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1. Adherence to Prescribed E-Diary Recording by Patients With Seasonal Allergic Rhinitis: Observational Study

Author

Di Fraia, Marco, Tripodi, Salvatore, Arasi, Stefania, Dramburg, Stephanie, Castelli, Sveva, Villalta, Danilo, Buzzulini, Francesca, Sfika, Ifigenia, Villella, Valeria, Potapova, Ekaterina, Perna, Serena, Brighetti, Maria Antonia, Travaglini, Alessandro, Verardo, Pierluigi, Pelosi, Simone, Zicari, Anna Maria, and Matricardi, Paolo Maria

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundComplete diagnosis and therapy of seasonal allergic rhinoconjunctivitis require evidence that exposure to the sensitizing pollen triggers allergic symptoms. Electronic clinical diaries, by recording disease severity scores and pollen exposure, can demonstrate this association. However, patients who spontaneously download an e-diary app show very low adherence to their recording. ObjectiveThe objective of our study was to assess adherence of patients with seasonal allergic rhinitis to symptom recording via e-diary explicitly prescribed by an allergist within a blended care approach. MethodsThe @IT-2020 project is investigating the diagnostic synergy of mobile health and molecular allergology in patients with seasonal allergic rhinitis. In the pilot phase of the study, we recruited Italian children (Rome, Italy) and adults (Pordenone, Italy) with seasonal allergic rhinitis and instructed them to record their symptoms, medication intake, and general conditions daily through a mobile app (Allergy.Monitor) during the relevant pollen season. ResultsOverall, we recruited 101 Italian children (Rome) and 93 adults (Pordenone) with seasonal allergic rhinitis. Adherence to device use slowly declined during monitoring in 3 phases: phase A: first week, ≥1267/1358, 90%; phase B: second to sixth week, 4992/5884, 80% to 90%; and phase C: seventh week onward, 2063/2606, 70% to 80%. At the individual level, the adherence assessed in the second and third weeks of recording predicted with enough confidence (Rome: Spearman ρ=0.75; P

Published
2020
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2. Seeing eye to eye: a modified Delphi method-based multidisciplinary expert consensus on the diagnosis and treatment of vernal keratoconjunctivitis

Author

Ghiglioni, Daniele Giovanni, Bruschi, Gaia, Chiappini, Elena, Consales, Alessandra, Allegri, Pia, Aragona, Pasquale, Bonini, Stefano, Caputo, Roberto, Cardinale, Fabio, Landi, Massimo, Leonardi, Andrea, Marseglia, Gian Luigi, Mori, Francesca, Nebbioso, Marcella, Nucci, Paolo, Osnaghi, Silvia, Procoli, Ugo, Villani, Edoardo, Zicari, Anna Maria, and Miraglia Del Giudice, Michele

Published
2024
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7. Internal Consistency, Responsiveness and Minimal Detectable Change of the TECO in the Bachelor's Degree Course in Pediatric Nursing at the 'Sapienza' University of Rome: A Cross Sectional Study

Author

Galeoto, Giovanni, D'Elpidio, Giuliana, Alvaro, Rosaria, Zicari, Anna Maria, Valente, Donatella, and Riccio, Marianna

Abstract

The Italian Disciplinary section of Test of Competences (TECO-D) project is an important longitudinal study used to analyze learning outcomes of ungraded students and to measure quality of the educational process. The aim of the present study was to evaluate the psychometric properties of the TECO-D in students enrolled in the Bachelor's Degree in Pediatric Nursing at "Sapienza" University of Rome. The other aim was to evaluate if TECO-D is able to assess the changes in skills between students of I and III year of the university course and to calculate the minimal detectable change. The sample was composed by 35 pediatric nursing students and was recruited in October 2019. The test was administered using a digital platform with multiple choice questions (MCQs). The reliability, as internal consistency, was excellent ([alpha]= 0.938). The responsiveness evaluated by t-test for independent samples, the Standard Error of Measurement (SEM) and Minimal Detectable Change (MDC) was supported by significant differences between two cohorts of pediatric nursing students, and adequate TECO-D is a reliable instrument for assessing the skills of pediatric nursing student evaluating the achievement of university goals and improving the quality of the training provided by the university. [For the full proceedings, see ED621108.]

