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Allylamines are important building blocks in the synthesis of bioactive compounds. The direct coupling of allylic C−H bonds and commonly available amines is a major synthetic challenge. An allylic C−H amination of 1,4‐dienes has been accomplished by palladium catalysis. With aromatic amines, branch‐selective allylic aminations are favored to generate thermodynamically unstable Z‐allylamines. In addition, more basic aliphatic cyclic amines can also engage in the reaction, but linear dienyl allylic amines are the major products. [ABSTRACT FROM AUTHOR]

A highly diastereoselective bidirectional C(sp3)−H bond functionalization of piperazine compounds, triggered by a Lewis acid catalyzed sequential hydride shift/cyclization process, is reported. Catalysts and ligands are key factors that control the diastereoselectivity of the reaction. The reaction affords the product with good yield and high diastereoselectivity. Detailed investigation of the reaction mechanism reveals that the energy barrier between the cis products and trans products results in the diastereoselectivity of the reaction. The trans products, which have higher energy and which are generated from the cis products, act as intermediate products. [ABSTRACT FROM AUTHOR]

The first highlystereoselective organocatalytic intermolecularallylic alkylation of allylic alcohols with 1,3-dicarbonyls has beendeveloped to allow the first enantioselective total synthesis of hydroxymetasequirin-Aand metasequirin-B tetramethyl ether diacetates. [ABSTRACT FROM AUTHOR]

The method serves for the [4 + 2]-cyclization of aliphatic enolizable aldehydes with quinone derivatives in the presence of molecular oxygen as oxidant and a prolinol-derived chiral catalyst. [ABSTRACT FROM AUTHOR]

Allylamines are important building blocks in the synthesis of bioactive compounds. The direct coupling of allylic C-H bonds and commonly available amines is a major synthetic challenge. An allylic C-H amination of 1,4-dienes has been accomplished by palladium catalysis. With aromatic amines, branch-selective allylic aminations are favored to generate thermodynamically unstable Z-allylamines. In addition, more basic aliphatic cyclic amines can also engage in the reaction, but linear dienyl allylic amines are the major products., (© 2022 Wiley-VCH GmbH.)

Cascading chemistry! The first practical relay catalytic cascade intramolecular hydrosiloxylation of arylacetylene and asymmetric Mukaiyama aldol reaction has been established to give synthetically useful products in high yields and with excellent ee (see scheme)., (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)