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183 results on '"Zhuo, Chun-Xiang"'

11. Synthesis of 2‑Boryl Allylboronates by a Bimetallic Platinum/Zinc-Promoted Diborylation of Propargylic Amines.

Author

Shi, Xiao-Nan, Wang, Jia-Le, Wu, Jiang-Bin, and Zhuo, Chun-Xiang

Subjects
AMINES, OXIDATIVE addition, SERVER farms (Computer network management), ORGANOPLATINUM compounds, PLATINUM compounds, KETONES
Abstract

Propargylic amines are versatile synthetic intermediates in organic synthesis and can be readily accessed through a catalytic three-component coupling of aldehydes, alkynes, and amines, termed the "A SP 3 sp coupling". [33] Moreover, reactions of propargylic amine substrates B 1n b and B 1o b bearing alternative amine moieties also proceeded smoothly (Scheme 3). Keywords: 2-boryl allylboronates; propargylic amines; platinum catalysis; bimetallic synergistic effect; diborylation EN 2-boryl allylboronates propargylic amines platinum catalysis bimetallic synergistic effect diborylation 1573 1576 4 07/31/23 20230815 NES 230815 Graph Organoboron compounds play essential roles in organic synthesis and in the pharmaceutical industry. [Extracted from the article]

Published
2023
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15. Catalytic Deoxygenative Cyclopropanation of 1,2-Dicarbonyl or Monocarbonyl Compounds via Molybdenum Catalysis.

Author

Wang, Jia-Le and Zhuo, Chun-Xiang

Subjects
*CYCLOPROPANATION, *METAL carbenes, *MOLYBDENUM, *CATALYSIS, *MOLYBDENUM compounds, *CYCLOPROPANE, *DIAZO compounds, *ALKENES
Abstract

The cyclopropanation of alkenes through the transition-metal-catalyzed decomposition of diazo compounds is a powerful and straightforward strategy to produce cyclopropanes. Nevertheless, the appeal of further application of this strategy is tempered by the potentially explosive nature of the diazo substrates. Therefore, it is highly desirable to develop sustainable and operationally safe surrogates for diazo compounds. In this Synpacts article, we discuss recent advances on the cyclopropane syntheses through the catalytic cyclopropanation of alkenes and metal carbenes generated in situ from nondiazo precursors as well as highlight our recent progress on the unprecedented molybdenum-catalyzed deoxygenative cyclopropanation reaction of 1,2-dicarbonyl or monocarbonyl compounds. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Anilines Formation via Molybdenum‐Catalyzed Intermolecular Reaction of Ynones with Allylic Amines.

Author

Yu, Yi‐Zhe, Su, Hong‐Yi, and Zhuo, Chun‐Xiang

Abstract

The multi‐substituted anilines are widely found in organic synthesis, medicinal chemistry and material science. The quest for robust and efficient methods to construct a diverse array of these compounds using readily accessible starting materials under simple reaction conditions is of utmost importance. Here, we report an unprecedented and efficient approach for the synthesis of 2,4‐di and 2,4,6‐trisubstituted anilines. With a simple molybdenum(VI) catalyst, a wide range of 2,4‐di and 2,4,6‐trisubstituted anilines were efficiently prepared in generally good to excellent yields from readily accessible ynones and allylic amines. The synthetic potential of this methodology was further underscored by its applications in several synthetic transformations, gram‐scale reactions, and derivatization of bioactive molecules. Preliminary mechanistic studies suggested that this aniline formation might involve a cascade of aza‐Michael addition, [1,6]‐proton shift, cyclization, dehydration, 6π‐electrocyclization, and aromatization. This novel strategy provided a robust, simple, and modular approach for the syntheses of various valuable di‐ or trisubstituted anilines, some of which were otherwise challenging to access. [ABSTRACT FROM AUTHOR]

Published
2024
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