Search

Your search keyword '"Zhou, Chensheng"' showing total 112 results
Start Over Author "Zhou, Chensheng"
112 results on '"Zhou, Chensheng"'

2. Novel PDI-NH/PDI-COOH Supramolecular Junction for Enhanced Visible-Light Photocatalytic Phenol Degradation.

Author

Xu, Yongzhang, Luo, Xingrui, Wang, Fulin, Xiang, Wentao, Zhou, Chensheng, Huang, Weiya, Lu, Kangqiang, Li, Shaoyu, Zhou, Man, and Yang, Kai

Subjects
ENVIRONMENTAL remediation, PHOTODEGRADATION, CHARGE transfer, ELECTRIC fields, PHENOL, PERYLENE
Abstract

The development of efficient and environmentally friendly photocatalysts is crucial for addressing global energy and environmental challenges. Perylene diimide, an organic supramolecular material, holds great potential for applications in mineralized phenol. In this study, through the integration of different mass ratios of unmodified perylenimide (PDI-NH) into the self-assembly of amino acid-substituted perylenimide (PDI-COOH), a novel supramolecular organic heterojunction (PDICOOH/PDINH) was fabricated. The ensuing investigation focuses on its visible-light mineralized phenol properties. The results show that the optimal performance is observed with a composite mass fraction of 10%, leading to complete mineralization of 5 mg/L phenol within 5 h. The reaction exhibits one-stage kinetics with rate constants 13.80 and 1.30 times higher than those of PDI-NH and PDI-COOH, respectively. SEM and TEM reveal a heterogeneous interface between PDI-NH and PDI-COOH. Photoelectrochemical and Kelvin probe characterization confirm the generation of a built-in electric field at the interface, which is 1.73 times stronger than that of PDI-COOH. The introduction of PDI-NH promotes π-π stacking of PDI-COOH, while the built-in electric field facilitates efficient charge transfer at the interface, thereby enhancing phenol decomposition. The finding demonstrates that supramolecular heterojunctions have great potential as highly effective photocatalysts for environmental remediation applications. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Ipilimumab for Patients with Relapse after Allogeneic Transplantation

Author

Davids, Matthew S, Kim, Haesook T, Bachireddy, Pavan, Costello, Caitlin, Liguori, Rebecca, Savell, Alexandra, Lukez, Alexander P, Avigan, David, Chen, Yi-Bin, McSweeney, Peter, LeBoeuf, Nicole R, Rooney, Michael S, Bowden, Michaela, Zhou, Chensheng W, Granter, Scott R, Hornick, Jason L, Rodig, Scott J, Hirakawa, Masahiro, Severgnini, Mariano, Hodi, F Stephen, Wu, Catherine J, Ho, Vincent T, Cutler, Corey, Koreth, John, Alyea, Edwin P, Antin, Joseph H, Armand, Philippe, Streicher, Howard, Ball, Edward D, Ritz, Jerome, Bashey, Asad, and Soiffer, Robert J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Hematology, Regenerative Medicine, Pediatric, Patient Safety, Stem Cell Research - Nonembryonic - Non-Human, Cancer, Rare Diseases, Pediatric Cancer, Clinical Trials and Supportive Activities, Stem Cell Research, Transplantation, Stem Cell Research - Nonembryonic - Human, 6.2 Cellular and gene therapies, 5.2 Cellular and gene therapies, 6.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Evaluation of treatments and therapeutic interventions, Adult, Aged, Antibodies, Monoclonal, CD4 Lymphocyte Count, Female, Hematologic Neoplasms, Hematopoietic Stem Cell Transplantation, Humans, Induction Chemotherapy, Ipilimumab, Leukemia, Lymphoma, Male, Middle Aged, Myeloproliferative Disorders, Recurrence, T-Lymphocytes, Regulatory, Transplantation Immunology, Transplantation, Homologous, Leukemia and Lymphoma Society Blood Cancer Research Partnership, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundLoss of donor-mediated immune antitumor activity after allogeneic hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. We hypothesized that immune checkpoint blockade established by targeting cytotoxic T-lymphocyte-associated protein 4 with ipilimumab could restore antitumor reactivity through a graft-versus-tumor effect.MethodsWe conducted a phase 1/1b multicenter, investigator-initiated study to determine the safety and efficacy of ipilimumab in patients with relapsed hematologic cancer after allogeneic HSCT. Patients received induction therapy with ipilimumab at a dose of 3 or 10 mg per kilogram of body weight every 3 weeks for a total of 4 doses, with additional doses every 12 weeks for up to 60 weeks in patients who had a clinical benefit.ResultsA total of 28 patients were enrolled. Immune-related adverse events, including one death, were observed in 6 patients (21%), and graft-versus-host disease (GVHD) that precluded further administration of ipilimumab was observed in 4 patients (14%). No responses that met formal response criteria occurred in patients who received a dose of 3 mg per kilogram. Among 22 patients who received a dose of 10 mg per kilogram, 5 (23%) had a complete response, 2 (9%) had a partial response, and 6 (27%) had decreased tumor burden. Complete responses occurred in 4 patients with extramedullary acute myeloid leukemia and 1 patient with the myelodysplastic syndrome developing into acute myeloid leukemia. Four patients had a durable response for more than 1 year. Responses were associated with in situ infiltration of cytotoxic CD8+ T cells, decreased activation of regulatory T cells, and expansion of subpopulations of effector T cells in the blood.ConclusionsOur early-phase data showed that administration of ipilimumab was feasible in patients with recurrent hematologic cancers after allogeneic HSCT, although immune-mediated toxic effects and GVHD occurred. Durable responses were observed in association with several histologic subtypes of these cancers, including extramedullary acute myeloid leukemia. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT01822509.).

Published
2016

9. Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Author

Deng, Jiehui, primary, Wang, Eric S., primary, Jenkins, Russell W., primary, Li, Shuai, primary, Dries, Ruben, primary, Yates, Kathleen, primary, Chhabra, Sandeep, primary, Huang, Wei, primary, Liu, Hongye, primary, Aref, Amir R., primary, Ivanova, Elena, primary, Paweletz, Cloud P., primary, Bowden, Michaela, primary, Zhou, Chensheng W., primary, Herter-Sprie, Grit S., primary, Sorrentino, Jessica A., primary, Bisi, John E., primary, Lizotte, Patrick H., primary, Merlino, Ashley A., primary, Quinn, Max M., primary, Bufe, Lauren E., primary, Yang, Annan, primary, Zhang, Yanxi, primary, Zhang, Hua, primary, Gao, Peng, primary, Chen, Ting, primary, Cavanaugh, Megan E., primary, Rode, Amanda J., primary, Haines, Eric, primary, Roberts, Patrick J., primary, Strum, Jay C., primary, Richards, William G., primary, Lorch, Jochen H., primary, Parangi, Sareh, primary, Gunda, Viswanath, primary, Boland, Genevieve M., primary, Bueno, Raphael, primary, Palakurthi, Sangeetha, primary, Freeman, Gordon J., primary, Ritz, Jerome, primary, Haining, W. Nicholas, primary, Sharpless, Norman E., primary, Arthanari, Haribabu, primary, Shapiro, Geoffrey I., primary, Barbie, David A., primary, Gray, Nathanael S., primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

