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Your search keyword '"Zhou, Wen-Wen"' showing total 173 results
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173 results on '"Zhou, Wen-Wen"'

5. The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment

Author

Lv, Jiawei, Wei, Yuan, Yin, Jian-Hua, Chen, Yu-Pei, Zhou, Guan-Qun, Wei, Chen, Liang, Xiao-Yu, Zhang, Yuan, Zhang, Cui-Juan, He, Shi-Wei, He, Qing-Mei, Huang, Zhuo-Li, Guan, Jia-Li, Shen, Jia-Yi, Li, Xiao-Min, Li, Jun-Yan, Li, Wen-Fei, Tang, Ling-Long, Mao, Yan-Ping, Guo, Rui, Sun, Rui, Zheng, Yu-Hui, Zhou, Wen-Wen, Xiong, Ke-Xu, Wang, Si-Qi, Jin, Xin, Liu, Na, Li, Gui-Bo, Kuang, Dong-Ming, Sun, Ying, and Ma, Jun

Published
2023
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13. Observation of novel interference patterns in Bi2-xFexTe3+d by Fourier transform scanning tunneling spectroscopy

Author

Okada, Y., Dhital, C., Zhou, Wen-Wen, Lin, Hsin, Basak, S., Bansil, A., Huang, Y. -B., Ding, H., Wang, Z., Wilson, Stephen D., and Madhavan, V.

Subjects
Condensed Matter - Materials Science
Abstract

In topological insulators (TI), strong spin-orbit coupling results in non-trivial scattering processes of the surface states, whose effects include suppressed back scattering1, 2, 3, 4 weak anti-localization5, 6 and the possibility of an exotic Kondo effect that mimics graphene7. Introducing time reversal breaking perturbations and establishing long-range magnetic order has been theorized to lead to the formation of quantized magnetoelectric phenomena8, fractionalized charge excitations, and the appearance of quantum wire states9. A key, elusive, step in exploring these and other novel electronic phases is the experimental observation of charge backscattering due to spin-flip processes at the surface of a magnetically-doped TI. Here we utilize Fourier transform scanning tunneling spectroscopy (FT-STS) to probe the surface of a magnetically doped TI, Bi2-xFexTe3+d. Our measurements show the appearance of a hitherto unobserved channel of electronic backscattering along surface q-vector \Gamma\kappa. By combining FT-STS with angle-resolved photoemission data, we identify the momentum space origins of the observed q-vectors, which on comparison to a model calculation are enhanced by spin-flip scattering. Our findings present compelling evidence for the first spatial and momentum resolved measurements of magnetic impurity induced backscattering in a prototypical TI.

Published
2010

19. The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment

Author

Lv, Jiawei, Wei, Yuan, Yin, Jian-Hua, Chen, Yu-Pei, Zhou, Guan-Qun, Wei, Chen, Liang, Xiao-Yu, Zhang, Yuan, Zhang, Cui-Juan, He, Shi-Wei, He, Qing-Mei, Huang, Zhuo-Li, Guan, Jia-Li, Shen, Jia-Yi, Li, Xiao-Min, Li, Jun-Yan, Li, Wen-Fei, Tang, Ling-Long, Mao, Yan-Ping, Guo, Rui, Sun, Rui, Zheng, Yu-Hui, Zhou, Wen-Wen, Xiong, Ke-Xu, Wang, Si-Qi, Jin, Xin, Liu, Na, Li, Gui-Bo, Kuang, Dong-Ming, Sun, Ying, and Ma, Jun

