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1,726 results on '"Ziegler L"'

1. Room-temperature emission of muonium from aerogel and zeolite targets

Author

Antognini, A., Crivelli, P., Gerchow, L., Hume, T. D., Kirch, K., Knecht, A., Nuber, J., Papa, A., Ritjoho, N., Sakurai, M., Soter, A., Taqqu, D., Vogiatzi, S. M., Zhang, J., and Ziegler, L.

Subjects
Physics - Atomic Physics, High Energy Physics - Experiment
Abstract

A low-emittance, high-intensity atomic beam of muonium ($\mathrm{M}=\mu^+ + \mathrm{e}^-$) using superfluid helium as muon-to-muonium converter is being developed at the Paul Scherrer Institute (PSI). This beam could advance laser spectroscopy of muonium and allow the first atomic interferometry experiments for the direct observation of the M gravitational interaction. In this paper, we describe the development of compact detection schemes which resulted in the background-suppressed observation of atomic muonium in vacuum, and can be adapted for cryogenic measurements. Using these setups, we compared the emission characteristics of various muonium production targets using low momentum ($p_{\mu} = 11$-$13~$MeV/c) muons, and observed muonium emission from zeolite targets into vacuum for the first time. For a specific laser-ablated aerogel target, we determined a muon-to-vacuum-muonium conversion efficiency of $7.23 \pm 0.05 \text{(stat)} ^{+1.06}_{-0.76}\text{(sys)}\,\text{%}$, assuming thermal emission of muonium. Moreover, we investigated muonium-helium collisions and from it we determined an upper temperature limit of 0.3 K for the superfluid helium converter.

Published
2022
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2. Large-$N$ Chern insulators: lattice field theory and quantum simulation approaches to correlation effects in the quantum anomalous Hall effect

Author

Ziegler, L., Tirrito, E., Lewenstein, M., Hands, S., and Bermudez, A.

Subjects
Condensed Matter - Quantum Gases, Condensed Matter - Strongly Correlated Electrons, High Energy Physics - Lattice, Quantum Physics
Abstract

Four-Fermi quantum field theories in (2+1) dimensions lie among the simplest models in high-energy physics, the understanding of which requires a non-perturbative lattice formulation addressing their strongly-coupled fixed points. These lattice models are also relevant in condensed matter, as they offer a neat playground to explore strong correlations in the quantum anomalous Hall (QAH) effect. We give a detailed description of our multidisciplinary approach to understand the fate of the QAH phases as the four-Fermi interactions are increased, which combines strong-coupling and effective-potential techniques, unveiling a rich phase diagram with large-$N$ Chern insulators and Lorentz-breaking fermion condensates. Moreover, this toolbox can be enlarged with recent advances in quantum information science, as we show that tensor-network algorithms based on projected entangled pairs can be used to improve our understanding of the strong-coupling limit. We also present a detailed scheme that uses ultra-cold atoms in optical lattices with synthetic spin-orbit coupling to build quantum simulators of these four-Fermi models. This yields a promising alternative to characterise the strongly-coupled fixed points and, moreover, could also explore real-time dynamics and finite-fermion densities.

Published
2021
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3. Correlated Chern insulators in two-dimensional Raman lattices: a cold-atom regularization of strongly-coupled four-Fermi field theories

Author

Ziegler, L., Tirrito, E., Lewenstein, M., Hands, S., and Bermudez, A.

Subjects
Condensed Matter - Quantum Gases, Condensed Matter - Strongly Correlated Electrons, High Energy Physics - Lattice, Quantum Physics
Abstract

We show that ultra-cold atoms with synthetic spin-orbit coupling in Raman lattices can be used as versatile quantum simulators to explore the connections between correlated Chern insulators and strongly-coupled four-Fermi field theories related to the Gross-Neveu model in (2+1) dimensions. Exploiting this multidisciplinary perspective, we identify a large-$N$ quantum anomalous Hall (QAH) effect in absence of any external magnetic field, and use it to delimit regions in parameter space where these correlated topological phases appear, the boundaries of which are controlled by strongly-coupled fixed points of the four-Fermi relativistic field theory. We further show how, for strong interactions, the QAH effect gives way to magnetic phases described by a two-dimensional quantum compass model in a transverse field. We present a detailed description of the phase diagram using the large-$N$ effective potential, and variational techniques such as projected entangled pairs.

