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500 results on '"Zhu Shuangli"'

1. Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China

Author

Liu Ying, Sun Qiang, Xiao Jinbo, Ren Binzhi, Zhao Hua, Shi Yong, Zhou Shuaifeng, Hong Mei, Zhou Kangping, Cun Jianping, Zeng Yunting, Chen Jianhua, Ge Qiong, Ju Yu, Lu Huanhuan, Li Jichen, Cong Ruyi, Yang Tingting, Wang Rui, Zong Yanjun, Sun Tiantian, Yu Liheng, Wang Xiaoyi, Zhu Shuangli, Yan Dongmei, Ji Tianjiao, Yang Qian, Zhu Zhen, and Zhang Yong

Subjects
Enterovirus, Echovirus 11, molecular epidemiology, variants, virus evolution, virus transmission, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Echovirus 11 (E11) has gained attention owing to its association with severe neonatal infections. From 2018 to 2023, a surge in severe neonatal cases and fatalities linked to a novel variant of genotype D5 was documented in China, France, and Italy. However, the prevention and control of E11 variants have been hampered by limited background data on the virus circulation and genetic variance. Therefore, the present study investigated the circulating dynamics of E11 and the genetic variation and molecular evolution of genotype D5 through the collection of strains from the national acute flaccid paralysis (AFP) and hand, foot, and mouth disease (HFMD) surveillance system in China during 2000–2022 and genetic sequences published in the GenBank database. The results of this study revealed a prevalent dynamic of E11 circulation, with D5 being the predominant genotype worldwide. Further phylogenetic analysis of genotype D5 indicated that it could be subdivided into three important geographic clusters (D5-CHN1: 2014–2019, D5-CHN2: 2016–2022, and D5-EUR: 2022–2023). Additionally, variant-specific (144) amino acid mutation sites and positive-selection pressure sites (132, 262) were identified in the VP1 region. Cluster-specific recombination patterns were also identified, with CVB5, E6, and CVB4 as the major recombinant viruses. These findings provide a preliminary landscape of E11 circulation worldwide and basic scientific data for further study of the pathogenicity of E11 variants.

Published
2024
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10. Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008

Author

Jiang Xiaohong, Yang Zhaohui, Zhu Hui, Tang Liuying, Tan Xiaojuan, Yan Dongmei, Wang Dongyan, Wang Jitao, Guo Xuebin, Zhu Shuangli, Zhu Zhen, Ji Yixin, Zhang Yong, and Xu Wenbo

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Large nationwide outbreaks of hand, foot, and mouth disease (HFMD) occurred in China from 2008; most of the cases were in children under 5 years. This study aims to identify the situation of natural human enterovirus 71 (HEV71) and coxsackievirus A16 (CVA16) infections in children before 2008 in China. Results Retrospective seroepidemiologic studies of HEV71 and CVA16 were performed with 900 serum samples collected from children ≤5 years of age in 2005. The samples were collected from 6 different geographical areas (Anhui, Guangdong, Hunan, Xinjiang, Yunnan, and Heilongjiang provinces) in mainland China. Of the 900 samples, 288 were positive for HEV71; the total positive rate was 32.0% and the geometric mean titer (GMT) was 1:8.5. Guangdong (43.7% and 1:10.8), Xinjiang (45.4% and 1:11.1), and Yunnan (43.4% and 1:12.0) provinces had relatively high rates of infection, while Heilongjiang province (8.1% and 1:4.9) had the lowest rate of infection. On the other hand, 390 samples were positive for CVA16; the total positive rate was 43.4% and the GMT was 1:9.5. Anhui (62.2% and 1:16.0) and Hunan (61.1% and 1:23.1) had relatively high rates, while Heilongjiang (8.0% and 1:4.6) had the lowest rate. Although there is a geographical difference in HEV71 and CVA16 infections, low neutralizing antibody positive rate and titer of both viruses were found in all 6 provinces. Conclusions This report confirmed that HEV71 and CVA16 had wildly circulated in a couple provinces in China before the large-scale outbreaks from 2008. This finding also suggests that public health measures to control the spread of HEV71 and CVA16 should be devised according to the different regional characteristics.

Published
2010
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11. Outbreak of acute hemorrhagic conjunctivitis in Yunnan, People's Republic of China, 2007

Author

Xu Wenbo, Zhou Yongming, Zhang Jing, Zhang Yong, Zhu Shuangli, and Yan Dongmei

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract An outbreak of acute hemorrhagic conjunctivitis (AHC) occurred in Yunnan Province, China between August and September in 2007. A total of 3,597 cases were officially reported and the incidence rate reached 1390.94/100,000. Descriptive epidemiological analysis of the outbreak was conducted using the data from National Disease Supervision Information Management System (NDSIMS). To determine the causative agent for this outbreak and to analyze their genetic features, 30 conjunctival swabs and 19 paired serum specimens of acute and convalescent phase were collected from 30 patients with AHC, and viral isolation, molecular typing, antibody assay and phylogenetic analysis were performed. 11 virus strains were isolated from 30 conjunctival swabs. Amplification and sequencing of the VP4 region of these strains identified that coxsackievirus A24 variant (CA24v) could be the causative agent of the AHC outbreak and this was further confirmed by subsequent virus neutralizing antibody test on 19 paired serum specimens. Phylogenetic analysis based on the 3C regions showed that the Yunnan CA24v strains belonged to Group 3 and clustered with the strains isolated from worldwide AHC outbreaks after 2002. Phylogenetic analysis based on the partial VP1 revealed that the Yunnan strains differed from the strains isolated from AHC outbreak in Guangdong of China in 2007 with 2.8 - 3.0% nucleotide divergence, suggesting that two different lineages of CA24v caused the independent AHC outbreaks in Yunnan and Guangdong, respectively.