Abstract

Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear. Here, using single-cell RNA sequencing and T cell and B cell receptor sequencing of matched, treatment-naive and post-GP chemotherapy NPC samples (n= 15 pairs), we show that GP chemotherapy activated an innate-like B cell (ILB)-dominant antitumor immune response. DNA fragments induced by chemotherapy activated the STING type-I-interferon-dependent pathway to increase major histocompatibility complex class I expression in cancer cells, and simultaneously induced ILB via Toll-like receptor 9 signaling. ILB further expanded follicular helper and helper type 1 T cells via the ICOSL–ICOS axis and subsequently enhanced cytotoxic T cells in tertiary lymphoid organ-like structures after chemotherapy that were deficient for germinal centers. ILB frequency was positively associated with overall and disease-free survival in a phase 3 trial of patients with NPC receiving GP chemotherapy (NCT01872962, n= 139). It also served as a predictor for favorable outcomes in patients with NPC treated with GP and immunotherapy combined treatment (n= 380). Collectively, our study provides a high-resolution map of the tumor immune microenvironment after GP chemotherapy and uncovers a role for B cell-centered antitumor immunity. We also identify and validate ILB as a potential biomarker for GP-based treatment in NPC, which could improve patient management.

Published
2024
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21. Detoxification of aflatoxin B1 by Bacillus aryabhattai through conversion of double bond in terminal furan.

Author

Tang, Xi, Cai, Yi-Fan, Yu, Xiao-Mei, and Zhou, Wen-Wen

Subjects
DOUBLE bonds, BACILLUS (Bacteria), HIGH performance liquid chromatography, ESCHERICHIA coli, COUMARINS, AFLATOXINS, MYCOTOXINS
Abstract

Aims This study aimed to screen a bacterial strain with high detoxifying capability for aflatoxin B1 (AFB1), verify its biotransformation efficiency, and detoxification process. Methods and results A total of 350 samples collected from different environmental niche were screened using coumarin as the sole carbon source. High Performance Liquid Chromatography (HPLC) was used to detect residues of AFB1, and 16S rRNA sequencing was performed on the isolated strain with the highest AFB1 removal ratio for identification. The detoxified products of this strain were tested for toxicity in Escherichia coli as well as LO2, Caco-2, and HaCaT human cell lines. HPLC-MS was applied to further confirm the AFB1 removal and detoxification process. Conclusions We identified a strain from plant leaf designated as DT with high AFB1-detoxifying ability that is highly homologous to Bacillus aryabhattai. The optimum detoxification conditions of this strain were 37°C and pH 8.0, resulting in 82.92% removal ratio of 2 μg mL−1 AFB1 in 72 h. The detoxified products were nontoxic for E. coli and significantly less toxic for the LO2, Caco-2, and HaCaT human cell lines. HPLC-MS analysis also confirmed the significant drop of the AFB1 characteristic peak. Two possible metabolic products, C19H15O8 (m/z 371) and C19H19O8 (m/z 375), were observed by mass spectrometry. Potential biotransformation pathway was based on the cleavage of double bond in the terminal furan of AFB1. These generated components had different chemical structures with AFB1, manifesting that the attenuation of AFB1 toxicity would be attributed to the destruction of lactone structure of AFB1 during the conversion process. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Effect of MUC2 antisense oligodeoxynucleotide on cell proliferation, adhesion, and proteolytic enzyme in human gastric carcinoma in vitro

Author

Yi yong-fen (易永芬), Lin Xiao (林晓), Zhou Wen-wen, Yang Ya-ying (杨雅莹), Xiao Chun-wei (肖春卫), and Zhang Xiao-yan (张晓燕)

Subjects
Cancer Research, Antisense oligodeoxynucleotides, Cell growth, Proteolytic enzymes, Adhesion, Gastric carcinoma, Biology, digestive system, Molecular biology, digestive system diseases, In vitro, Oncology, Cell culture, Human gastric carcinoma
Abstract

Objective To investigate the effect of MUC2 antisense oligodeoxynucleotide (ASODN) on cell proliferation, adhesion and proteolytic enzyme in human gastric carcinoma cell line (SGC7901).

Published
2007

50. Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder

Author

Qiu, Zhi-Kun, primary, Zhang, Li-Ming, additional, Zhao, Nan, additional, Chen, Hong-Xia, additional, Zhang, You-Zhi, additional, Liu, Yan-Qin, additional, Mi, Tian-Yue, additional, Zhou, Wen-Wen, additional, Li, Yang, additional, Yang, Ri-Fang, additional, Xu, Jiang-Ping, additional, and Li, Yun-Feng, additional

Published
2013
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