Published
2020

10. Pitchfork Bifurcation and Zharov Splitting in Nonlinear Mid-infrared Photothermal Spectroscopy in a liquid crystal using a Quantum Cascade Laser

Author

Mertiri, Alket, Altug, Hatice, Hong, M. K., Mehta, P., Mertz, J., Ziegler, L. D., and Erramilli, Shyamsunder

Subjects
Physics - Optics
Abstract

We report on the mid-infrared nonlinear photothermal spectrum of the neat liquid crystal 4-Octyl-4'-Cyanobiphenyl (8CB) using a tunable Quantum Cascade Laser (QCL). The nonequilibrium steady state characterized by the nonlinear photothermal infrared response undergoes a supercritical pitchfork bifurcation. The bifurcation, observed in heterodyne two-color pump-probe detection, leads to ultrasharp nonlinear infrared spectra similar to those reported in the visible region. A systematic study of the peak splitting as function of absorbed infrared power shows the bifurcation has a critical exponent of 0.5. The surprising observation of an apparently universal critical exponent in a nonequilibrium state is explained using a simple model reminiscent of mean field theory. Apart from the intrinsic interest for nonequilibrium studies, nonlinear photothermal methods lead to a dramatic narrowing of spectral lines, giving rise to a potential new contrast mechanism for the rapidly emerging new field of mid-infrared microspectroscopy using QCLs., Comment: 15 pages, 5 figures, preprint

Published
2013

12. Vibrational line shape effects in plasmon-enhanced stimulated Raman spectroscopies.

Author

Mandal, Aritra and Ziegler, L. D.

Subjects
*RAMAN spectroscopy, *ANTI-Stokes scattering, *DENSITY matrices, *MOLECULAR spectroscopy, *PICOSECOND pulses, *FEMTOSECOND pulses, *SERS spectroscopy
Abstract

A density matrix treatment of plasmon-enhanced (PE) stimulated Raman spectroscopies is developed. Specifically, PE stimulated Raman Gain/Loss (PE-SRG/L) and coherent anti-Stokes Raman scattering (PE-CARS) due to monochromatic excitation and PE femtosecond stimulated Raman spectroscopy (PE-FSRS) are considered. A Lorentz oscillator model is used to explicitly describe the time dependence of plasmon-enhanced optical fields. These temporal characteristics are required for a density matrix based description of all plasmon-enhanced nonlinear molecular spectroscopies. Dispersive vibrational line shapes in PE-SRG/L and PE-FSRS spectra are shown to result primarily from terms proportional to the square of the complex optical field enhancement factor. The dependence on the plasmon resonance, picosecond and femtosecond pulse characteristics, and molecular vibrational properties are evident in the density matrix derived PE-FSRS intensity expression. The difference in signal detection mechanisms accounts for the lack of dispersive line shapes in PE spontaneous Raman spectroscopy. This density matrix treatment of PE-FSRS line shapes is compared with prior coupled wave results. [ABSTRACT FROM AUTHOR]

Published
2021
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16. Non-pharmacological interventions to manage psychological distress in patients living with cancer: a systematic review

Author

Paley, CA, Boland, JW, Santarelli, M, Murtagh, FEM, Ziegler, L, Chapman, EJ, Paley, CA, Boland, JW, Santarelli, M, Murtagh, FEM, Ziegler, L, and Chapman, EJ

