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The comorbidities between gastroesophageal reflux disease (GERD) and various neurodegenerative and psychiatric disorders have been widely reported. However, the genetic correlations, causal relationships, and underlying mechanisms linking GERD to these disorders remain largely unknown. Here, we conducted a bidirectional Mendelian randomization (MR) analysis to determine the causality between GERD and 6 neurodegenerative and psychiatric disorders. Sensitivity analyses and multivariable MR were performed to test the robustness of our findings. Linkage disequilibrium score regression was used to assess the genetic correlation between these diseases as affected by heredity. Multiple bioinformatics tools combining two machine learning algorithms were applied to further investigate the potential mechanisms underlying these diseases. We found that genetically predicted GERD significantly increased the risk of Alzheimer's disease, major depressive disorder, and anxiety disorders. There might be a bidirectional relationship between GERD and insomnia. GERD has varying degrees of genetic correlations with AD, ALS, anxiety disorders, insomnia, and depressive disorder. Bioinformatics analyses revealed the hub shared genes and the common pathways between GERD and 6 neurodegenerative and psychiatric disorders. Our findings demonstrated the complex nature of the genetic architecture across these diseases and clarified their causality, highlighting that treatments for the cure or remission of GERD may serve as potential strategies for preventing and managing neurodegenerative and psychiatric disorders. [ABSTRACT FROM AUTHOR]

Pulse current cathodic protection had obvious advantages over traditional DC cathodic protection, but when square-wave pulse current was used for cathodic protection of oil well casing, the influence of pulse protection parameters on potential distribution was not very clear. Therefore, according to the current situation of oil fields in China, the typical formation characteristic structure of oil wells was selected and the cathodic protection model of pulse current for oil well casing was established. Based on the established model, the effects of pulse current parameters (frequency and duty cycle) and anode distance on the cathodic protection effect of square-wave pulse current were studied. The results showed that better protection effect could be obtained by choosing appropriate anode distance, high frequency, and moderate duty cycle. [ABSTRACT FROM AUTHOR]