10. Data from BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer

Author

Adeegbe, Dennis O., primary, Liu, Shengwu, primary, Hattersley, Maureen M., primary, Bowden, Michaela, primary, Zhou, Chensheng W., primary, Li, Shuai, primary, Vlahos, Raven, primary, Grondine, Michael, primary, Dolgalev, Igor, primary, Ivanova, Elena V., primary, Quinn, Max M., primary, Gao, Peng, primary, Hammerman, Peter S., primary, Bradner, James E., primary, Diehl, J. Alan, primary, Rustgi, Anil K., primary, Bass, Adam J., primary, Tsirigos, Aristotelis, primary, Freeman, Gordon J., primary, Chen, Huawei, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

11. Data from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
Full Text
View/download PDF

12. Supp. Movie 3 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Author

Deng, Jiehui, primary, Wang, Eric S., primary, Jenkins, Russell W., primary, Li, Shuai, primary, Dries, Ruben, primary, Yates, Kathleen, primary, Chhabra, Sandeep, primary, Huang, Wei, primary, Liu, Hongye, primary, Aref, Amir R., primary, Ivanova, Elena, primary, Paweletz, Cloud P., primary, Bowden, Michaela, primary, Zhou, Chensheng W., primary, Herter-Sprie, Grit S., primary, Sorrentino, Jessica A., primary, Bisi, John E., primary, Lizotte, Patrick H., primary, Merlino, Ashley A., primary, Quinn, Max M., primary, Bufe, Lauren E., primary, Yang, Annan, primary, Zhang, Yanxi, primary, Zhang, Hua, primary, Gao, Peng, primary, Chen, Ting, primary, Cavanaugh, Megan E., primary, Rode, Amanda J., primary, Haines, Eric, primary, Roberts, Patrick J., primary, Strum, Jay C., primary, Richards, William G., primary, Lorch, Jochen H., primary, Parangi, Sareh, primary, Gunda, Viswanath, primary, Boland, Genevieve M., primary, Bueno, Raphael, primary, Palakurthi, Sangeetha, primary, Freeman, Gordon J., primary, Ritz, Jerome, primary, Haining, W. Nicholas, primary, Sharpless, Norman E., primary, Arthanari, Haribabu, primary, Shapiro, Geoffrey I., primary, Barbie, David A., primary, Gray, Nathanael S., primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

14. Supp. Movie 1 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
Full Text
View/download PDF

15. Table S3 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Figure Legends from BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer

Author

Adeegbe, Dennis O., primary, Liu, Shengwu, primary, Hattersley, Maureen M., primary, Bowden, Michaela, primary, Zhou, Chensheng W., primary, Li, Shuai, primary, Vlahos, Raven, primary, Grondine, Michael, primary, Dolgalev, Igor, primary, Ivanova, Elena V., primary, Quinn, Max M., primary, Gao, Peng, primary, Hammerman, Peter S., primary, Bradner, James E., primary, Diehl, J. Alan, primary, Rustgi, Anil K., primary, Bass, Adam J., primary, Tsirigos, Aristotelis, primary, Freeman, Gordon J., primary, Chen, Huawei, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

17. Table S1-S3; Figure S1-S13 from BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer

Author

Adeegbe, Dennis O., primary, Liu, Shengwu, primary, Hattersley, Maureen M., primary, Bowden, Michaela, primary, Zhou, Chensheng W., primary, Li, Shuai, primary, Vlahos, Raven, primary, Grondine, Michael, primary, Dolgalev, Igor, primary, Ivanova, Elena V., primary, Quinn, Max M., primary, Gao, Peng, primary, Hammerman, Peter S., primary, Bradner, James E., primary, Diehl, J. Alan, primary, Rustgi, Anil K., primary, Bass, Adam J., primary, Tsirigos, Aristotelis, primary, Freeman, Gordon J., primary, Chen, Huawei, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

18. Supplementary Data from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
Full Text
View/download PDF

19. Supp. Movie 2 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
Full Text
View/download PDF

21. Reply to ‘H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines’

Author

Alvarez, Mariano J., Yan, Pengrong, Alpaugh, Mary L., Bowden, Michaela, Sicinska, Ewa, Zhou, Chensheng W., Karan, Charles, Realubit, Ronald B., Mundi, Prabhjot S., Grunn, Adina, Jäger, Dirk, Chabot, John A., Fojo, Antonio T., Oberstein, Paul E., Hibshoosh, Hanina, Milsom, Jeffrey W., Kulke, Matthew H., Loda, Massimo, Chiosis, Gabriela, Reidy-Lagunes, Diane L., and Califano, Andrea

Published
2019
Full Text
View/download PDF

22. Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles

Author

Cejas, Paloma, Li, Lewyn, O'Neill, Nicholas K., Duarte, Melissa, Rao, Prakash, Bowden, Michaela, Zhou, Chensheng W., Mendiola, Marta, Burgos, Emilio, Feliu, Jaime, Moreno-Rubio, Juan, Guadalajara, Hector, Moreno, Victor, Garcia-Olmo, Damian, Bellmunt, Joaquim, Mullane, Stephanie, Hirsch, Michelle, Sweeney, Christopher J., Richardson, Andrea, Liu, X. Shirley, Brown, Myles, Shivdasani, Ramesh A., and Long, Henry W.

Subjects
Physiological aspects, Usage, Development and progression, Genetic aspects, Research, Cancer -- Development and progression -- Genetic aspects -- Research, Chromatin -- Physiological aspects -- Genetic aspects -- Research, DNA sequencing -- Usage -- Research, Nucleotide sequencing -- Usage -- Research
Abstract

The occurrence of recurrent mutations in chromatin-modifying genes in many human cancers (1) underscores the importance of chromatin in disease pathogenesis, and distinctive chromatin features in tumors correlate with clinical [...], Extensive cross-linking introduced during routine tissue fixation of clinical pathology specimens severely hampers chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq) analysis from archived tissue samples. This limits the ability to study the epigenomes of valuable, clinically annotated tissue resources. Here we describe fixed-tissue chromatin immunoprecipitation sequencing (FiT-seq), a method that enables reliable extraction of soluble chromatin from formalin-fixed paraffin-embedded (FFPE) tissue samples for accurate detection of histone marks. We demonstrate that FiT-seq data from FFPE specimens are concordant with ChIP-seq data from fresh-frozen samples of the same tumors. By using multiple histone marks, we generate chromatin-state maps and identify c/s-regulatory elements in clinical samples from various tumor types that can readily allow us to distinguish between cancers by the tissue of origin. Tumor-specific enhancers and superenhancers that are elucidated by FiT-seq analysis correlate with known oncogenic drivers in different tissues and can assist in the understanding of how chromatin states affect gene regulation.

