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11. Author Correction: Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

Author

Wang, Yumin, Gao, Boya, Zhang, Luyuan, Wang, Xudong, Zhu, Xiaolan, Yang, Haibo, Zhang, Fengqi, Zhu, Xueping, Zhou, Badi, Yao, Sean, Nagayama, Aiko, Lee, Sanghoon, Ouyang, Jian, Koh, Siang-Boon, Eisenhauer, Eric L., Zarrella, Dominique, Lu, Kate, Rueda, Bo R., Zou, Lee, Su, Xiaofeng A., Yeku, Oladapo, Ellisen, Leif W., Wang, Xiao-Song, and Lan, Li

Published
2024
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13. Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

Author

Wang, Yumin, Gao, Boya, Zhang, Luyuan, Wang, Xudong, Zhu, Xiaolan, Yang, Haibo, Zhang, Fengqi, Zhu, Xueping, Zhou, Badi, Yao, Sean, Nagayama, Aiko, Lee, Sanghoon, Ouyang, Jian, Koh, Siang-Boon, Eisenhauer, Eric L., Zarrella, Dominique, Lu, Kate, Rueda, Bo R., Zou, Lee, Su, Xiaofeng A., Yeku, Oladapo, Ellisen, Leif W., Wang, Xiao-Song, and Lan, Li

Published
2024
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25. Design and application of inter-hospital transfer form based on SBAR communication mode for transferring critically ill patients in the Psychiatric Department (基于SBAR沟通模式的院内转科交接单在精神科危重患者院内转科中的应用)

Author

GU Liqin (顾丽琴), KONG Fanzhen (孔凡贞), JI Caifang (季彩芳), and ZHU Xiaolan (朱晓岚)

Subjects
in-hospital transfer, sbar communication mode, transfer and handover, patient safety, 院内转运, sbar沟通模式, 转科交接, 患者安全, Nursing, RT1-120
Abstract

Objective To explore the application of inter-hospital transfer form based on SBAR communication mode for transferring critically ill patients in the Psychiatric Department. Methods A total of 188 critically ill psychiatric patients were selected as the research subjects, and were divided into control group (n=94) and observation group (n=94) according to the order of admission. The control group used the conventional inter-hospital transfer form for nursing handover, while the observation group used the self-designed standardized transfer sheet based on SBAR communication mode to assist the transfer. The incidence of adverse events in hospital transfer, the evaluation of nurses on hospital transfer and the satisfaction of patients' families on nursing work were compared between the two groups. Results The incidence of adverse events in hospital transfer in the observation group was lower than that in the observation group (3. 19% vs. 12. 77%, P＜0. 05). Except for issue of “access to important information” and “chance of problems consulting”, the dimensional score of Handover Evaluation Scale (HES) in the observation group was higher than that in the control group (P＜0. 05). The nursing satisfaction rate was 94. 57% in the observation group, indicating a high level of satisfaction among family members. Conclusion The inter-hospital transfer form based on SBAR communication mode can reduce the occurrence of transfer problems , help nurses improve the quality of transfer and handover, improve the patient's family satisfaction with nursing work, and ensure the safety of patients. It is worthy of promotion and application. (目的 探讨基于SBAR沟通模式的院内转科交接单在精神科危重症患者院内转运中的应用效果。方法 选选取2020年9月—11月住院的94例精神科危重患者为对照组, 采用常规的院内转科交接单进行交接; 另选取2020年12月—2021年2月住院的94例精神科危重患者为观察组, 采用根据SBAR沟通结构框架制作的院内交接单辅助交接。比较2组院内转科交接问题的发生率、护士对院内转科交接的评价情况及患者家属对护理工作的满意度。结果 观察组转运交接问题发生率3. 19%(3/94), 低于对照组的12. 77%(12/94), 差异有统计学意义(P＜0. 05)。观察组护理交接班评价量表(HES)各条目评分均高于对照组, 除“重要信息我总是可以收到”“我有机会请教我不理解的问题”条目外, 差异有统计学意义(P＜0. 05)。观察组满意度94. 57%, 提示满意度较高。结论 应用基于SBAR沟通模式院内转科交接单能够减少院内转科交接问题的发生, 提高转运质量, 提升患者家属对护理工作的满意度, 保证了患者的安全, 值得推广和应用。)

Published
2021
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29. M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis.

Author

Zhu, Xiaolan, Li, Wenxin, Lu, Minjun, Shang, Junyu, Zhou, Jiamin, Lin, Li, Liu, Yueqin, Xing, Jie, Zhang, Mengxue, Zhao, Shijie, Lu, Jingjing, and Shi, Xuyan

Subjects
*SEXUAL cycle, *GRANULOSA cells, *EXOSOMES, *OVARIAN reserve, *OVARIES, *PREMATURE ovarian failure, *OXIDATIVE stress, *OVARIAN follicle
Abstract

