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640 results on '"Zhu, Guo-Qing"'

11. FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway.

Author

Li, Na, Wang, Xiao‐Li, Ge, Rui, Wang, Yu, Tian, Xiao‐Lei, Zhu, Guo‐Qing, and Zhou, Bing

Subjects
PI3K/AKT pathway, CERVICAL cancer, CANCER cells, HUMAN growth, HELA cells
Abstract

Cervical cancer (CxCa) is the fourth most frequent cancer in women. This study aimed to determine the role and underlying mechanism of fibronectin type III domain‐containing protein 5 (FNDC5) in inhibiting CxCa growth. Experiments were performed in human CxCa tissues, human CxCa cell lines (HeLa and SiHa), and xenograft mouse model established by subcutaneous injection of SiHa cells in nude mice. Bioinformatics analysis showed that CxCa patients with high FNDC5 levels have a longer overall survival period. FNDC5 expression was increased in human CxCa tissues, HeLa and SiHa cells. FNDC5 overexpression or FNDC5 protein not only inhibited proliferation, but also restrained invasion and migration of HeLa and SiHa cells. The effects of FNDC5 were prevented by inhibiting integrin with cilengitide, activating PI3K with recilisib or activating Akt with SC79. FNDC5 inhibited the phosphorylation of PI3K and Akt, which was attenuated by recilisib. PI3K inhibitor LY294002 showed similar effects to FNDC5 in HeLa and SiHa cells. Intravenous injection of FNDC5 (20 μg/day) for 14 days inhibited the tumor growth, and reduced the proliferation marker Ki67 expression and the Akt phosphorylation in the CxCa xenograft mouse model. These results indicate that FNDC5 inhibits the malignant phenotype of CxCa cells through restraining PI3K/Akt signaling. Upregulation of FNDC5 may play a beneficial role in retarding the tumor growth of CxCa. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Casein kinase 1 AELs promote senescence by enhancing ethylene biosynthesis through phosphorylating WRKY22 transcription factor.

Author

Zhu, Guo‐Qing, Qu, Li, and Xue, Hong‐Wei

Abstract

Summary Leaf senescence is a complex process regulated by developmental and environmental factors, and plays a pivotal role in the development and life cycle of higher plants. Casein kinase 1 (CK1) is a highly conserved serine/threonine protein kinase in eukaryotes and functions in various cellular processes including cell proliferation, light signaling and hormone effects of plants. However, the biological function of CK1 in plant senescence remains unclear. Through systemic genetic and biochemical studies, we here characterized the function of Arabidopsis EL1‐like (AEL), a CK1, in promoting leaf senescence by stimulating ethylene biosynthesis through phosphorylating transcription factor WRKY22. Seedlings lacking or overexpressing AELs presented delayed or accelerated leaf senescence, respectively. AELs interact with and phosphorylate WRKY22 at Thr57, Thr60 and Ser69 residues to enhance whose transactivation activity. Being consistent, increased or suppressed phosphorylation of WRKY22 resulted in the promoted or delayed leaf senescence. WRKY22 directly binds to promoter region and stimulates the transcription of 1‐amino‐cyclopropane‐1‐carboxylate synthase 7 gene to promote ethylene level and hence leaf senescence. Our studies demonstrated the crucial role of AEL‐mediated phosphorylation in regulating ethylene biosynthesis and promoting leaf senescence by enhancing WRKY22 transactivation activity, which helps to elucidate the fine‐controlled ethylene biosynthesis and regulatory network of leaf senescence. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Correction to: Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats

Author

Wang, Fang-Fang, Bai, Juan, Yu, Xiao-Jing, Shi, Xiao-Lian, Liu, Jin-Jun, Liu, Kai-Li, Fu, Li-Yan, Su, Qing, Li, Hong-Bao, Kang, Kai B., Yi, Qiu-Yue, Wang, Shu-Qiu, Gao, Hong-Li, Qi, Jie, Li, Ying, Zhu, Guo-Qing, and Kang, Yu-Ming

Published
2021
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35. Cardiomyocyte‐specific Peli1 contributes to the pressure overload‐induced cardiac fibrosis through miR ‐494‐3p‐dependent exosomal communication

Author

Tang, Chao, primary, Hou, Yu‐xing, additional, Shi, Peng‐xi, additional, Zhu, Cheng‐hao, additional, Lu, Xia, additional, Wang, Xiao‐lu, additional, Que, Lin‐li, additional, Zhu, Guo‐qing, additional, Liu, Li, additional, Chen, Qi, additional, Li, Chuan‐fu, additional, Xu, Yong, additional, Li, Jian‐tao, additional, and Li, Yue‐hua, additional

Published
2022
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49. Efficient Simulation Method for High Quality SAR Images of Complex Ground Vehicles

Author

Dong Chun-zhu, Hu Li-ping, Zhu Guo-qing, and Yin Hong-cheng

Subjects
Electromagnetic scattering, SAR image simulation, Ray-tracing technique, Stochastic Scattering Approach (SSA), Image evaluation, Electricity and magnetism, QC501-766
Abstract

Aiming at meeting the requirement of the amass high-quality SAR images needed by template-based ground target recognition engineering practice, a novel efficient SAR signal level simulation method is proposed. The electromagnetic scattering interaction mechanisms including coherent clutter of ground, multiple reflection and edge diffraction of vehicle, coupling-scattering between vehicle and ground are accurately estimated by utilizing an efficient ray-tracing technique. High quality SAR images are finally created through the SAR imaging procedure. Simulation results show that, the new method is feasible and effective.

Published
2015

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