION This case was diagnosed with a Dieulafoy’s lesion inside a duodenal diverticulum which has rarely been reported. Hematemesis was stopped by clamping the vessel stump with titanium clips. No complications occurred.
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- 2020
19. Preparation and Characterization of Low Dielectric Constant Films Using Silicon Sources
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Swati A. Gupta, Mei Zhou, Ashok M. Mahajan, Chun Yan Li, Hong Xiao Lin, and Zhi Wei He
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010302 applied physics ,Materials science ,Silicon ,Mechanical Engineering ,chemistry.chemical_element ,02 engineering and technology ,Dielectric ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Characterization (materials science) ,Chemical engineering ,chemistry ,Mechanics of Materials ,0103 physical sciences ,General Materials Science ,Fourier transform infrared spectroscopy ,0210 nano-technology - Abstract
Effect of various silicon sources, such as TEOS, MTES mixed with TEOS and 1,3,5-tris(triethoxymethyl) on SiO2 films was investigated. The synthesized solutions were used as silicon sources to prepare silica-like backbone films. The investigation showed that all precursors can able to produce the flat and uniform films. An FTIR spectrum confirmed the formation of SiO2 in film matrix. The results indicated that the internal microstructure of each film is different. The incorporation of less polar bonds such as F and C was carried out using various Si sources, while the introduction of these sources confirmed through FTIR spectra. Optical properties of the films were carried out by using ellipsometric porosometry (EP) measurement. The leakage current density for the films prepared by using TEOS, MTES and 135TTEB was observed to be 2.8 × 10-7 A/cm2, 2.9 × 10-8 A / cm2, and 4.1 × 10-6 A / cm2, respectively, at 1 MV/cm electric field strength by the IV curves obtained by semiconductor characterization after fabricating MIS devices. The calculated dielectric constants from RI of the deposited SiO2 films were 2.0, 1.9 and 2.5 respectively. When the microstructure of the precursor solution changed, the introduction of atomic morphology or terminal inerted group ratio changed the internal bridging mode of SiO2, and thereby significantly reduced the dielectric constant and improved insulation.
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- 2020
20. Machine Learning for Identifying the Risk Factors of ICU-Acquired Fungal Infections Using a Clinical Cohort Data
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Yi-si Zhao, Qingpei Lai, Hong Tang, Ren-jie Luo, Zhi-wei He, Wei Huang, Liu-yang Wang, Zheng-tao Zhang, Shi-hui Lin, Wenjian Qin, and Fang Xu
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
21. Study on low-temperature heat capacity of nano-materials
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Zhi Wei He, Li Liu, and Jia Fu Zhong
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General Materials Science - Published
- 2023
22. Effect of catalyst HF concentration on the electrical characteristics of ultra low-k materials
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Yu-Yuan Guan, Zheng Qi, Sheng-Li Wang, Shi-Qiu Zhu, and Zhi-Wei He
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SiOF films ,FTIR ,SAXS ,Electrical properties ,Low dielectric constant ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
The effects of catalyst HF concentration on the dielectric and electrical properties of SiOF films are discussed. From the current density-voltage and capacitance-voltage curves, we observed that the film catalyzed with the special concentration of HF (the ratio of HF/H2O = 1/5) shows good moisture resistance, low leakage current (10-11 A/cm2 at 1 MV/cm) and high breakdown field (6 MV/cm), which can be explained by the results of Fourier transform infrared spectra. The dielectric constant value is also very low and reaches about 1.75 after annealing at the temperature of 450 °C. Therefore, the concentration of HF catalyst is an important factor in the sol-gel process.