Published
2016
Full Text
View/download PDF

23. Probing the Gluonic Structure of the Deuteron with J/ψ Photoproduction in d+Au Ultraperipheral Collisions

Author

Abdallah, Mohamed, Aboona, Bassam, Adam, Jaroslav, Adamczyk, Leszek, Adams, Joseph, Adkins, Kevin, Agakishiev, Geydar, Aggarwal, Ishu, Aggarwal, Madan, Ahammed, Zubayer, Aitbaev, A., Alekseev, Igor, Anderson, Derek, Aparin, Alexey, Aschenauer, Elke-Caroline, Ashraf, Muhammad Usman, Atetalla, Fareha, Attri, Anjali, Averichev, Georgy, Bairathi, Vipul, Baker, William, Ball Cap, Jonathan Gonzalo, Barish, Kenneth, Behera, Arabinda, Bellwied, Rene, Bhagat, Pratibha, Bhasin, Anju, Bielcik, Jaroslav, Bielcikova, Jana, Bordyuzhin, Igor, Brandenburg, James, Brandin, Andrei, Bunzarov, Ivan, Cai, Xiang-Zhou, Caines, Helen, Calderon de la Barca Sanchez, Manuel, Cebra, Daniel, Chakaberia, Irakli, Chaloupka, Petr, Chan, Brian, Chang, Feng-Han, Chang, Zilong, Chankova-Bunzarova, Nedialka, Chatterjee, Arghya, Chattopadhyay, Subhasis, Chen, Ding, Chen, Jia, Chen, Jinhui, Chen, Xiaolong, Chen, Zhenyu, Cheng, Jianping, Chevalier, Malia, Choudhury, Subikash, Christie, W., Christie, Bill, Chu, Xiaoxuan, Crawford, Hank, Csanad, Mate, Daugherity, Michael, Dedovich, Tatiana, Deppner, Ingo, Derevschikov, Anatoly, Dhamija, Arushi, Di Carlo, Launa, Didenko, Lidia, Dixit, Prabhupada, Dong, Xin, Drachenberg, James, Duckworth, Eddie, Dunlop, James, Elsey, Nicholas, Engelage, Jack, Eppley, Geary, Esumi, ShinIchi, Evdokimov, Olga, Ewigleben, Annika, Eyser, Oleg, Fatemi, Renee, Fawzi, Fares, Fazio, Salvatore, Federic, Pavol, Fedorisin, Jan, Feng, Chan-Jui, Feng, Yicheng, Filip, Peter, Finch, Evan, Fisyak, Yuri, Francisco, Audrey, Fu, Chuan, Fulek, Lukasz, Gagliardi, Carl, Galatyuk, Tatyana, Geurts, Frank, Ghimire, Navagyan, Gibson, Adam, Gopal, Krishan, Gou, Xingrui, Grosnick, David, Gupta, Anik, Guryn, Wlodek, Hamad, Ayman, Hamed, Ahmed, Han, Yiding, Harabasz, Szymon, Harasty, Matthew, Harris, John, Harrison, Hannah, He, Shu, He, Wanbing, He, Xionghong, He, Yang, Heppelmann, Samuel, Heppelmann, Steven, Herrmann, Norbert, Hoffman, Eric, Holub, Lukas, Hu, C., Hu, Q., Hu, Yu, Huang, Hao, Huang, Huan, Huang, Shengli, Huang, Te-Chuan, Huang, Xinjie, Huang, Yan, Humanic, T.J., Igo, George, Isenhower, Donald, Isshiki, M., Jacobs, William, Jena, Chitrasen, Jentsch, Alexander, Ji, Yuanjing, Jia, Jiangyong, Jiang, Kun, Ju, Xinyue, Judd, Eleanor, Kabana, Sonia, Kabir, Md Latiful, Kagamaster, Skipper, Kalinkin, Dmitry, Kang, Kejun, Kapukchyan, David, Kauder, Kolja, Ke, Hongwei, Keane, Declan, Kechechyan, Armen, Kelsey, Matthew, Khyzhniak, Yevheniia, Kikola, Daniel, Kim, Chong, Kimelman, Benjamin, Kincses, Daniel, Kisel, Ivan, Kiselev, Alexander, Knospe, Anders, Ko, Ho San, Kochenda, Leonid, Korobitsin, A., Kosarzewski, Leszek, Kramarik, Lukas, Kravtsov, Petr, Kumar, Lokesh, Kumar, Shyam, Kunnawalkam Elayavalli, Raghav, Kwasizur, Joseph, Lacey, Roy, Lan, Shaowei, Landgraf, Jeffery, Lauret, Jerome, Lebedev, Alexei, Lednicky, Richard, Lee, Jeong-Hun, Leung, Yue-Hang, Lewis, Nicole, Li, Changfeng, Li, Cheng, Li, Wei, Li, Xin, Li, Yuanjing, Liang, Xilin, Liang, Yue, Licenik, Robert, Lin, Ting, Lin, Yufu, Lisa, Mike, Liu, Feng, Liu, Huanzhao, Liu, Hui, Liu, Peifeng, Liu, Tong, Liu, Xiaoyu, Liu, Yanfang, Liu, Zhen, Ljubicic, Tonko, Llope, W.J., Longacre, R.S., Loyd, Erik, Lu, T., Lukow, Nicholas, Luo, Xiaofeng, Ma, Long, Ma, Rongrong, Ma, Yu-Gang, Magdy Abdelwahab Abdelrahman, Niseem, Mallick, Debasish, Manukhov, S.L., Margetis, Spiros, Markert, Christina, Matis, Howard, Mazer, Joel, Minaev, Nikolai, Mioduszewski, Saskia, Mohanty, Bedanga, Mondal, Mriganka, Mooney, Isaac, Morozov, Dmitry, Mukherjee, Ayon, Nagy, Marton, Nam, J.D., Nasim, Md., Nayak, Kishora, Neff, Dylan, Nelson, John, Nemes, Daniel, Nie, Maowu, Nigmatkulov, Grigory, Niida, Takafumi, Nishitani, Risa, Nogach, Larisa, Nonaka, Toshihiro, Nunes, Ana Sofia, Odyniec, Grazyna, Ogawa, Akio, Oh, Saehanseul, Okorokov, Vitalii, Okubo, K., Page, Brian, Pak, Robert, Pan, Jinjin, Pandav, Ashish, Pandey, Ashutosh, Panebratsev, Yuri, Parfenov, Petr, Pinsky, Lawrence, Paul, A., Pawlik, Bogdan, Pawlowska, Diana, Perkins, Chris, Pluta, Jan, Pokhrel, Babu, Ponimatkin, Georgij, Porter, Jeff, Posik, Matthew, Prozorova, Veronika, Pruthi, Navneet Kumar, Przybycien, Mariusz, Putschke, Joern, Qiu, Hao, Quintero, Amilkar, Racz, Cameron, Radhakrishnan, Sooraj, Raha, Nandita, Ray, Lanny, Reed, Rosi, Ritter, Hans Georg, Robotkova, Monika, Rogachevskiy, Oleg, Romero, Juan, Roy, Diptanil, Ruan, Lijuan, Rusnak, Jan, Sahoo, Aswini, Sahoo, Nihar, Sako, Hiroyuki, Salur, Sevil, Samigullin, E., Sandweiss, Jack, Sato, Susumu, Schmidke, Bill, Schmitz, Norbert, Schweid, Benjamin, Seck, Florian, Seger, Janet, Sergeeva, Maria, Seto, Richard, Seyboth, Peter, Shah, Neha, Shahaliev, Ehtiram, Shanmuganathan, Prashanth, Shao, Ming, Shao, Tianhao, Sharma, R., Sheikh, Ashik Ikbal, Shen, Diyu, Shi, Shusu, Shi, Yingying, Shou, Qi-Ye, Sichtermann, Ernst, Sikora, Rafal, Simko, Miroslav, Singh, Jagbir, Singha, Subhash, Sorensen, Paul, Sinha, P., Skoby, Michael, Smirnov, Nikolai, Soehngen, Yannick, Solyst, William, Song, Youqi, Spinka, H.M., Srivastava, Brijesh, Stanislaus, Shirvel, Stefaniak, Maria, Stewart, David, Strikhanov, Mikhail, Stringfellow, Blair, Suaide, Alexandre Alarcon, Sumbera, Michal, Summa, Branden, Sun, Xiangming, Sun, Xu, Sun, Yongjie, Sun, Yuliang, Surrow, Bernd, Svirida, Dmitry, Sweger, Zachary, Szymanski, Pawel, Tang, Aihong, Tang, Zebo, Taranenko, Arkadiy, Tarnowsky, Terry, Thomas, J.H., Timmins, Anthony, Tlusty, David, Todoroki, Takahito, Tokarev, Michael, Tomkiel, Catherine, Trentalange, Steven, Tribble, Robert, Tribedy, Prithwish, Tripathy, Srikanta Kumar, Truhlar, Tomas, Trzeciak, Barbara, Tsai, Oleg, Tu, Zhoudunming (Kong), Ullrich, Thomas, Underwood, Dave, Upsal, Isaac, Van Buren, Gene, Vanek, Jan, Vasiliev, Alexander, Vassiliev, Iouri, Verkest, Veronica, Videbaek, Flemming, Vokal, Stanislav, Voloshin, Sergei, Wang, Fuqiang, Wang, Gang, Wang, Jiansong, Wang, Pengfei, Wang, Xiaofeng, Wang, Yaping, Wang, Yi, Wang, Zhen, Webb, Jason, Weidenkaff, Philipp, Wen, Liwen, Westfall, Gary, Wieman, Howard, Wissink, Scott, Witt, Richard, Wu, Jin, Wu, Junlin, Wu, Yang, Xi, Baoshan, Xiao, Zhigang, Xie, Guannan, Xie, Wei, Xu, Haojie, Xu, Nu, Xu, Qinghua, Xu, Yike, Xu, Zhangbu, Xu, Zhiwan, Yan, Gaoguo, Yang, Chi, Yang, Qian, Yang, Shuai, Yang, Yi, Ye, Zaochen, Ye, Zhenyu, Yi, Li, Yip, Kin, Yu, Yi, Zbroszczyk, Hanna, Zha, Wangmei, Zhang, ChunJian, Zhang, Dingwei, Zhang, Jinlong, Zhang, Xiaoping, Zhao, F., Zhang, Shenghui, Zhang, Song, Zhang, Yapeng, Zhang, Yifei, Zhang, Yu, Zhang, Zhe-Jia, Zhang, Zhengqiao, Zhang, Ziyue, Zhao, Jie, Zhao, M., Zhou, Chensheng, Zhou, Yingjie, Zhu, Xianglei, Zurek, Maria, and Zyzak, Maksym

