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224 results on '"Zhu, Xiao-xia"'

15. Increased plasma levels of S100A8, S100A9, and S100A12 in chronic spontaneous urticaria

Author

Zhou, Qiong-Yan, Lin, Wei, Zhu, Xiao-Xia, Xu, Su-Ling, Ying, Meng-Xia, Shi, Lei, and Lin, Bing-Jiang

Subjects
Hives (Disease), Medical research, Skin, Inflammation, Family, Autoimmune diseases, Health
Abstract

Byline: Qiong-Yan. Zhou, Wei. Lin, Xiao-Xia. Zhu, Su-Ling. Xu, Meng-Xia. Ying, Lei. Shi, Bing-Jiang. Lin Background: Chronic spontaneous urticaria (CSU) is a skin disorder with an important immunologic profile. S100A8, [...]

Published
2019

23. Radiotherapy combined with PD‐1/PD‐L1 inhibitors in NSCLC brain metastases treatment: The mechanisms, advances, opportunities, and challenges.

Author

Chen, Zi‐Ying, Duan, Xiao‐Tong, Qiao, Si‐Miao, and Zhu, Xiao‐Xia

Subjects
BRAIN metastasis, PROGRAMMED cell death 1 receptors, NON-small-cell lung carcinoma, PROGRAMMED death-ligand 1, RADIOTHERAPY
Abstract

At present, whole‐brain radiation therapy/stereotactic radiosurgery is one of the main local treatments for brain metastasis of non‐small‐cell lung cancer (NSCLC). Currently, it has been proved that radiotherapy (RT) can regulate the immune response, and small‐sample studies have shown that patients with NSCLC brain metastases (BMs) can benefit from RT combined with immunotherapy (IO). However, the efficacy and safety of the combination treatment have not been deeply elaborated. Notably, as a challenge that is still being explored, the timing of RT combined with IO is likely to be an important factor affecting efficacy and prognosis. This article reviews the current application and challenges of RT combined with IO from the perspectives of molecular mechanism, combination timing, safety, and efficacy. The purpose is to provide information on clinical evidence‐based medicine of combination between RT with IO. For further investigation, we also discuss the major challenges and prospects of RT combined with IO in NSCLC BMs. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Buserelin Inhibits the Immunosuppressive Activity of Regulatory T Cells through the Protein Kinase A Signaling in a Central Precocious Puberty Model.

Author

Li, Hua, Zhu, Xiao-Xia, Xiang, Jin-Bo, and Jian, Lei

Abstract

Gonadotropin-releasing hormone analogs (GnRHas) are used for treating central precocious puberty (CPP). However, their roles in the regulation of immune cells especially regulatory T cells (Tregs) remains elusive. Therefore, we characterized buserelin-induced phenotypical and functional changes of Tregs. A rat CPP model was established followed by administration of buserelin acetate. Flow cytometry was used to evaluate the expression of functional molecules in splenic Tregs. The suppressive activity of Tregs was determined by the suppression assay. GnRHR expression in Tregs was assessed by flow cytometry analysis and Immunoblotting. Normal Tregs were then stimulated and treated with buserelin acetate in vitro. After that, Foxp3 expression, Treg proliferation, and cytokine production were analyzed by flow cytometry. Intracellular signaling was evaluated by Immunoblotting, and Treg function was determined by the suppression assay. After in vivo buserelin treatment, the frequency of splenic Tregs was decreased, with the reduction in the expression of Foxp3, IL-10, and TGF-β. The suppressive activity of Tregs was weakened. Buserelin down-regulated Foxp3 expression while promoting the expression of RORγt and IL-17 in Tregs through activating the protein kinase A (PKA) pathway in vitro. The PKA inhibitor H-89 abolished the effect of buserelin and enhanced Treg function. Buserelin impaired the immunosuppressive activity of Tregs through the PKA signal pathway. Buserelin-induced activation of PKA signaling down-regulated Foxp3 expression while promoting RORγt expression in Tregs, and subsequently weakened Treg function. Our study indicates the necessity of monitoring Treg activity in CPP patients to avoid potential autoimmunity or inflammation. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Visualizing phase transition of upper critical solution temperature (UCST) polymers with AIE

Author

Jia, Yong Guang, Chen, Kai Feng, Gao, Meng, Liu, Sa, Wang, Jin, Chen, Xiaohui, Wang, Lin, Chen, Yunhua, Song, Wenjing, Zhang, Huatang, Ren, Li, Zhu, Xiao Xia, Tang, Benzhong, Jia, Yong Guang, Chen, Kai Feng, Gao, Meng, Liu, Sa, Wang, Jin, Chen, Xiaohui, Wang, Lin, Chen, Yunhua, Song, Wenjing, Zhang, Huatang, Ren, Li, Zhu, Xiao Xia, and Tang, Benzhong

Abstract

The stimuli-responsive polymers with upper critical solution temperatures (UCST) are highly attractive for drug delivery applications. However, the phase transition process of UCST polymer is usually characterized by turbidity measurement and electron microscopy, which are significantly restricted by low sensitivity and static observation. In contrary, the fluorescence technique has significant advantages in terms of high sensitivity, easy operation, and dynamic observation. However, the conventional fluorophores suffer from the drawbacks of aggregation-caused quenching (ACQ) after being encapsulated by UCST polymers, which are not suitable for direct visualization of the phase transition process. To tackle this challenge, we herein developed a series of UCST polymers based on polyacrylamides decorated with bile acid and aggregation-induced emission (AIE)-active tetraphenylethene (TPE) groups, which can be used for direct fluorescence monitoring of the phase transition process. Moreover, the AIE-active UCST polymers can serve as drug carriers, which can not only monitor the drug release process under thermal stimuli, but also verify the drug release by fluorescence recovery after thermal stimuli. It is expected that the AIE-active UCST polymers with self-monitoring ability are promising for biomedical applications. © 2020, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.