Abstract

BACKGROUND: Psychological distress is common in patients with cancer; interfering with physical and psychological wellbeing, and hindering management of physical symptoms. Our aim was to systematically review published evidence on non-pharmacological interventions for cancer-related psychological distress, at all stages of the disease. METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review was registered on PROSPERO (CRD42022311729). Searches were made using eight online databases to identify studies meeting our inclusion criteria. Data were collected on outcome measures, modes of delivery, resources and evidence of efficacy. A meta-analysis was planned if data allowed. Quality was assessed using the Mixed Methods Appraisal Tool (MMAT). RESULTS: Fifty-nine studies with 17,628 participants were included. One third of studies included mindfulness, talking or group therapies. Half of all studies reported statistically significant improvements in distress. Statistically significant intervention effects on distress were most prevalent for mindfulness techniques. Four of these mindfulness studies had moderate effect sizes (d = -0.71[95% CI: -1.04, -0.37] p < 0.001) (d = -0.60 [95% CI: -3.44, -0.89] p < 0.001) (d = -0.77 [CI: -0.146, -1.954] p < 0.01) (d = -0.69 [CI: -0.18, -1.19] p = 0.008) and one had a large effect size (d = -1.03 [95% CI: -1.51, -0.54] p < 0.001). Heterogeneity of studies precluded meta-analysis. Study quality was variable and some had a high risk of bias. CONCLUSIONS: The majority of studies using a mindfulness intervention in this review are efficacious at alleviating distress. Mindfulness-including brief, self-administered interventions-merits further investigation, using adequately powered, high-quality studies. SYSTEMATIC REVIEW REGISTRATION: This systematic review is registered on PROSPERO, number CRD42022311729.

Published
2023

18. Room-temperature emission of muonium from aerogel and zeolite targets

Author

Antognini, A., primary, Crivelli, P., additional, Gerchow, L., additional, Hume, T. D., additional, Kirch, K., additional, Knecht, A., additional, Nuber, J., additional, Papa, A., additional, Ritjoho, N., additional, Sakurai, M., additional, Soter, A., additional, Taqqu, D., additional, Vogiatzi, S. M., additional, Zhang, J., additional, and Ziegler, L., additional

Published
2022
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20. Sleep apnoea in school-age children living at high and low altitude

Author

Grimm, M, primary, Seglias, A, additional, Ziegler, L, additional, Mademilov, M, additional, Isaeva, E, additional, Tynybekov, K, additional, Tilebalieva, A, additional, Osmonbekova, N, additional, Mirzalieva, G, additional, Magdieva, K, additional, Taalaibekova, A, additional, Buenzli, S, additional, Furian, M, additional, Sooronbaev, T, additional, Ulrich, S, additional, and Bloch, K E, additional

Published
2022
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21. Investigation into diseases in free-ranging ring-necked pheasants (Phasianus colchicus) in northwestern Germany during population decline with special reference to infectious pathogens

Author

Curland, N., Gethöffer, F., van Neer, A., Ziegler, L., Heffels-Redmann, U., Lierz, M., Baumgärtner, W., Wohlsein, P., Völker, I., Lapp, S., Bello, A., Pfankuche, V. M., Braune, S., Runge, M., Moss, A., Rautenschlein, S., Jung, A., Teske, L., Strube, C., Schulz, J., Bodewes, R., Osterhaus, A. D. M. E., and Siebert, U.

Published
2018
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24. Large-N Chern insulators: lattice field theory and quantum simulation approaches to correlation effects in the quantum anomalous Hall effect

Author

Ziegler, L., Tirrito, E., Lewenstein, M., Hands, S., Bermúdez Carballo, Alejandro, Ziegler, L., Tirrito, E., Lewenstein, M., Hands, S., and Bermúdez Carballo, Alejandro