Subjects
Nuclear Theory, nucl-th, hep-ex, FOS: Physical sciences, nucl-ex, High Energy Physics - Experiment, Nuclear Theory (nucl-th), High Energy Physics - Experiment (hep-ex), Nuclear Physics - Theory, High Energy Physics::Experiment, Nuclear Physics - Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment, Particle Physics - Experiment
Abstract

Understanding gluon density distributions and how they are modified in nuclei are among the most important goals in nuclear physics. In recent years, diffractive vector meson production measured in ultra-peripheral collisions (UPCs) at heavy-ion colliders has provided a new tool for probing the gluon density. In this Letter, we report the first measurement of $J/\psi$ photoproduction off the deuteron in UPCs at the center-of-mass energy $\sqrt{s_{_{\rm NN}}}=200~\rm GeV$ in d$+$Au collisions. The differential cross section as a function of momentum transfer $-t$ is measured. In addition, data with a neutron tagged in the deuteron-going Zero-Degree Calorimeter is investigated for the first time, which is found to be consistent with the expectation of incoherent diffractive scattering at low momentum transfer. Theoretical predictions based on the Color Glass Condensate saturation model and the gluon shadowing model are compared with the data quantitatively. A better agreement with the saturation model has been observed. With the current measurement, the results are found to be directly sensitive to the gluon density distribution of the deuteron and the deuteron breakup, which provides insights into the nuclear gluonic structure., Comment: Final published version Phys. Rev. Lett. 128, 122303

Published
2021

25. Employing facile molten-salt strategy towards erbium ornamentation over CuInS2for upgrading visible-light-driven hydrogen production and Cr(VI) reduction

Author

Wang, Fulin, Yang, Yanming, Li, Xiangwei, Huang, Weiya, Lu, Kangqiang, Ouyang, Shaobo, Xiang, Wentao, Zhou, Chensheng, Yu, Changlin, Zhou, Man, and Yang, Kai

Abstract

Rare earth ions can serve as the focal point of electron capture states, thereby enhancing the effectiveness of separating photogenerated carriers, which is an effective strategy for boosting the photocatalytic efficiency of metal sulfides. Despite this, the efficient doping all at once remains a challenge. In this research, we successfully synthesized highly dispersed Er-doped CuInS2nanosheet-connected nanoblocks (Er-CIS) using the facile molten salt method. Erbium ornamentation over CuInS2exhibits the enhanced photocatalytic activities and the faster reaction rate for the hydrogen generation and the reduction of Cr(VI) under visible light irradiation. Specifically, the optimal 5 %Er-CIS displays a 2.0-fold and 4.89-fold increase in the ability to produce hydrogen and reduce Cr(VI), respectively, in comparison to that of pristine CuInS2. The upgrading results of photocatalytic activities can be attributed to multiple effects of Er ornamentation over CuInS2: 1) the substitution of Er atoms for CuInS2nanosheet-connected nanoblocks structure broadens the absorption range of visible light and further promotes the efficiency of separating the carriers; 2) the excellent hydrophilicity behavior for Er doping is propitious to lower the energy barrier for H2O dissociation and promote the generation and the transformation of protons; 3) furthermore, DFT calculations and photoelectrochemical measurements demonstrate that the presence of high dispersed Er effectively enhances the liberation of electrons and augments the active surface area. This finding presents a facile method for activating metal sulfides by incorporating rare earth elements to improve photocatalytic efficiency. This discovery highlights the activated photocatalytic behavior of metal sulfides through facile molten salt approach with the use of rare earth.

