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Shimmy is one of the important factors affecting the ride comfort and lateral stability of straddle-type monorail vehicles with single-axle bogies (SMVS). To obtain the main parameters affecting SMVS shimmy, a global sensitivity analysis strategy for SMVS shimmy is proposed. The shimmy response surface model is constructed, and the sensitivity analysis of the shimmy response surface model is carried out by the Sobol method. Based on this, the shimmy factor model of SMVS is established by factor analysis method. A novel SMVS shimmy analysis method based on factor model is proposed. The shimmy factor model is verified by the dynamic model of SMVS. The results show that 11 main factors affecting the shimmy are obtained by sensitivity analysis. Through the dimension reduction technology of factor analysis, four main factors affecting SMVS shimmy are extracted. The complex coupling relationship between the shimmy factors of SMVS is revealed. The established shimmy factor model can effectively analyse the shimmy state of SMVS, and the dynamic simulation results also show consistency. This study not only proposes a new perspective to understand the SMVS shimmy mechanism, but also provides the foundation for further optimal design of monorail vehicle stability. [ABSTRACT FROM AUTHOR]

In order to study the influence of the space linkage system on the stability of the straddle-type monorail vehicle with single-axle bogies, the sensitivity analysis of the space linkage system is identified based on the Pearson coefficient method to determine the importance of each component of the single-axle bogies. The dynamics model of straddle-type monorail vehicle with single-axle bogies is established by the multi-rigid body dynamics. The Pearson analysis method is used to identify the key parameters of the space linkage system. Based on that, dynamic response optimization model of space bar system is developed to carry out a multi-objective suspension design optimization process. The results show that the maximum sensitivity parameter for the RMS value of yaw acceleration and pitch angle acceleration is the length of the longitudinal tow bar; there is a correlation of approximately 0.088 between the stiffness K and the damping coefficient C of the hydraulic shock absorber. After optimization the root mean square of lateral acceleration of the optimized single-axle bogie vehicle is reduced by 6.0%. [ABSTRACT FROM AUTHOR]

Mid-infrared (mid-IR) sensors consisting of silicon nitride (SiN) waveguides were designed and tested to detect volatile organic compounds (VOCs). SiN thin films, prepared by low-pressure chemical vapor deposition (LPCVD), have a broad mid-IR transparent region and a lower refractive index (nSiN = 2.0) than conventional materials such as Si (nSi = 3.4), which leads to a stronger evanescent wave and therefore higher sensitivity, as confirmed by a finite-difference eigenmode (FDE) calculation. Further, in-situ monitoring of three VOCs (acetone, ethanol, and isoprene) was experimentally demonstrated through characteristic absorption measurements at wavelengths λ = 3.0–3.6 μm. The SiN waveguide showed a five-fold sensitivity improvement over the Si waveguide due to its stronger evanescent field. To our knowledge, this is the first time SiN waveguides are used to perform on-chip mid-IR spectral measurements for VOC detection. Thus, the developed waveguide sensor has the potential to be used as a compact device module capable of monitoring multiple gaseous analytes for health, agricultural and environmental applications. [ABSTRACT FROM AUTHOR]

Functionalization of optical waveguides with submicron coatings of zinc peroxide (ZnO2) and silica (SiO2) nanoparticles (NPs) is reported that enabled selective concentration of acetone vapors in the vicinity of the waveguide, boosting the sensitivity of a mid infrared (MIR) on-chip detector. Controlled thickness was achieved by introducing precise control of the substrate withdrawal speed to the layer-by-layer (LbL) deposition technique. [ABSTRACT FROM AUTHOR]

The dynamic parameters of Straddle-type monorail vehicles with single-axle bogies are optimised by utilising the multi-body dynamic method. The dynamic parameter optimisation is conducted aiming at the curve negotiation properties, comfort and tire eccentric wear of monorail vehicles. The optimisation model is established with software ADAMS and modeFRONTIER and the Sobol is adopted for sensitivity analysis to acquire the optimised parameters. Finally, the multiobjective collaborative optimisation algorithm is utilised for optimised analysis. According to the results, the proposed method can conduct multi-objective optimisation to the monorail vehicles in a successful way. The curve negotiation properties and comfort are improved, and the tire wear is reduced with dynamic parameters after optimisation. Especially, a conversion strategy of the consistent objective function is proposed aiming at multiobjective nonlinear convergence. [ABSTRACT FROM AUTHOR]