Abstract

CRUE-CSIC (Acuerdos Transformativos 2022). © 2022 The Author(s). His is an open access article under the CC BY-NC-ND license. The ICFO group acknowledges support from ERC AdG NOQIA, State Research Agency AEI (‘‘Severo Ochoa’’ Center of Excellence CEX2019-000910-S) Plan National FIDEUA PID2019-106901GB-I00 project funded by MCIN/AEI /10.13039/501100011033, FPI, QUANTERA MAQS PCI2019-111828-2 project funded by MCIN/AEI /10.13039/501100011033, Proyectos de I+D+I ‘‘Retos Colaboración’’ RTC2019-007196-7 project funded by MCIN/AEI /10.13039/501100011033, Fundació Privada Cellex, Fundació Mir-Puig, Generalitat de Catalunya (AGAUR Grant No. 2017 SGR 1341, CERCA program, QuantumCAT U16-011424, co-funded by ERDF Operational Program of Catalonia 2014–2020), EU Horizon 2020 FET-OPEN OPTOLogic (Grant No 899794), and the National Science Centre, Poland (Symfonia Grant No. 2016/20/W/ST4/00314), Marie Skłodowska-Curie grant STREDCH No 101029393, ‘‘La Caixa’’ Junior Leaders fellowships (ID100010434), and EU Horizon 2020 under Marie Skłodowska-Curie grant agreement No. 847648 (LCF/BQ/PI19/11690013, LCF/BQ/PI20/11760031, LCF/BQ/PR20/11770012).). A.B. acknowledges support from the Ramón y Cajal program RYC- 2016-20066, CAM/FEDER Project S2018/TCS- 4342 (QUITEMADCM), and PGC2018-099169-B-I00 (MCIU/AEI/FEDER, UE). S.J.H. acknowledges the support of STFC grant ST/T000813, Four-Fermi quantum field theories in (2+1) dimensions lie among the simplest models in high-energy physics, the understanding of which requires a non-perturbative lattice formulation addressing their strongly-coupled fixed points. These lattice models are also relevant in condensed matter, as they offer a neat playground to explore strong correlations in the quantum anomalous Hall (QAH) effect. We give a detailed description of our multidisciplinary approach to understand the fate of the QAH phases as the four-Fermi interactions are increased, which combines strong-coupling and effective-potential techniques, unveiling a rich phase diagram with large -N Chern insulators and Lorentz breaking fermion condensates. Moreover, this toolbox can be enlarged with recent advances in quantum information science, as we show that tensor-network algorithms based on projected entangled pairs can be used to improve our understanding of the strong-coupling limit. We also present a detailed scheme that uses ultra-cold atoms in optical lattices with synthetic spin- orbit coupling to build quantum simulators of these four-Fermi models. This yields a promising alternative to characterize the strongly-coupled fixed points and, moreover, could also explore real-time dynamics and finite-fermion densities.(c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)., Unión Europea. Horizonte 2020, Ministerio de Ciencia e Innovación (MICINN)/AEI, Ministerio de Ciencia, Innovación y Universidades (MCIU)/AEI/FEDER, National Science Centre, Poland, Comunidad de Madrid/FEDER, Generalidad de Cataluña/FEDER, Centros de Excelencia Severo Ochoa (MICINN), Programa Ramón y Cajal, Depto. de Física Teórica, Fac. de Ciencias Físicas, TRUE, pub