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- 2012
23. Preparation, characterization, thermal behavior and decomposition kinetics of new high-nitrogen energetic salts based on 3-amino-5-hydrazinopyrazole
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Zhen-Li Yang, Yue-Mei Wu, Jian-Guo Zhang, Qiang Xie, Quan Wang, Zhi-Wei He, and Wen-Shuai Dong
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Physical and Theoretical Chemistry ,Condensed Matter Physics ,Instrumentation - Published
- 2022
24. Magnetically separatable CoFe2O4/BiOCl: Controllable synthesis, superior photocatalytic performance and mechanism towards decomposing RhB, NOR and Cr(VI) under visible light
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Jun Liu, Hui Wang, Meng-Jie Chang, Meng Sun, Zhi-Wei He, Cong-Miao Zhang, Wen-Yao Zhu, Jia-Liang Chen, Hui-Ling Du, Long-Gui Peng, Zhen-Min Luo, and Li Zhang
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Colloid and Surface Chemistry - Published
- 2022
25. Real-time monitoring the hydrolysis of chiral molecules by optical weak measurement
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Xiang-Lin Fang, Rui-Tong Zhao, Na Chen, Xin Wang, Peng Wang, Zhi-Wei He, Shao-Xin Li, Yang Xu, and Yong-Hong He
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Electrical and Electronic Engineering ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Published
- 2022
26. Dynamics of Mixed Lump-Soliton Solutions According to a (2+1)-Dimensional Coupled Nonlinear Partial Differential Like Equation
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Fudong Wang, Zhi-Wei He, Yong-Li Sun, and Bo Ren
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010302 applied physics ,Physics ,Mathematical analysis ,One-dimensional space ,Prime number ,General Physics and Astronomy ,02 engineering and technology ,Quadratic function ,021001 nanoscience & nanotechnology ,01 natural sciences ,Exponential function ,Nonlinear system ,0103 physical sciences ,Partial derivative ,Soliton ,Rogue wave ,0210 nano-technology ,Nonlinear Sciences::Pattern Formation and Solitons - Abstract
Based on the generalized bilinear operators in a prime number p = 3, we introduce a (2+1)-dimensional coupled nonlinear partial differential like equation. By combining an exponential function with a quadratic function, an interaction between a lump wave and a one-kink soliton is generated. In addition, an interaction between a lump wave and a two-kink soliton, which is called a special rogue wave, can be obtained by adding two additional exponential functions. The dynamic properties of these interactions are depicted by selecting appropriate parameters.
- Published
- 2019
27. Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats
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Hong-Fu Wu, Yuhui Wang, Zhang Xiaomin, Lu Ding, Tao Wang, Zhi-Wei He, Zhe Zhu, Zeng Lini, and Wei-Bin Luo
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Nerve root ,ischemia ,lcsh:RC346-429 ,Avulsion ,brachial plexus avulsion ,03 medical and health sciences ,Hypoxia-Inducible Factor 1-Alpha ,angiogenesis ,0302 clinical medicine ,Developmental Neuroscience ,medicine ,peripheral nerve injury ,motor neurons ,nerve regeneration ,lcsh:Neurology. Diseases of the nervous system ,Plexus ,business.industry ,hypoxia ,axonal regeneration ,Motor neuron ,hypoxia-inducible factor 1α overexpression ,Spinal cord ,030104 developmental biology ,medicine.anatomical_structure ,Peripheral nerve injury ,business ,neural regeneration ,Brachial plexus ,pluronic F-127 ,030217 neurology & neurosurgery ,Research Article - Abstract
Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available. Hypoxia-inducible factor 1α is a critical molecule targeting several genes associated with ischemia-hypoxia damage and angiogenesis. In this study, a rat model of brachial plexus avulsion-reimplantation was established, in which C5-7 ventral nerve roots were avulsed and only the C6 root reimplanted. Different implants were immediately injected using a microsyringe into the avulsion-reimplantation site of the C6 root post-brachial plexus avulsion. Rats were randomly divided into five groups: phosphate-buffered saline, negative control of lentivirus, hypoxia-inducible factor 1α (hypoxia-inducible factor 1α overexpression lentivirus), gel (pluronic F-127 hydrogel), and gel + hypoxia-inducible factor 1α (pluronic F-127 hydrogel + hypoxia-inducible factor 1α overexpression lentivirus). The Terzis grooming test was performed to assess recovery of motor function. Scores were higher in the hypoxia-inducible factor 1α and gel + hypoxia-inducible factor 1α groups (in particular the gel + hypoxia-inducible factor 1α group) compared with the phosphate-buffered saline group. Electrophysiology, fluorogold retrograde tracing, and immunofluorescent staining were further performed to investigate neural pathway reconstruction and changes of neurons, motor endplates, and angiogenesis. Compared with the phosphate-buffered saline group, action potential latency of musculocutaneous nerves was markedly shortened in the hypoxia-inducible factor 1α and gel + hypoxia-inducible factor 1α groups. Meanwhile, the number of fluorogold-positive cells and ChAT-positive neurons, neovascular area (labeled by CD31 around avulsed sites in ipsilateral spinal cord segments), and the number of motor endplates in biceps brachii (identified by α-bungarotoxin) were all visibly increased, as well as the morphology of motor endplate in biceps brachil was clear in the hypoxia-inducible factor 1α and gel + hypoxia-inducible factor 1α groups. Taken together, delivery of hypoxia-inducible factor 1α overexpression lentiviral vectors mediated by pluronic F-127 effectively promotes spinal root regeneration and functional recovery post-brachial plexus avulsion. All animal procedures were approved by the Institutional Animal Care and Use Committee of Guangdong Medical University, China.
