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355 results on '"Zhong, Weide"'

2. Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer.

Author

Ye, Jianheng, Cai, Shanghua, Feng, Yuanfa, Li, Jinchuang, Cai, Zhiduan, Deng, Yulin, Liu, Ren, Zhu, Xuejin, Lu, Jianming, Zhuo, Yangjia, Liang, Yingke, Xie, Jianjiang, Zhang, Yanqiong, He, Huichan, Han, Zhaodong, Zhong, Weide, and Jia, Zhenyu

Subjects
Male, Humans, Metformin, Cell Line, Tumor, Prostatic Neoplasms, Transcription Factors, Cell Cycle
Abstract

The therapeutic efficacy of metformin in prostate cancer (PCa) appears uncertain based on various clinical trials. Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation, which leads to drug resistance. However, the underlying mechanism is still unclear. In this study, we found evidences that metformin resistance in PCa cells may be linked to cell cycle reactivation. Super-enhancers (SEs), crucial regulatory elements, have been shown to be associated with drug resistance in various cancers. Our analysis of SEs in metformin-resistant (MetR) PCa cells revealed a correlation with Prostaglandin Reductase 1 (PTGR1) expression, which was identified as significantly increased in a cluster of cells with metformin resistance through single-cell transcriptome sequencing. Our functional experiments showed that PTGR1 overexpression accelerated cell cycle progression by promoting progression from the G0/G1 to the S and G2/M phases, resulting in reduced sensitivity to metformin. Additionally, we identified key transcription factors that significantly increase PTGR1 expression, such as SRF and RUNX3, providing potential new targets to address metformin resistance in PCa. In conclusion, our study sheds new light on the cellular mechanism underlying metformin resistance and the regulation of the SE-TFs-PTGR1 axis, offering potential avenues to enhance metformins therapeutic efficacy in PCa.

Published
2023

17. A Unique Approach: Biomimetic Graphdiyne-Based Nanoplatform to Treat Prostate Cancer by Combining Cuproptosis and Enhanced Chemodynamic Therapy

Author

Xie,Wenjie, Zhang,Yixun, Xu,Qianfeng, Zhong,Guowei, Lin,Jundong, He,Huichan, Du,Qiuling, Tan,Huijing, Chen,Muqi, Wu,Zhenjie, Deng,Yulin, Han,Zhaodong, Lu,Jianming, Ye,Jianheng, Zou,Fen, Zhuo,Yangjia, Zhong,Weide, Xie,Wenjie, Zhang,Yixun, Xu,Qianfeng, Zhong,Guowei, Lin,Jundong, He,Huichan, Du,Qiuling, Tan,Huijing, Chen,Muqi, Wu,Zhenjie, Deng,Yulin, Han,Zhaodong, Lu,Jianming, Ye,Jianheng, Zou,Fen, Zhuo,Yangjia, and Zhong,Weide

Abstract

Wenjie Xie,1,2,* Yixun Zhang,1,2,* Qianfeng Xu,1,2,* Guowei Zhong,1,2 Jundong Lin,2,3 Huichan He,3 Qiuling Du,2 Huijing Tan,1,2 Muqi Chen,1,2 Zhenjie Wu,1– 3 Yulin Deng,1,2 Zhaodong Han,1– 3 Jianming Lu,1,2,4 Jianheng Ye,1,2,4 Fen Zou,1,2 Yangjia Zhuo,1,2 Weide Zhong1– 4 1Department of Urology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, People’s Republic of China; 2Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, People’s Republic of China; 3Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510230, People’s Republic of China; 4State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, 999078, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yangjia Zhuo; WeideZhong, Email eyyangjiazhuo@scut.edu.cn; zhongwd2009@live.cnPurpose: Current treatment approaches for Prostate cancer (PCa) often come with debilitating side effects and limited therapeutic outcomes. There is urgent need for an alternative effective and safe treatment for PCa.Methods: We developed a nanoplatform to target prostate cancer cells based on graphdiyne (GDY) and a copper-based metal-organic framework (GDY-CuMOF), that carries the chemotherapy drug doxorubicin (DOX) for cancer treatment. Moreover, to provide GDY-CuMOF@DOX with homotypic targeting capability, we coated the PCa cell membrane (DU145 cell membrane, DCM) onto the surface of GDY-CuMOF@DOX, thus obtaining a biomimetic nanoplatform (DCM@GDY-CuMOF@DOX). The nanoplatform was characterized by using transmission electron microscope, atomic force microscope, X-ray diffraction, etc. Drug release behavior, antitumor effects in vivo and i

