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Abstract Aim/Introduction The recent adverse reactions associated with semaglutide have led the Food and Drug Administration (FDA) to issue a “black box warning”, and it is necessary to analyze all reports of adverse reactions to improve the safety of its clinical use. Materials and Methods Statistical analyses and signal mining were performed by obtaining the adverse event reports related to semaglutide in the FAERS database from the first quarter of 2018 to the fourth quarter of 2023. We used disproportionality and Bayesian analysis to examine clinical and demographic attributes, trends reported quarterly, and contrasts between two distinct indications (obesity and type 2 diabetes). Results We found 10 unexpected adverse signals related to “pancreatic cancer”, “intestinal obstruction”, “cholecystitis”, and “polycystic ovary” and both the two different indications had the same serious adverse reaction events occurring. Conclusions This study identified many unexpected signals of serious adverse reactions, suggesting the importance of continuous post‐marketing surveillance of semaglutide to understand its potential risks.

Male infertility, age-related changes, and tumors have been increasingly studied in the field of male reproductive health due to the emergence of environmental stressors, declining fertility rates, and aging populations. Numerous studies have demonstrated that the ERK1/2 signaling pathway plays a significant role in male reproduction. The ERK1/2 pathway is associated with several signaling pathways and has a complex interplay that influences the spermatogenic microenvironment, sperm viability, gonadal axis regulation, as well as resistance to testicular aging and tumors. Moreover, the ERK1/2 pathway directly or indirectly regulates testicular somatic cells, which are crucial for maintaining spermatogenesis and microenvironment regulation. Given the critical role of the ERK1/2 signaling pathway in male reproductive health, comprehensive exploration of its multifaceted effects on male reproduction and underlying mechanisms is necessary. This study aims to provide a solid foundation for in-depth research in the field of male reproduction and further enhance the reproductive health of males.