Published
2021

8. Effects of the supplementation of single and multi-strain probiotics, alone or in combination with other treatments, on asthma in children: A systematic review of the randomized, placebo-controlled clinical studies

Author

Daglia, Maria, Drago, Lorenzo, Ullah, Hammad, Di Minno, Alessandro, Brindisi, Giulia, Brunese, Francesco Paolo, Dinardo, Giulio, Gori, Alessandra, Indolfi, Cristiana, Naso, Matteo, Tondina, Enrico, Trincianti, Chiara, Varricchio, Attilio, Zicari, Anna Maria, and Ciprandi, Giorgio

Published
2024
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10. Impaired arterial dilation and increased NOX2 generated oxidative stress in subjects with ataxia-telangiectasia mutated (ATM) kinase

Author

Palumbo, Ilaria Maria, Magna, Arianna, Fallarino, Alessia, Pannunzio, Arianna, Maggio, Enrico, Bagnato, Chiara, Cammisotto, Vittoria, Castellani, Valentina, Loffredo, Lorenzo, Soresina, Annarosa, Cinicola, Bianca Laura, Capponi, Martina, Salvatori, Francesca, Bartimoccia, Simona, Picchio, Vittorio, Forte, Maurizio, Caputi, Caterina, Poscia, Roberto, Leuzzi, Vincenzo, Spalice, Alberto, Pignatelli, Pasquale, Badolato, Raffaele, Duse, Marzia, Violi, Francesco, Carnevale, Roberto, and Zicari, Anna Maria

Published
2024
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11. Inverse association between the molecular spreading of IgE to grass pollen and the IgE response to Dermatophagoides pteronyssinus among children with seasonal allergic rhinitis

Author

Brindisi, Giulia, Cipriani, Francesca, Potapova, Ekaterina, Tripodi, Salvatore, Panetta, Valentina, Bernardini, Roberto, Caffarelli, Carlo, Casani, Antonella, Cervone, Rosa, Chini, Loredana, Comberiati, Pasquale, Castro, Giovanna De, Del Giudice, Michele Miraglia, Iacono, Iride Dello, Businco, Andrea Di Rienzo, Dramburg, Stephanie, Gallucci, Marcella, Giannetti, Arianna, Moschese, Viviana, Sfika, Ifigenia, Varin, Elena, Ricci, Giampaolo, Reese, Gerald, Zicari, Anna Maria, and Matricardi, Paolo Maria

Published
2024
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12. IgE to cyclophilins in pollen-allergic children: Epidemiologic, clinical, and diagnostic relevance of a neglected panallergen

Author

Matricardi, Paolo Maria, Potapova, Ekaterina, Panetta, Valentina, Lidholm, Jonas, Mattsson, Lars, Scala, Enrico, Bernardini, Roberto, Caffarelli, Carlo, Casani, Antonella, Cervone, Rosa, Chini, Loredana, Comberiati, Pasquale, De Castro, Giovanna, Miraglia del Giudice, Michele, Dello Iacono, Iride, Di Rienzo Businco, Andrea, Gallucci, Marcella, Giannetti, Arianna, Moschese, Viviana, Varin, Elena, Bianchi, Annamaria, Calvani, Mauro, Frediani, Tullio, Macrì, Francesco, Maiello, Nunzia, Paravati, Francesco, Pelosi, Umberto, Peroni, Diego, Pingitore, Giuseppe, Tosca, Mariangela, Zicari, Anna Maria, Ricci, Giampaolo, Asero, Riccardo, and Tripodi, Salvatore

Published
2024
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14. Impact of heat-not-burn cigarette passive smoking on children's oxidative stress, endothelial and platelet function