Real-time gas analysis on-a-chip was demonstrated using a mid-infrared (mid-IR) microcavity. Optical apertures for the microcavity were made of ultrathin silicate membranes embedded in a silicon chip using the complementary metal-oxide-semiconductor (CMOS) process. Fourier transform infrared spectroscopy (FTIR) shows that the silicate membrane is transparent in the range of 2.5-6.0 μm, a region that overlaps with multiple characteristic gas absorption lines and therefore enables gas detection applications. A test station integrating a mid-IR tunable laser, a microgas delivery system, and a mid-IR camera was assembled to evaluate the gas detection performance. CH4, CO2, and N2O were selected as analytes due to their strong absorption bands at λ = 3.25-3.50, 4.20-4.35, and 4.40-4.65 μm, which correspond to C-H, C-O, and O-N stretching, respectively. A short subsecond response time and high gas identification accuracy were achieved. Therefore, our chip-scale mid-IR sensor provides a new platform for an in situ, remote, and embedded gas monitoring system. [ABSTRACT FROM AUTHOR]

• Demonstrate of Orbital Angular Momentum (OAM) in the mid-Infrared region. • Apply mid-Infrared transparent polymers for mid-Infrared applications. • Develop high-throughput fabrication methods for mid-Infrared components. • Demonstrate high conversion efficiency from Gaussian beam to vortex beam. Light carrying vortex beam characteristics were demonstrated in the mid-infrared (mid-IR) region using polymer based spiral phase plates (SPP). The SPP was fabricated through three dimensional (3-D) direct laser writing method, which can construct the optical phase according to the mid-IR wavelength of interest. The fabricated SPP consisted of 32 layers and the layer thickness was precisely adjusted between 100 and 600 nm to create 2π helical phase change. The ideal SPP structure and the gradient optical phase diagram were designed and simulated by the finite-difference time-domain (FDTD) method. Characteristic vortex beam profiles with a ring-shaped pattern and a sharp centric dark spot were experimentally illustrated at a wavelength range of λ = 3.1–3.3 µm. The formation of mid-IR OAM through high throughput 3-D writing technology provides critical integrated components to explore quantum photonics and optical communications. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the feasibility, pharmacokinetics, efficacy and toxicity of intrapleural paclitaxel liposome injection in non-small cell lung cancer (NSCLC) patients with malignant pleural effusions. Patients and methods: Twelve of 15 NSCLC patients with malignant pleural effusions were treated with paclitaxel liposome and three were treated with free paclitaxel. Adequate pleural fluid, blood and urine were collected for pharmacokinetic study. The clinical efficacy and toxicity were synthetically evaluated according to the correlative criteria. Results: The overall toxicity of paclitaxel liposome was lower than that of free paclitaxel. In the patients treated with paclitaxel liposome, there were minimal local chest pain, anaphylaxis, anaemia, neutropaenia and hepatotoxicity. The complete response rates of pleural effusion at the first, second, third and sixth month were, respectively, 27.3%, 18.2%, 9.1% and 9.1%, and overall response rates were 90.9%, 72.7%, 63.6% and 54.5%, respectively. Pharmacokinetic study showed that mean C max,IP, T 1/2 and AUC0→96,IP in pleural fluid were, respectively, about 2-fold, 2-fold and 2.5-fold than those of free paclitaxel, and AUC0→96,Pla in plasma was also much higher than that of free paclitaxel, however, excretory rate in 24h from urine was lower than that of free paclitaxel. Conclusions: This study demonstrated that paclitaxel liposome was a more useful agent than free paclitaxel for the treatment of malignant pleural effusions because of its relatively low toxicity and distinct pharmacokinetic characteristics. The phase II study of a large number of patients was recommended to confirm this finding. [Copyright &y& Elsevier]

