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Providing appropriate feedback is important when learning to program. However, it is still unclear how different feedback strategies affect learning outcomes in programming. This study designed four different two-step programming feedback strategies and explored their impact on novice programmers' academic achievement, learning motivations, and self-efficacy. A quasi-experimental study was conducted for four classes of freshmen (261 students, average age = 19) in computer science over six weeks. The students received four different feedback strategies including "programming template and correct code without comments", "programming template and correct code with comments", "flowchart and correct code without comments", and "flowchart and correct code with comments" during their C language programming course. The results showed that none of the feedback strategies can promote novice programmers' learning motivations and self-efficacy, but using "programming template and correct code without comments" can improve academic achievement of these novice programmers. Further analysis of students' reflection demonstrated that providing "programming template and correct code without comments" had advantage in helping students interpret code, thereby guiding the students to think comprehensively and face challenges positively, as well as promoting student success when learning to program.

Previous research in alphabetic languages has shown that both position (external, internal) and distance (adjacent, nonadjacent) modulate letter position encoding during reading. To examine the generality of this pattern for a comprehensive model of word recognition and reading, we examined these effects during Chinese reading (i.e., an unspaced logographic language). Participants in two experiments read intact sentences and sentences containing transposed-character nonwords while their eye movements were monitored. Experiment 1 manipulated the distance between the transposed characters (adjacent vs. nonadjacent) within three-character words. Reading times were longer when nonadjacent characters were transposed compared with adjacent characters. Also, for adjacent character transpositions, a word-beginning character transposition led to longer reading times than a word-ending character transposition. Experiment 2 manipulated orthogonally character transposition distance (adjacent vs. nonadjacent) and position within four-character words, including the beginning versus the last character. Reading times were longer when the transposition involves the first character than when involves the ending character. Fixation durations on the target regions in the nonadjacent character transposition condition were longer than those in the adjacent character transposition condition. Taken together, these results reveal robust effects of both the initial character position and transposed-character distance in Chinese reading. Thus, the privileged status of the initial character is intrinsically related to how we access lexical information.

Objective To investigate the effect of MDM2 inhibitor RG-7388 on the proliferation, cell cycle, and apoptosis of diffuse large B-lymphoma (DLBCL) cells. Methods DLBCL cell strains SUDHL2 and HBL1 were treated with 2, 4, and 8 μmol/LRG7388, respectively. Cell proliferation was detected by CCK8 and EdU methods. Apoptosis was measured by Annexin V–FITC/PI double staining and Caspase 3/7-Glo enzyme activity methods. Cell cycle was assessed by flow cytometry. Changes in the expression of cell cycle and apoptosis-related proteins were determined by Western blot. Results The IC50 of RG7388 for inhibiting SUDHL2 and HBL1 cells were 3.36 and 3.76 μmol/L, respectively, and the inhibitory effect of RG7388 was dose dependent. The proportions of G1 phase and apoptotic cells in the SUDHL2 and HBL1 cells treated with different doses of RG7388 were significantly higher than those in the control group (all P

In the present article, we report two eye-tracking experiments on how Chinese readers segment incremental words while reading Chinese. Incremental words are multicharacter words containing a subset of characters that constitute another word (referred to as the "embedded word"). For example, in a word containing three characters ABC (e.g., "[Chinese characters omitted]," meaning landlady), the first two characters AB ("[Chinese characters omitted]," meaning boss) constitute an embedded word. In the two experiments, Chinese readers read sentences with 3-character incremental words. In Experiment 1, the incremental words were always plausible, and the verbs prior to the target words were manipulated so that the embedded word of the incremental word was either plausible or implausible as an independent word. The eye-movement data showed that the plausibility manipulation did not influence the reading times on the incremental words nor their embedded words. In Experiment 2, we manipulated the plausibility of both incremental and embedded words. No plausibility effect of the embedded word was observed when the incremental words were plausible. However, the plausibility effect of the embedded word was obtained when the incremental words were implausible. These results suggest that Chinese readers tend to segment and integrate incremental words as a whole unit when they are plausible. However, when incremental words are implausible, the embedded words are segmented as independent words.

An asymmetrical wound dressing functions akin to human skin by serving as a protective barrier between a wound and its immediate environment. However, significant challenges persist concerning the robust adhesion and asymmetrical adhesion properties of hydrogels, particularly when applied in emergency hemostasis and wound healing contexts. Herein, the study has successfully synthesized hydrogel patches with Janus asymmetric‐adhesion, denoted as HGO‐C, exclusively comprised of natural polymers. This achievement is realized through the assembly of adhesive hydrogel (HGO) and non‐adhesive hydrogel (CGC), thereby amalgamating their distinct functionalities. The non‐adhesive hydrogel component served as a physical shield and safeguarding the wound against contamination, while the adhesive hydrogel, when in contacted with the wound surface, firmly adhered to it, swiftly arresting bleeding and facilitating wound healing. Cytocompatibility tests, hemolysis tests, antibacterial assays, and coagulation assays demonstrated excellent biocompatibility, antibacterial, and hemostatic properties of HGO‐C. Finally, the in vivo experiments, including a liver hemorrhage assay and a wound healing assay, unequivocally showed the rapid hemostatic and enhanced wound healing capabilities of HGO‐C. Consequently, these distinctive hydrogel patches, derived from natural polymers and characterized by their asymmetric adhesion properties, may have great potential for real‐life usage in clinical patients. [ABSTRACT FROM AUTHOR]

Low-value care is associated with increased healthcare costs and direct harm to patients. We sought to develop and validate a simple diagnostic intensity index (DII) to quantify hospital-level diagnostic intensity, defined by the prevalence of advanced imaging among patients with selected clinical diagnoses that may not require imaging, and to describe hospital characteristics associated with high diagnostic intensity. We utilized State Inpatient Database data for inpatient hospitalizations with one or more pre-defined discharge diagnoses at acute care hospitals. We measured receipt of advanced imaging for an associated diagnosis. Candidate metrics were defined by the proportion of inpatients at a hospital with a given diagnosis who underwent associated imaging. Candidate metrics exhibiting temporal stability and internal consistency were included in the final DII. Hospitals were stratified according to the DII, and the relationship between hospital characteristics and DII score was described. Multilevel regression was used to externally validate the index using pre-specified Medicare county-level cost measures, a Dartmouth Atlas measure, and a previously developed hospital-level utilization index. This novel DII, comprised of eight metrics, correlated in a dose-dependent fashion with four of these five measures. The strongest relationship was with imaging costs (odds ratio of 3.41 of being in a higher DII tertile when comparing tertiles three and one of imaging costs (95 % CI 2.02–5.75)). A small set of medical conditions and related imaging can be used to draw meaningful inferences more broadly on hospital diagnostic intensity. This could be used to better understand hospital characteristics associated with low-value care. [ABSTRACT FROM AUTHOR]