28 results on '"Zhi-Wen, Cui"'
Search Results
2. Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors
- Author
-
Cheng-Zhi Gao, Wei Dong, Zhi-Wen Cui, Qiong Yuan, Xia-Min Hu, Qing-Ming Wu, Xianlin Han, Yao Xu, and Zhen-Li Min
- Subjects
parp-1 inhibitor ,olaparib ,ache ,bche ,alzheimer's disease ,Therapeutics. Pharmacology ,RM1-950 - Abstract
A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP-1 enzyme (16.10 ± 1.25 nM) and MDA-MB-436 cancer cell (11.62 ± 2.15 μM), which was close to that of Olaparib. As a PARP-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (MTDLs) for the treatment of Alzheimer’s disease (AD), the inhibitory activities of the synthesized compounds against the enzymes AChE (from electric eel) and BChE (from equine serum) were also tested. Compound 5l displayed moderate BChE inhibitory activity (9.16 ± 0.91 μM) which was stronger than neostigmine (12.01 ± 0.45 μM) and exhibited selectivity for BChE over AChE to some degree. Molecular docking studies indicated that 5l could bind simultaneously to the catalytic active of PARP-1, but it could not interact well with huBChE. For pursuit of PARP-1 and BChE dual-targeted inhibitors against AD, small and flexible non-polar groups introduced to the compound seemed to be conducive to improving its inhibitory potency on huBChE, while keeping phthalazine-1-one moiety unchanged which was mainly responsible for PARP-1 inhibitory activity. Our research gave a clue to search for new agents based on AChE and PARP-1 dual-inhibited activities to treat Alzheimer’s disease.
- Published
- 2019
- Full Text
- View/download PDF
3. Effect of Oral Administration of Enterococcus faecium Ef1 on Innate Immunity of Sucking Piglets
- Author
-
Wei-fen Li, Yi Huang§, Ya-li Li, Qin Huang, Zhi-wen Cui, Dong-you Yu, Imran R. Rajput and Cai-hong Hu
- Subjects
Cytokine ,Enterococcus faecium ,Piglets ,Toll-like receptors ,Animal culture ,SF1-1100 ,Veterinary medicine ,SF600-1100 - Abstract
The objective of this study was to evaluate the effect of orally administered Enterococcus faecium EF1 on innate immune responses of jejunal mucosa in newborn piglets. Twenty-four commercial crossbred healthy newborn piglets were randomly divided into two groups, control (T0) and treatment (T1) group. Each group consists of 12 piglets. T1 was administered sterilized skim milk 2 ml piglet-1 day-1 with addition of E. faecium EF1 (5~6×108 cfu/ml) by oral gavage on alternative odd days (1st, 3rd and 5th) after birth. T0 fed with the same volume of sterilized skim milk without probiotics. The merciful killing of piglets at the 25th day after birth was performed to collect the samples of jejunal mucosa to measure the innate cytokine responses and the Toll-like receptors gene expression by quantitative real time PCR. The results showed that TGF-β1 and TNF-α concentrations increased and mRNA expression levels also improved significantly in T1 as compared to T0. While, the production of IFN-γ and IL-8 decreased significantly in T1 and gene expression modification was not observed. In addition, TLR (Toll-like receptor) 2 and TLR 9 transcription levels were up-regulated in treatment (T1) group. These findings revealed that oral administration of E. faecium EF1 was effective to activate innate immunity and could modulate the TLRs expression in jejunal mucosa of piglets.