Published
2010
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12. An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of Hand Foot and Mouth Disease in Fuyang city of China

Author

Sun Junling, Feng Zijian, Wan Junfeng, Zhao Yueping, Zhang Jing, Dong Xiaoping, Li Qun, Yan Dongmei, Zhang Yong, Cui Aili, Zhu Shuangli, Xu Songtao, Mao Naiying, Wang Yu, Ren Jun, Tan Xiaojuan, Yang Weizhong, Zhu Zhen, Zhang Yan, Wang Shiwen, Li Dexin, and Xu Wenbo

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Hand, foot and mouth disease (HFMD), a common contagious disease that usually affects children, is normally mild but can have life-threatening manifestations. It can be caused by enteroviruses, particularly Coxsackieviruses and human enterovirus 71 (HEV71) with highly variable clinical manifestations. In the spring of 2008, a large, unprecedented HFMD outbreak in Fuyang city of Anhui province in the central part of southeastern China resulted in a high aggregation of fatal cases. In this study, epidemiologic and clinical investigations, laboratory testing, and genetic analyses were performed to identify the causal pathogen of the outbreak. Of the 6,049 cases reported between 1 March and 9 May of 2008, 3023 (50%) were hospitalized, 353 (5.8%) were severe and 22 (0.36%) were fatal. HEV71 was confirmed as the etiological pathogen of the outbreak. Phylogenetic analyses of entire VP1 capsid protein sequence of 45 Fuyang HEV71 isolates showed that they belong to C4a cluster of the C4 subgenotype. In addition, genetic recombinations were found in the 3D region (RNA-dependent RNA polymerase, a major component of the viral replication complex of the genome) between the Fuyang HEV71 strain and Coxsackievirus A16 (CV-A16), resulting in a recombination virus. In conclusion, an emerging recombinant HEV71 was responsible for the HFMD outbreak in Fuyang City of China, 2008.

Published
2010
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30. Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

Author

Ma, Hang, Guo, Yingying, Tang, Haoneng, Tseng, Chien-Te K., Wang, Lei, Zong, Huifang, Wang, Zhenyu, He, Yang, Chang, Yunsong, Wang, Shusheng, Huang, Haiqiu, Ke, Yong, Yuan, Yunsheng, Wu, Mingyuan, Zhang, Yuanyuan, Drelich, Aleksandra, Kempaiah, Kempaiah Rayavara, Peng, Bi-Hung, Wang, Ailin, Yang, Kaiyong, Yin, Haiyang, Liu, Junjun, Yue, Yali, Xu, Wenbo, Zhu, Shuangli, Ji, Tianjiao, Zhang, Xiaoju, Wang, Ziqi, Li, Gang, Liu, Guangchun, Song, Jingjing, Mu, Lingling, Xiang, ZongShang, Song, Zhangyi, Chen, Hua, Bian, Yanlin, Zhang, Baohong, Chen, Hui, Zhang, Jiawei, Liao, Yunji, Zhang, Li, Yang, Li, Chen, Yi, Gilly, John, Xiao, Xiaodong, Han, Lei, Jiang, Hua, Xie, Yueqing, Zhou, Qiang, and Zhu, Jianwei

Published
2022
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43. Characterizing enterovirus C96 genome and phylodynamics analysis

Author

Yang, Tingting, primary, Sun, Qiang, additional, Yan, Dongmei, additional, Zhu, Shuangli, additional, Ji, Tianjiao, additional, Xiao, Jinbo, additional, Lu, Huanhuan, additional, Liu, Ying, additional, He, Yun, additional, Wang, Wenhui, additional, Cong, Ruyi, additional, Wang, Xiaoyi, additional, Yang, Qian, additional, Xing, Weijia, additional, and Zhang, Yong, additional

Published
2023
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48. Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana

Author

Wang, Ji, Zhou, Weimin, Ling, Hua, Dong, Xiaoping, Zhang, Yi, Li, Jiandong, Zhang, Yong, Song, Jingdong, Liu, William J., Li, Yang, Zhang, Ruiqing, Zhen, Wei, Cai, Kun, Zhu, Shuangli, Wang, Dongyan, Xiao, Jinbo, Tong, Yigang, Liu, Wenli, Song, Lihua, Wu, Wei, Liu, Yang, Zhao, Xiang, Wang, Ruihuan, Ye, Sheng, Wang, Jing, Lu, Roujian, Huang, Baoying, Ye, Fei, Lei, Wenwen, Gao, Rongbao, Shi, Qi, Chen, Cao, Han, Jun, Xu, Wenbo, Gao, George F., Ma, Xuejun, and Wu, Guizhen

Published
2019
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