Published
2020

36. Polymeric materials containing bile acids

Author

Zhu, Xiao-Xia and Nichifor, Marieta

Subjects
Chemical research -- Analysis, Bile acids -- Physiological aspects, Polymers -- Physiological aspects, Chemical reactions -- Analysis, Chemistry, Science and technology
Abstract

Research has been conducted on the bile acids. The synthesis of different polymers carried out from these acids and the applications proposed for such polymers are discussed.

Published
2002

45. Melatonin Alleviates Acute Gouty Inflammation In Vivoand In Vitro

Author

Xiao, Wen-ze, Zhao, Li, Cao, Lin, Zhu, Xiao-xia, and Zou, He-jian

Abstract

The aim of this study was to identify the effects of melatonin on acute gouty inflammation and to investigate the underlying mechanisms. We found significantly lower serum melatonin levels in gout patients in the acute phase than in those in the remission phase or in normal individuals. The mRNA expression of melatonin receptor 2 (MT2) was also lower in gout patients than in normal individuals. To verify the in-vivorole of melatonin, a gouty arthritis model was established by intraarticular injection of monosodium urate (MSU, 1 mg) crystals into the paws of C57BL/6 mice. Joint inflammation in the mouse model was evaluated by measuring the thickness of the right paw/left paw, and the inflammation index was determined by examining infiltrating neutrophils with haematoxylin and eosin (H&E) staining. Melatonin was found to reduce both paw thickness and the inflammation index in the mouse model, and melatonin also reduced the mRNA levels of interleukin-1 beta (IL-1β), IL-6 and NLR family pyrin domain containing 3 (NLRP3) inflammasome. To mimic gouty inflammation in vitro, mouse peritoneal macrophages were stimulated with lipopolysaccharides (LPS) plus MSU. Melatonin was revealed to reduce IL-1β secretion by stimulated macrophages. The mRNA expression levels of IL-1β and IL-6 were also inhibited by melatonin. Western blot analysis showed that the expression of NLRP3, caspase-1 and pro-IL-1β was also inhibited by melatonin. In conclusion, our study demonstrated that melatonin alleviated gouty inflammation in vivoand in vitro, and the underlying mechanism may involve inhibiting the assembly of the NLRP3 inflammasome.

Published
2021
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47. Production and Characterization of Polyclonal Antibody for the N-Methylcarbamate Insecticide Metolcarb

Author

Zhu Xiao-xia, Cao Bin, Hu BaiShi, XU Li-na, Liu FengQuan, Jiang Ying-hua, Zhang Qi, and LI Tie-jun

Subjects
Antiserum, Chromatography, biology, Plant Science, chemistry.chemical_compound, Titer, Metolcarb, chemistry, Polyclonal antibodies, biology.protein, Bovine serum albumin, Antibody, Agronomy and Crop Science, Hapten, Conjugate
Abstract

The hapten, 3-{[1-(3-(methyl)phenyloxy)-carbonyl]amino}propanoic acid (HOM), mimicking the analyte metolcarb. was synthesized and verified by mass spectrometry (MS) and 1H-nuclear magnetic resonance spectrometry (1H-NMR). Then, HOM was conjugated with the carrier proteins bovine serum albumin (BSA) and ovalbumin (OVA) with stoichiometric amounts of N-hydroxysuccinimide/dicyclohexylcarbodimide (NHS/DCC) using the activated ester method. Polyclonal antibodies were raised against the conjugate of HOM-BSA in rabbits. Antiserum titres were determined by noncompetitive indirect ELISA procedures and the titer of pAb01 reached 1.28 × 106. The cross-reactivities of the structurally related N-methylcarbamate insecticides were 0.0% except for dimethacarb. These results indicate that the antibody pAb01 with strong affinity and high specificity can be used to develop a sensitive and rapid detection protocol for metolcarb residue.

Published
2007

50. The influence of social relationship quality on employee creativity

Author

Zhu Xiao-xia and Peng Fang-xiang

Subjects
Effect analysis, Social exchange theory, media_common.quotation_subject, Human resource management, Social relationship, Survey data collection, Intrinsic motivation, Quality (business), Psychology, Creativity, Social psychology, media_common, Management
Abstract

Using survey data from 398 professional or technical workers and their direct supervisors in a large automobile manufacturing enterprise, we built and tested a model to connect the quality of two main social exchange relationships (leader-member exchange: LMX, team-member exchange: TMX) and employee creativity. The results of our study showed that both LMX quality and TMX quality positively related to employees' intrinsic motivation, which in turn has a positive influence on employee creativity. Furthermore, moderate effect analysis showed that creative self-efficacy weakened LMX quality's positive effect on intrinsic motivation but had no significant negative moderate effect on TMX quality's influence on intrinsic motivation. Future research directions and limitations of the study were also discussed.

Published
2013

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