Author

Magna, Arianna, Izzo, Raffaella, Capponi, Martina, Brindisi, Giulia, Salvatori, Francesca, Castellani, Valentina, Amico, Alessandra D’, Trivigno, Chiara, Totè, Chiara, Maggio, Enrico, Miraldi, Fabio, Duse, Marzia, Pignatelli, Pasquale, Spalice, Alberto, Antonucci, Flavia, Loffredo, Lorenzo, Carnevale, Roberto, Pannunzio, Arianna, Cinicola, Bianca Laura, Palumbo, Ilaria Maria, Bartimoccia, Simona, Nocella, Cristina, Cammisotto, Vittoria, Violi, Francesco, Biondi-Zoccai, Giuseppe, Frati, Giacomo, and Zicari, Anna Maria

Published
2024
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16. Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients

Author

Loffredo, Lorenzo, Pignatelli, Pasquale, Pirro, Matteo, Ceccarelli, Giancarlo, Oliva, Alessandra, Maggio, Enrico, Cancelli, Francesca, D’Ardes, Damiano, Amitrano, Maria, Zicari, Anna Maria, Cinicola, Bianca Laura, Taliani, Gloria, Cangemi, Roberto, Lichtner, Miriam, Falcone, Marco, Orlando, Federica, Pugliese, Francesco, Venditti, Mario, Mastroianni, Claudio Maria, and Violi, Francesco

Published
2023
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17. Effect of Supplementation with a Specific Probiotic (Bifidobacterium bifidum PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial.

Author

Anania, Caterina, Matys, Viviana, Marra, Simona, De Canditiis, Daniela, Olivero, Francesca, Carraro, Carlo, Giugliano, Anna, Zicari, Anna Maria, and Piccioni, Maria Grazia

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the appearance of recurrent eczematous lesions and intense itching. The World Allergy Organization (WAO) suggested the administration of probiotics in pregnant women at high risk of allergies in their children. Objectives: Our study aims to evaluate the role of administering the Bifidobacterium bifidum strain PRL2010 during pregnancy and breastfeeding in preventing and/or reducing the severity of AD manifestations in children. Methods: It is a monocentric, randomized, double-blind, placebo-controlled trial with probiotic/placebo administration since the 36th week of gestation to mothers with atopy or a family history of atopy; the effects were evaluated over the first 12 months of the children's lives. Results: No severe adverse effects due to probiotic intake were reported in our cohort. Although proportionally fewer children with AD were in the probiotic group, the statistical analysis showed no significant differences between the probiotic and placebo groups. However, infants who developed the most severe forms of AD in the probiotic group showed a better clinical course during follow-up compared to those in the placebo group. Conclusions: In conclusion, administering the probiotic Bifidobacterium bifidum strain PRL2010 during pregnancy and breastfeeding is safe and potentially beneficial; further large-scale studies may confirm its usefulness in improving the clinical manifestation of AD in children with a family history of atopy. [ABSTRACT FROM AUTHOR]

Published
2025
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18. Nickel-induced labial angioedema in a pediatric patient with orthodontic braces: a case report.

Author

Leone, Fabrizio, Gori, Alessandra, Cinicola, Bianca Laura, Coletti, Giorgio, Pignataro, Elia, Martina, Capponi, Giulia, Brindisi, Anania, Caterina, and Zicari, Anna Maria

Subjects
MEDICAL device removal, TREATMENT effectiveness, ORTHODONTIC appliances, NICKEL, ANGIONEUROTIC edema, DISEASE relapse, SKIN tests
Abstract