- Published
- 2013
4. Effect of Orally Administered Enterococcus faecium EF1 on Intestinal Cytokines and Chemokines Production of Suckling Piglets
- Author
-
Yi Huang§, Ya-li Li, Qin Huang, Zhi-wen Cui, Dong-you Yu, Imran Rashid Rajput, Cai-hong Hu and Wei-fen Li
- Subjects
Chemokine ,Cytokine ,Enterococcus faecium ,Intestinal mucosa ,Animal culture ,SF1-1100 ,Veterinary medicine ,SF600-1100 - Abstract
The objective of this study was to determine the effect of orally administered Enterococcus faecium EF1 on intestinal cytokines and chemokines production in piglets. Twenty-four newborn piglets were randomly divided into two groups. The treatment group (T1), orally administered sterilized (110 ºC for 30 min) skim milk 10% (2 ml/piglet/day) with addition of viable E. faecium EF1 (5~6×108 cfu/ml) on 1st, 3rd and 5th day after birth. The control group (T0), were fed the same volume of sterilized skim milk without addition of probiotics. Feeding trial was conducted for 25 days of suckling age. At the end of trail six piglets were randomly selected from each group to collect the samples of jejunum and ileum mucosa to observe the cytokines and chemokines production. The results showed that concentrations of IL-10 and TGF-β1 significantly increased in T1 group. Whereas, production of IL-1β, IL-6, IL-12, IFN-γ and IL-8 decreased in T1 compared to T0. Levels of TNF-α were increased in jejunal mucosa, while decreased in ileal mucosa comparatively in T1 group. Our findings revealed that oral administration of E. faecium EF1 induced a strong anti-inflammatory response in the small intestine. These immunomodulatory effects of this bacterium might contribute to maintenance of immune homeostasis in the intestine of piglets.
- Published
- 2012
5. Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets
- Author
-
Yang Wang, Weifen Li, Xiaoping Zhang, Li Gong, Zhi-wen Cui, Yong-qiang Wang, Yi Huang, and Yanping Wu
- Subjects
Male ,0301 basic medicine ,Swine ,animal diseases ,Administration, Oral ,Weaning ,Article ,General Biochemistry, Genetics and Molecular Biology ,law.invention ,Andrology ,03 medical and health sciences ,Probiotic ,fluids and secretions ,0302 clinical medicine ,Intestinal mucosa ,Lactobacillus rhamnosus ,law ,Oral administration ,Animals ,Medicine ,Intestinal Mucosa ,General Pharmacology, Toxicology and Pharmaceutics ,Barrier function ,General Veterinary ,biology ,Lacticaseibacillus rhamnosus ,business.industry ,Probiotics ,food and beverages ,General Medicine ,biology.organism_classification ,Immunity, Innate ,Gastrointestinal Microbiome ,Diarrhea ,030104 developmental biology ,Animals, Newborn ,030220 oncology & carcinogenesis ,Cytokines ,Female ,medicine.symptom ,business ,Weight gain ,Signal Transduction - Abstract
To understand the effects of Lactobacillus rhamnosus GG (ATCC 53103) on intestinal barrier function in pre-weaning piglets under normal conditions, twenty-four newborn littermate piglets were randomly divided into two groups. Piglets in the control group were orally administered with 2 mL 0.1 g/mL sterilized skim milk while the treatment group was administered the same volume of sterilized skim milk with the addition of viable L. rhamnosus at the 1st, 3rd, and 5th days after birth. The feeding trial was conducted for 25 d. Results showed that piglets in the L. rhamnosus group exhibited increased weaning weight and average daily weight gain, whereas diarrhea incidence was decreased. The bacterial abundance and composition of cecal contents, especially Firmicutes, Bacteroidetes, and Fusobacteria, were altered by probiotic treatment. In addition, L. rhamnosus increased the jejunal permeability and promoted the immunologic barrier through regulating antimicrobial peptides, cytokines, and chemokines via Toll-like receptors. Our findings indicate that oral administration of L. rhamnosus GG to newborn piglets is beneficial for intestinal health of pre-weaning piglets by improving the biological, physical, and immunologic barriers of intestinal mucosa.
