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The effectiveness of cancer immunization is largely dependent on the tumor's microenvironment, especially the tumor immune microenvironment. Emerging studies say microbes exist in tumor cells and immune cells, suggesting that these microbes can affect the state of the immune microenvironment of the tumor. Our comprehensive review navigates the intricate nexus between intratumoral microorganisms and their role in tumor biology and immune modulation. Beginning with an exploration of the historical acknowledgment of microorganisms within tumors, the article underscores the evolution of the tumor microenvironment (TME) and its subsequent implications. Using findings from recent studies, we delve into the unique bacterial compositions across different tumor types and their influence on tumor growth, DNA damage, and immune regulation. Furthermore, we illuminate the potential therapeutic implications of targeting these intratumoral microorganisms, emphasizing their multifaceted roles from drug delivery agents to immunotherapy enhancers. As advancements in next-generation sequencing (NGS) technology redefine our understanding of the tumor microbiome, the article underscores the importance of discerning their precise role in tumor progression and tailoring therapeutic interventions. The review culminates by emphasizing ongoing challenges and the pressing need for further research to harness the potential of intratumoral microorganisms in cancer care. [ABSTRACT FROM AUTHOR]

We studied the local structure and properties of six-fold coordinated silicon (Si[6]) in BaO-SiO2-P2O5 glasses. Nuclear magnetic resonance (NMR) and Raman spectroscopy revealed the existence of six-fold coordinated silicon species and network former units (NFUs) in the BaO-SiO2-P2O5 glasses. The glass transition temperature (Tg), which was measured by differential scanning calorimetry, increased rapidly along with the increase of SiO2 from 0 to 10 mol%, then declined and finally increased again, which showed a "Z" trend along with the increase of SiO2 while the density of the glasses showed the opposite trend. When the addition of SiO2 is 16 mol%, Tg decreased to an extremely low value (807.9 K). Besides, the Vickers indentation hardness (Hv) had been significantly enhanced from 4.66 to 6.63 GPa by adding 16 mol% SiO2. Furthermore, the liquid fragility index (m) of the glasses declined slowly firstly and then increased rapidly when the amount of SiO2 is greater than 13 mol%. [ABSTRACT FROM AUTHOR]

An effective interface engineering method is developed to improve performance of SrTiO3-based hetero-oxide transistors. HfO2/SrTiO3 hetero-oxide transistors made on argon ions bombarded SrTiO3 surfaces show eight times increase in drive currents and more than five times increase in mobility when compared with the un-bombarded HfO2/SrTiO3 transistors. The improvement is attributed to the Fermi-level shift as the results of the bombardment. These HfO2/SrTiO3-based nMOSFETs show field-effect electron mobility up to 4.2 cm^2/Vs, which is among the best results ever reported. [ABSTRACT FROM PUBLISHER]