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A major hurdle in cardiac cell therapy is the lack of a bona fide autologous stem-cell type that can be expanded long-term and has authentic cardiovascular differentiation potential. Here we report that a proliferative cell population with robust cardiovascular differentiation potential can be generated from mouse or human fibroblasts via a combination of six small molecules. These chemically induced cardiovascular progenitor cells (ciCPCs) self-renew long-term in fully chemically defined and xeno-free conditions, with faithful preservation of the CPC phenotype and of cardiovascular differentiation capacity in vitro and in vivo. Transplantation of ciCPCs into infarcted mouse hearts improved animal survival and cardiac function up to 13 weeks post-infarction. Mechanistically, activated fibroblasts revert to a plastic state permissive to cardiogenic signals, enabling their reprogramming into ciCPCs. Expanded autologous cardiovascular cells may find uses in drug discovery, disease modelling and cardiac cell therapy.

Although seeking an effective strategy for further improving their optical properties is a great challenge, two-dimensional (2D) halide perovskites have attracted a significant amount of attention because of their performance. In this regard, the pressure-induced emission accompanied by a remarkable pressure-enhanced emission is achieved without a phase transition in 2D vacancy-ordered perovskite Cs

Pyrolysis process is a basic process to convert polyacrylonitrile (PAN)-based precursors fiber into PAN-based carbon fibers. Herein, pyrolysis behavior of pure PAN precursor and PAN precursor modified by transition metal Co and Fe was online analyzed. The effect of metal salts addition, pyrolysis temperature, and peroxidation on the formation of pyrolysis products were online analyzed via analytical pyrolysis gas chromatography/mass spectrometry (Py-GC/MS). The results showed that the weight loss of Co-Fe/PAN-1 can be divided into two stages with the addition of transition metal Co and Fe, and it is contributed to the formation of C2H4N2, C4H8N2, C6H6N2, and C6H8N2 at the temperature range of 400 ℃–800 ℃. The number of pyrolysis products decreases, and CO2 is the main pyrolysis product after pre-oxidation of PAN-2 and Co-Fe/PAN-2. After carbonization, the formation of Co-Fe alloy was detected in Co-Fe/PAN-2@CNFs because of the addition of Co and Fe, and the specific surface area of Co-Fe/PAN-2@CNFs is 426 m2/g.

Nine kinds of general solutions of certain popular first-order ordinary differential equation are obtained by direct calculations. Compared with complete discrimination system for polynomials, our classifications of solutions straightly depend on the coefficients of the ordinary differential equation and hence are easier to be employed. According to the nine kinds of solutions, we establish thirty traveling wave solutions to the coupled systems of ion sound and Langmuir waves, including rational function solution, exponential function solution, trigonometric function solutions, hyperbolic function solutions and Jacobi elliptic function solutions. To the best of our knowledge, many of them are new. Solutions discussed in two recent articles are showed to be equivalent to some special cases of our thirty traveling wave solutions. Our solutions include the kink and anti-kink soliton solutions, dark and bright soliton solutions as well as periodic soliton solutions and solitary wave solutions. We believe that these solutions will be of great use to researchers concerning with nonlinear physical phenomena. In addition, the famous (1+1)-dimensional dispersive long wave equations is taken to illustrate the applicability of these thirty solutions.

Heart diseases are prevalent worldwide and account for the highest mortality than any other illness. Although investment in drug discovery and development has increased, the amount of drug approvals has seen a progressive decline. Moreover, adverse side effects to the heart have become the most common reasons for preclinical project cessation, partly due to the lack of suitable humanized preclinical models. Human pluripotent stem cells (hPSCs) have emerged as a powerful non-animal platform to model heart disease, to screen for novel drugs, and to test drug cardiotoxicity in a high-throughput and cost-effective manner. Here, we review and discuss recent breakthroughs in the development of cardiovascular modeling and their current and future applications of hPSC-based drug discovery and testing.

Background Esophageal squamous cell carcinoma (ESCC) is the leading cause of cancer death in men and women worldwide. The poor prognosis and rapid increase in ESCC incidence highlight the need to promote early detection and prediction. Identifying key molecular targets involved in ESCC monitoring and progression is critical for ESCC patients. Methods This study examined miR-25/miR-203 as a biomarker for ESCC patients. Real-time quantitative polymerase chain reaction (PCR) was used to detect miR-25/miR-203 expression levels in tissues and serum exosomes, and MiR-25/miR-203 upregulation was confirmed in ESCC. Results We found that the miR-25/miR-203 ratio in cancer tissues from 36 ESCC patients was significantly enhanced compared with that in adjacent tissues. Moreover, the serum level of miR-25/miR-203 in 57 ESCC patients was higher than that in 31 healthy volunteers. Intriguingly, in 38 ESCC patients, the level of miR-25/miR-203 decreased significantly after surgery. Using ROC curve statistical analysis, we found that each group of miR-25/miR-203 had obvious sensitivity and high specificity. The miR-25/miR-203 relationship with the clinicopathological features of ESCC patients was also analyzed. MiR-25/miR-203 was significantly associated with the ESCC TNM-stage and lymph node metastasis, which predicts the prognosis of ESCC and reflects tumor progression. Conclusions This study highlights the feasibility of using exosome-mediated miR-25/miR-203 as a vital noninvasive biomarker for the detection and treatment monitoring of ESCC.