- Published
- 2019
6. Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors
- Author
-
Qing Ming Wu, Xianlin Han, Cheng Zhi Gao, Wei Dong, Zhi-wen Cui, Qiong Yuan, Xia Min Hu, Yao Xu, and Zhen Li Min
- Subjects
Poly ADP ribose polymerase ,Poly (ADP-Ribose) Polymerase-1 ,Antineoplastic Agents ,Alzheimer's Disease ,01 natural sciences ,Molecular Docking Simulation ,Piperazines ,Olaparib ,chemistry.chemical_compound ,Structure-Activity Relationship ,Cell Line, Tumor ,Drug Discovery ,BChE ,Structure–activity relationship ,Animals ,Humans ,Horses ,Butyrylcholinesterase ,Cell Proliferation ,Pharmacology ,chemistry.chemical_classification ,Dose-Response Relationship, Drug ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Cell growth ,lcsh:RM1-950 ,General Medicine ,PARP-1 inhibitor ,In vitro ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,lcsh:Therapeutics. Pharmacology ,Enzyme ,Biochemistry ,Electrophorus ,Acetylcholinesterase ,AChE ,Phthalazines ,Cholinesterase Inhibitors ,Drug Screening Assays, Antitumor ,Research Paper - Abstract
A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP-1 enzyme (16.10 ± 1.25 nM) and MDA-MB-436 cancer cell (11.62 ± 2.15 μM), which was close to that of Olaparib. As a PARP-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (MTDLs) for the treatment of Alzheimer’s disease (AD), the inhibitory activities of the synthesized compounds against the enzymes AChE (from electric eel) and BChE (from equine serum) were also tested. Compound 5l displayed moderate BChE inhibitory activity (9.16 ± 0.91 μM) which was stronger than neostigmine (12.01 ± 0.45 μM) and exhibited selectivity for BChE over AChE to some degree. Molecular docking studies indicated that 5l could bind simultaneously to the catalytic active of PARP-1, but it could not interact well with huBChE. For pursuit of PARP-1 and BChE dual-targeted inhibitors against AD, small and flexible non-polar groups introduced to the compound seemed to be conducive to improving its inhibitory potency on huBChE, while keeping phthalazine-1-one moiety unchanged which was mainly responsible for PARP-1 inhibitory activity. Our research gave a clue to search for new agents based on AChE and PARP-1 dual-inhibited activities to treat Alzheimer’s disease.
- Published
- 2018
7. [Adsorption Characteristics and Mechanism of Cadmium in Water by Alkali and Magnetic Composite Modified Wheat Straw Biochar]
- Author
-
Zhi-Wen, Cui, Yan-Fang, Ren, Wei, Wang, Li-Ming, Zhang, Lu-Yun, Zhang, Xi-Yue, Wang, and Jun-Yu, He
- Abstract
Wheat straw biochar (BC) was modified by KOH and magnetics to generate composited modified biochar (FKC). Based on characterization by scanning electron microscopy-energy dispersive spectrometry (SEM-EDS), Brunauer-Emmett-Teller (BET), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and magnetic (VSM) techniques, the adsorption characteristics and mechanisms of Cd
- Published
- 2020
8. Synthesis and antitumor activity of novel phenylhydrazonopyrazolone derivatives and molecular dynamics simulations
- Author
-
Zhijun Yu, Zhen-Li Min, Qiong Yuan, Yue Zhu, Cheng-zhi Gao, Xiamin Hu, Zhi-wen Cui, Wei Dong, and Shi-qiang Xu
- Subjects
0301 basic medicine ,Antitumor activity ,chemistry.chemical_classification ,Chemistry ,Drug discovery ,Cell ,General Chemistry ,Combinatorial chemistry ,03 medical and health sciences ,Molecular dynamics ,030104 developmental biology ,medicine.anatomical_structure ,Enzyme ,Cancer cell ,medicine ,IC50 - Abstract
SHP2 is a new promising target for anti-cancer drug discovery. A series of novel phenylhydrazonopyrazolone derivatives was synthesized by a more convenient method, and their chemical structures were characterized by various spectroscopic methods. The inhibitory effects of these compounds on SHP2 enzyme and SHP2-dependent cancer cell H1975 were evaluated. The compound 11f with IC50 value of 3.38 μmol/L exhibited more potent antitumor activity against H1975 cell than GS-493 (IC50 = 20.92 μmol/L). Molecular dynamics simulation of compound 11f displayed a possible mode of interaction between this compound and SHP2 enzyme.