Published
2022

34. Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss

Author

Parsons, Camille M., Judge, Andrew, Leyland, Kirsten, Bruyere, Olivier, Dop, Florence Petit, Chapurlat, Roland, Reginster, Jean-yves, Edwards, Mark H., Dennison, Elaine M., Cooper, Cyrus, Inskip, Hazel, Reginster, J. -y., Christiansen, C., Delmas, P., Genant, H., Zacher, J., Bellamy, N., Speirs, C., Breart, G., Meyer, O., Gensburger, D., Arlot, M., Roux, J. -P., Deroisy, R., Sambrook, P., Leeb, B., Verbruggen, A., Bensen, W. G., Hala, T., Holm−bentzen, M., Valter, I., Chevalier, X., Swoboda, B., Adami, S., Kloppenburg, M., Grazuleviciute, E., Badurski, J., Branco, J., Nasonov, E., Navarro, F., Spector, T., Barnsley, L., Hall, S., Jones, G., Klestov, A., March, L., Nash, P., Romas, E., Will, R., Erlacher, L., Leeb, F. B., Resch, H., Rainer, F., Zamani, O., Appelboom, T., Devogelaer, J. P., Kvasz, A., Raeman, F., Beaulieu, A. D., Brown, J., Cividino, A. A., Morin, F., Olszynski, W. P., Raynauld, J. P., Thorne, J. C., Pavelka, K., Alexandersen, P., Hoeck, H. C., Holm-Bentzen, M., Lundqvist, P., Aim, L., Audouy, P., Beaunier, P., Benhamou, C. L., Berenbaum, F., Chabaud, E., Cohen-Solal, M., Delbecq, D., Euller-Ziegler, L., Fardellone, Patrice, Hilliquin, P., Jacquety, E., Jude, N., Lechevalier, D., Mouchet, J. C., Richette, P., Sainte Lorette, E., Schaeverbeke, T., Sebbah, A., Vignot, E., Brabant, T., Burm-Ester, G. R., Grifka, J., Mueller, P. E. M., Bianchi, G., Grassi, W., Di Matteo, L., Modena, V., Di Munno, O., Orto-Lani, S., Punzi, L., Zangari, M., Roorda, L. D., van Riel, P. L. C. M., Czerwinski, E., Gorecki, A., Tlustochowicz, W., da Silva, J. Canas, Gomes, J. A. Melo, Miranda, L. M., Radulescu, F., Alexeeva, L. I., Orlov-Morozov, A. V., Pikhlak, E. G., Pilyaev, V. G., Shostak, N. A., Shmidt, E. I., Zagorodniy, N. V., Rodriguez, L. Arboleya, Ruiz, P. Benito, Carmona, E. Chamizo, Estevez, E. Collantes, Herrero-Beaumont, G., Mola, E. Martin, Moreno, A., Hernandez, A. Naranjo, Sarabia, F. Navarro, Padrino, J. M., Palacios, C., Serna, A. Rodriguez, Ivorra, J. A. Roman, Torrijos, A., Abdulhakim, E., Arden, N., Birrell, F., Donnachie, H., Fraser, W., Keen, R., Sarmiento, R., Stone, M. D., Grp, Sekoia Study, Department of public health, Université de Liège, Service de Rhumatologie et Pathologie Osseuse [Lyon], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), World Health Organization (WHO), World Health Organization, University of Southampton, University of Bristol [Bristol], Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR), Department of Public Health, Epidemiology and Health Economics, Center for Permafrost (CENPERM), Department of Geosciences and Natural Resource Management [Copenhagen] (IGN), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Queen's University [Kingston, Canada], Department of Computer Science [Auckland], University of Auckland [Auckland], Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Antwerp (UA), Arkema (Arkema), Hutchinson SA, Chair of Aerodynamics and Fluid Mechanics, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Leiden University Medical Center (LUMC), Universiteit Leiden, CEDOC - Department of Rheumatology, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), CHLO/Hospital Egas Moniz, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Radio and Space Plasma Physics Group [Leicester] (RSPP), University of Leicester, School of Environmental Sciences, University of Greenwich, Johns Hopkins University (JHU), University of Queensland [Brisbane], Université Laval [Québec] (ULaval), Intergroupe Francophone de Cancérologie Thoracique [Paris] (IFCT), Intergroupe Francophone de Cancérologie thoracique, Institute of Rheumatology, University Prague, Oskar Klein Centre [Stockholm], Stockholm University, Laboratoire de Réactivité de Surface (LRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Biologie de l'Os et du Cartilage : Régulations et Ciblages Thérapeutiques (BIOSCAR (UMR_S_1132 / U1132)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de rhumatologie, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet, Département de Rhumatologie, CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre Hospitalier Sud Francilien, Laboratoire d'Electronique, d'Informatique et d'Image [EA 7508] (Le2i), Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Aquitaine’s Care and Research organisation for inflammatory and Immune-Mediated diseases [CHU Bordeaux] (FHU ACRONIM), CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL), Department of Bone and Joint Diseases, Faculty of Medicine and Health Sciences, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Departamento de Construcción y Agronomía, Facultad de Ciencias Agrarias y Ambientales, University of Oxford, The University of Sydney, IUMEA, University of Las Palmas de Gran Canaria (ULPGC), the SEKOIA management team, Bradford Teaching Hospitals NHS Foundation Trust [Bradford, Royaume-Uni], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford], APH - Aging & Later Life, and Rehabilitation medicine