The rapid development of the semiconductor industry has motivated researchers passion for accelerating the discovery of advanced optoelectronic materials. Computational functionality‐driven design is an emerging branch of material science that has become effective at making material predictions. By combining advanced solid‐state knowledge and high‐throughput first‐principles computational approaches with intelligent algorithms plus database development, experts can now efficiently explore many novel materials by taking advantage of the power of supercomputer architectures. Here, we discuss a set of typical design strategies that can be used to accelerate inorganic optoelectronic materials discovery from computer simulations: In silico computational screening; knowledge‐based inverse design; and algorithm‐based searching. A few representative examples in optoelectronic materials design are discussed to illustrate these computational functionality‐driven modalities. Challenges and prospects for the computational functionality‐driven design of materials are further highlighted at the end of the review.

It has been identified that malnutrition can influence the immune system and time of engraftment, and it's also associated with increased incidence of complications, prolonged length of hospital stays, and transplant mortality and morbidity in patients undergoing hematopoietic stem cell transplantation (HSCT), so dynamic nutrition care is highly important. The aim of this study was to better understand the differences between clinical nutrition practices and international recommendations as well as possible barriers to the use of nutrition support in HSCT patients. An evidence-based nutrition support pathway was constructed through a systematic literature review to identify evidence and recommendations relating to the relevant issues. Then, a questionnaire consisting of 28 questions that focused on the 4 topics, namely, assessment and screening for malnutrition, nutrition support interventions, nutrition support in gastrointestinal graft-versus-host disease (GVHD) and neutropenic diet was developed by the study authors and used for data collection. Responses of 18 HSCT centers from 17 provinces were received. General assessment for malnutrition was performed at 72% (13/18) centers. Parenteral nutrition (PN) was given as the first option to HSCT patients in the majority of centers, despite the fact that current guidelines recommend enteral nutrition (EN) over PN. As many as 72% (13/18) of the centers considered a neutropenic diet in the management of HSCT patients, but only one center had a formal neutropenic diet protocol in place for transplant recipients. Criteria for initiating nutrition support in patients with gastrointestinal GVHD were heterogeneous among the centers, and PN was the most widely used technique. The survey results revealed significant heterogeneity with regard to nutrition support practices among the centers, as well as between the practices and the guidelines. Standard nutrition support guidelines or protocols for nutrition support practices were absent in most of the centers.

Zhimin Shen,1,* Tianci Chai,1,* Fei Luo,1 Zhun Liu,1 Hui Xu,1 Peipei Zhang,1 Mingqiang Kang,1– 3 Sui Chen1 1Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, People’s Republic of China; 2Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350001, People’s Republic of China; 3Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou 350122, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mingqiang Kang; Sui ChenDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou 350001, People’s Republic of ChinaTel +86-18805910101; +86-13600867301Email mingqiang_k068@163.com; chensui_567@163.comPurpose: MicroRNAs dysregulation has been confirmed in multiple malignancies. This paper reported the molecular mechanism of miR-204-5p in esophageal squamous cell carcinoma (ESCC).Methods: miR-204-5p expression in 30 ESCC tumor tissues and 10 normal tissues was downloaded from RNA-seq data. ESCC tissues/normal tissues of 97 ESCC patients were collected. TE-1 and KYSE510 cells were transfected by miR-204-5p mimic, inhibitor, siYWHAZ or their corresponding controls. The phenotype of cells was detected by CCK-8 assay, transwell experiment, and flow cytometry. Luciferase reporter gene assay and RNA-binding protein immunoprecipitation (RIP) were performed to verify the targeting relationship between miR-204-5p and YWHAZ. miR-204-5p and YWHAZ expression in tissues/cells was detected by qRT-PCR and Western blot. Xenograft tumor experiment was performed.Results: miR-204-5p expression was declined in ESCC patients and cells, which was indicated the poor outcome of patients. Compared with siNC group, TE-1 cells in miR-204-5p inhibitor group had higher OD450 value, less cell percentage in G1 phase, and more cell percentage in S phase, lower apoptosis percentage, and higher migration and invasion cell numbers. Moreover, KYSE510 cells of miR-204-5p mimic group showed lower OD450 value, more cell percentage in G1 phase and less cell percentage in S phase, higher apoptosis percentage, and lower migration and invasion cell numbers than control. YWHAZ was directly inhibited by miR-204-5p. Relative to siNC group, TE-1 cells of miR-inhibitor group exhibited higher YWHAZ protein expression, higher OD450 value, less cell percentage in G1 phase and more cell percentage in S phase, lower apoptosis percentage, higher migration and invasion cell numbers, and higher p-PI3K/PI3K and p-AKT/AKT protein expression, while siYWHAZ rescued the effects of miR-inhibitor. miR-204-5p up-regulation inhibited ESCC growth in vivo.Conclusion: miR-204-5p inhibits ESCC progression by targeted inhibition of YWHAZ/PI3K/AKT.Keywords: ESCC, progression, miR-204-5p, YWHAZ, PI3K/AKT

In their recently published article, G. Akram et al. investigated (1 + 1) dimensional cubic–quintic complex Ginzburg–Landau equation and constructed its exact solutions via the first integral method. We argue that all of solutions obtained by G. Akram et al. are incorrect and do not satisfy the considered equation. Furthermore, we present correct solutions as well as constraint conditions in this article.