Background: Angioedema is a condition marked by sudden, intense swelling of the subcutaneous and submucosal tissues, typically associated with hypersensitivity reactions, genetic mutations, or reactions to medications. It can also result from contact with allergens such as nickel, leading to dermatitis. Case presentation: : A 12-year-old girl presented at our Pediatric Immunology and Allergology service with recurrent labial angioedema for over a year, linked to the consumption of legumes and tomatoes, and following the use of a metal flute. Despite a nickel-positive patch test and subsequent avoidance of nickel, her symptoms persisted. Further investigations to rule out other causes of angioedema were unproductive. It was later discovered that she had been wearing a nickel-containing orthodontic device applied a year earlier. The removal of this orthodontic device led to a cessation of the angioedema episodes, highlighting nickel as the likely trigger. Conclusions: This case underscores the importance of considering prolonged nickel exposure from dental devices as a potential cause of angioedema. For patients predisposed to nickel hypersensitivity, using nickel-free alternatives such as ceramic for orthodontic appliances is crucial. Additionally, comprehensive allergen screening, including latex testing, should be conducted before the placement of such devices to prevent similar adverse reactions. [ABSTRACT FROM AUTHOR]

Published
2025
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19. Fecal Calprotectin Determination in a Cohort of Children with Cow's Milk Allergy.

Author

Anania, Caterina, Mondì, Filippo, Brindisi, Giulia, Spagnoli, Alessandra, De Canditiis, Daniela, Gesmini, Arianna, Marchetti, Lavinia, Fichera, Alessia, Piccioni, Maria Grazia, Zicari, Anna Maria, and Olivero, Francesca

Abstract

Cow's milk allergy (CMA) is the most common food allergy among children. An oral food challenge (OFC) remains a mainstay of the diagnosis of CMA, especially for the non-IgE-mediated type; however, this test can be risky and time-consuming. Hence, there is a need to identify biomarkers. Fecal calprotectin (FC) showed variable results, with good reliability and reproducibility in CMA patients. In this prospective study, we enrolled 76 children (aged 5–18 months) with CMA-related gastrointestinal and cutaneous symptoms following guidelines from the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. Clinical assessments included history, physical examination, skin prick tests, and IgE assays. FC levels and the Cow's Milk Related Symptom Score (CoMiSS) were measured in 51 patients pre (T1) and post-diet (T2), with a subgroup analysis of 15 patients with elevated baseline FC (>50 mg/kg). The results showed that FC levels significantly decreased after the elimination diet (median: 30 mg/kg at T1, 16 mg/kg at T2; p < 0.01). In the subgroup with higher FC levels, median values dropped from 90 mg/kg to 33 mg/kg (p < 0.01). CoMiSS also improved (median: 8.50 at T1, 3.00 at T2; p < 0.01). Linear regression analysis showed no correlation between FC values and the CoMiSS at T1 and T2. In conclusion, the reduction in FC value after an elimination diet suggests that it could be considered a possible biomarker of bowel inflammation in CMA patients. Further studies are necessary to confirm these data and to evaluate and standardize the use of FC for diagnosis and follow-up of CMA. [ABSTRACT FROM AUTHOR]

Published
2025
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20. Correction: Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

Author

Duse, Marzia, Santamaria, Francesca, Verga, Maria Carmen, Bergamini, Marcello, Simeone, Giovanni, Leonardi, Lucia, Tezza, Giovanna, Bianchi, Annamaria, Capuano, Annalisa, Cardinale, Fabio, Cerimoniale, Giovanni, Landi, Massimo, Malventano, Monica, Tosca, Mariangela, Varricchio, Attilio, Zicari, Anna Maria, Alfaro, Carlo, Barberi, Salvatore, Becherucci, Paolo, Bernardini, Roberto, Biasci, Paolo, Caffarelli, Carlo, Caldarelli, Valeria, Capristo, Carlo, Castronuovo, Serenella, Chiappini, Elena, Cutrera, Renato, De Castro, Giovanna, De Franciscis, Luca, Decimo, Fabio, Iacono, Iride Dello, Diaferio, Lucia, Di Cicco, Maria Elisa, Di Mauro, Caterina, Di Mauro, Cristina, Di Mauro, Dora, Di Mauro, Francesco, Di Mauro, Gabriella, Doria, Mattia, Falsaperla, Raffaele, Ferraro, Valentina, Fanos, Vassilios, Galli, Elena, Ghiglioni, Daniele Giovanni, Indinnimeo, Luciana, Kantar, Ahmad, Lamborghini, Adima, Licari, Amelia, Lubrano, Riccardo, Luciani, Stefano, Macrì, Francesco, Marseglia, Gianluigi, Martelli, Alberto Giuseppe, Masini, Luigi, Midulla, Fabio, Minasi, Domenico, Miniello, Vito Leonardo, Del Giudice, Michele Miraglia, Morandini, Sergio Renzo, Nardini, Germana, Nocerino, Agostino, Novembre, Elio, Pajno, Giovanni Battista, Paravati, Francesco, Piacentini, Giorgio, Piersantelli, Cristina, Pozzobon, Gabriella, Ricci, Giampaolo, Spanevello, Valter, Turra, Renato, Zanconato, Stefania, Borrelli, Melissa, Villani, Alberto, Corsello, Giovanni, Di Mauro, Giuseppe, and Peroni, Diego