Subjects
Male, medicine.medical_specialty, Knee Joint, [SDV]Life Sciences [q-bio], Radiography, Osteoarthritis, Thiophenes, Placebo, Severity of Illness Index, Article, law.invention, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Rheumatology, Randomized controlled trial, Strontium ranelate, law, Internal medicine, Severity of illness, Medicine, Humans, skin and connective tissue diseases, Aged, Bone Density Conservation Agents, business.industry, Reproducibility of Results, Middle Aged, Osteoarthritis, Knee, medicine.disease, Multicenter study, Physical therapy, Disease Progression, Female, sense organs, business, medicine.drug
Abstract

Contains fulltext : 202254.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. METHODS: Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. RESULTS: Between consecutive years, 57-69% of participants had an apparent decrease (change

Published
2019
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36. PE.Di-059 - Un tiers des patients atteints de polyarthrite rhumatoïde (PR) établie sont correctement vaccinés contre la grippe et le pneumocoque et cette proportion augmente : évaluation longitudinale sur 3 ans des 769 patients de l’étude COMEDRA

Author

Gossec, L., Soubrier, M., Frantz, F., Molto, A., Fayet, F., Bardin, T., Balandraud, N., Cerato, M.H., Chalès, G., Valckenaere, I. Chary, Dernis, E., Ziegler, L. Euller, Flipo, R.M., Gaudin, P., Gilson, M., Mariette, X., Mouterde, G., Pouplin, S., Richette, P., Ruyssen-Witrand, A., Saraux, A., Berenbaum, F., Schaeverbeke, T., Sibilia, J., and Dougados, M.

Published
2016
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37. PE.Di-058 - L’auto-évaluation de la maladie dans la polyarthrite rhumatoïde (PR) par l’auto-DAS28 est-elle acceptable au long cours ? Suivi à 3 ans d’un programme réalisé par des infirmiers (COMEDRA) chez 771 patients atteints de PR établie

Author

Gossec, L., Frantz, F., Soubrier, M., Molto, A., Fayet, F., Bardin, T., Berenbaum, F., Cerato, M.H., Chalès, G., Valckenaere, I. Chary, Dernis, E., Ziegler, L. Euller, Flipo, R.M., Gaudin, P., Gilson, M., Guis, S., Mariette, X., Mouterde, G., Pouplin, S., Richette, P., Ruyssen-Witrand, A., Saraux, A., Schaeverbeke, T., Sibilia, J., and Dougados, M.

Published
2016
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38. PE.Di-057 - Le dépistage et la prévention des comorbidités dans la polyarthrite rhumatoïde (PR) après un programme d’information par infirmier : suivi à 3 ans de 769 patients atteints de PR établie de l’étude COMEDRA

Author

Gossec, L., Soubrier, M., Frantz, F., Molto, A., Fayet, F., Bardin, T., Berenbaum, F., Cerato, M.H., Chalès, G., Valckenaere, I. Chary, Dernis, E., Ziegler, L. Euller, Flipo, R.M., Gaudin, P., Gilson, M., Guis, S., Mariette, X., Mouterde, G., Pouplin, S., Richette, P., Ruyssen-Witrand, A., Saraux, A., Schaeverbeke, T., Sibilia, J., and Dougados, M.

Published
2016
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40. Optogenetic activation of striatal D1/D2 medium spiny neurons differentially engages downstream connected areas beyond the basal ganglia

Author

Daniel Razansky, Johannes Bohacek, Nici Wenderoth, Klaas E. Stephan, Oliver Sturman, von Ziegler L, Steger C, Christina Grimm, Stefan Frässle, Zerbi, and Noam Shemesh

Subjects
education.field_of_study, Thalamus, Population, Striatum, Optogenetics, Biology, Medium spiny neuron, medicine.anatomical_structure, Basal ganglia, medicine, Motor learning, education, Neuroscience, Motor cortex
Abstract