In this paper, a multiscale analysis strategy was proposed to analyze the failure behaviors of open-hole compressive (OHC) CFRP laminates. Micro-level intralaminar failure was defined in the constituents (fiber and matrix) with a modified micromechanics failure theory. In the multiscale stress transformation, the effect of thermal residual stress was considered using constant thermal amplification factor. Meanwhile, macro-level interlaminar failure was defined with cohesive elements. Based on the simulated and experimental results, the sub-laminate scaled OHC laminates of the stacking sequence [45/0/−45/90]4s were studied at different temperatures. The established multiscale model showed good precision in the strength and failure mode predictions. Transverse throughout damage at the hole section led to the final failure. As the temperature increased, the damage process began at a lower load level and the strength of the laminates decreased significantly. Stiffness reductions and small load drops were more likely to occur before final failure. The differences in the delamination size among all interfaces tended to be smaller. Besides, matrix failure lagged under shear loading conditions if the thermal residual stress was neglected in the multiscale analysis.

In recent years, the Chinese logistics industry has developed rapidly. However, the rough handling in the express service and the inappropriate transportation environment has seriously affected the user experience and caused huge material waste. The reasons for the phenomena can be attributed to the lack of objective and quantified monitoring and evaluation methods. Therefore, a real-time monitoring system for the logistics status of express packages was proposed. It consists of a data acquisition terminal, a server, and a client. The terminal integrates sensors such as accelerometer, gyroscope, temperature and humidity sensors, and it is placed in the express package to collect triaxial acceleration, temperature and other data in the express logistics. Abnormal data is screened out by the on-chip classification algorithm, and written into a memory card or transmitted to the server via GPRS. The database is built on the server. Regulators, managers, and consumers can review the data on the database on the client based on their permission levels. An acquisition device is designed, and a binary classification method that can be executed on a chip and has an accuracy rate of 96.78% is proposed.

Pressure-induced emission (PIE) is extensively studied in halide perovskites or derivative hybrid halides. However, owing to the soft inorganic lattice of these materials, the intense emission is barely retained under ambient conditions, thus largely limiting their practical applications in optoelectronics at atmospheric pressure. Here, remarkably enhanced emission in microtubules of the 0D hybrid halide (C5 H7 N2 )2 ZnBr4 ((4AMP)2 ZnBr4 ) is successfully achieved by means of pressure treatment at room temperature. Notably, the emission, which is over ten times more intense than the emission in the initial state, is retained under ambient conditions upon the complete release of pressure. Furthermore, the pressure processing enables the tuning of "sky blue light" before compression to "cool daylight" with a remarkable quantum yield of 88.52% after decompression, which is of considerable interest for applications in next-generation lighting and displays. The irreversible electronic structural transition, induced by the steric hindrance with respect to complexly configurational organic molecules [4AMP], is highly responsible for the eventual retention of PIE and tuning of the color temperature. The findings represent a significant step toward the capture of PIE under ambient conditions, thus facilitating its potential solid-state lighting applications.

Graphene-coated substrates have a significant effect on regulating the commensurate epilayer growth of ionic thin-films, which has demonstrated that the polarity of atomic binding in ionic-bonded materials is strong enough to penetrate through a few-layer graphene, but that from the covalent-bonded material is screened even by a monolayer graphene (MLG). However, recent studies have demonstrated that the covalent-bonded stanene film can also be obtained by the remote heteroepitaxy on the monolayer graphene-covered Cu(111) substrate. In this work, we use first-principles calculations to uncover the microscopic mechanism of the unusual remote interactions, which facilitate the Sn adatom growth on the MLG-covered Cu substrate. Our calculations suggest that the lattice sites of MLG determine the adatom registry and provide an essential mediator role in the extended adatom-linking-substrate interactions, whereas the Cu substrate under the MLG reinforces the adsorption on the entire surface by the extended hybridization of MLG/Cu(111) interfacial states with the Sn adatom localized states. This finding provides a novel insight into the remote epitaxial mechanism of 2D films on the MLG-covered metal substrates, which opens the opportunity in the field of vdW (van der Waals) epitaxial of low-dimensional element crystalline and their transferable integration.

Close-range photogrammetry, as an important part of non-contact measurement, plays an important role in industrial manufacturing. This paper summarizes the basic principle of digital close-range industrial survey, introduces the structure and function of photogrammetric system, and focuses on the key techniques of photogrammetric technology, including the acquisition of high-quality images, central positioning of landmarks, camera calibration and automation technology, etc. Next has analyzed the current research direction of digital photogrammetry system and its application in different industrial fields. Finally, the demand of digital photogrammetry is summarized in the thesis, and put forward the development direction of close-range photogrammetry in large size and high precision, automation, specialized data analysis, etc.