Search

Your search keyword '"Zhu, Hongkai"' showing total 459 results
Start Over Author "Zhu, Hongkai"
459 results on '"Zhu, Hongkai"'

5. Exposure to melamine and its derivatives and aromatic amines among pregnant women in the United States: The ECHO Program

Author

Choi, Giehae, Kuiper, Jordan R, Bennett, Deborah H, Barrett, Emily S, Bastain, Theresa M, Breton, Carrie V, Chinthakindi, Sridhar, Dunlop, Anne L, Farzan, Shohreh F, Herbstman, Julie B, Karagas, Margaret R, Marsit, Carmen J, Meeker, John D, Morello-Frosch, Rachel, O'Connor, Thomas G, Pellizzari, Edo D, Romano, Megan E, Sathyanarayana, Sheela, Schantz, Susan, Schmidt, Rebecca J, Watkins, Deborah J, Zhu, Hongkai, Kannan, Kurunthachalam, Buckley, Jessie P, Woodruff, Tracey J, and Outcomes, program collaborators for Environmental influences on Child Health

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Chemical Sciences, Clinical Research, Amines, Aniline Compounds, Cotinine, Female, Humans, Nitrogen, Pregnancy, Pregnant Women, Toluidines, Triazines, United States, Biomonitoring, chemical exposure, pregnancy, aromatic amines, melamine, tobacco, program collaborators for Environmental influences on Child Health Outcomes, Aromatic amines, Melamine, Tobacco, Environmental Sciences, Meteorology & Atmospheric Sciences
Abstract

BackgroundMelamine, melamine derivatives, and aromatic amines are nitrogen-containing compounds with known toxicity and widespread commercial uses. Nevertheless, biomonitoring of these chemicals is lacking, particularly during pregnancy, a period of increased susceptibility to adverse health effects.ObjectivesWe aimed to measure melamine, melamine derivatives, and aromatic amine exposure in pregnant women across the United States (U.S.) and evaluate associations with participant and urine sample collection characteristics.MethodsWe measured 43 analytes, representing 45 chemicals (i.e., melamine, three melamine derivatives, and 41 aromatic amines), in urine from pregnant women in nine diverse ECHO cohorts during 2008-2020 (N = 171). To assess relations with participant and urine sample collection characteristics, we used generalized estimating equations to estimate prevalence ratios (PRs) for analytes dichotomized at the detection limit, % differences (%Δ) for continuous analytes, and 95% confidence intervals. Multivariable models included age, race/ethnicity, marital status, urinary cotinine, and year of sample collection.ResultsTwelve chemicals were detected in >60% of samples, with near ubiquitous detection of cyanuric acid, melamine, aniline, 4,4'-methylenedianiline, and a composite of o-toluidine and m-toluidine (99-100%). In multivariable adjusted models, most chemicals were associated with higher exposures among Hispanic and non-Hispanic Black participants. For example, concentrations of 3,4-dichloroaniline were higher among Hispanic (%Δ: +149, 95% CI: +17, +431) and non-Hispanic Black (%Δ: +136, 95% CI: +35, +311) women compared with non-Hispanic White women. We observed similar results for ammelide, o-/m-toluidine, 4,4'-methylenedianiline, and 4-chloroaniline. Most chemicals were positively associated with urinary cotinine, with strongest associations observed for o-/m-toluidine (%Δ: +23; 95% CI: +16, +31) and 3,4-dichloroaniline (%Δ: +25; 95% CI: +17, +33). Some chemicals exhibited annual trends (e.g., %Δ in melamine per year: -11; 95% CI: -19, -1) or time of day, seasonal, and geographic variability.DiscussionExposure to melamine, cyanuric acid, and some aromatic amines was ubiquitous in this first investigation of these analytes in pregnant women. Future research should expand biomonitoring, identify sources of exposure disparities by race/ethnicity, and evaluate potential adverse health effects.

Published
2022

12. Exposure to Contemporary and Emerging Chemicals in Commerce among Pregnant Women in the United States: The Environmental influences on Child Health Outcome (ECHO) Program

Author

Buckley, Jessie P, Kuiper, Jordan R, Bennett, Deborah H, Barrett, Emily S, Bastain, Tracy, Breton, Carrie V, Chinthakindi, Sridhar, Dunlop, Anne L, Farzan, Shohreh F, Herbstman, Julie B, Karagas, Margaret R, Marsit, Carmen J, Meeker, John D, Morello-Frosch, Rachel, O’Connor, Thomas G, Romano, Megan E, Schantz, Susan, Schmidt, Rebecca J, Watkins, Deborah J, Zhu, Hongkai, Pellizzari, Edo D, Kannan, Kurunthachalam, and Woodruff, Tracey J

Subjects
Environmental Sciences, Pollution and Contamination, Health Sciences, Pediatric, Behavioral and Social Science, Clinical Research, Basic Behavioral and Social Science, Conditions Affecting the Embryonic and Fetal Periods, Aetiology, 2.2 Factors relating to the physical environment, Good Health and Well Being, Child, Commerce, Environmental Exposure, Environmental Pollutants, Female, Humans, Outcome Assessment, Health Care, Phthalic Acids, Plasticizers, Pregnancy, Pregnant Women, United States, pregnancychild health, industrial chemical, pesticides, flame retardants, phthalates, bisphenols, parabens
Abstract

Prenatal chemical exposures can influence maternal and child health; however, few industrial chemicals are routinely biomonitored. We assessed an extensive panel of contemporary and emerging chemicals in 171 pregnant women across the United States (U.S.) and Puerto Rico in the Environmental influences on Child Health Outcomes (ECHO) Program. We simultaneously measured urinary concentrations of 89 analytes (103 total chemicals representing 73 parent compounds) in nine chemical groups: bactericides, benzophenones, bisphenols, fungicides and herbicides, insecticides, organophosphate esters (OPEs), parabens, phthalates/alternative plasticizers, and polycyclic aromatic hydrocarbons (PAHs). We estimated associations of creatinine-adjusted concentrations with sociodemographic and specimen characteristics. Among our diverse prenatal population (60% non-Hispanic Black or Hispanic), we detected 73 of 89 analytes in ≥1 participant and 36 in >50% of participants. Five analytes not currently included in the U.S. biomonitoring were detected in ≥90% of samples: benzophenone-1, thiamethoxam, mono-2-(propyl-6-carboxy-hexyl) phthalate, monocarboxy isooctyl phthalate, and monohydroxy-iso-decyl phthalate. Many analyte concentrations were higher among women of Hispanic ethnicity compared to those of non-Hispanic White women. Concentrations of certain chemicals decreased with the calendar year, whereas concentrations of their replacements increased. Our largest study to date identified widespread exposures to prevalent and understudied chemicals in a diverse sample of pregnant women in the U.S.

Published
2022

33. Novel IKZF1 rearrangement identified in a patient with blastic plasmacytoid dendritic cell neoplasm decreased haematopoietic stem cell function and promoted plasmacytoid dendritic cell abnormality

Author

Yin, Le, primary, Yu, Qian, additional, Zhang, Huifang, additional, Zhu, Hongkai, additional, Deng, Zeyu, additional, Xing, Cheng, additional, Wang, Peilong, additional, Zeng, Xiangju, additional, Cheng, Zhao, additional, Sheng, Yue, additional, and Peng, Hongling, additional

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results