Search

Openbite is a common type of malformation, which is difficult to treat, requires long course of treatment, and is likely to recur after orthodontic treatment. In this article, we reported a 20-year-old female case of severe anterior tooth openbite. Clinical examination found no occlusal contact between the anterior teeth, and the maximum opening was approximately 8 mm. Panoramic radiograph showed that 11 was impacted between 12 and 21. For the reduced maxillary bilateral central incisors, the straight wire arch appliance was utilized for 25 months, and the multi-curved square wire arch technique combined with implant treatment were employed to improve the occlusal relationship after the correction, establish normal overlying of the anterior teeth, and enhance the appearance. Clinical data of this case and literature review were analyzed and summarized, aiming to explore the orthodontic treatment for openbite cases and provide reference for individualized orthodontic treatment.

Background: SERPINB2, a biomarker of Type‐2 (T2) inflammatory processes, has been described in the context of asthma. Chronic rhinosinusitis with nasal polyps (CRSwNP) is also correlated with T2 inflammation and elevated 15LO1 induced by IL‐4/13 in nasal epithelial cells. The aim of this study was to evaluate the expression and location of SERPINB2 in nasal epithelial cells (NECs) and determine whether SERPINB2 regulates 15LO1 and downstream T2 markers in NECs via STAT6 signalling. Methods: SERPINB2 gene expression in bulk and single‐cell RNAseq database was analysed by bioinformatics analysis. SERPINB2, 15LO1 and other T2 markers were evaluated from CRSwNP and HCs NECs. The colocalization of SERPINB2 and 15LO1 was evaluated by immunofluorescence. Fresh NECs were cultured at an air‐liquid interface with or without IL‐13, SERPINB2 Dicer‐substrate short interfering RNAs (DsiRNAs) transfection, exogenous SERPINB2, 15‐HETE recombinant protein and pSTAT6 inhibitors. 15LO1, 15‐HETE and downstream T2 markers were analysed by qRT‐PCR, western blot and ELISA. Results: SERPINB2 expression was increased in eosinophilic nasal polyps compared with that in noneosinophilic nasal polyps and control tissues and positively correlated with 15LO1 and other downstream T2 markers. SERPINB2 was predominantly expressed by epithelial cells in NP tissue and was colocalized with 15LO1. In primary NECs in vitro, SERPINB2 expression was induced by IL‐13. Knockdown or overexpression SERPINB2 decreased or enhanced expression of 15LO1 and 15‐HETE in NECs, respectively, in a STAT6‐dependent manner. SERPINB2 siRNA also inhibited the expression of the 15LO1 downstream genes, such as CCL26, POSTN and NOS2. STAT6 inhibition similarly decreased SERPINB2‐induced 15LO1. Conclusions: SERPINB2 is increased in NP epithelial cells of eosinophilic CRSwNP (eCRSwNP) and contributes to T2 inflammation via STAT6 signalling. SERPINB2 could be considered a novel therapeutic target for eCRSwNP. [ABSTRACT FROM AUTHOR]

Work context transformed. Employees increasingly interact with enterprise social media, wherein employees may feel disconnected from workplace. Drawing on social affiliation theory, we develop and examine a moderated mediation model to explore the indirect effect of enterprise social media usage on counterproductive work behavior (CWB) via workplace loneliness and the moderating role of information and communication technology hassle (ICT hassle). We test hypotheses by conducting a three-wave survey of 345 knowledge workers. Results indicate that enterprise social media usage has a positive effect on workplace loneliness, and workplace loneliness mediated the indirect effect of enterprise social media usage on CWB. The moderated mediation analysis indicated that ICT hassle positively moderates the above mediation effect. We discuss the theoretical and practical implications of our findings., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhou, Cao, Goh and Kong.)

Background: Aspiration pneumonitis (AP) secondary to cerebrospinal fluid (CSF) leak is underestimated and rarely discussed. This study aimed to evaluate the association between AP and CSF leaks., Methods: Clinical and surgical characteristics of CSF leak patients with and without AP between January 2010 and December 2022 were included and compared., Results: This study included 159 patients, 16 with CSF otorrhea and 143 with CSF rhinorrhea. Among them, 40 (25.2%) had AP. Bilateral pneumonitis was identified in 32 cases, of which 11 showed severe pneumonitis in the right upper lung lobe. Twenty-one (52.5%) asymptomatic and 19 (47.5%) symptomatic cases were documented. The major clinical manifestations included cough (n = 19, 47.5%) and expectoration (n = 9, 22.5%). The prevalence of pneumonitis was significantly higher in the spontaneous group than in the traumatic group. High-flow CSF leak was associated with AP (42.5% vs. 16.8%, p = 0.001). No significant differences were identified in defect locations between patients with and without AP. Patients with pneumonitis had a higher prevalence of meningitis (32.5% vs. 12.6%, p = 0.003). Multiple logistic regression results revealed that meningitis, spontaneous and high-flow CSF leaks are independent factors for AP occurrence. Both the CSF leak and pulmonary complications resolved following successful surgical repair., Conclusions: AP secondary to CSF leaks is frequently underdiagnosed, with a higher incidence identified in spontaneous cases. The occurrence of AP was associated with high-flow CSF leak., Key Points: A pneumonitis rate of 25.2% in cerebrospinal fluid (CSF) leak patients was reported for the first time. A higher prevalence of aspiration pneumonitis was identified in spontaneous CSF leak. Meningitis, spontaneous and high-flow CSF leaks are independent factors for aspiration pneumonitis occurrence., (© 2023 ARS‐AAOA, LLC.)