Published
2024

21. Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression

Author

Ren, Shancheng, Wei, Gong-Hong, Liu, Dongbing, Wang, Liguo, Hou, Yong, Zhu, Shida, Peng, Lihua, Zhang, Qin, Cheng, Yanbing, Su, Hong, Zhou, Xiuqing, Zhang, Jibin, Li, Fuqiang, Zheng, Hancheng, Zhao, Zhikun, Yin, Changjun, He, Zengquan, Gao, Xin, Zhau, Haiyen E., Chu, Chia-Yi, Wu, Jason Boyang, Collins, Colin, Volik, Stanislav V., Bell, Robert, Huang, Jiaoti, Wu, Kui, Xu, Danfeng, Ye, Dingwei, Yu, Yongwei, Zhu, Lianhui, Qiao, Meng, Lee, Hang-Mao, Yang, Yuehong, Zhu, Yasheng, Shi, Xiaolei, Chen, Rui, Wang, Yang, Xu, Weidong, Cheng, Yanqiong, Xu, Chuanliang, Gao, Xu, Zhou, Tie, Yang, Bo, Hou, Jianguo, Liu, Li, Zhang, Zhensheng, Zhu, Yao, Qin, Chao, Shao, Pengfei, Pang, Jun, Chung, Leland W.K., Xu, Jianfeng, Wu, Chin-Lee, Zhong, Weide, Xu, Xun, Li, Yingrui, Zhang, Xiuqing, Wang, Jian, Yang, Huanming, Wang, Jun, Huang, Haojie, and Sun, Yinghao

Published
2018
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22. N6-methyladenosine modified lncRNAs signature for stratification of biochemical recurrence in prostate cancer

Author

Liang, Yingke, primary, Yin, Wenjun, additional, Cai, Zhouda, additional, Luo, Hongwei, additional, Liu, Qinwei, additional, Zhong, Chuanfan, additional, Chen, Jiahong, additional, Lin, Zhuoyuan, additional, Huang, Yaqiang, additional, Liang, Zhenguo, additional, Deng, Junhong, additional, Zhong, Weide, additional, Cai, Chao, additional, and Lu, Jianming, additional

Published
2023
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26. A prognostic signature consisting of N6-methyladenosine modified mRNAs demonstrates clinical potential in prediction of biochemical recurrence and guidance on precision therapy in prostate cancer

Author

Lu, Jianming, primary, Chen, Jiahong, additional, Lin, Zhuoyuan, additional, Liu, Qinwei, additional, Zhong, Chuanfan, additional, Cai, Zhouda, additional, Jia, Zhenyu, additional, Zhong, Weide, additional, Liang, Yingke, additional, and Cai, Chao, additional

Published
2023
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28. Supplemental Table 1 from Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer

Author

Liu, Junchen, primary, Chen, Guo, primary, Liu, Zezhen, primary, Liu, Shaoyou, primary, Cai, Zhiduan, primary, You, Pan, primary, Ke, Yuepeng, primary, Lai, Li, primary, Huang, Yun, primary, Gao, Hongchang, primary, Zhao, Liangcai, primary, Pelicano, Helene, primary, Huang, Peng, primary, McKeehan, Wallace L., primary, Wu, Chin-Lee, primary, Wang, Cong, primary, Zhong, Weide, primary, and Wang, Fen, primary

Published
2023
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29. Data from Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer

Author

Liu, Junchen, primary, Chen, Guo, primary, Liu, Zezhen, primary, Liu, Shaoyou, primary, Cai, Zhiduan, primary, You, Pan, primary, Ke, Yuepeng, primary, Lai, Li, primary, Huang, Yun, primary, Gao, Hongchang, primary, Zhao, Liangcai, primary, Pelicano, Helene, primary, Huang, Peng, primary, McKeehan, Wallace L., primary, Wu, Chin-Lee, primary, Wang, Cong, primary, Zhong, Weide, primary, and Wang, Fen, primary

Published
2023
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30. Figure S5 from GPD1 Enhances the Anticancer Effects of Metformin by Synergistically Increasing Total Cellular Glycerol-3-Phosphate