- Published
- 2018
9. In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer’s disease
- Author
-
Zhen-Li Min, Wei Dong, Cheng-zhi Gao, Zhi-wen Cui, Xiamin Hu, Qiong Yuan, and Zhijun Yu
- Subjects
0301 basic medicine ,Aché ,In silico ,Poly (ADP-Ribose) Polymerase-1 ,Quantitative Structure-Activity Relationship ,Molecular Dynamics Simulation ,Pharmacology ,Ligands ,Catalysis ,Inorganic Chemistry ,Inhibitory Concentration 50 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Alzheimer Disease ,Drug Discovery ,Humans ,Medicine ,Enzyme Inhibitors ,Physical and Theoretical Chemistry ,Virtual screening ,Molecular Structure ,business.industry ,Organic Chemistry ,Glutamate receptor ,Antagonist ,Molecular medicine ,Acetylcholinesterase ,language.human_language ,Computer Science Applications ,Molecular Docking Simulation ,030104 developmental biology ,Computational Theory and Mathematics ,chemistry ,Docking (molecular) ,language ,Cholinesterase Inhibitors ,business ,030217 neurology & neurosurgery - Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disease of the elderly that seriously affects the quality of life and the life expectancy of those affected. There is, as yet, no effective drug treatment of AD, although several acetylcholinesterase (AChE) inhibitors and a glutamate antagonist can provide relief from its symptoms. Recent studies have indicated that the overactivation of poly(ADP-ribose) polymerase-1 (PARP-1) may promote nerve cell death in the brains of AD patients, implying that PARP-1 inhibition may have therapeutic value for the treatment of AD. Therefore, it is important to investigate novel agents with both AChE- and PARP-1-inhibitory bioactivities. In this study, the structure-based virtual screening of PARP-1 inhibitors was performed to search for potential agents with high affinities for AChE. The dynamic stability of the selected AChE-ligand complexes was investigated by molecular dynamics (MD) simulation. Two compounds, CID57390505 and CID71605390, showed high affinities for and stability in complex with AChE in docking and MD simulations. Thus, our in silico research identified two compounds with AChE and PARP-1 dual-targeted activities, indicating that this technique could aid attempts to develop more potent agents against AD.
- Published
- 2018
10. Notice of Retraction
- Author
-
Ye Xia, Xiaojuan Sun, Yaoting Gui, Zhiming Cai, Pingping Fa, Aifa Tang, Zhi-Wen Cui, Zesong Li, and Liang Sun
- Subjects
MAPK/ERK pathway ,Cancer Research ,Matrigel ,biology ,Chemistry ,Integrin ,Cell migration ,General Medicine ,Cell biology ,Fibronectin ,biology.protein ,Epithelial–mesenchymal transition ,Wound healing ,Protein kinase B - Abstract
Cellular fibronectin (cFN) is one of the main components of tissue extracellular matrices and is involved in multiple physiologic and pathologic processes such as embryogenesis, wound healing, inflammation and tumor progression. The function of fibronectin in regulating normal cell adhesion and migration is well documented, but its function in cancer progression is only partially unraveled. We have reported previously that fibronectin stimulates the proliferation and survival of non-small lung carcinoma cells through upregulation of pro-oncogenic signals related to cyclooxygenase-2/phosphatidylinositol-3-kinase/protein kinase B (COX-2/PI3-K/AKT)/mammalian target of rapamycin triggered by activation of the integrin α5β1. Here, we extend these studies by showing that fibronectin promotes epithelial-mesenchymal transition (EMT) in lung cancer cells. We found that cFN, but not plasma fibronectin or type 1 collagen, induces lung carcinoma cell scattering in vitro, promotes cell migration and invasion of Matrigel and stimulates the expression of the mesenchymal marker α-smooth muscle actin while decreasing the expression of the epithelial marker E-cadherin through PI3-K and Erk pathways. Interestingly, the extra domain A (EDA) within cFN was found to be crucial for this process, as confirmed by testing cells overexpressing EDA or cells exposed to EDA-containing matrices. We found that the integrin α9, but not α5, mediated cFN-induced EMT as silencing integrin α9 neutralized cFN-induced EMT. Overall, our findings show that the EDA domain within cFN induces EMT in lung carcinoma cells through integrin α9-mediated activation of PI3-K and Erk.