Published
2022
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26. Extra X, extra questions: Trisomy X syndrome and IgA deficiency – a case report.

Author

Leone, Fabrizio, Gori, Alessandra, Cinicola, Bianca Laura, Brindisi, Giulia, Maglione, Vittorio, Anania, Caterina, and Zicari, Anna Maria

Subjects
REGULATORY T cells, X chromosome, TRISOMY, HEPATITIS B vaccines, RESPIRATORY infections
Abstract

While Trisomy X syndrome is typically characterized by developmental and cognitive variations, it is not commonly associated with immunodeficiencies. We report the unique case of a 6-year-old girl with Trisomy X presenting with selective IgA deficiency, challenging the conventional understanding of this chromosomal condition. The patient exhibited recurrent respiratory infections and gastrointestinal symptoms, evaluated in the context of her genetic background of Trisomy X and significantly low levels of IgA (0.03 g/L), yet normal IgG and IgM levels. Immunological assessment revealed a poor response to vaccination to HBV, necessitating an adapted vaccination strategy. Gastrointestinal investigations indicated paradoxical diarrhea secondary to chronic constipation, managed with dietary interventions. The presence of an extra X chromosome raises questions about the potential over-expression of genes that escape X-chromosome inactivation, such as FOXP3 , which is crucial for the regulation of regulatory T cells. An abnormal expression of FOXP3 could lead to either heightened immune regulation, increasing susceptibility to infections, or to immune dysregulation. Although Trisomy X is not typically associated with immunodeficiencies, this case, paralleled by another patient with Trisomy X and CVID, suggests a need for further speculative research into possible genetic links. Moreover, a 1969 study reported lower IgA levels in women with an extra X chromosome. In conclusion, this case aims to underscore the necessity for a deeper genetic and immunological evaluation in chromosomal anomalies like Trisomy X to fully understand their speculative impact on immune function. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Resveratrol: immunological activity and possible application in children and adolescents with allergic rhinitis.

Author

Naso, Matteo, Trincianti, Chiara, Drago, Lorenzo, Daglia, Maria, Brindisi, Giulia, Brunese, Francesco Paolo, Dinardo, Giulio, Gori, Alessandra, Indolfi, Cristiana, Tondina, Enrico, Varricchio, Attilio, Zicari, Anna Maria, and Ciprandi, Giorgio

Subjects
NUCLEAR factor E2 related factor, NF-kappa B, ANTIALLERGIC agents, CHOLERA toxin, TH2 cells, RESPIRATORY infections in children
Abstract

The document explores the potential use of resveratrol in managing allergic rhinitis in children and adolescents. Resveratrol, a polyphenol found in various plants, has shown antioxidant and anti-inflammatory properties that may benefit individuals with allergic conditions. Studies have demonstrated resveratrol's ability to modulate immune responses and reduce allergic symptoms in both in vitro and animal experiments. Clinical trials have also indicated the effectiveness of intranasal resveratrol in alleviating allergic symptoms, although further research is needed to establish its optimal dosage, safety, and bioavailability. [Extracted from the article]

Published
2025
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30. Dietary Intervention during Weaning and Development of Food Allergy: What Is the State of the Art?