- Published
- 2019
28. Expression and clinical significance of C14orf166 in esophageal squamous cell carcinoma
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Yang Gao, Chao‑Jun Duan, Rong Li, Yuan‑Da Cheng, Chun‑Fang Zhang, Zhi‑Wei He, Jun‑Xian Zeng, and Yan‑Wu Zhou
- Subjects
Male ,0301 basic medicine ,Oncology ,Cancer Research ,Esophageal Neoplasms ,Kaplan-Meier Estimate ,medicine.disease_cause ,Biochemistry ,0302 clinical medicine ,Medicine ,lymph node metastasis ,Articles ,Middle Aged ,Prognosis ,Immunohistochemistry ,esophageal squamous cell carcinoma ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,C14orf166 ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Molecular Medicine ,Female ,Adult ,medicine.medical_specialty ,Blotting, Western ,Disease-Free Survival ,03 medical and health sciences ,Internal medicine ,Biomarkers, Tumor ,Genetics ,Carcinoma ,Humans ,Clinical significance ,RNA, Messenger ,neoplasms ,Molecular Biology ,Survival analysis ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,Oncogene ,business.industry ,Cancer ,medicine.disease ,Molecular medicine ,digestive system diseases ,030104 developmental biology ,Trans-Activators ,Cancer research ,business ,Carcinogenesis ,Follow-Up Studies - Abstract
C14orf166, a 28 kD protein regulating RNA transcription and translation, may serve a critical role in oncogenesis. The aim of the current study was to explore the association between C14orf166 expression and esophageal squamous cell carcinoma (ESCC) and to draw attention to the association between C14orf166 and the initiation, progression and prognosis of ESCC. C14orf166 expression in ESCC and paired normal tissues was detected by immunohistochemical staining, western blotting and reverse transcription-quantitative polymerase chain reaction, and the association between C14orf166 expression and clinicopathological characters of ESCC was analyzed. Survival analysis was used to assess the prognostic significance of C14orf166 and it was observed that C14orf166 expression was higher in the ESCC tissues when compared with adjacent non-cancerous tissues at protein (P
- Published
- 2016
29. Scalable preparation of functionalized graphite nanoplatelets via magnetic grinding as lubricity-enhanced additive
- Author
-
Sha-sha Song, Zhi-wei He, Hai-bin Ji, and Zeng-dian Zhao
- Subjects
Friction coefficient ,Materials science ,Metals and Alloys ,General Engineering ,02 engineering and technology ,Tribology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Grinding ,Lubricity ,Silanization ,Graphite ,Composite material ,Lubricant ,0210 nano-technology ,Mass fraction - Abstract
Graphite nanoplatelets were prepared by a novel magnetic-grinding method using self-made equipments. Under a variant magnetic field, magnetic needles collided at a high rotating speed and exfoliated pristine graphite into graphite nanoplatelets with high efficiency. The obtained graphite nanoplatelets are highly crystalline, and the thickness is less than 10 nm. Moreover, the surface area could reached 738.1 m2/g with a grinding time of 4 h. Silanized graphite nanoplatelets can disperse well in SG 15W-40 engine oil and serve as lubricant additive. Tribological results indicate that the friction coefficient and wear-scar of the friction pairs are lower than 76% and 41%, respectively, by adding 1.5‰ (mass fraction) of silanized graphite nanoplatelets. Notably, the functionalized graphite nanoplatelets can realize large-scale production and commercial application.