Author

Xie, Jianjiang, primary, Ye, Jianheng, primary, Cai, Zhiduan, primary, Luo, Yong, primary, Zhu, Xuejin, primary, Deng, Yulin, primary, Feng, Yuanfa, primary, Liang, Yingke, primary, Liu, Ren, primary, Han, Zhaodong, primary, Liang, Yuxiang, primary, Zheng, Yu, primary, Mo, Rujun, primary, Zhuo, Yangjia, primary, Wu, Yongding, primary, Jiang, Funeng, primary, Zhu, Jianguo, primary, Wu, Chin-Lee, primary, and Zhong, Weide, primary

Published
2023
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31. Table S1 from GPD1 Enhances the Anticancer Effects of Metformin by Synergistically Increasing Total Cellular Glycerol-3-Phosphate

Author

Xie, Jianjiang, primary, Ye, Jianheng, primary, Cai, Zhiduan, primary, Luo, Yong, primary, Zhu, Xuejin, primary, Deng, Yulin, primary, Feng, Yuanfa, primary, Liang, Yingke, primary, Liu, Ren, primary, Han, Zhaodong, primary, Liang, Yuxiang, primary, Zheng, Yu, primary, Mo, Rujun, primary, Zhuo, Yangjia, primary, Wu, Yongding, primary, Jiang, Funeng, primary, Zhu, Jianguo, primary, Wu, Chin-Lee, primary, and Zhong, Weide, primary

Published
2023
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32. Data from GPD1 Enhances the Anticancer Effects of Metformin by Synergistically Increasing Total Cellular Glycerol-3-Phosphate

Author

Xie, Jianjiang, primary, Ye, Jianheng, primary, Cai, Zhiduan, primary, Luo, Yong, primary, Zhu, Xuejin, primary, Deng, Yulin, primary, Feng, Yuanfa, primary, Liang, Yingke, primary, Liu, Ren, primary, Han, Zhaodong, primary, Liang, Yuxiang, primary, Zheng, Yu, primary, Mo, Rujun, primary, Zhuo, Yangjia, primary, Wu, Yongding, primary, Jiang, Funeng, primary, Zhu, Jianguo, primary, Wu, Chin-Lee, primary, and Zhong, Weide, primary

Published
2023
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33. Fig s1-s8 from Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer

Author

Liu, Junchen, primary, Chen, Guo, primary, Liu, Zezhen, primary, Liu, Shaoyou, primary, Cai, Zhiduan, primary, You, Pan, primary, Ke, Yuepeng, primary, Lai, Li, primary, Huang, Yun, primary, Gao, Hongchang, primary, Zhao, Liangcai, primary, Pelicano, Helene, primary, Huang, Peng, primary, McKeehan, Wallace L., primary, Wu, Chin-Lee, primary, Wang, Cong, primary, Zhong, Weide, primary, and Wang, Fen, primary

Published
2023
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34. Supplementary information from GPD1 Enhances the Anticancer Effects of Metformin by Synergistically Increasing Total Cellular Glycerol-3-Phosphate

Author

Xie, Jianjiang, primary, Ye, Jianheng, primary, Cai, Zhiduan, primary, Luo, Yong, primary, Zhu, Xuejin, primary, Deng, Yulin, primary, Feng, Yuanfa, primary, Liang, Yingke, primary, Liu, Ren, primary, Han, Zhaodong, primary, Liang, Yuxiang, primary, Zheng, Yu, primary, Mo, Rujun, primary, Zhuo, Yangjia, primary, Wu, Yongding, primary, Jiang, Funeng, primary, Zhu, Jianguo, primary, Wu, Chin-Lee, primary, and Zhong, Weide, primary

Published
2023
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40. IIIandMe: An Algorithm for Chromosome-scale Haplotype Determination Using Genome-wide Variants of Three Haploid Reproductive Cells

Author

Qu, Han, primary, Li, Ruidong, additional, Yu, Lei, additional, Chen, Weiming, additional, Feng, Yuanfa, additional, Jia, Qiong, additional, Traband, Ryan, additional, Wang, Xuesong, additional, Wang, Shibo, additional, He, Luoxian, additional, Wang, Zixian, additional, Qu, Meng, additional, Ferrante, Sergio Pietro, additional, Zhu, Jianguo, additional, Zhong, Weide, additional, Roose, Mikeal, additional, and Jia, Zhenyu, additional

Published
2022
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42. FCGR3A: A new biomarker with potential prognostic value for prostate cancer

Author

Zha, Zeyu, Hong, Yuan, Tang, ZhenFeng, Du, Qiuling, Wang, Yan, Yang, Shengbang, Wu, Yongding, Tan, Huijing, Jiang, Funneng, and Zhong, Weide