Author

Gravina, Alessandro, primary, Olivero, Francesca, additional, Brindisi, Giulia, additional, Comerci, Antonia Fortunata, additional, Ranucci, Chiara, additional, Fiorentini, Cinzia, additional, Sculco, Eleonora, additional, Figliozzi, Ethel, additional, Tudini, Laura, additional, Matys, Viviana, additional, De Canditiis, Daniela, additional, Piccioni, Maria Grazia, additional, Zicari, Anna Maria, additional, and Anania, Caterina, additional

Published
2024
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31. Weaning and Development of Food Allergy: What Is the State of the Art?

Author

Gravina, Alessandro, primary, Olivero, Francesca, additional, Brindisi, Giulia, additional, Comerci, Antonia Fortunata, additional, Ranucci, Chiara, additional, Fiorentini, Cinzia, additional, Sculco, Eleonora, additional, Figliozzi, Ethel, additional, Tudini, Laura, additional, Matys, Viviana, additional, De Canditiis, Daniela, additional, Piccioni, Maria Grazia, additional, Zicari, Anna Maria, additional, and Anania, Caterina, additional

Published
2024
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32. Immunological characterization of an Italian PANDAS cohort

Author

Leonardi, Lucia, primary, Lorenzetti, Giulia, additional, Carsetti, Rita, additional, Piano Mortari, Eva, additional, Guido, Cristiana Alessia, additional, Zicari, Anna Maria, additional, Förster-Waldl, Elisabeth, additional, Loffredo, Lorenzo, additional, Duse, Marzia, additional, and Spalice, Alberto, additional

Published
2024
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33. Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

Author

Duse, Marzia, Santamaria, Francesca, Verga, Maria Carmen, Bergamini, Marcello, Simeone, Giovanni, Leonardi, Lucia, Tezza, Giovanna, Bianchi, Annamaria, Capuano, Annalisa, Cardinale, Fabio, Cerimoniale, Giovanni, Landi, Massimo, Malventano, Monica, Tosca, Mariangela, Varricchio, Attilio, Zicari, Anna Maria, Alfaro, Carlo, Barberi, Salvatore, Becherucci, Paolo, Bernardini, Roberto, Biasci, Paolo, Caffarelli, Carlo, Caldarelli, Valeria, Capristo, Carlo, Castronuovo, Serenella, Chiappini, Elena, Cutrera, Renato, De Castro, Giovanna, De Franciscis, Luca, Decimo, Fabio, Iacono, Iride Dello, Diaferio, Lucia, Di Cicco, Maria Elisa, Di Mauro, Caterina, Di Mauro, Cristina, Di Mauro, Dora, Di Mauro, Francesco, Di Mauro, Gabriella, Doria, Mattia, Falsaperla, Raffaele, Ferraro, Valentina, Fanos, Vassilios, Galli, Elena, Ghiglioni, Daniele Giovanni, Indinnimeo, Luciana, Kantar, Ahmad, Lamborghini, Adima, Licari, Amelia, Lubrano, Riccardo, Luciani, Stefano, Macrì, Francesco, Marseglia, Gianluigi, Martelli, Alberto Giuseppe, Masini, Luigi, Midulla, Fabio, Minasi, Domenico, Miniello, Vito Leonardo, del Giudice, Michele Miraglia, Morandini, Sergio Renzo, Nardini, Germana, Nocerino, Agostino, Novembre, Elio, Pajno, Giovanni Battista, Paravati, Francesco, Piacentini, Giorgio, Piersantelli, Cristina, Pozzobon, Gabriella, Ricci, Giampaolo, Spanevello, Valter, Turra, Renato, Zanconato, Stefania, Borrelli, Melissa, Villani, Alberto, Corsello, Giovanni, Di Mauro, Giuseppe, and Peroni, Diego

Published
2021
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34. Oral Food Challenge in Children with Tree Nut and Peanut Allergy: The Predictive Value of Diagnostic Tests.