- Published
- 2016
30. ZMYND10 downregulates cyclins B1 and D1 to arrest cell cycle by trimethylating lysine 9 on histone 3
- Author
-
Jing Huang, Jian Wang, Biying Zheng, Xia Kong, Xiang-Ning Zhang, Zhi-Wei He, Long-Ji Wu, and HongBing Yu
- Subjects
Histone ,biology ,Chemistry ,Lysine ,biology.protein ,Cell cycle ,Cyclin ,Cell biology - Published
- 2021
31. Fabrication of Convex Plate-Shaped Micro Tool Electrode and its Application in Micro Hole Machining by ECM
- Author
-
Zhi Wei He, Ming Huan Wang, Wei Peng, and Li Zhang
- Subjects
Engineering drawing ,Fabrication ,Materials science ,Cylindrical electrode ,Mechanical Engineering ,Regular polygon ,Machining ,Mechanics of Materials ,Etching (microfabrication) ,Electrode ,Micro electrode ,General Materials Science ,Electrochemical etching ,Composite material - Abstract
A method of fabricating convex plate-shaped micro electrode was proposed based on the electrochemical etching principle. The square sectional electrodes were prepared in advanced using wire-EDM, The micro cylindrical electrode was fabricated firstly by using the eletrochechemical etching method. Then the top end was insulated to protect it from etching. Then the convex plate-shaped micro electrode was obtained in subsequent etching. Comparative experiments in drilling micro-hole in stainless steel with the thickness of 1mm were done by using the cylindrical and convex plate-shaped micro electrode. Results shows that the better locality, smaller side-gap and hole taper could be obtain by using convex plate-shaped micro electrode.
- Published
- 2015
32. The Transplantion and Realization of Qt4.7.0 Based on ARM9 and Linux
- Author
-
Chuan Qiang Zang, Ming Yu Gao, and Zhi Wei He
- Subjects
Engineering ,ARM9 ,business.industry ,Interface (computing) ,Linux kernel ,General Medicine ,computer.software_genre ,Field (computer science) ,Transplantation ,Embedded system ,Operating system ,business ,Realization (systems) ,Mobile device ,computer ,Graphical user interface - Abstract
With continuous improvement and update of embedded Linux kernel, embedded technology has been widely used in handheld devices and industrial control field. Therefore, a user-friendly graphical user interface (GUI) is essential for these applications. This paper firstly presents the design method for transplanting Qt on embedded platform of ARM9. Secondly it elaborates the device driver development and Qt interface development in Linux system with a Qt test program. All transplantation method of Qt and test program have been tested and verified on the ARM9 platform.
- Published
- 2015
33. Design and Realization of CAN-Based Main Control System of Multi-Station Meter Testing Equipment
- Author
-
Bu Sen Cai, Ji Ye Huang, Ming Yu Gao, Zhi Wei He, and Wei Wei Zhou
- Subjects
Engineering ,business.industry ,Interface (computing) ,Windows CE ,Electrical engineering ,General Medicine ,Gas meter prover ,Embedded operating system ,CAN bus ,Control system ,business ,Computer hardware ,Control bus ,System bus - Abstract
In this paper, 0.05 grade three-phase main control system of multi-station meter testing equipment (MTE) is presented. This design is based on the S3C2440 core board as the control core, and the software is based on Windows CE(WINCE) embedded operating system. The device is displayed and controlled by 7-inch Touch Screen. The main control system communicate with the error instrument and PC through Controller Area Network (CAN) bus, and the largest number of error instruments can connect to CAN bus is 100. The main control system communicates through RS232 bus with three-phase signal source and standard electric energy meter, through RS485 bus with programmable power amplifier. In this device, calibration of energy meters can not only through the PC software, but also use the main control system. Compared to the traditional design of the electric energy meter calibration device, the design’s the man-machine interface is more optimized, the number of electric energy meters can be test in the same time is more, faster communication, stronger anti-interference ability, and calibration is more efficiency.
- Published
- 2015
34. Design and Implementation of Control Software Based on Linux and QT for Electric Energy Meter Calibration Device
- Author
-
Lei Luo, Jie Wang, and Zhi-Wei He
- Subjects
Electric energy ,Computer science ,business.industry ,Embedded system ,Signal source ,Control software ,Thread (computing) ,business ,Computer hardware - Published
- 2017
35. Preparation and Properties Research of Mesoporous Low-k Silica with Electric Field Induction
- Author
-
Jian Jun Zhang, Bai He Chen, Huan Cui, Zhi Wei He, and Chunyan Li
- Subjects
Materials science ,Scanning electron microscope ,Electric field ,General Engineering ,Analytical chemistry ,Dielectric ,Electrostatic induction ,Microstructure ,Mesoporous material ,Porosity ,Sol-gel - Abstract
The preparation of mesoporous SiO2 with electric field (EF) induced different molecular templates method was reported. The effect of EF on the microstructure of the material has been investigated by scanning electron microscopy and static nitrogen adsorption analyzer. Results showed that the molecular regularly arranged by high voltage electrostatic field could effectively affect the porosity of the samples. The dielectric constant estimated from the Rayleigh and Lorentz-Lorenz classic models, was1.90.
