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370 results on '"Zhu, Dingliang"'

3. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Author

Wen, Wanqing, Zheng, Wei, Okada, Yukinori, Takeuchi, Fumihiko, Tabara, Yasuharu, Hwang, Joo-Yeon, Dorajoo, Rajkumar, Li, Huaixing, Tsai, Fuu-Jen, Yang, Xiaobo, He, Jiang, Wu, Ying, He, Meian, Zhang, Yi, Liang, Jun, Guo, Xiuqing, Sheu, Wayne Huey-Herng, Delahanty, Ryan, Guo, Xingyi, Kubo, Michiaki, Yamamoto, Ken, Ohkubo, Takayoshi, Go, Min Jin, Liu, Jian Jun, Gan, Wei, Chen, Ching-Chu, Gao, Yong, Li, Shengxu, Lee, Nanette R, Wu, Chen, Zhou, Xueya, Song, Huaidong, Yao, Jie, Lee, I-Te, Long, Jirong, Tsunoda, Tatsuhiko, Akiyama, Koichi, Takashima, Naoyuki, Cho, Yoon Shin, Ong, Rick TH, Lu, Ling, Chen, Chien-Hsiun, Tan, Aihua, Rice, Treva K, Adair, Linda S, Gui, Lixuan, Allison, Matthew, Lee, Wen-Jane, Cai, Qiuyin, Isomura, Minoru, Umemura, Satoshi, Kim, Young Jin, Seielstad, Mark, Hixson, James, Xiang, Yong-Bing, Isono, Masato, Kim, Bong-Jo, Sim, Xueling, Lu, Wei, Nabika, Toru, Lee, Juyoung, Lim, Wei-Yen, Gao, Yu-Tang, Takayanagi, Ryoichi, Kang, Dae-Hee, Wong, Tien Yin, Hsiung, Chao Agnes, Wu, I-Chien, Juang, Jyh-Ming Jimmy, Shi, Jiajun, Choi, Bo Youl, Aung, Tin, Hu, Frank, Kim, Mi Kyung, Lim, Wei Yen, Wang, Tzung-Dao, Shin, Min-Ho, Lee, Jeannette, Ji, Bu-Tian, Lee, Young-Hoon, Young, Terri L, Shin, Dong Hoon, Chun, Byung-Yeol, Cho, Myeong-Chan, Han, Bok-Ghee, Hwu, Chii-Min, Assimes, Themistocles L, Absher, Devin, Yan, Xiaofei, Kim, Eric, Kuo, Jane Z, Kwon, Soonil, Taylor, Kent D, Chen, Yii-Der I, Rotter, Jerome I, Qi, Lu, Zhu, Dingliang, Wu, Tangchun, Mohlke, Karen L, and Gu, Dongfeng

Subjects
Biological Sciences, Genetics, Obesity, Nutrition, Human Genome, Women's Health, 5'-Nucleotidase, Aldehyde Dehydrogenase, Aldehyde Dehydrogenase, Mitochondrial, Asian People, Blood Proteins, Body Mass Index, Cardiac Myosins, Asia, Eastern, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glycoproteins, Humans, KCNQ1 Potassium Channel, Male, Myosin Light Chains, Polymorphism, Single Nucleotide, Proteinase Inhibitory Proteins, Secretory, Medical and Health Sciences, Genetics & Heredity
Abstract

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.

Published
2014

11. African Origin of Modern Humans in East Asia: A Tale of 12,000 Y Chromosomes

Author

Ke, Yuehai, Su, Bing, Song, Xiufeng, Lu, Daru, Chen, Lifeng, Li, Hongyu, Qi, Chunjian, Marzuki, Sangkot, Deka, Ranjan, Underhill, Peter, Xiao, Chunjie, Shriver, Mark, Lell, Jeff, Wallace, Douglas, Wells, R Spencer, Seielstad, Mark, Oefner, Peter, Zhu, Dingliang, Jin, Jianzhong, Huang, Wei, Chakraborty, Ranajit, Chen, Zhu, and Jin, Li

Published
2001

22. Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China: The CSPPT Randomized Clinical Trial

