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This study aims to meticulously map the bibliometric landscape of drug‐drug interactions (DDIs) in clinical research. This represents the first use of bibliometric analysis to comprehensively highlight the evolutionary trends and core themes in this critical field of pharmacology. An exhaustive bibliometric search was performed within the Web of Science Core Collection, aiming to comprehensively gather literature on DDIs in clinical settings. A combination of sophisticated analytical tools including DIKW, VOSviewer, and Citespace was utilized for an in‐depth exploration of bibliometric patterns and trends. Of the 3421 initially identified articles, 2622 were considered relevant. The analysis revealed a marked escalation in DDIs publications, with a peak observed in 2020. Five principal thematic clusters emerged: Safety and Adverse Reactions, Drug Metabolism and Efficacy, Disease and Drug Treatment, Research Methods and Practices, and Special Populations and Combined Medication. Key insights included the escalating significance of drug metabolism in pharmacokinetics, heightened focus on cardiovascular and antiviral therapeutics, and the advancing frontier of personalized medicine. Additionally, the analysis underscored the necessity for strategic attention to vulnerable populations and innovative methodological approaches. This study calls for the global harmonization of research methods in DDIs clinical investigations, advocating for the integration of personalized medicine paradigms and the implementation of cutting‐edge computational analytics. It highlights the imperative for inclusive and collaborative research approaches to adeptly address the intricate challenges of contemporary pharmacotherapy. [ABSTRACT FROM AUTHOR]

ObjectivesIn this study, we analyzed the metabonomics of intermingled phlegm and blood stasis (IPBS) and its three concurrent syndromes in patients with stable angina pectoris of coronary heart disease.MethodsA total of 164 sera of separated outpatients from 12 national tradition Chinese medicine clinical research centers with IPBS or concurrent syndromes were collected for the study and assessed with LC-ESI-MS/MS (liquid chromatography—electrospray ionization tandem—mass spectrometry)-based metabolomics and multivariate statistical analysis.ResultsNon-differential metabolites between IPBS and its separate syndrome combined with the top 100 most abundant metabolites in four groups were screened to reflect the essence of IPBS. Amino acid and its metabolomics and glycerol phospholipids were screened for common metabolites, and these metabolites were mainly enriched in valine, leucine, and isoleucine metabolism and glycerophospholipid metabolism. Principal component analysis revealed that the difference between IPBS and its separate concurrent syndromes was not distinct. Compared with IPBS, anserine, cytidine 5′-diphosphocholine, and 7,8-dihydro-L-biopterin separately significant increase in phlegm stasis and toxin (PST), phlegm stasis and Qi stagnation (PQS), and phlegm stasis and Qi deficiency (PQD). While these different metabolites were associated with histidine metabolism, beta-alanine metabolism, glycerophospholipid metabolism, and folate biosynthesis. Three accurate identification models were obtained to identify the difference between IPBS and its concurrent syndromes.ConclusionOur study indicated that valine, leucine, and isoleucine metabolism and glycerophospholipid metabolism could represent the essence of IPBS; dysregulated metabolites were valuable in identifying PST from IPBS.

The design and analysis of a low‐power multi‐band injection‐locked wireless receiver, implemented in complementary metal–oxide–semiconductor (CMOS) 130 nm technology, for wireless sensor network (WSN) applications are presented. The proposed receiver composed of an injection‐locked oscillator (ILO), low‐noise amplifier (LNA), and an envelope detector utilizes non‐coherent detection based on the frequency‐to‐amplitude conversion property of the injection‐locking phenomena. A lock range enhancement method is proposed through analytically and numerically determining the optimum biasing point of the injection transistor. The lock range of divide‐by‐4 super‐harmonic injection‐locking dictated by the third‐order non‐linear coefficient of the injection transistor is first investigated. The receiver applies divide‐by‐4, divide‐by‐2, and fundamental injection to demodulate the frequency‐shift‐key (FSK) and ON/OFF‐key (OOK) modulated signals from 433, 860–868, 902–928, 950–956, and 2360–2400 MHz frequency bands while keeping the power consumption in sub‐mW range. Post‐layout simulation results demonstrate that the proposed design achieves a maximum data rate of 5 Mbps for both FSK and OOK signals. With two modes of operation (high‐band and low‐band), the receiver consumes 762 and 675 μW of static power from a 0.7 V supply, achieving a sensitivity of −77 and −70 dBm at BER of 2 × 10−3. The FOMs for each mode are 152 and 135 pJ/b, respectively. [ABSTRACT FROM AUTHOR]

Recently, a method was proposed to determine the parameters for each Class DE driver in high-intensity focused ultrasound arrays for efficient operation and to compensate for variations in the impedance of each array element. This work extends that method to consider the effect of switch resistance and to provide limited control on the power delivered to the transducers with a constant supply voltage while keeping a good efficiency. The method is experimentally validated using an integrated driver developed by the authors. This paper also shows that the frequency range for efficient electrical operation is close to the frequency where the transducer array presents a peak in the conversion efficiency. [ABSTRACT FROM AUTHOR]