Subjects
Cancer Research, Oncology
Abstract

To screen target gene cluster by bioinformatics analysis and verify them by in vitro experiment and clinicopathological correlation analysis. We try to find a new biomarker with prognostic value for prostate cancer (PCa). 42 candidate marker genes were constructed by protein protein interaction (PPI) network and enriched by KEGG pathway to find out the gene cluster we are interested in. Prognostic model was established to preliminarily analyze the prognostic value of this gene cluster in PCa, and Cox risk regression was used for comparative analysis. Immunohistochemistry was used to detect the expression of each gene in clinical tissue microarray. Finally, we analyzed the correlation between each gene and their clinicopathological features of PCa combined with TCGA clinical data. Based on the analysis of PPI and KEGG, we found the target gene cluster (FCGR3A, HAVCR2, CCR7 and CD28). Prognostic model analysis showed that this gene cluster had the ability to predict biochemical recurrence, and the survival rate and ROC analysis showed favorable prediction effect. Univariate Cox regression analysis showed that the risk scores of Gleason score (GS), T stage, N stage and PSA were significantly different (PP=0.004). However, it was not statistically significant in multivariate Cox regression analysis (P>0.05). The results of tissue microarray showed that FCGR3A and HAVCR2 were highly expressed in PCa (PP>0.05). Kaplan-Meier analysis showed that there was significant difference in BCR free survival of FCGR3A and HAVCR2 (FCGR3A, P=0.010; HAVCR2, P=0.018), while the expression of CCR7 and CD28 had no significant difference on the survival and prognosis of PCa patients (P>0.05). TCGA clinical data analysis found that the expression of FCGR3A had a unique correlation with the clinicopathological features of PCa, which was closely related to the tumor stage. The expression of FCGR3A is related to BCR free survival of PCa patients. Therefore, FCGR3A is a new biomarker with potential prognostic value of PCa.

Published
2022
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43. Identification and experimental validation of a tumor-infiltrating lymphocytes–related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma

Author

Deng, Yulin, primary, Guo, Kai, additional, Tang, Zhenfeng, additional, Feng, Yuanfa, additional, Cai, Shanghua, additional, Ye, Jianheng, additional, Xi, Yuanxue, additional, Li, Jinchuang, additional, Liu, Ren, additional, Cai, Chao, additional, Tan, Zeheng, additional, Zhang, Yixun, additional, Han, Zhaodong, additional, Zeng, Guohua, additional, and Zhong, Weide, additional

Published
2022
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44. Untargeted metabolomics to analyze alterations in two-dimensional graphdiyne–copper nanocomposite on the metabolic reprogramming of prostate cancer

Author

Zhang, Yixun, primary, Xie, Wenjie, additional, Lin, Jundong, additional, Zhuo, Yangjia, additional, Zou, Zhihao, additional, He, Huichan, additional, Xu, Qianfeng, additional, Tang, Zhenfeng, additional, Tan, Huijing, additional, Liu, Ren, additional, Deng, Yulin, additional, Cai, Shanghua, additional, Ye, Jianheng, additional, Wang, Lude, additional, Zou, Fen, additional, and Zhong, Weide, additional

Published
2022
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45. Ferrocene‐Based Polymeric Nanoparticles Carrying Doxorubicin for Oncotherapeutic Combination of Chemotherapy and Ferroptosis

Author

Lin, Jundong, primary, Yang, Huikang, additional, Zhang, Yixun, additional, Zou, Fen, additional, He, Huichan, additional, Xie, Wenjie, additional, Zou, Zhihao, additional, Liu, Ren, additional, Xu, Qianfeng, additional, Zhang, Jie, additional, Zhong, Guowei, additional, Li, Yuejiao, additional, Tang, ZhenFeng, additional, Deng, Yulin, additional, Cai, Shanghua, additional, Wang, Linyao, additional, Huang, Yugang, additional, Zhuo, Yangjia, additional, Jiang, Xinqing, additional, and Zhong, Weide, additional

Published
2022
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46. Sodium butyrate treatment and fecal microbiota transplantation provide relief from ulcerative colitis-induced prostate enlargement

Author

Dong, Weimin, primary, Zheng, Jiefang, additional, Huang, Yiqiao, additional, Tan, Huijing, additional, Yang, Shengbang, additional, Zhang, Zhiming, additional, Liang, Xue, additional, Liu, Hao, additional, Zeng, Guohao, additional, Xu, Haoming, additional, Jiang, Xianhan, additional, and Zhong, Weide, additional

Published
2022
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