Author

Cela, Ludovica, Gravina, Alessandro, Semeraro, Antonio, Pastore, Francesca, Morelli, Rebecca, Marchetti, Lavinia, Brindisi, Giulia, Olivero, Francesca, Piccioni, Maria Grazia, Zicari, Anna Maria, and Anania, Caterina

Subjects
FOOD allergy, CHILD nutrition, DIAGNOSIS methods, SKIN tests, IMMUNOGLOBULIN E
Abstract

Food allergy (FA) affects approximately 6–8% of young children, with a peak prevalence at approximately one year of age. Tree nut and peanut allergies are among the main causes of anaphylaxis in the world. The gold standard for the diagnosis of FAs is the oral food challenge (OFC). Other diagnostic tests used in the clinical practice are skin prick tests (SPTs) and laboratory tests to measure out the presence of serum specific IgE (sIgE). In this narrative review, we collect the current evidence of the predictive value (PV) of SPTs and sIgE for the outcome of the OFCs. In literature, data are conflicting as to whether increasing sIgE concentration and wheal size in SPTs correlate with OFC outcomes. Most studies included in our review have shown that in vivo and in vitro tests may predict OFC outcomes with variable PV, but data are not conclusive; therefore, the OFC currently remains the gold standard for FA diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Allergic rhinitis

Author

Miraglia del Giudice, Michele, primary, Allegorico, Annalisa, additional, Decimo, Fabio, additional, and Zicari, Anna Maria, additional

Published
2021
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36. Passive Smoking Exacerbates Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Isoform 2–Induced Oxidative Stress and Arterial Dysfunction in Children with Persistent Allergic Rhinitis

Author

Loffredo, Lorenzo, Zicari, Anna Maria, Occasi, Francesca, Perri, Ludovica, Carnevale, Roberto, Battaglia, Simona, Angelico, Francesco, Del Ben, Maria, Martino, Francesco, Nocella, Cristina, Farcomeni, Alessio, De Castro, Giovanna, Duse, Marzia, and Violi, Francesco

Published
2018
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37. Reply to Özdemir, Ö. Allergic Disease with Selective IgA Deficiency. Comment on “Cinicola et al. The Allergic Phenotype of Children and Adolescents with Selective IgA Deficiency: A Longitudinal Monocentric Study. J. Clin. Med. 2022, 11, 5705”

Author

Cinicola, Bianca Laura, primary, Brindisi, Giulia, additional, Capponi, Martina, additional, Gori, Alessandra, additional, Loffredo, Lorenzo, additional, De Castro, Giovanna, additional, Anania, Caterina, additional, Spalice, Alberto, additional, Guido, Cristiana Alessia, additional, Milito, Cinzia, additional, Duse, Marzia, additional, Quinti, Isabella, additional, Pulvirenti, Federica, additional, and Zicari, Anna Maria, additional

Published
2023
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41. Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough.

Author

Gori, Alessandra, Brindisi, Giulia, Daglia, Maria, Giudice, Michele Miraglia del, Dinardo, Giulio, Di Minno, Alessandro, Drago, Lorenzo, Indolfi, Cristiana, Naso, Matteo, Trincianti, Chiara, Tondina, Enrico, Brunese, Francesco Paolo, Ullah, Hammad, Varricchio, Attilio, Ciprandi, Giorgio, and Zicari, Anna Maria