Published
2024
Full Text
View/download PDF

27. 733 Integrative molecular profiling of high-grade primary prostate cancer identifies patients with a biomarker profile that favors the combination of standard of care (SOC) therapy with immunotherapy

Author

Gjini, Evisa, primary, Trillo-Tinoco, Jimena, additional, Browne, Andrew, additional, Powles, Ryan, additional, Wang, Tai, additional, Tauras, Christine, additional, Lako, Ana, additional, Ferrer-Luna, Ruben, additional, Bleicher, Zoe, additional, Consedine, Timothy, additional, Zhou, Chensheng, additional, Kelemen, Evan, additional, Lewin, Anne, additional, King, Catherine, additional, Bhattacharya, Sumit, additional, Bell-Temin, Harris, additional, Dongre, Ashok, additional, Nelson, David, additional, Hatzis, Christos, additional, Macisaac, Kenzie, additional, Towfic, Fadi, additional, Chen, Benjamin, additional, and Bowden, Michaela, additional

Published
2020
Full Text
View/download PDF

28. Abstract LB-003: OncoMatch: Unbiased, quantitative assessment of cancer model fidelity for drug sensitivity and mechanism of action elucidation

Author

Alvarez, Mariano J., primary, Pengrong, Yan, additional, Alpaugh, Mary L., additional, Bowden, Michaela, additional, Sicinska, Ewa T., additional, Zhou, Chensheng W., additional, Karan, Charles, additional, Realubit, Ronald B., additional, Mundi, Prabhjot S., additional, Grunn, Adina, additional, Dirk, Jager, additional, Chabot, John A., additional, Fojo, Antonio T., additional, Oberstein, Paul E., additional, Hibshoosh, Hanina, additional, Milsom, Jeffrey W., additional, Kulke, Matthew H., additional, Loda, Massimo, additional, Chiosis, Gabriela, additional, Reidy-Lagunes, Diane L., additional, and Califano, Andrea, additional

Published
2020
Full Text
View/download PDF

29. Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis

Author

Alvarez, Mariano J., primary, Yan, Pengrong, additional, Alpaugh, Mary L., additional, Bowden, Michaela, additional, Sicinska, Ewa, additional, Zhou, Chensheng W., additional, Karan, Charles, additional, Realubit, Ronald B., additional, Mundi, Prabhjot S., additional, Grunn, Adina, additional, Jäger, Dirk, additional, Chabot, John A., additional, Fojo, Antonio T., additional, Oberstein, Paul E., additional, Hibshoosh, Hanina, additional, Milsom, Jeffrey W., additional, Kulke, Matthew H., additional, Loda, Massimo, additional, Chiosis, Gabriela, additional, Reidy-Lagunes, Diane L., additional, and Califano, Andrea, additional

Published
2019
Full Text
View/download PDF

31. BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer

Author

Adeegbe, Dennis O., primary, Liu, Shengwu, additional, Hattersley, Maureen M., additional, Bowden, Michaela, additional, Zhou, Chensheng W., additional, Li, Shuai, additional, Vlahos, Raven, additional, Grondine, Michael, additional, Dolgalev, Igor, additional, Ivanova, Elena V., additional, Quinn, Max M., additional, Gao, Peng, additional, Hammerman, Peter S., additional, Bradner, James E., additional, Diehl, J. Alan, additional, Rustgi, Anil K., additional, Bass, Adam J., additional, Tsirigos, Aristotelis, additional, Freeman, Gordon J., additional, Chen, Huawei, additional, and Wong, Kwok-Kin, additional

Published
2018
Full Text
View/download PDF

33. 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

Author

Institute for Medical Engineering and Science, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Aref, Amir Reza, Ivanova, Elena, Campisi, Marco, Hill, Sarah J, Barbie, David, Kamm, Roger Dale, Portell, Andrew, Larios, Dalia, Piel, Brandon P., Mathur, Natasha, Zhou, Chensheng, Coakley, Raven Vlahos, Bartels, Alan, Bowden, Michaela, Herbert, Zach, Gilhooley, Sean, Carter, Jacob, Cañadas, Israel, Thai, Tran C., Kitajima, Shunsuke, Chiono, Valeria, Paweletz, Cloud P., Jenkins, Russell W., Institute for Medical Engineering and Science, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Aref, Amir Reza, Ivanova, Elena, Campisi, Marco, Hill, Sarah J, Barbie, David, Kamm, Roger Dale, Portell, Andrew, Larios, Dalia, Piel, Brandon P., Mathur, Natasha, Zhou, Chensheng, Coakley, Raven Vlahos, Bartels, Alan, Bowden, Michaela, Herbert, Zach, Gilhooley, Sean, Carter, Jacob, Cañadas, Israel, Thai, Tran C., Kitajima, Shunsuke, Chiono, Valeria, Paweletz, Cloud P., and Jenkins, Russell W.

Abstract

Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed, several micro- devices are being developed specifically for clinical use to test novel cancer therapeutics. To be effective, these platforms need to replicate the continuous interactions that exist between tumor cells and non- tumor cell elements of the tumor microenvironment through direct cell – cell or cell – matrix contact or by the secretion of signaling factors such as cytokines, chemokines and growth factors. Given the challenges of personalized or precision cancer therapy, especially with the advent of novel immunotherapies, a critical need exists for more sophisticated ex vivo diagnostic systems that recapitulate patient-specific tumor biol- ogy with the potential to predict response to immune-based therapies in real-time. Here, we present de- tails of a method to screen for the response of patient tumors to immune checkpoint blockade therapy, first reported in Jenkins et al. Cancer Discovery, 2018, 8,196 – 215, with updated evaluation of murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS), including evaluation of the requirement for 3D microfluidic culture in MDOTS, demonstration of immune-checkpoint sensitivity of PDOTS, and ex- panded evaluation of tumor – immune interactions using RNA-sequencing to infer changes in the tumor – immune microenvironment. We also examine some potential improvements to current systems and dis- cuss the challenges in translating such diagnostic assays to the clinic., Robert A. and Renée E. Belfer Foundation, Ermenegildo Zegna Founder (scholarship), National Cancer Institute (U.S.) (NCI-R01 CA190394-01), MIT-POLITO grant BIOMODE – Compagnia di San Paolo, National Cancer Institute (U.S.) (NCI-U01 CA214381-01), Gloria T. Maheu and Heerwagen Family Funds for Lung Cancer Research, American Cancer Society. Lung Cancer Dream Team Translational Research Grant (SU2C-AACR-DT17-15)