Background: Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical and psychological health of patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H-Exs) have exhibited protective effects on ovarian function with unclear mechanisms. Methods: A comprehensive analysis of the Gene Expression Omnibus (GEO) database were used to identify POI-associated circRNAs and miRNAs. The relationship between HucMSC-derived exosomal circBRCA1/miR-642a-5p/FOXO1 axis and POI was examined by RT-qPCR, Western blotting, reactive oxygen species (ROS) staining, senescence-associated β-gal (SA-β-gal) staining, JC-1 staining, TEM, oxygen consumption rate (OCR) measurements and ATP assay in vivo and in vitro. RT-qPCR detected the expression of circBRCA1 in GCs and serum of patients with normal ovarian reserve function (n = 50) and patients with POI (n = 50); then, the correlation of circBRCA1 with ovarian reserve function indexes was analyzed. Results: Herein, we found that circBRCA1 was decreased in the serum and ovarian granulosa cells (GCs) of patients with POI and was associated with decreased ovarian reserve. H-Exs improved the disorder of the estrous cycles and reproductive hormone levels, reduced the number of atretic follicles, and alleviated the apoptosis and senescence of GCs in rats with POI. Moreover, H-Exs mitigated mitochondrial damage and reversed the reduced circBRCA1 expression induced by oxidative stress in GCs. Mechanistically, FTO served as an eraser to increase the stability and expression of circBRCA1 by mediating the m6A demethylation of circBRCA1, and exosomal circBRCA1 sponged miR-642a-5p to block its interaction with FOXO1. CircBRCA1 insufficiency aggravated mitochondrial dysfunction, mimicking FTO or FOXO1 depletion effects, which was counteracted by miR-642a-5p inhibition. Conclusion: H-Exs secreted circBRCA1 regulated by m6A modification, directly sponged miR-642a-5p to upregulate FOXO1, resisted oxidative stress injuries in GCs and protected ovarian function in rats with POI. Exosomal circBRCA1 supplementation may be a general prospect for the prevention and treatment of POI. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Research on Wine Analysis Based on Data Preprocessing

Author

Meng, Xinfei, Zhu, Xiaolan, Yang, Shenghao, Wang, Lu, Qi, Jun, Yang, Pei, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Liu, Yong, editor, Wang, Lipo, editor, Zhao, Liang, editor, and Yu, Zhengtao, editor

Published
2020
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38. Stimuli-Responsive mRNA Vaccines to Induce Robust CD8+T Cell Response via ROS-Mediated Innate Immunity Boosting

Author

Dong, Linying, Deng, Xuqian, Li, Yan, Zhu, Xiaolan, Shu, Mingbo, Chen, Jingyi, Luo, Huacheng, An, Keli, Cheng, Ming, Zhang, Penghui, and Tan, Weihong

Abstract

The messenger RNA (mRNA) vaccines hold great significance in contagion prevention and cancer immunotherapy. However, safely and effectively harnessing innate immunity to stimulate robust and durable adaptive immune protection is crucial, yet challenging. In this study, we synthesized a library of stimuli-responsive bivalent ionizable lipids (srBiv iLPs) with smart molecular blocks responsive to esterase, H2O2, cytochrome P450, alkaline phosphatase, nitroreductase, or glutathione (GSH), aiming to leverage physiological cues to trigger fast lipid degradation, promote mRNA translation, and induce robust antitumor immunity via reactive oxygen species (ROS)-mediated boosting. After subcutaneous immunization, esterase-responsive vaccine (eBiv-mVac) was rapidly internalized and transported into the draining lymph nodes. It then underwent fast decaging and self-immolative degradation in esterase-rich antigen-presenting cells, releasing sufficient mRNA for antigen translation and massive reactive quinone methides to elevate ROS levels. This resulted in broad activation of innate immunity to boost T cell response, prompting a large number of primed antigen-specific CD8+T cells to circulate and infiltrate into tumors (>1000-fold versus unvaccinated control), thereby orchestrating innate and adaptive immunity to control tumor growth. Moreover, by further combining our vaccination strategy with immune checkpoint blockade, we demonstrated a synergism that significantly amplified the magnitude and function of antigen-specific CD8+T cells. This, in turn, caused potent systemic antitumor efficacy and prolonged survival with high complete response rate in xenograft and metastasis models. Overall, our generalized stimuli-responsive mRNA delivery platform promises a paradigm shift in the design of potent vaccines for cancer immunotherapy, as well as effective and precise carriers for gene editing, protein replacement, and cell engineering.

Published
2024
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41. Review of Tibetan Medical Data Mining

Author

Zhang, Lei, Zhu, Xiaolan, Wang, Shiying, Wang, Lu, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Xiong, Ning, editor, Xiao, Zheng, editor, Tong, Zhao, editor, Du, Jiayi, editor, Wang, Lipo, editor, and Li, Maozhen, editor

Published
2019
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42. Classification Based on Association with Atomic Association—Prediction of Tibetan Medicine in Common Plateau Diseases

Author

Wang, Xuexi, Zhang, Lei, Wang, Lu, Zhu, Xiaolan, Wang, Shiying, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Xiong, Ning, editor, Xiao, Zheng, editor, Tong, Zhao, editor, Du, Jiayi, editor, Wang, Lipo, editor, and Li, Maozhen, editor

Published
2019
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48. Research on Syndrome Classification and Risk Factors Extraction of Tibetan Medicine Based on Clustering

Author

Liu, Chaoyi, Zhang, Lei, Wang, Lu, Zhu, Xiaolan, Wang, Xiaoying, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Sun, Xingming, editor, Pan, Zhaoqing, editor, and Bertino, Elisa, editor

Published
2018
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