Abstract

The prevalence of allergic diseases has dramatically increased among children in recent decades. These conditions significantly impact the quality of life of allergic children and their families. Lactoferrin, a multifunctional glycoprotein found in various biological fluids, is emerging as a promising immunomodulatory agent that can potentially alleviate allergic diseases in children. Lactoferrin's multifaceted properties make it a compelling candidate for managing these conditions. Firstly, lactoferrin exhibits potent anti-inflammatory and antioxidant activities, which can mitigate the chronic inflammation characteristic of allergic diseases. Secondly, its iron-binding capabilities may help regulate the iron balance in allergic children, potentially influencing the severity of their symptoms. Lactoferrin also demonstrates antimicrobial properties, making it beneficial in preventing secondary infections often associated with respiratory allergies. Furthermore, its ability to modulate the immune response and regulate inflammatory pathways suggests its potential as an immune-balancing agent. This review of the current literature emphasises the need for further research to elucidate the precise roles of lactoferrin in allergic diseases. Harnessing the immunomodulatory potential of lactoferrin could provide a novel add-on approach to managing allergic diseases in children, offering hope for improved outcomes and an enhanced quality of life for paediatric patients and their families. As lactoferrin continues to capture the attention of researchers, its properties and diverse applications make it an intriguing subject of study with a rich history and a promising future. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Kiwifruit’s Allergy in Children: What Do We Know?

Author

Bringheli, Ivana, primary, Brindisi, Giulia, additional, Morelli, Rebecca, additional, Marchetti, Lavinia, additional, Cela, Ludovica, additional, Gravina, Alessandro, additional, Pastore, Francesca, additional, Semeraro, Antonio, additional, Cinicola, Bianca, additional, Capponi, Martina, additional, Gori, Alessandra, additional, Pignataro, Elia, additional, Piccioni, Maria Grazia, additional, Zicari, Anna Maria, additional, and Anania, Caterina, additional

Published
2023
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44. Oxidative stress and gut-derived lipopolysaccharides in children affected by paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections

Author

Loffredo, Lorenzo, Spalice, Alberto, Salvatori, Francesca, De Castro, Giovanna, Guido, Cristiana Alessia, Zicari, Anna Maria, Ciacci, Paolo, Battaglia, Simona, Brindisi, Giulia, Ettorre, Evaristo, Nocella, Cristina, Salvatori, Guglielmo, Duse, Marzia, Violi, Francesco, and Carnevale, Roberto

Published
2020
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48. Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow’s Milk Protein Allergy

Author

Cela, Ludovica, primary, Brindisi, Giulia, additional, Gravina, Alessandro, additional, Pastore, Francesca, additional, Semeraro, Antonio, additional, Bringheli, Ivana, additional, Marchetti, Lavinia, additional, Morelli, Rebecca, additional, Cinicola, Bianca, additional, Capponi, Martina, additional, Gori, Alessandra, additional, Pignataro, Elia, additional, Piccioni, Maria Grazia, additional, Zicari, Anna Maria, additional, and Anania, Caterina, additional

Published
2023
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49. Genetic bases of C7 deficiency: systematic review and report of a novel deletion determining functional hemizygosity

Author

Balduit, Andrea, primary, Bianco, Anna Monica, additional, Mangogna, Alessandro, additional, Zicari, Anna Maria, additional, Leonardi, Lucia, additional, Cinicola, Bianca Laura, additional, Capponi, Martina, additional, Tommasini, Alberto, additional, Agostinis, Chiara, additional, d’Adamo, Adamo Pio, additional, and Bulla, Roberta, additional

Published
2023
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50. Case Report: Interindividual variability and possible role of heterozygous variants in a family with deficiency of adenosine deaminase 2: are all heterozygous born equals?

Author

Pulvirenti, Federica, primary, Cinicola, Bianca Laura, additional, Ferrari, Simona, additional, Guadagnolo, Daniele, additional, Sculco, Eleonora, additional, Capponi, Martina, additional, Loffredo, Lorenzo, additional, Sciannamea, Maddalena, additional, Insalaco, Antonella, additional, Quinti, Isabella, additional, De Benedetti, Fabrizio, additional, and Zicari, Anna Maria, additional

Published
2023
Full Text
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