Published
2018

34. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., additional, Lizotte, Patrick H., additional, Ivanova, Elena, additional, Stinson, Susanna, additional, Zhou, Chensheng W., additional, Bowden, Michaela, additional, Deng, Jiehui, additional, Liu, Hongye, additional, Miao, Diana, additional, He, Meng Xiao, additional, Walker, William, additional, Zhang, Gao, additional, Tian, Tian, additional, Cheng, Chaoran, additional, Wei, Zhi, additional, Palakurthi, Sangeetha, additional, Bittinger, Mark, additional, Vitzthum, Hans, additional, Kim, Jong Wook, additional, Merlino, Ashley, additional, Quinn, Max, additional, Venkataramani, Chandrasekar, additional, Kaplan, Joshua A., additional, Portell, Andrew, additional, Gokhale, Prafulla C., additional, Phillips, Bart, additional, Smart, Alicia, additional, Rotem, Asaf, additional, Jones, Robert E., additional, Keogh, Lauren, additional, Anguiano, Maria, additional, Stapleton, Lance, additional, Jia, Zhiheng, additional, Barzily-Rokni, Michal, additional, Cañadas, Israel, additional, Thai, Tran C., additional, Hammond, Marc R., additional, Vlahos, Raven, additional, Wang, Eric S., additional, Zhang, Hua, additional, Li, Shuai, additional, Hanna, Glenn J., additional, Huang, Wei, additional, Hoang, Mai P., additional, Piris, Adriano, additional, Eliane, Jean-Pierre, additional, Stemmer-Rachamimov, Anat O., additional, Cameron, Lisa, additional, Su, Mei-Ju, additional, Shah, Parin, additional, Izar, Benjamin, additional, Thakuria, Manisha, additional, LeBoeuf, Nicole R., additional, Rabinowits, Guilherme, additional, Gunda, Viswanath, additional, Parangi, Sareh, additional, Cleary, James M., additional, Miller, Brian C., additional, Kitajima, Shunsuke, additional, Thummalapalli, Rohit, additional, Miao, Benchun, additional, Barbie, Thanh U., additional, Sivathanu, Vivek, additional, Wong, Joshua, additional, Richards, William G., additional, Bueno, Raphael, additional, Yoon, Charles H., additional, Miret, Juan, additional, Herlyn, Meenhard, additional, Garraway, Levi A., additional, Van Allen, Eliezer M., additional, Freeman, Gordon J., additional, Kirschmeier, Paul T., additional, Lorch, Jochen H., additional, Ott, Patrick A., additional, Hodi, F. Stephen, additional, Flaherty, Keith T., additional, Kamm, Roger D., additional, Boland, Genevieve M., additional, Wong, Kwok-Kin, additional, Dornan, David, additional, Paweletz, Cloud Peter, additional, and Barbie, David A., additional

Published
2018
Full Text
View/download PDF

35. CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Author

Deng, Jiehui, primary, Wang, Eric S., additional, Jenkins, Russell W., additional, Li, Shuai, additional, Dries, Ruben, additional, Yates, Kathleen, additional, Chhabra, Sandeep, additional, Huang, Wei, additional, Liu, Hongye, additional, Aref, Amir R., additional, Ivanova, Elena, additional, Paweletz, Cloud P., additional, Bowden, Michaela, additional, Zhou, Chensheng W., additional, Herter-Sprie, Grit S., additional, Sorrentino, Jessica A., additional, Bisi, John E., additional, Lizotte, Patrick H., additional, Merlino, Ashley A., additional, Quinn, Max M., additional, Bufe, Lauren E., additional, Yang, Annan, additional, Zhang, Yanxi, additional, Zhang, Hua, additional, Gao, Peng, additional, Chen, Ting, additional, Cavanaugh, Megan E., additional, Rode, Amanda J., additional, Haines, Eric, additional, Roberts, Patrick J., additional, Strum, Jay C., additional, Richards, William G., additional, Lorch, Jochen H., additional, Parangi, Sareh, additional, Gunda, Viswanath, additional, Boland, Genevieve M., additional, Bueno, Raphael, additional, Palakurthi, Sangeetha, additional, Freeman, Gordon J., additional, Ritz, Jerome, additional, Haining, W. Nicholas, additional, Sharpless, Norman E., additional, Arthanari, Haribabu, additional, Shapiro, Geoffrey I., additional, Barbie, David A., additional, Gray, Nathanael S., additional, and Wong, Kwok-Kin, additional

Published
2018
Full Text
View/download PDF

36. 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

Author

Aref, Amir R., primary, Campisi, Marco, additional, Ivanova, Elena, additional, Portell, Andrew, additional, Larios, Dalia, additional, Piel, Brandon P., additional, Mathur, Natasha, additional, Zhou, Chensheng, additional, Coakley, Raven Vlahos, additional, Bartels, Alan, additional, Bowden, Michaela, additional, Herbert, Zach, additional, Hill, Sarah, additional, Gilhooley, Sean, additional, Carter, Jacob, additional, Cañadas, Israel, additional, Thai, Tran C., additional, Kitajima, Shunsuke, additional, Chiono, Valeria, additional, Paweletz, Cloud P., additional, Barbie, David A., additional, Kamm, Roger D., additional, and Jenkins, Russell W., additional

Published
2018
Full Text
View/download PDF

37. Abstract 27: Integrated analysis of targeted single-cell genetic and transcriptional heterogeneity suggests novel drivers of chronic lymphocytic leukemia

Author

Fan, Jean, primary, Wang, Lili, additional, Francis, Joshua M., additional, Georghiou, George, additional, Hergert, Sarah, additional, Li, Shuqiang, additional, Gambe, Rutendo, additional, Zhou, Chensheng W., additional, Yang, Chunxiao, additional, Xiao, Sheng, additional, Chin, Paola Dal, additional, Bowden, Michaela, additional, Kotliar, Dylan, additional, Shukla, Sachet A., additional, Brown, Jennifer R., additional, Neuberg, Donna, additional, Alessi, Dario R., additional, Zhang, Cheng-Zhong, additional, Kharchenko, Peter V., additional, Livak, Kenneth J., additional, and Wu, Catherine J., additional

Published
2017
Full Text
View/download PDF

38. Abstract 17: In situ immune expression signatures before and after ipilimumab therapy for relapsed acute myeloid leukemia after allogeneic stem cell transplantation

Author

Bachireddy, Pavan, primary, Davids, Matthew S., additional, Rooney, Michael S., additional, Bowden, Michaela, additional, Zhou, Chensheng W., additional, Rodig, Scott J., additional, Ho, Vincent, additional, Antin, Joseph, additional, Koreth, John, additional, Alyea, Edwin, additional, Soiffer, Robert J., additional, and Wu, Catherine J., additional

