1. Electrochemical C−H deuteration of pyridine derivatives with D2O
- Author
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Zhiwei Zhao, Ranran Zhang, Yaowen Liu, Zile Zhu, Qiuyan Wang, and Youai Qiu
- Subjects
Science - Abstract
Abstract Herein, we develop a straightforward, metal-free, and acid-/base-free electrochemical C4-selective C − H deuteration of pyridine derivatives with economic and convenient D2O at room temperature. This strategy features an efficient and environmentally friendly approach with high chemo- and regioselectivity, affording a wide range of D-compounds, such as pyridines, quinolones, N-ligands and biorelevant compounds. Notably, the mechanistic experiments and cyclic voltammetry (CV) studies demonstrate that N-butyl-2-phenylpyridinium iodide is a crucial intermediate during the electrochemical transformation, which provides a general and efficient way for deuteration of pyridine derivatives.
- Published
- 2024
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