- Published
- 2014
36. Deep Level Centers in Carbon-Doped High Resistivity GaN
- Author
-
Zhi Wei He, Bo Shen, Huan Cui, Li Wu Lu, Bai He Chen, Ling Sang, and Xue Lin Yang
- Subjects
Materials science ,High resistivity ,Deep level ,chemistry ,Hall effect ,General Engineering ,Analytical chemistry ,chemistry.chemical_element ,Chemical vapor deposition ,Activation energy ,Metalorganic vapour phase epitaxy ,Spectroscopy ,Carbon - Abstract
The deep levels of carbon doped high resistivity (HR) GaN samples grown by metal-organic chemical vapor deposition (MOCVD) has been investigated using thermally stimulated current (TSC) spectroscopy and high temperature (HT) Hall measurement. Two different thickness of 100 and 300 nm were used to be compared. It was found that four distinct deep levels by TSC and one deep level by HT Hall measurement were observed in both samples, which means great help for the decrease of leakage current and lifetime limitations of device utilizing the structure. The activation energy of these levels was calculated and their possible origins were also proposed. The low temperature traps, might be related to VN, 0.50 and 0.52eV related to incorporate a high level carbon, 0.57eV related to VGa, 0.59eV related to CGaor NGa, 0.91 and 0.97eV related to interstitial N1.
- Published
- 2014
37. An Anti-Ribboning Method for Winder Based on Brushless DC Motor
- Author
-
Zhi Wei He, Ming Yu Gao, Chen Hui Zhu, and Yu Xiang Yang
- Subjects
Engineering ,Bobbin ,Ratio value ,business.industry ,General Engineering ,Relative velocity ,Improved method ,Yarn ,Drum ,DC motor ,Control theory ,visual_art ,visual_art.visual_art_medium ,business ,Dc motor control - Abstract
This paper is about how to design an improved anti-ribboning method for the winder system. The system is based on the principle of a brushless DC motor control, which constantly changes relative velocity between the grooved drum and the yarn bobbin. This in turn, causes the changing of the winding ratio value. Therefore, it will accomplish the anti-ribboning control. Compared with the traditional anti-ribboning methods, the improved method can save more mechanical components and maintenance costs. Also, this method can develop different programs for different yarns. Therefore, this method is more efficient and versatile.
- Published
- 2014
38. Study of Subdivision Stepping Motor Driver Based on the Controllable Dead-Time Compensation
- Author
-
Zhi Wei He, Chuan Qiang Zang, Ming Yu Gao, and Liu Yunfei
- Subjects
Engineering ,business.industry ,STM32 ,Control engineering ,General Medicine ,Dead time ,Complex programmable logic device ,Signal ,Compensation (engineering) ,Microcontroller ,Control theory ,Stepper motor ,business ,Subdivision - Abstract
In order to improve the step accuracy of two-phase hybrid stepping motors, this paper presents a high-performance stepping motor driver based on controllable dead-time compensation. After CPLD(Complex Programmable Logic Device) logical processing, the subdivision drive signal created by microcontroller STM32 becomes a complementary dead-time compensation drive signal which can realize precise control of stepper motor. The experiment shows that this program not only has effectively reduced the power consumption of the stepping motor, but also made whole system cost less.
- Published
- 2014
39. Design and Implementation of Gas Stove and Range Hood Integrated Intelligent Control System
- Author
-
Zhi Wei He, Qi Zhu, Ming Yu Gao, and Jian Jing Xie
- Subjects
Engineering ,business.industry ,Stove ,Range (aeronautics) ,General Engineering ,Intelligent control system ,Wireless ,business ,GeneralLiterature_MISCELLANEOUS ,Automotive engineering ,Simulation - Abstract
In this paper, a gas stove and range hood integrated intelligent control system based on wireless communication is introduced. This system enables range hood running through wireless communication without human intervention, and gas stove can directly and automatically control the opening, the wind speed and closed of range hood. Compared to traditional gas stove and range hood, it implements the gas stove and range hood work together to make the operation more safe, convenient and fast. Through experimental test, the proposed design is feasible to achieve the gas stove and range hood integrated intelligent control system design requirements.