Author

Huo, Yong, Li, Jianping, Qin, Xianhui, Huang, Yining, Wang, Xiaobin, Gottesman, Rebecca F., Tang, Genfu, Wang, Binyan, Chen, Dafang, He, Mingli, Fu, Jia, Cai, Yefeng, Shi, Xiuli, Zhang, Yan, Cui, Yimin, Sun, Ningling, Li, Xiaoying, Cheng, Xiaoshu, Wang, Jian’an, Yang, Xinchun, Yang, Tianlun, Xiao, Chuanshi, Zhao, Gang, Dong, Qiang, Zhu, Dingliang, Wang, Xian, Ge, Junbo, Zhao, Lianyou, Hu, Dayi, Liu, Lisheng, and Hou, Fan Fan

Published
2015
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44. Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling

Author

Zuo, Caojian, primary, Li, Xiaodong, additional, Huang, Jun, additional, Chen, Dongrui, additional, Ji, Kaida, additional, Yang, Yan, additional, Xu, Tingyan, additional, Zhu, Dingliang, additional, Yan, Chen, additional, and Gao, Pingjin, additional

Published
2018
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48. Association of ATP2B1 common variants with asymptomatic intracranial and extracranial large artery stenosis in hypertension patients.

Author

An, Dewei, Zhang, Jin, Tang, Xiaofeng, Gao, Pingjin, Li, Yan, Wang, Yan, and Zhu, Dingliang

Subjects
ARTERIAL stenosis, ARTERIAL diseases, HYPERTENSION, THORACIC aorta, SKULL base
Abstract

Background and aims: Genetic factors play an important role in the cervico-cerebral large-artery atherosclerotic stenosis (LAS), and ATP2B1 gene has been associated with the process of atherosclerosis disorders, such as coronary artery disease and arterial stiffness. But there is little information about the relationship between ATP2B1 gene and atherosclerosis in the intracranial arteries. We hereby investigated the association of common variants in ATP2B1 gene with LAS in asymptomatic Chinese hypertension patients. Methods: The stenosis of intracranial and extracranial arteries were evaluated in 899 subjects through computerized tomography angiography from the aortic arch to the skull base. A total of 11 ATP2B1 common variants were genotyped. Multivariate logistic regression was carried out in a dominant model with confounding factors adjusted. Results: rs17249754-A (OR = 0.43, p = 0.0002) and rs1401982-G (OR = 0.47, p = 0.0007) were associated with decreased susceptibility of concurrent extra and intracranial stenosis even after Bonferroni correction. These two minor alleles were also significantly associated with less stenotic arteries and moderate-to-severe stenosis. Conclusion: rs17249754 and rs1401982 were associated with asymptomatic LAS in stroke-free Chinese hypertension patients and might benefit early recognition of LAS patients in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Linkage analysis of five candidate genes and essential hypertension in 106 Chinese nuclear families

Author

Wei Huang, Guliang Wang, Zhu Dingliang, and Xin He

Subjects
Genetic Markers, Leptin, Male, China, Candidate gene, Genotype, Genetic Linkage, Receptors, Cell Surface, Biology, Risk Assessment, Genetic determinism, Nuclear Family, Asian People, Genetic linkage, Prevalence, Internal Medicine, Humans, Polymorphic Microsatellite Marker, Genetic Predisposition to Disease, Genetic Testing, Allele, Genotyping, Genetics, Leptin receptor, Lipoprotein Lipase, Receptors, Adrenergic, beta-3, Hypertension, Receptors, Leptin, Calmodulin-Binding Proteins, Female
Abstract

Five candidate genes including the lipoprotein lipase, leptin, leptin receptor, alpha-adducin and beta3 adrenergic receptor were selected to examine their possible contribution to essential hypertension (EH) in a Chinese population. On each side of the candidate gene loci, one to two highly polymorphic microsatellite markers were genotyped in 474 subjects recruited from 106 hypertension nuclear families in Shanghai. Both parametric and nonparametric linkage analyses were carried out using GENEHUNTER (version 2.0) after genotyping. Extended transmission disequilibrium testing (ETDT) was also conducted to detect preferential transmission of alleles to affected offspring. We failed to find the linkage between all these loci and EH by either parametric or nonparametric analysis, nor did we detect any significant transmission disequilibrium by ETDT. Our findings provide no support for a significant contribution of these five genes to the pathogenesis of EH among Shanghai people.

Published
2003

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