Search

Abstract Peri‐implant infection is one of the major causes for implant failure. The transmucosal/transcutaneous surface of implant abutment is directly connected to the external environment and constantly exposed to a large number of bacteria. Establishing a robust anti‐biofilm barrier at the abutment surface to minimize the risk of peri‐implant infection is highly desirable in the field of dental implantology but remains challenging. Herein, a new class of therapeutic abutments featuring excellent anti‐biofilm performance is developed, which is achieved by admirably integrating the outstanding self‐cleaning property of polyethylene glycol and the long‐lasting renewable antibacterial property of N‐halamine. Through a comprehensive series of in vitro and in vivo experiments closely mimicking clinical conditions, therapeutic abutments have been successfully demonstrated to possess the ability of inhibiting biofilm accumulation to prevent peri‐implant infection, as well as to achieve persistent and accurate administration to reverse early‐stage peri‐implant infection. Furthermore, the therapeutic abutment could be repeatedly used, representing the characteristic of sustainable medical devices. These findings indicate a new paradigm for the prevention and treatment of peri‐implant infection.

Abstract Using bone regeneration scaffolds to repair craniomaxillofacial bone defects is a promising strategy. However, most bone regeneration scaffolds still exist some issues such as a lack of barrier structure, inability to precisely match bone defects, and necessity to incorporate biological components to enhance efficacy. Herein, inspired by a periosteum‐bone complex, a class of multifunctional hierarchical porous poly(lactic‐co‐glycolic acid)/baicalein scaffolds is facilely prepared by the union of personalized negative mold technique and phase separation strategy and demonstrated to precisely fit intricate bone defect cavity. The dense up‐surface of the scaffold can prevent soft tissue cell penetration, while the loose bottom‐surface can promote protein adsorption, cell adhesion, and cell infiltration. The interior macropores of the scaffold and the loaded baicalein can synergistically promote cell differentiation, angiogenesis, and osteogenesis. These findings can open an appealing avenue for the development of personalized multifunctional hierarchical materials for bone repair.

Abstract The sophisticated hierarchical structure that precisely combines contradictory mechanical and biological characteristics is ideal for biomaterials, but it is challenging to achieve. Herein, we engineer a spatiotemporally hierarchical guided bone regeneration (GBR) membrane by rational bilayer integration of densely porous N-halamine functionalized bacterial cellulose nanonetwork facing the gingiva and loosely porous chitosan-hydroxyapatite composite micronetwork facing the alveolar bone. Our GBR membrane asymmetrically combine stiffness and flexibility, ingrowth barrier and ingrowth guiding, as well as anti-bacteria and cell-activation. The dense layer has a mechanically matched space maintenance capacity toward gingiva, continuously blocks fibroblasts, and prevents bacterial invasion with multiple mechanisms including release-killing, contact-killing, anti-adhesion, and nanopore-blocking; the loose layer is ultra-soft to conformally cover bone surfaces and defect cavity edges, enables ingrowth of osteogenesis-associated cells, and creates a favorable osteogenic microenvironment. As a result, our all-in-one porous membrane possesses full protective abilities in GBR.