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INTRODUCTION: Inflammatory bowel disease (IBD) is a non-specific chronic inflammatory disease. Previous studies confirmed that inflammation plays an important role and red blood cell distribution width (RDW) is related to the activity of IBD. OBJECTIVES: To identify the prognosis value of RDW in the intestinal resection of IBD. PATIENTS AND METHODS: A total of 366 patients were included in this retrospective analysis, diagnosed with IBD between March 2012 and November 2014 in the Sixth Affiliated Hospital of Sun Yat-Sen University. All participants were followed up at least 5years. Patients’ demographic characteristics and laboratory data were obtained from medical record within 24h at first hospitalization. We compared the clinical features in the intestinal resection and non-intestinal resection groups. Kaplan–Meier estimates of the probability of intestinal resection post-admission time were computed, and compared with log-rank test according to stratification of RDW value. RESULTS: There were 93 patients in the intestinal resection group and 273 in the non- intestinal resection group. Significant higher RDW values were detected in the intestinal resection group (P

Hydroquinone is one of the main pollutants in coal-gasification wastewater, which is biologically toxic and difficult to remove. The aerobic biodegradation rate, organic toxicity, and microbial community structure at different acclimation stages of degradation of hydroquinone by activated sludge were investigated. In each acclimation cycle, the removal of hydroquinone reached 100% after 5 days, indicating that high-concentration hydroquinone in the activated sludge could be completely biodegraded. When the microbial flora was inhibited by the influent hydroquinone, the enzyme system experienced stress conditions and led to the secretion of secondary metabolites, extracellular protein of 5-10 kDa mainly contributing to the sludge organic toxicity. Microbial diversity analysis showed that with the increase of the concentration of hydroquinone, β-Proteus bacteria such as Azoarcus and Dechloromonas gradually accumulated, which improved the removal of hydroquinone with aerobic activated sludge in the sequencing batch reactor (SBR) system. As the inhibition degree exceeded the appropriate tolerance range of microorganisms, bacteria would secrete much more secondary metabolites, and the organic toxicity of sludge would reach a relatively high level.

Supplemental material, sj-docx-4-sci-10.1177_00368504211003762 for Urban index and lifestyle risk factors for cardiovascular diseases in China: A cross-sectional study by Zhichong Chen, Menghui Liu, Shaozhao Zhang, Zhenyu Xiong, Xiangbin Zhong, Daya Yang, Jianqiu Kong, Xin He, Yuan Zhu, Xun Hu and Xiaodong Zhuang in Science Progress

Supplemental material, sj-docx-3-sci-10.1177_00368504211003762 for Urban index and lifestyle risk factors for cardiovascular diseases in China: A cross-sectional study by Zhichong Chen, Menghui Liu, Shaozhao Zhang, Zhenyu Xiong, Xiangbin Zhong, Daya Yang, Jianqiu Kong, Xin He, Yuan Zhu, Xun Hu and Xiaodong Zhuang in Science Progress

Supplemental material, sj-docx-2-sci-10.1177_00368504211003762 for Urban index and lifestyle risk factors for cardiovascular diseases in China: A cross-sectional study by Zhichong Chen, Menghui Liu, Shaozhao Zhang, Zhenyu Xiong, Xiangbin Zhong, Daya Yang, Jianqiu Kong, Xin He, Yuan Zhu, Xun Hu and Xiaodong Zhuang in Science Progress

Supplemental material, sj-docx-1-sci-10.1177_00368504211003762 for Urban index and lifestyle risk factors for cardiovascular diseases in China: A cross-sectional study by Zhichong Chen, Menghui Liu, Shaozhao Zhang, Zhenyu Xiong, Xiangbin Zhong, Daya Yang, Jianqiu Kong, Xin He, Yuan Zhu, Xun Hu and Xiaodong Zhuang in Science Progress

This study test was designed to investigate the possible modulatory effect of rapamycin combined with HO-3867 in monocrotaline(MCT)-induced pulmonary arterial hypertension in rats. We hypothesized that combined treatment with rapamycin and HO-3867 is superior to either alone in attenuating MCT-induced rat pulmonary arterial hypertension (PAH). Pulmonary arterial hypertension was induced by a single intraperitoneal injection of monocrotaline (60 mg/kg). 2 weeks later, rapamycin (2 mg/kg i.p.) and HO3867 (10 mg/kg i.h.) were administered daily, alone and in combination, for 2 weeks. Right ventricular systolic pressure, echocardiography were recorded and then rats were sacrificed. Histological analysis of pulmonary arteries medial wall thickness, right ventricular hypertrophy index (RVHI), the ratio of right ventricular to body weight, and collagen volume fraction (CVF) of right ventricular were performed. Moreover, the expression of t-STAT3, p-STAT3, t-Akt, p-Akt in lung and t-STAT3, p-STAT3, t-S6, p-S6 in right ventricular were examined. The result showed that combined treatment provided a considerable improvement toward maintaining hemodynamic changes, lung vascular remodeling as well as amending RV remodeling and function. Furthermore, Combined treatment can normalize the protein levels of two signal pathways in lung and heart tissue, where p-S6 or p-Akt significantly decreased compared to HO-3867 alone, or p-STAT3 significantly reduced compared to rapamycin alone. In conclusion, combined treatment with rapamycin and HO-3867 is superior to either alone in attenuating MCT-induced PAH in rats.