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Wind observations by Meteor radars from the year of 2009 to 2018 are utilized to knowledge the climatological characteristics at Mohe (53.1N), Beijing (40.3N), Wuhan (30.5N), Kunming (25.6N) and Sanya (18N). The tidal components with the period of 24h (diurnal), 12h (semidiurnal) are derived by the decomposition of observations using harmonic fitting method. The results show that the magnitude of diurnal tidal amplitude in the zonal and meridional winds increases with decreasing latitude, especially for the meridional wind. Annual and semi-annual changes dominate the main features. However, large difference of annual and semi-annual changes between the zonal and meridional could be seen clearly. Moreover, the diurnal tidal amplitude in the zonal wind at Mohe shows opposite changes above 90km and below 88 km, which is that the amplitude displays large value below 88km during February and March, while small value is prevailing above 90km during this time. When the diurnal amplitude above 90km is large accompanying with small value below 88 km. For the semidiurnal tide, the annual variation is clearly found for the zonal and meridional winds in their amplitudes at all stations. Meanwhile, the magnitude of semidiurnal tidal amplitude decreases with decreasing latitude, and that of meridional amplitude is larger than that of zonal amplitude. At all stations, the zonal diurnal tidal amplitude at Wuhan is largest above 88km in Spring and 94 km in Summer, that at Kunming is largest below 92 km in autumn and winter. The meridional diurnal amplitude at Sanya is biggest above 88 km in four seasons, and that at Kunming is biggest below 86 km in four seasons. For all seasons, the amplitudes in the zonal and meridional winds at Mohe are smallest. For the zonal wind, semidiurnal tidal amplitude at Beijing is largest at 82 – 94 km in Spring, 82 – 96 km in Summer, above 92 km in Autumn. Meantime, the semidiurnal tidal amplitude at Mohe is larger above 94 km and below 82 in Spring, above 96 km and 82 km in Summer, below 90 km in Autumn and at all heights in Winter. Simultaneously, the semidiurnal tidal amplitude at Sanya is smallest in Spring, Summer, Autumn and above 98 km in Winter. However, the variation of meridional semidiurnal tidal amplitude becomes complicated.

An iron-catalyzed dearomative spirocyclization of biaryl ynones with sodium metabisulfite and cycloketone oxime esters is developed for the construction of sulfonated spiro[5,5]trienones.

A mild copper-catalyzed four-component selenosulfonylation of alkynes, cycloketone oxime esters, DABCO (SO2)2 and diselenides has been developed. This method enables the rapid assembly of β-cyanoalkylsulfonylated vinyl selenides in moderate to good yields. Advantages of this protocol include a broad substrate scope, good functional group tolerance and the late-stage functionalization of complex molecules. Moreover, the potential utility of this methodology is demonstrated through simple oxidation of the products to access synthetically important alkynyl sulfones. Mechanistic studies suggest that a cyanoalkylsulfonyl radical intermediate is involved in this process.

An efficient copper-catalyzed regio- and chemoselective multicomponent reaction of 1,6-enynes, diselenides, DABCO·(SO2)2 and cycloketone oxime esters is described. Under mild conditions, this protocol exhibits a broad substrate scope and high functional group compatibility, enabling rapid access to cyanoalkylsulfonylated pyrrolidines in moderate to good yields. This radical-triggered cyclization reaction allows the formation of four new bonds including the C–SO2, C–C and C–Se bonds in a single step. A plausible mechanism is proposed on the basis of control experiments, and a cyanoalkylsulfonyl radical species is involved during the reaction process.

A photoinduced sulfonylvinylation of unactivated C(sp3)–H bonds through a three-component reaction of propargyl alcohols, potassium metabisulfite and cycloketone oxime esters is developed. This approach enables rapid access to cyanoalkylated vinyl sulfones in moderate to good yields at room temperature under transition-metal-free and external base-free conditions with the formation of three new C–SO2 and C–C bonds in one pot. A radical mechanism involving the insertion of sulfur dioxide with a cyanoalkyl radical and vinyl radical-triggered 1,5-hydrogen atom transfer and functional group migration sequence is proposed.

A photoredox-catalyzed sulfonylation of silyl enol ethers with DABCO·(SO

In order to observe the effects of Wu Ling Capsule on the quality of patients' life and depression, have an influence on blood glucose, glycosylated hemoglobin, islet function, and explore the mechanism form inflammatory factors and oxidative stress about improving depression and controlling steadily of blood glucose.