- Published
- 2013
11. Probiotic Bacillus amyloliquefaciens mediate M1 macrophage polarization in mouse bone marrow-derived macrophages
- Author
-
Zhi-Wen Cui, Jian Ji, Wei-Fen Li, and Shenglan Hu
- Subjects
Bacillus amyloliquefaciens ,Macrophage polarization ,Bacillus ,Nitric Oxide ,Endocytosis ,Biochemistry ,Microbiology ,law.invention ,Mice ,Probiotic ,law ,Genetics ,Animals ,Molecular Biology ,biology ,Effector ,Macrophages ,Probiotics ,Intracellular parasite ,General Medicine ,Macrophage Activation ,biology.organism_classification ,M2 Macrophage ,Mice, Inbred C57BL ,Transcriptome ,Wound healing - Abstract
Depending on the microenvironment, macrophages can acquire distinct functional phenotypes, referred to as classically activated M1 and M2. M1 macrophages are considered potent effector cells that kill intracellular pathogens, and M2 macrophages promote the resolution of wound healing. In this study, we are interested to know whether probiotic Bacillus amyloliquefaciens (Ba) can induce macrophages polarization. Real-time fluorescence PCR analysis demonstrated that the expression of IL-1β, iNOS, TNF-α and IL-6 genes for M1 macrophages was significantly increased at 1.5 h after probiotic Ba treatment compared to the probiotic Ba-free treatment (P < 0.01), whereas the expression of M2 macrophage marker genes (Arg1, Fizz1, MR, Ym1) was decreased (P < 0.05). Furthermore, the phagocytic activity was dramatically increased in the Ba-treated BMDMs using a FITC-dextran endocytosis assay. Together, these findings indicated that probiotic Ba facilitated polarization of M1 macrophages and enhanced its phagocytic capacity. The results expanded our knowledge about probiotic function-involved macrophage polarization.
- Published
- 2013
12. Immunomodulatory effects ofBacillus subtilis(natto) B4 spores on murine macrophages
- Author
-
Zhi-wen Cui, Imran Rashid Rajput, Dongyou Yu, Qin Huang, Yulong Mao, Yi Huang, Weifen Li, Xin Xu, and Yali Li
- Subjects
biology ,medicine.medical_treatment ,fungi ,Immunology ,Interleukin ,Bacillus subtilis ,biology.organism_classification ,Microbiology ,Nitric oxide synthase ,chemistry.chemical_compound ,Cytokine ,chemistry ,Cell culture ,Virology ,Lactate dehydrogenase ,biology.protein ,medicine ,Macrophage ,Tumor necrosis factor alpha - Abstract
To investigate the immunomodulatory effects of Bacillus subtilis (B. subtilis) (natto) B4 spores on murine macrophage, RAW 264.7 cells were cultured alone or with B subtilis (natto) B4 spores at 37°C for 12 hrs, then both cells and culture supernatants were collected for analyses. Exposure of RAW 264.7 cells to B. subtilis (natto) B4 spores had no significant effects on macrophage viability and amounts of extracellular lactate dehydrogenase (LDH). However, it remarkably increased the activities of acid phosphatase (ACP), lactate dehydrogenase (LDH) and inducible nitric oxide synthase (iNOS) in cells and the amounts of nitric oxide (NO) and cytokines (tumor necrosis factor-alpha, interferon-gamma, interleukin [IL]-1 beta, IL-6, IL-12, IL-10 and macrophage inflammatory protein-2) in culture supernatants. These results demonstrate that B. subtilis (natto) B4 spores are harmless to murine macrophages and can stimulate their activation through up-regulation of ACP and LDH activities and enhance their immune function by increasing iNOS activity and stimulating NO and cytokine production. The above findings suggest that B. subtilis (natto) B4 spores have immunomodulatory effects on macrophages.