Published
2017
Full Text
View/download PDF

39. Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

Author

Tyekucheva, Svitlana, primary, Bowden, Michaela, additional, Bango, Clyde, additional, Giunchi, Francesca, additional, Huang, Ying, additional, Zhou, Chensheng, additional, Bondi, Arrigo, additional, Lis, Rosina, additional, Van Hemelrijck, Mieke, additional, Andrén, Ove, additional, Andersson, Sven-Olof, additional, Watson, R. William, additional, Pennington, Stephen, additional, Finn, Stephen P., additional, Martin, Neil E., additional, Stampfer, Meir J., additional, Parmigiani, Giovanni, additional, Penney, Kathryn L., additional, Fiorentino, Michelangelo, additional, Mucci, Lorelei A., additional, and Loda, Massimo, additional

Published
2017
Full Text
View/download PDF

40. Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia

Author

Wang, Lili, primary, Fan, Jean, additional, Francis, Joshua M., additional, Georghiou, George, additional, Hergert, Sarah, additional, Li, Shuqiang, additional, Gambe, Rutendo, additional, Zhou, Chensheng W., additional, Yang, Chunxiao, additional, Xiao, Sheng, additional, Cin, Paola Dal, additional, Bowden, Michaela, additional, Kotliar, Dylan, additional, Shukla, Sachet A., additional, Brown, Jennifer R., additional, Neuberg, Donna, additional, Alessi, Dario R., additional, Zhang, Cheng-Zhong, additional, Kharchenko, Peter V., additional, Livak, Kenneth J., additional, and Wu, Catherine J., additional

Published
2017
Full Text
View/download PDF

42. Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

Author

Tyekucheva, Svitlana, Bowden, Michaela, Bango, Clyde, Giunchi, Francesca, Huang, Ying, Zhou, Chensheng, Bondi, Arrigo, Lis, Rosina, Van Hemelrijck, Mieke, Andrén, Ove, Andersson, Sven-Olof, Watson, R. William, Pennington, Stephen, Finn, Stephen P., Martin, Neil E., Stampfer, Meir J., Parmigiani, Giovanni, Penney, Kathryn L., Fiorentino, Michelangelo, Mucci, Lorelei A., Loda, Massimo, Tyekucheva, Svitlana, Bowden, Michaela, Bango, Clyde, Giunchi, Francesca, Huang, Ying, Zhou, Chensheng, Bondi, Arrigo, Lis, Rosina, Van Hemelrijck, Mieke, Andrén, Ove, Andersson, Sven-Olof, Watson, R. William, Pennington, Stephen, Finn, Stephen P., Martin, Neil E., Stampfer, Meir J., Parmigiani, Giovanni, Penney, Kathryn L., Fiorentino, Michelangelo, Mucci, Lorelei A., and Loda, Massimo

Abstract

While progression from normal prostatic epithelium to invasive cancer is driven by molecular alterations, tumor cells and cells in the cancer microenvironment are co-dependent and co-evolve. Few human studies to date have focused on stroma. Here, we performed gene expression profiling of laser capture microdissected normal non-neoplastic prostate epithelial tissue and compared it to non-transformed and neoplastic low-grade and high-grade prostate epithelial tissue from radical prostatectomies, each with its immediately surrounding stroma. Whereas benign epithelium in prostates with and without tumor were similar in gene expression space, stroma away from tumor was significantly different from that in prostates without cancer. A stromal gene signature reflecting bone remodeling and immune-related pathways was upregulated in high compared to low-Gleason grade cases. In validation data, the signature discriminated cases that developed metastasis from those that did not. These data suggest that the microenvironment may influence prostate cancer initiation, maintenance, and metastatic progression.Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses., Funding Agencies:Challenge award from the Prostate Cancer FoundationProstate Cancer Foundation Irish Cancer Society Wellcome Trust-Health Research Board Dublin Centre for Clinical Research

Published
2017
Full Text
View/download PDF

44. Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy

Author

Bellmunt, Joaquim, primary, Zhou, Chensheng Willa, additional, Mullane, Stephanie A, additional, Werner, Lillian, additional, Taplin, Mary-Ellen, additional, Fay, André P, additional, Choueiri, Toni K, additional, Orsola, Anna, additional, Takeda, David Y, additional, Hahn, William C, additional, Kim, Jaegil, additional, Sonpavde, Guru, additional, and Bowden, Michaela, additional

Published
2016
Full Text
View/download PDF

50. Longitudinal Double-Spin Asymmetries for Dijet Production at Intermediate Pseudorapidity in Polarized $pp$ Collisions at $\sqrt{s}$ = 200 GeV