The basal ganglia (BG) are a group of subcortical nuclei responsible for motor control, motor learning and executive function. Central to BG function are striatal medium spiny neurons (MSNs) expressing D1 and D2 dopamine receptors. D1 and D2 MSNs are typically considered functional antagonists that facilitate voluntary movements and inhibit competing motor patterns, respectively. While their opposite role is well documented for certain sensorimotor loops of the BG-thalamocortical network, it is unclear whether MSNs maintain a uniform functional role across the striatum and which influence they exert on brain areas outside the BG. Here, we addressed these questions by combining optogenetic activation of D1 and D2 MSNs in the mouse ventrolateral caudoputamen (vl CPu) with whole-brain functional MRI (fMRI) recordings. Neuronal excitation of either cell population in the vl CPu evoked distinct activity patterns in key regions of the BG-thalamocortical network including the pallidum, thalamus and motor cortex. Importantly, we report that striatal D1 and D2 MSN stimulation differentially engaged cerebellar and prefrontal regions. We characterised these long-range interactions by computational modelling of effective connectivity and confirmed that changes in D1 / D2 output drive functional relationships between regions within and beyond the BG. These results suggest a more complex functional organization of MSNs across the striatum than previously anticipated and provide evidence for the existence of an interconnected fronto - BG - cerebellar network modulated by striatal D1 and D2 MSNs.Graphical Abstract

Published
2021
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41. Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study

Author

Lloyd, KE, Hall, LH, Ziegler, L, and Smith, SG

Abstract

Purpose\ud \ud Women’s worry about developing breast cancer may influence their decision to use preventive therapy. However, the direction of this relationship has been questioned. We prospectively investigated the relationship between breast cancer worry and uptake of preventive therapy. The socio-demographic and clinical factors associated with high breast cancer worry were also investigated.\ud \ud \ud \ud Methods\ud \ud Women at increased risk of developing breast cancer were recruited from clinics across England (n = 408). Participants completed a survey on their breast cancer worry, socio-demographic and clinical factors. Uptake of tamoxifen was recorded at 3 months (n = 258 women, 63.2%). Both primary and sensitivity analyses were conducted using different classifications of low, medium and high worry.\ud \ud \ud \ud Results\ud \ud 39.5% of respondents reported medium breast cancer worry at baseline and 21.2% reported high worry. Ethnic minority women were more likely to report high worry than white women (OR = 3.02, 95%CI 1.02, 8.91, p = 0.046). Women educated below degree level were more likely to report high worry than those with higher education (OR = 2.29, 95%CI 1.28, 4.09, p = 0.005). No statistically significant association was observed between worry and uptake. In the primary analysis, fewer respondents with medium worry at baseline initiated tamoxifen (low worry = 15.5%, medium = 13.5%, high = 15.7%). In the sensitivity analysis, participants with medium worry reported the highest uptake of tamoxifen (19.7%).\ud \ud \ud \ud Conclusions\ud \ud No association was observed between worry and uptake, although the relationship was affected by the categorisation of worry. Standardised reporting of the classification of worry is warranted to allow transparent comparisons across cohorts.

Published
2021

49. Translatomic profiling of the acute stress response: It’s a TRAP

Author

Pierre-Luc Germain, Johannes Bohacek, and von Ziegler L

Subjects
Fight-or-flight response, Cell type, Genotype, Gene expression, RNA, Translation (biology), Biology, Gene, Ribosome, Cell biology
Abstract

The impact of stress on gene expression in different cell types of the brain remains poorly characterized. Three pioneering studies have recently used translating ribosome affinity purification followed by RNA sequencing (TRAP-seq) to assess the response to stress in CA3 pyramidal neurons of the hippocampus. The results suggest that acute stress alters the translation of thousands of genes in CA3 pyramidal neurons, and that this response is strongly modulated by factors such as sex, genotype and a history of early life stress. However, our reanalysis of these datasets leads to different conclusions. We confirm that acute stress induces robust translational changes in a small set of genes. However, we found no evidence that either early life stress or sex have an effect on gene translation induced by acute stress. Our findings highlight the need for additional studies with adequate sample sizes and proper methods of analysis to assess the impact of stress across cell types in the brain.

Published
2020
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