- Published
- 2012
13. RALY RNA Binding Protein-like Reduced Expression is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma
- Author
-
Liang Sun, Xiao-Juan Sun, Jianting Wu, Yaoting Gui, Zhimao Jiang, Jun Zhao, Yadong Wang, Zhi-Wen Cui, Ye Xia, Pingping Fa, Zhi-Mingn Cai, and Yiwang Ye
- Subjects
Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Epidemiology ,Kaplan-Meier Estimate ,Biology ,Andrology ,medicine ,Carcinoma ,Humans ,RNA, Messenger ,Carcinoma, Renal Cell ,Survival rate ,Survival analysis ,Proportional Hazards Models ,Proportional hazards model ,Heterogeneous-Nuclear Ribonucleoprotein Group C ,Public Health, Environmental and Occupational Health ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Kidney Neoplasms ,Survival Rate ,Clear cell renal cell carcinoma ,Oncology ,T-stage ,Female ,Clear cell ,Follow-Up Studies - Abstract
The molecular mechanisms involved in the progression of clear cell renal cell carcinomas (ccRCCs) are still unclear. The aim of this study was to analyse the relationships between expression of RALYL and clinical characteristics. In 41 paired samples of ccRCCs and adjacent normal tissues, we used real-time qPCR to evaluate the expression of RALYL mRNA. RALYL protein levels were determined in 146 samples of ccRCC and 37 adjacent normal tissues by immunohistochemistry. Statistical analysis was used to explore the relationships between expression of RALYL and the clinical characteristics (gender, age, tumor size, T stage, N stage, M stage, survival times and survival outcome) in ccRCC. In addition, these patients were follow-up period 64 months (range: 4~116 months) to investigate the influence on prognosis. We found significantly differences between ccRCC tissues and normal tissues (p
- Published
- 2012
14. Fast Compressional Wave Scattering from Cylinder in Porous Media
- Author
-
Zhi Wen Cui, Chun Xia Wang, He Feng Dong, Yang Jun Han, Xu Jing Lu, and Ke Xie Wang
- Subjects
Materials science ,Biot number ,business.industry ,Cauchy stress tensor ,Isotropy ,Poromechanics ,Plane wave ,General Medicine ,Mechanics ,Physics::Classical Physics ,Physics::Geophysics ,Physics::Fluid Dynamics ,Optics ,Cylinder ,business ,Porous medium ,Longitudinal wave - Abstract
A mathematical model is presented to describe the scattering of a fast compressional plane wave (fast P-wave) incident at an arbitrary angle on isotropic cylinder embedded in a fluid-saturated porous medium. The expressions of components of solid and filtration displacement, pore fluid pressure and stress tensor in porous medium are obtained by potential function using the Biot’s theory and that of isotropic cylinder are also given. We investigate the properties of the form function of a backscatted fast P-wave for cement and steel cylinder system. It shows the influence of incident angle on form function for steel is more obvious than that for cement cylinder and form function curves are very different between steel and cement cylinder.
- Published
- 2012
15. Numerical Simulation of Acoustic Wave Propagation in Cylindrical Fluid-Saturated Poroelastic Shell Immersed in Fluids
- Author
-
Kei Xie Wang, Wen Yang Gao, He Feng Dong, Qian Wu, and Zhi Wen Cui
- Subjects
Longitudinal mode ,Materials science ,Amplitude ,Acoustics ,Poromechanics ,Shell (structure) ,Stoneley wave ,Acoustic wave equation ,General Medicine ,Mechanics ,Acoustic wave ,Displacement (fluid) - Abstract
Acoustic wave propagation in fluid-saturated porous cylindrical shell is investigated in this paper by using the Biot’s theory. The Expressions for acoustic pressure and radical displacement in and out fluid, the expressions for components of solid and filtration displacement and pore fluid pressure and stress tensor are given. The numerical simulation is operated on acoustic field in fluid of poroelastic cylindrical shell, and the full-waveform is obtained by Fourier transform, and acoustic pressure field in frequency-wavenumber domain is analyzed, as well as the influence of inner and outer radii on wave amplitude is discussed. It shows that if the thickness of shell remains constant, the amplitude of longitudinal mode increases and that of Stoneley wave decreases when inner and outer radii increasing. In the fast formation the influence of inner and outer radii on the amplitude of longitudinal mode is notable. In the slow formation the amplitude of Stoneley wave will decrease with inner and outer radii increasing.
- Published
- 2011
16. Self assembly of particles using phononic crystal slabs
- Author
-
Zhi-wen Cui, Feiyan Cai, Hairong Zheng, and Qian Wu
- Subjects
Physical acoustics ,Wavelength ,Optics ,Materials science ,business.industry ,Particle ,Particle size ,Acoustic wave ,Acoustic radiation ,Ion acoustic wave ,Acoustic radiation force ,business - Abstract
By numerically studying the acoustic radiation forces on particle above the phononic crystal slabs (PCS), we show that a guided resonant mode of PCS yields a resonantly-enhanced, stably trapped acoustic radiation force on the particle. These trapping patterns and acoustic radiation force dependent on the wavelength, particle size, and particle material are investigated, respectively. It is shown that tuning the wavelength of incident acoustic wave may thus allow the formation and reconfiguration of patterns. We expect that this system may thus allow to realize self-assembly particles.