- Published
- 2014
40. Variable Frequency and Multi-Pressure Water Supply Control System Based on STM32 Processor
- Author
-
Hong Fang Zhang, Zhi Wei He, Jia Xiang Lou, and Ming Yu Gao
- Subjects
Engineering ,Water flow ,business.industry ,Control (management) ,Real-time computing ,Flow (psychology) ,General Engineering ,STM32 ,Water supply ,Energy consumption ,Automotive engineering ,Variable (computer science) ,Control system ,business - Abstract
In this paper, a kind of variable frequency and multi-pressure water supply control system based on STM32 processor is designed. It can adjust the water pressure dynamically, according to the changes of water flow. Therefore, it can economize the energy consumption significantly. In order to improve real-time performance, the system adopts STs STM32F407 series processor which is based on ARM® CortexTM-M4 32-bit RISC core. It is used to collect the water flow, pressure and other data in real time, and automatically adjust the output frequency to control the motor speed, according to the set pressure value, and ultimately control the flow and pressure of the water supply system. According to the test, this variable frequency and multi-pressure water supply control system based on STM32 processor can meet the design requirements.
- Published
- 2014
41. Dynamical analysis of solitary waves, lumps and interaction phenomena of a (2+1)-dimensional high-order nonlinear evolution equation
- Author
-
Yong-Li Sun, Zhi-Mei Lou, Zhi-Wei He, and Bo Ren
- Subjects
Physics ,Variables ,Integrable system ,media_common.quotation_subject ,One-dimensional space ,Statistical and Nonlinear Physics ,Function (mathematics) ,Bilinear form ,Condensed Matter Physics ,01 natural sciences ,Nonlinear Sciences::Exactly Solvable and Integrable Systems ,0103 physical sciences ,Rogue wave ,High order ,010306 general physics ,Nonlinear evolution ,Nonlinear Sciences::Pattern Formation and Solitons ,010301 acoustics ,media_common ,Mathematical physics - Abstract
A (2[Formula: see text]+[Formula: see text]1)-dimensional high-order nonlinear evolution (HNE) equation is considered in this paper. A Hirota bilinear form of the HNE equation is constructed by the dependent variable function. Solitary waves are derived by solving the Hirota bilinear form of the HNE equation. Lump waves of the HNE equation are obtained by introducing a positive quadratic function. By mixing an exponential function or two exponential functions with a quadratic function, interaction solutions between a lump and a one-soliton, and between a lump and a two-soliton are presented. For the interaction solution between a lump and a two-soliton, this kind of solution can be considered as a special rogue wave. The propagation phenomena of these explicit solutions are illustrated by some graphs.
- Published
- 2019
42. Synthesis of Water-Soluble Fluorescent Carbon Dots from a One-Step Hydrothermal Method with Potato
- Author
-
Xiang Bao Sun, Zhi Wei He, Ying Xiang Sun, and Zeng Dian Zhao
- Subjects
Materials science ,General Engineering ,Quantum yield ,chemistry.chemical_element ,Nanotechnology ,One-Step ,Fluorescence ,Hydrothermal circulation ,Water soluble ,chemistry ,Chemical engineering ,Absorption (chemistry) ,High-resolution transmission electron microscopy ,Carbon - Abstract
Water-soluble fluorescent carbon dots (CDs) have been synthesized in one step by hydrothermal treatment of potato. Effects of the hydrothermal treatment time, temperature, potato additive amount and pH on the light emissions of the CDs were also studied. HRTEM images of the CDs showed spherical particles with fairly uniform diameter of approximate 2~3 nm, which also dispersed excellently in water. The characteristic absorption peak of CDs appeared at about 280 nm and exhibits a strong bright blue light emission with a high quantum yield (14.2%). The mechanism of the fluorescent emission from CDs was proposed. Moreover, some highly fluorescent CDs were also prepared with other vegetables under the same condition.