Author

Adam, Jaroslav, Leszek Adamczyk, Adams, Joseph, Adkins, Kevin, Agakishiev, Geydar, Aggarwal, Madan, Ahammed, Zubayer, Ajitanand, Nuggehalli, Alekseev, Igor, Anderson, Derek, Aoyama, Ryo, Aparin, Alexey, Arkhipkin, Dmitry, Aschenauer, Elke-Caroline, Ashraf, Muhammad Usman, Atetalla, Fareha, Attri, Anjali, Averichev, Georgy, Bai, Xiaozhi, Bairathi, Vipul, Barish, Kenneth, Bassill, Aj, Behera, Arabinda, Bellwied, Rene, Bhasin, Anju, Bhati, Ashok, Bielcik, Jaroslav, Bielcikova, Jana, Bland, Leslie, Bordyuzhin, Igor, Brandenburg, James, Brandin, Andrei, Brown, Daniel, Bryslawskyj, Jason, Bunzarov, Ivan, Butterworth, Joseph, Caines, Helen, Calderon La Barca Sanchez, Manuel, Campbell, John, Cebra, Daniel, Chakaberia, Irakli, Chaloupka, Petr, Chang, Feng-Han, Chang, Zilong, Chankova-Bunzarova, Nedialka, Chatterjee, Arghya, Chattopadhyay, Subhasis, Chen, Jinhui, Chen, Xiaolong, Chen, Xurong, Cheng, Jianping, Cherney, Mike, Christie, Bill, Contin, Giacomo, Crawford, Hank, Das, Sabita, Dedovich, Tatiana, Deppner, Ingo, Derevschikov, Anatoly, Didenko, Lidia, Dilks, Christopher, Dong, Xin, Drachenberg, James, Dunlop, James, Efimov, Leonid, Elsey, Nicholas, Engelage, Jack, Eppley, Geary, Esha, Roli, Esumi, Shinichi, Evdokimov, Olga, Ewigleben, Justin, Eyser, Oleg, Fatemi, Renee, Fazio, Salvatore, Federic, Pavol, Federicova, Pavla, Fedorisin, Jan, Filip, Peter, Finch, Evan, Fisyak, Yuri, Flores, Chris, Fulek, Lukasz, Gagliardi, Carl, Galatyuk, Tatyana, Geurts, Frank, Gibson, Adam, Grosnick, David, Gunarathne, Devika, Guo, Yi, Gupta, Anik, Guryn, Wlodek, Hamad, Ayman, Hamed, Ahmed, Harlenderova, Alena, Harris, John, He, Liang, Heppelmann, Steven, Heppelmann, Samuel, Herrmann, Norbert, Hirsch, Andy, Holub, Lukas, Horvat, Stephen, Huang, Xinjie, Huang, Bingchu, Huang, Shengli, Huang, Huan, Huang, Te-Chuan, Humanic, Tom, Huo, Peng, Igo, George, Jacobs, William, Jentsch, Alexander, Jia, Jiangyong, Jiang, Kun, Jowzaee, Sedigheh, Judd, Eleanor, Kabana, Sonya, Kalinkin, Dmitry, Kang, Kejun, Kapukchyan, David, Kauder, Kolja, Ke, Hongwei, Keane, Declan, Kechechyan, Armen, Kikola, Daniel, Kim, Chong, Kinghorn, Todd, Kisel, Ivan, Kisiel, Adam, Kochenda, Leonid, Kosarzewski, Leszek, Kraishan, Amani, Kramarik, Lukas, Krauth, Luke, Kravtsov, Peter, Krueger, Keith, Kulathunga, Nalinda, Kumar, Sumit, Kumar, Lokesh, Kvapil, Jakub, Kwasizur, Joseph, Lacey, Roy, Landgraf, Jeffery, Lauret, Jerome, Lebedev, Alexei, Lednicky, Richard, Lee, Jeong-Hun, Li, Xin, Li, Cheng, Li, Wei, Li, Yuanjing, Liang, Yue, Lidrych, Jindrich, Lin, Ting, Lipiec, Andrzej, Lisa, Mike, Liu, Feng, Liu, Peifeng, Liu, Huanzhao, Liu, Yanfang, Ljubicic, Tonko, Llope, Wj, Lomnitz, Michael, Longacre, Ron, Luo, Xiaofeng, Luo, Siwei, Ma, Guo-Liang, Ma, Yu-Gang, Ma, Long, Ma, Rongrong, Magdy Abdelwahab Abdelrahman, Niseem, Majka, Richard, Mallick, Debasish, Margetis, Spiros, Markert, Christina, Matis, Howard, Matonoha, Oliver, Mayes, David, Mazer, Joel, Meehan, Kathryn, Mei, Jincheng, Minaev, Nikolai, Mioduszewski, Saskia, Mishra, Debadeepti, Mohanty, Bedanga, Mondal, Mriganka, Mooney, Isaac, Morozov, Dmitry, Nasim, Md, Negrete, Jesus, Nelson, John, Nemes, Daniel, Nie, Maowu, Nigmatkulov, Grigory, Niida, Takafumi, Nogach, Larisa, Nonaka, Toshihiro, Nurushev, Sandibek, Odyniec, Grazyna, Ogawa, Akio, Oh, Kunsu, Oh, Saehanseul, Okorokov, Vitalii, Olvitt Jr, Daniel, Page, Brian, Pak, Robert, Panebratsev, Yuri, Pawlik, Bogdan, Pei, Hua, Perkins, Chris, Pluta, Jan, Porter, Jeff, Posik, Matthew, Pruthi, Navneet Kumar, Przybycien, Mariusz, Putschke, Joern, Quintero, Amilkar, Radhakrishnan, Sooraj, Ramachandran, Suvarna, Ray, Lanny, Reed, Rosi, Ritter, Hans Georg, Roberts, Jay, Rogachevskiy, Oleg, Romero, Juan, Ruan, Lijuan, Rusnak, Jan, Rusnakova, Olga, Sahoo, Nihar, Sahu, Pradip Kumar, Salur, Sevil, Sandweiss, Jack, Schambach, Joachim, Schmah, Alexander, Schmidke, Bill, Schmitz, Norbert, Schweid, Benjamin, Seck, Florian, Seger, Janet, Sergeeva, Maria, Seto, Richard, Seyboth, Peter, Shah, Neha, Shahaliev, Ehtiram, Shanmuganathan, Prashanth, Shao, Ming, Shen, Wen-Qing, Shen, Fuwang, Shi, Shusu, Shou, Qi-Ye, Sichtermann, Ernst, Siejka, Sebastian, Sikora, Rafal, Simko, Miroslav, Singha, Subhash, Smirnov, Nikolai, Smirnov, Dmitri, Solyst, William, Sorensen, Paul, Spinka, Hal, Srivastava, Brijesh, Stanislaus, Shirvel, Stewart, David, Strikhanov, Mikhail, Stringfellow, Blair, Suaide, Alexandre Alarcon, Sugiura, Tetsuro, Sumbera, Michal, Summa, Branden, Sun, Yongjie, Sun, Xu, Sun, Xiangming, Surrow, Bernd, Svirida, Dmitry, Szymanski, Pawel, Tang, Zebo, Tang, Aihong, Taranenko, Arkadiy, Tarnowsky, Terry, Thomas, Jim, Timmins, Anthony, Tlusty, David, Todoroki, Takahito, Tokarev, Michael, Tomkiel, Catherine, Trentalange, Steven, Tribble, Robert, Tribedy, Prithwish, Tripathy, Srikanta Kumar, Tsai, Oleg, Tu, Biao, Ullrich, Thomas, Underwood, Dave, Upsal, Isaac, Buren, Gene, Vanek, Jan, Vasiliev, Alexander, Vassiliev, Iouri, Videbaek, Flemming, Vokal, Stanislav, Voloshin, Sergei, Vossen, Anselm, Wang, Gang, Wang, Yaping, Wang, Fuqiang, Wang, Yi, Webb, Jason, Wen, Liwen, Westfall, Gary, Wieman, Howard, Wissink, Scott, Witt, Richard, Wu, Yang, Xiao, Zhigang, Xie, Guannan, Xie, Wei, Xu, Qinghua, Xu, Zhangbu, Xu, Ji, Xu, Yi-Fei, Xu, Nu, Yang, Shuai, Yang, Chi, Yang, Qian, Yang, Yi, Ye, Zhenyu, Ye, Zaochen, Yi, Li, Yip, Kin, Yoo, In-Kwon, Yu, Ning, Zbroszczyk, Hanna, Zha, Wangmei, Zhang, Zhengqiao, Zhang, Liang, Zhang, Yifei, Zhang, Xiaoping, Zhang, Jinlong, Zhang, Song, Zhang, Shenghui, Zhao, Jie, Zhong, Chen, Zhou, Chensheng, Zhou, Long, Zhu, Zhanwen, Zhu, Xianglei, and Zyzak, Maksym

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment, High Energy Physics - Experiment
Abstract

We present the first measurements of the longitudinal double-spin asymmetry $A_{LL}$ for dijets with at least one jet reconstructed within the pseudorapidity range $0.8 < \eta < 1.8$. The dijets were measured in polarized $pp$ collisions at a center-of-mass energy $\sqrt{s}$ = 200 GeV. Values for $A_{LL}$ are determined for several distinct event topologies, defined by the jet pseudorapidities, and span a range of parton momentum fraction $x$ down to $x \sim$ 0.01. The measured asymmetries are found to be consistent with the predictions of global analyses that incorporate the results of previous RHIC measurements. They will provide new constraints on $\Delta g(x)$ in this poorly constrained region when included in future global analyses.

Catalog

Books, media, physical & digital resources
See catalog results