- Published
- 2012
17. Borehole guided waves in a non-Newtonian (Maxwell) fluid-saturated porous medium
- Author
-
Zhi-Wen, Cui, primary, Jin-Xia, Liu, additional, Gui-Jin, Yao, additional, and Ke-Xie, Wang, additional
- Published
- 2010
- Full Text
- View/download PDF
18. Determination of the parameters of a linear-viscoelastic thin layer using the normally-incident ultrasonic waves
- Author
-
Gui-Jin, Yao, primary, Wei-Guo, Lü, additional, Ruo-Long, Song, additional, Zhi-Wen, Cui, additional, Xiang-Lin, Zhang, additional, and Ke-Xie, Wang, additional
- Published
- 2010
- Full Text
- View/download PDF
19. The relationships between uniaxial stress and reflection coefficients
- Author
-
Jin-Xia, Liu, primary, Zhi-Wen, Cui, additional, and Ke-Xie, Wang, additional
- Published
- 2009
- Full Text
- View/download PDF
20. Coupling of Acoustical Plane p-Wave to a Cased Borehole
- Author
-
Chang-Chun, Qiu, primary, Bi-Xing, Zhang, additional, Yu-Jun, Zhang, additional, and Zhi-Wen, Cui, additional
- Published
- 2009
- Full Text
- View/download PDF
21. Numerical Simulation of Shear-Horizontal-Wave-Induced Electromagnetic Field in Borehole Surrounded by Porous Formation
- Author
-
Zhi-Wen, Cui, primary, Ke-Xie, Wang, additional, Jian-Guo, Sun, additional, Zheng-Ya, Zhu, additional, Gui-Jin, Yao, additional, and Heng-Shan, Hu, additional
- Published
- 2007
- Full Text
- View/download PDF
22. The acoustoelastic effect on Rayleigh waves in elastic–plastic deformed layered rocks
- Author
-
Jin-Xia, Liu, primary, Zhi-Wen, Cui, additional, and Ke-Xie, Wang, additional
- Published
- 2007
- Full Text
- View/download PDF
23. Acousto-electric well logging by eccentric source and extraction of shear wave
- Author
-
Zhi-Wen, Cui, primary, Ke-Xie, Wang, additional, Heng-Shan, Hu, additional, and Jian-Guo, Sun, additional
- Published
- 2007
- Full Text
- View/download PDF
24. Seismoelectric waves in a borehole excited by an external explosive source.
- Author
-
Jiu-Guang, Zhou, Zhi-Wen, Cui, Wei-Guo, Lü, Yu-Jun, Zhang, and Ke-Xie, Wang
- Subjects
- *
ELECTROMAGNETIC waves , *POROUS materials , *ELECTROMAGNETIC fields , *ENERGY conversion , *WAVE packets - Abstract
The conversion of energy between seismic and electromagnetic wave fields has been described by Pride's coupled equations in porous media. In this paper, the seismoelectric field excited by the explosive point source located at the outside of the borehole is studied. The scattering fields inside and outside a borehole are analyzed and deduced under the boundary conditions at the interface between fluid and porous media. The influences of the distance of the point source, multipole components of the eccentric explosive source, and the receiving position along the axis of vertical borehole, on the converted waves inside the borehole are all investigated. When the distance from the acoustic source to the axis of a borehole is far enough, the longitudinal and coseismic longitudinal wave packets dominate the acoustic and electric field, respectively. The three components of both electric field and magnetic field can be detected, and the radial electric field is mainly excited and converted by the dipole component. Owing to the existence of borehole, the electric fields and magnetic fields in the borehole are azimuthal. The distance from the point where the maximum amplitude of the axial components of electric field is recorded, to the origin of coordinate indicates the horizontal distance from the explosive source to the axis of vertical borehole. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
25. Establishment of Optimal Culturing Method and Biological Activity Analysis of Chicken Bone Marrow Dendritic Cells using Chi-rGM-CSF.