- Published
- 2013
43. High-Speed Acquisition and Filtering of Yarn Signal
- Author
-
Ming Yu Gao, Ying Jie Xu, and Zhi Wei He
- Subjects
Engineering ,business.industry ,Low-pass filter ,Wiener filter ,Filter factor ,General Medicine ,Adaptive filter ,Filter design ,symbols.namesake ,Electronic engineering ,symbols ,business ,High-pass filter ,Digital filter ,Root-raised-cosine filter - Abstract
We have designed a photoelectric yarn signal acquisition system, which is based on the STM32 processor, having a sample rate up to 270kHz, and uploading data collection through synchronous parallel communication mode; Owing to the large noise of yarn signal and the unobviousness of yarn defect, we respectively adopting wiener filter and mean filter to filter this signal; The simulation result of matlab has manifested that both the wiener filter and mean filter can effectively decrease the noise level of the yarn signal and make the nep defects easier to identify, and that the wiener filter applies to application where the yarn speed is higher , while the mean filter is appropriate to the lower speed spinner.
- Published
- 2013
44. Theoretical and Experimental Study on Trans-Scale Properties of Soil Strength
- Author
-
De Luan Feng, Zhi Wei He, Ren Guo Gu, and Ying Guang Fang
- Subjects
Length scale ,Materials science ,Scale (ratio) ,General Engineering ,Gradation ,Geotechnical engineering ,Particle size ,Composite material ,Reinforcement ,Compression (physics) ,Microstructure ,Matrix (geology) - Abstract
According to the size and connecting characters of soil particles, soil is discomposed into two components as matrix and reinforcement particles respectively with a demarcation size fixed at 0.075mm to investigate the influence of the microstructures on soil strength. Based on the strain gradient theory, a multi-scale matrix-reinforcement particle model was established to study the trans-scale properties of soil strength which indicates that the soil strength is related to the intrinsic length scale, the strain gradient, the matrix properties and the gradation and size of reinforcement particles. A series of consolidated and undrained compression tests of unsaturated remoulded soil were designed to study the trans-scale properties of soil strength. The results showed that: the yield stress of soil increased as the reinforcement particle size decreased, displaying the trans-scale properties of soil strength. The research result is significant to the development of strength theory of soil.
- Published
- 2013
45. Line‐profile Analysis of Excitation Spectroscopy in Even 5p5(2P1/2)nl′ [K′]J (l′=1, 3) Autoionizing Resonances of Xe
- Author
-
Chun‐yan Li, Ting‐ting Wang, Jun‐feng Zhen, Yang Chen, and Zhi‐wei He
- Subjects
Physical and Theoretical Chemistry - Published
- 2013
46. Reinforcement of a new calcium phosphate cement with RGD-chitosan-fiber
- Author
-
Ye Huang, Zu Bin Zhou, Xiao Wei Yu, Zhi Wei He, Wei Ping Ren, and Tian Yi Wu
- Subjects
Scaffold ,Materials science ,Biocompatibility ,technology, industry, and agriculture ,Metals and Alloys ,Biomedical Engineering ,macromolecular substances ,Biomaterials ,Chitosan ,chemistry.chemical_compound ,Animal model ,chemistry ,Flexural strength ,Ceramics and Composites ,Fiber ,Calcium phosphate cement ,Reinforcement ,Biomedical engineering - Abstract
Calcium phosphate cement (CPC) has been widely used in orthopedic and dental applications. A critical limitation of CPC is low strength and high susceptibility to severe fracture. Surgeons can use it only to reconstruct non-stress bearing bone, raising the need for a tougher new generation of CPC. Fibers have been used as a reinforcement of CPC to improve the strength of a pure CPC scaffold. The RGD peptides (Arg-Gly-Asp) have been used to improve the biocompatibility of the scaffold, via physical adsorption. The purpose of this study was to develop a novel CPC scaffold reinforced by RGD peptide-bearing chitosan fibers (RGD-fiber-CPC). Our data showed that the RGD-fiber-CPC scaffold had an increased flexural strength, and stimulated new bone formation in an animal model. The RGD-fiber-CPC is a novel bone graft substitute in orthopedic surgery. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 68–75, 2014.
