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212 results on '"Zhou, Honglan"'

12. Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers

Author

Wang Yuxiong, Li Faping, Liu Bin, Zhang Yanghe, Li Yao, Li Yunkuo, Wang Yishu, and Zhou Honglan

Subjects
CREB3 family, Carcinogenesis, Protein metabolism, Unfolded protein response, Endoplasmic reticulum stress, Malignant phenotypes, Therapeutics. Pharmacology, RM1-950
Abstract

The CREB3 family of proteins, encompassing CREB3 and its four homologs (CREB3L1, CREB3L2, CREB3L3, and CREB3L4), exerts pivotal control over cellular protein metabolism in response to unfolded protein reactions. Under conditions of endoplasmic reticulum stress, activation of the CREB3 family occurs through regulated intramembrane proteolysis within the endoplasmic reticulum membrane. Perturbations in the function and expression of the CREB3 family have been closely associated with the development of diverse diseases, with a particular emphasis on cancer. Recent investigations have shed light on the indispensable role played by CREB3 family members in modulating the onset and progression of various human cancers. This comprehensive review endeavors to provide an in-depth examination of the involvement of CREB3 family members in distinct human cancer types, accentuating their significance in the pathogenesis of cancer and the manifestation of malignant phenotypes.

Published
2023
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31. Key events in cancer: Dysregulation of SREBPs

Author

Li, Yunkuo, primary, Wu, Shouwang, additional, Zhao, Xiaodong, additional, Hao, Shiming, additional, Li, Faping, additional, Wang, Yuxiong, additional, Liu, Bin, additional, Zhang, Difei, additional, Wang, Yishu, additional, and Zhou, Honglan, additional

Published
2023
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37. Efficacy and safety of stratified versus routine prophylaxis in living kidney transplantation from HBsAg+ donors to HBsAg− recipients: protocol for a multicentre, prospective, observational study

Author

Wang, Xianding, primary, Yin, Saifu, additional, Song, Turun, additional, Huang, Zhongli, additional, Fan, Yu, additional, Liu, Hongtao, additional, Shang, Wenjun, additional, Zhou, Honglan, additional, Li, Xiaohong, additional, and Lin, Tao, additional

Published
2021
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40. Effect of preoperative hydromorphone in patients undergoing laparoscopic radical gastrectomy

Author

Wang, Jinguo, Wang, Na, Zhou, Honglan, and Wang, Yuanyuan

Subjects
Male, Pain, Postoperative, Hemodynamics, Middle Aged, Analgesics, Opioid, Double-Blind Method, Gastrectomy, Humans, Hydromorphone, Original Article, Female, Laparoscopy, Prospective Studies, Preanesthetic Medication, Aged, Monitoring, Physiologic, Pain Measurement
Abstract

Objectives: To determine the efficacy of preemptive hydromorphone for laparoscopic radical gastrectomy. Methods: The present prospective and double-blinded study was performed in the The First Hospital, Jilin University, Changchun, China, between July 2017 and April 2018. Fifty patients scheduled for laparoscopic radical, gastrectomy were equally randomized into 2 groups, which were administrated different drugs 10 minutes before surgery. Group P (the preemptive hydromorphone group) was administrated 2 mg hydromorphone (2 mL), and Group C (the control group) was administrated 2 mL normal saline intravenously. A standardized general anesthesia were conducted. Blood pressure and heart rate, postoperative morphine consumption, pain intensity, sedation status, and side effects were recorded. Results: Group C had larger intraoperative hemodynamic changes, higher postoperative visual analogue scale score, more morphine consumption and lower overall satisfaction degree than Group P. No difference was found between the 2 groups in sedation status and adverse effects. Conclusion: Preoperative 2 mg hydromorphone could reduce intraoperative changes of blood pressure and heart rate, postoperative pain intensity, and morphine consumption without an increase of adverse effects.

Published
2018

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