- Author
-
Rashid Rajput, Imran, Bing Bing Wu, Li Ya Li, Xin Xu, Zhi Wen Cui, Dong-You Yu, and Wei Fen Li
- Subjects
DENDRITIC cells ,ANTIGEN presenting cells ,IMMUNE system ,GRANULOCYTES ,MACROPHAGES ,BONE marrow - Abstract
Denderitic cells (DCs) play a central role in immune regulation and antigen presentation in animals, but quantitative description of chicken DCs culturing method employing rGM-CSF and optimal biological response is still lacking. Therefore, we designed the study to obtain the chicken recombinant granulocyte-macrophage colony-stimulating factor (chi-rGM-CSF), expressed in E. coli BL21 and established a standard concentration unit of chi-rGM-CSF to generate optimal biological respondent denderitic cells from chicken bone marrow. DCs were divided into two groups, (A and B) each was employed two level of chi-rGM-CSF (10 and 20 ng/mL) respectively, co-cultured with interleukin-4 (IL-4, 10 ng/mL), and treated with lipopolysachride (LPS, 1 μg/mL). The results showed that chi-rGM-CSF was effective to induce avian DCs growth. However, no significant difference was observed in cell proliferation, morphology and phenotype between group A and B, but the mRNA expression levels of surface marker genes, MHC-II, CD40, CD80, CD83 and CD86 were up regulated (<0.05) after LPS stimulation. DCs in group B showed significantly higher response to LPS with increased mRNA expression levels of pro-inflammatory cytokines (INFγ?, IL-1β, IL-2 and IL-6) and anti-inflammatory cytokine (IL-10) as compared with group A. Therefore, it could be concluded that E. coli expressed rGM-CSF with concentration unit (20 ng/mL) is more effective to obtain optimal culturing and biological response of avian BMDCs. [ABSTRACT FROM AUTHOR]
- Published
- 2013
26. Roles of Enterococcus faecium in composition of the intestinal microflora and chemistry barrier in newborn piglets by oral administration.
- Author
-
HUANG Yi, HUANG Qin, Zhi-wen, CUI, Wei-fen, LI, and Dong-you, YU
- Abstract
The article presents information on a study related to the roles of Enterococcus faecium in composition of the intestinal microflora and chemistry barrier in newborn piglets by oral administration. It informs that during the study influences of Enterococcus faecium on health of piglets during the suckling period were studied. It further informs that the expression level of genes involved in chemistry barrier were also detected.
- Published
- 2012
27. A Discussion on the Formula Construction of the BISQ Model.
- Author
-
Zhi-Wen Cui and Ke-Xie Wang
- Subjects
- *
BIOT theory (Mechanics) , *MATHEMATICAL formulas , *DEFORMATIONS (Mechanics) , *PORE fluids , *MATHEMATICAL combinations - Abstract
The formula construction of the unified model with the squirt and the Biot mechanism, i.e. the BISQ model [Geophysics 58 (1993) 524], is discussed. The inconsistent formula construction caused by the self-contradictions of key assumptions is pointed out and demonstrated. Once the deformation of the solid skeleton is assumed to be in the uniaxial mode, the deformation of pore fluid is not able to be non-uniaxial at all, but must be uniaxial. Therefore, the expected results in the BISQ model's paper are doubtful and this model needs to be improved. A combination of the two mechanisms simultaneously in theory is significant and still needs more research. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
28. Seismoelectric wave propagation modeling in a borehole in water-saturated porous medium having an electrochemical interface.
- Author
-
Hao-Ran Ding, Jin-Xia Liu, Zhi-Wen Cui, and Tribikram Kundu
- Subjects
THEORY of wave motion ,POROUS materials ,ELECTROCHEMICAL analysis ,INTERFACES (Physical sciences) ,SIMULATION methods & models - Abstract
Water-saturated porous media often exhibit a seismoelectric effect due to the existence of an electrical double layer and a relative flow of pore fluid. Here we consider the seismoelectric waves in an open borehole surrounded by water-saturated porous formation which exhibits discontinuity of electrochemical properties at a cylindrical interface. We carefully analyze the seismoelectric interface response since these signals show sensitivity to contrasts in electrochemical properties across an interface. Both coupled and approximate methods are used to compute borehole seismoelectric fields. The simulation results show that the radiated electromagnetic wave from the electrochemical interface is generated due to the change of salinity in pore fluid in the porous formation. However, the elastic properties of the formation remain unchanged across such an electrochemical interface. As a result it is difficult to recognize such a change in electrochemical properties using only elastic waves. Therefore, the seismoelectric interface response is potentially used to detect the changes of the electrochemical properties in the formation. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.