- Published
- 2013
47. Orphan Nuclear Receptor Nurr1 as a Potential Novel Marker for Progression in Human Prostate Cancer
- Author
-
Jian Wang, Guo-Liang Huang, Zhi-Wei He, Jing Yang, and Ying Zou
- Subjects
Adult ,Male ,PCA3 ,Oncology ,Cancer Research ,medicine.medical_specialty ,Small interfering RNA ,Epidemiology ,Blotting, Western ,Prostatic Hyperplasia ,Apoptosis ,Biology ,medicine.disease_cause ,Immunoenzyme Techniques ,Prostate cancer ,Cell Movement ,Internal medicine ,Nuclear Receptor Subfamily 4, Group A, Member 2 ,Biomarkers, Tumor ,Cell Adhesion ,Tumor Cells, Cultured ,medicine ,Humans ,Gene silencing ,RNA, Small Interfering ,Aged ,Cell Proliferation ,Neoplasm Staging ,Aged, 80 and over ,Public Health, Environmental and Occupational Health ,Prostatic Neoplasms ,Cancer ,Middle Aged ,Flow Cytometry ,Prognosis ,medicine.disease ,Cancer cell ,Disease Progression ,Carcinogenesis ,Follow-Up Studies - Abstract
A number of studies have indicated that Nurr1, which belongs to a novel class of orphan nuclear receptors (the NR4A family), is important for carcinogenesis. Here we investigated expression of Nurr1 protein in benign and malignant human prostate tissues and association with clinicopathologic features using immunohistochemical techniques. Moreover, we also investigated the ability of Nurr1 to influence proliferation, migration, invasion and apoptosis of human prostate cancer cells using small interfering RNA silencing. Immunohistochemical analysis revealed that the expression of Nurr1 protein was higher in prostate cancer tissues than in benign prostate tissue (P < 0.001), levels being positively correlated with tumor T classification (P = 0.003), N classification (P = 0.017), M classification (P = 0.011) and the Gleason score (P = 0.020) of prostate cancer patients. In vitro, silencing of endogenous Nurr1 attenuated cell proliferation, migration and invasion, and induced apoptosis of prostate cancer cells. These results suggest that Nurr1 may be used as an indicator for prostate cancer progression and be useful for novel potential therapeutic strategies.
- Published
- 2013
48. Design of the Equalizing Charge Circuit Based on Bidirectional Energy Transfer
- Author
-
Kang Ping Xu, Yu Zeng, Zhi Wei He, Hui Jiang Liang, and Ming Yu Gao
- Subjects
Engineering ,Program analysis ,Hardware_GENERAL ,business.industry ,Energy transfer ,General Engineering ,Electrical engineering ,Electronic engineering ,Mechanism based ,business ,Battery pack - Abstract
The batteries in a battery pack may have different internal resistances, and this inconsistency may lead to fast aging of the whole pack. In order to overcome the shortcomings of existing equalizing charge method, a bidirectional energy transfer mechanism based battery equalizing charge schema is given. We detailed analysis the working principle of equalization circuit and equalization work process, and the program analysis and argument by experiments. Experiments show that the method structure is simple, and it can quickly realize the dynamic transfer of energy between the batteries. The battery power charging imbalance can be effectively solved.
- Published
- 2012
49. An FPGA Based Frame Rate Enhancer for LCD Display in Embedded Systems
- Author
-
Ji Ye Huang, Hui Jiang Liang, Kang Ping Xu, Ming Yu Gao, and Zhi Wei He
- Subjects
Engineering ,Liquid-crystal display ,business.industry ,Flicker ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,General Engineering ,Frame rate ,law.invention ,law ,Embedded system ,Computer data storage ,business ,Field-programmable gate array ,Computer hardware - Abstract
CPUs in embedded systems sometimes have limited performance for the sake of cost, so there may be impossible for these systems to drive a LCD display with a high frame rate. An FPGA based schema is proposed to increase the frame rate of the LCD display so that the texts etc. can be seen fluently. The frame rate enhancer is composed of three parts, an FPGA for receiving the data to be displayed, an SDRAM for data storage and an LCD controller for display control. The designed frame rate enhancer can be used in an embedded system, which has a large LCD display but a low performance CPU, without any flicker.
- Published
- 2012
50. SELF-ASSEMBLY PREPARATION AND PROPERTIES OF POLY(ANILINE-co-PYRROLE) HOLLOW SPHERES
- Author
-
Qiu-feng Lü, Zhi-wei He, and Jia-Yin Zhang
- Subjects
chemistry.chemical_compound ,Aniline ,Materials science ,Polymers and Plastics ,chemistry ,Chemical engineering ,General Chemical Engineering ,SPHERES ,General Chemistry ,Self-assembly ,Pyrrole - Published
- 2012
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