Tunable photonic circuits were demonstrated in the mid-Infrared (mid-IR) regime using integrated TiO2-on-LiNbO3 (ToL) waveguides. The upper waveguide ridge was made by a sputtered TiO2 thin film with broad transparency at λ = 0.4–8 µm and an optimized refractive index n = 2.39. The waveguide substrate is a z-cut single crystalline LiNbO3 (LN) wafer that has strong Pockels effect, thus enabling the tunability of the device through electro-optical (E-O) modulation. A sharp waveguide mode was obtained at λ = 2.5 µm without scattering or mode distortion found. The measured E-O coefficient γeff was 5.9 pm/V approaching γ31 of 8.6 pm/V of LN. The ToL waveguide showed a hybrid mode profile where its optical field can be modified by adjusting the TiO2 ridge height. Our monolithically integrated ToL modulator is an efficient and small footprint optical switch critical for the development of reconfigurable photonic chips. [ABSTRACT FROM AUTHOR]

Automatic building extraction using a single data type, either 2D remotely-sensed images or light detection and ranging 3D point clouds, remains insufficient to accurately delineate building outlines for automatic mapping, despite active research in this area and the significant progress which has been achieved in the past decade. This paper presents an effective approach to extracting buildings from Unmanned Aerial Vehicle (UAV) images through the incorporation of superpixel segmentation and semantic recognition. A framework for building extraction is constructed by jointly using an improved Simple Linear Iterative Clustering (SLIC) algorithm and Multiscale Siamese Convolutional Networks (MSCNs). The SLIC algorithm, improved by additionally imposing a digital surface model for superpixel segmentation, namely 6D-SLIC, is suited for building boundary detection under building and image backgrounds with similar radiometric signatures. The proposed MSCNs, including a feature learning network and a binary decision network, are used to automatically learn a multiscale hierarchical feature representation and detect building objects under various complex backgrounds. In addition, a gamma-transform green leaf index is proposed to truncate vegetation superpixels for further processing to improve the robustness and efficiency of building detection, the Douglas–Peucker algorithm and iterative optimization are used to eliminate jagged details generated from small structures as a result of superpixel segmentation. In the experiments, the UAV datasets, including many buildings in urban and rural areas with irregular shapes and different heights and that are obscured by trees, are collected to evaluate the proposed method. The experimental results based on the qualitative and quantitative measures confirm the effectiveness and high accuracy of the proposed framework relative to the digitized results. The proposed framework performs better than state-of-the-art building extraction methods, given its higher values of recall, precision, and intersection over Union (IoU). [ABSTRACT FROM AUTHOR]

Background: The widespread use of telemedicine systems and medical information networks has made telemedicine one of the current trends in health care. The purpose of this article is to propose a community health intervention with remote monitoring and teleconsultation during COVID-19 for the prevention and control of COVID-19 at the rural level. Methods: In this intervention study, a randomized group of 1,500 community residents was selected. A questionnaire with acceptable validity and reliability was used to collect data. The study was conducted with the test group itself as a control, and the questionnaire was completed again 6 months after the health intervention through remote monitoring. The extent of the effect of the remote monitoring intervention on community health during COVID-19 was measured. The data were entered into SPSS 26, and the data were analyzed using the K–S normality test, t-test, and chi-square test. Results: After 6 months of the intervention, the differences in mean scores of the test group were statistically significant (p < 0.05) in cognition, perceived benefits, self-efficacy, and behavioral outcomes, with a substantial increase in mean scores for all variables. Conclusions: The application of remote monitoring during COVID-19 in rural communities can influence the health perception, benefit perception, self-efficacy, and behavior of community residents, thus effectively preventing and controlling the spread of COVID-19 in rural communities. It reduces medical barriers for rural areas while meeting. [ABSTRACT FROM AUTHOR]

This article focus on the dynamic behavior of straddle-type monorail composed of multiple vehicles. The four-vehicle dynamic model of straddle-type monorail considering the coupler force is established on the basis of the coupler dynamic model. The correctness of the model is verified by the real experimental vehicle test of Chongqing straddle monorail line 3 from Huixing station to Changfuroad station. The stable wheel overturning coefficient suitable for monorail is proposed which is used to evaluate the anti-overturning performance of straddle monorail. The vibration response, riding comfort, and dynamic curving behavior are analyzed using the dynamic model. The results show that the vibration response of car body accelerations obtained by single-car model is much different from that obtained by train model. The riding comfort of straddle-type calculated by the single-car model would make large mistake, and a multiple train model is needed. The dynamic curving behavior of straddle-type monorail obtained by the single-car model could represent the dynamic curving behavior well. [ABSTRACT FROM AUTHOR]

In Eurocrypt’18, Cid et al. proposed a new cryptanalysis tool called Boomerang Connectivity Table (BCT), to evaluate S-boxes of block ciphers. Later, Boura and Canteaut further investigated the new parameter Boomerang uniformity for cryptographic S-boxes. It is of great interest to find new S-boxes with low Boomerang uniformity for even dimensions. In this paper, we prove that a class of permutation quadrinomials over $\mathbb {F}_{2^{2m}}$ with $m$ odd has Boomerang uniformity four, which gives the fifth class of such kind of permutation polynomials. Further, the occurrences of 0 and 4 in the BCTs of the investigated permutation polynomials are also completely determined. [ABSTRACT FROM AUTHOR]

Background MiR-34 family members have been previously shown to play potential functional role in Parkinson’s disease (PD) pathogenesis. However, the regulatory role of miR-34a has not been demonstrated in PD yet. This study aims to clarify the potential neuroprotective effect of Schisandrin B (Sch B) involving miR-34a function in 6-OHDA-induced PD model. Methods The expression changes of miR-34a and Nrf2 pathway related genes were detected in 6-OHDA-treated SH-SY5Y cells under Sch B pretreatment. Cell viability and PD feathers of 6-OHDA-induced PD mice were measured for neuroprotection assessment. The regulation of miR-34a on Nrf2 activity and expression was demonstrated through gain-of-function and loss-of-function studies, while the regulatory role of miR-34a in the neuroprotection of Sch B was investigated both in vitr o and in vivo. Results Sch B pretreatment ameliorated 6-OHDA-induced changes in vitro, like upregulated miR-34a expression, inhibited Nrf2 pathways and decreased cell survival, and PD feathers in vivo. Moreover, Nrf2 was negatively regulated by miR-34a, while miR-34a overexpression inhibited the neuroprotection of Sch B in both dopaminergic SH-SY5Y cells and PD mice. Conclusion Sch B showed neuroprotective effect in 6-OHDA-induced PD pathogenesis, which could be inhibited by miR-34a, involving the negative regulatory mechanism of miR-34a on Nrf2 pathways. [ABSTRACT FROM AUTHOR]

In this paper, we find three classes of complete permutation polynomials over finite fields of even characteristic. The first class of quadrinomials is complete in the sense of addition. The second and third classes of binomials and trinomials are complete in multiplication. Moreover, a result related to the complete property in multiplication of a special class of polynomials is also given. [ABSTRACT FROM AUTHOR]

Subtropical ecosystems are often characterized by high N cycling rates, but net nitrification rates are often low in subtropical acid soils. NO3−-N immobilization into organic N may be a contributing factor to understand the observed low net nitrification rates in these acid soils. The effects of Fe oxide and organic matter on soil N transformations were evaluated using a 15N tracing study. Soil net nitrification was low for highly acidic yellow soil (Ferralsols), but gross ammonia oxidation was 7 times higher than net nitrification. In weakly acidic purple soil (Cambisols), net nitrification was 8 times higher than in Ferralsols. The addition of 5% Fe oxide to Cambisols, reduced the net nitrification rate to a negative rate, while NO3−-N immobilization rate increased 8 fold. NO3−-N immobilization was also observed in Ferralsols which contained high Fe oxides levels. A possible mechanism for these reactions could be stimulation of NO3−-N immobilization by Fe oxide which promoted the abiotic formation of nitrogenous polymers, suggesting that the absence of net nitrification in some highly acid soils may be due to high rates of NO3−-N immobilization caused by high Fe oxide content rather than a low pH. [ABSTRACT FROM AUTHOR]