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145 results on '"Zieker, D."'

3. Einfluss des IDO2 Inhibitors D-1-Methyltryptophan auf die IDO Aktivität humaner Tumore und dendritischer Zellen

Author

Löb, S., Terness, P., Zieker, D., Schäfer, R., Brücher, B., Rammensee, H. -G., Königsrainer, A., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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4. Laktat stimuliert Kollagensynthese, VEGF Expression und Migration von Endothelzellen durch Produktion von Sauerstoffradikalen

Author

Zieker, D., Küper, M., Löffler, M., Northoff, H., Königsrainer, A., Hunt, T. K., Beckert, S., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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5. Laktat moduliert die Genexpression mesenchymaler Stammzellen (MSC)

Author

Zieker, D., Schäfer, R., Coerper, S., Königsrainer, A., Northoff, H., Hunt, T. K., Beckert, Stefan, Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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16. Randomized-controlled-trial to prevent peritnoal seeding in gastric cancer

Author

Zieker, D

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: The gastric carcinoma is one of the four most common tumors occurring worldwide. The advanced phase is characterized by metastasis and poses a very poor prognosis for survival. In 20%-30% of gastric carcinomas the tumor spreads into the abdominal cavity, which leads to metastases[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013
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17. Rezidive nach Peritonektomie und intraoperativer hyperthermer Chemotherapie (HIPEC) bei metachroner Peritonealkarzinose

Author

Königsrainer, I, Zieker, D, Glatzle, J, Fehm, T, Forkl, V, Brücher, B, Königsrainer, A, and Beckert, S

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Peritonektomieund intraoperative hypertherme Chemotherapie (HIPEC) verbessert bei selektionierten Patienten das Überleben im Vergleich zur alleinigen palliativen Chemotherapie. Risikofaktoren für Tumorrezidive nach zytoreduktiver Chirurgie sind bisher nicht bekannt. Material[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2012
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18. Wie baut man ein Peritonealkarzinosezentrum auf? Erste Erfahrungen nach 100 konsekutiven Peritonektomien mit hyperthermer intraabdomineller Chemotherapie (HIPEC) aus Tübingen

Author

Königsrainer, I, Zieker, D, Löb, S, Grischke, EM, Mayer, F, Beckert, S, Brücher, B, and Königsrainer, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Peritonealkarzinose (PC) gilt bei den allermeisten Patienten mit gastrointestinalen und gynäkologischen Tumoren als Endstadium der Erkrankung. Nachdem das Abdomen als geschlossenes Kompartment gesehen werden kann, besteht bei selektionierten Patienten noch eine kurative chirurgische[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
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19. Die PGK1-Überexpression im Magenkarzinom induziert Metastasierung und peritoneale Tumoraussaat

Author

Königsrainer, I, Beckert, S, Glatzle, J, Brücher, B, Königsrainer, A, and Zieker, D

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Metastasen und Peritonealkarzinose sind die wesentlichen limitierenden Prognosefaktoren beim diffusen Magenkarzinom. Dabei scheint die Überexpression des glykolytischen Enzyms PGK1 eine Schlüsselrolle zu spielen. Material und Methoden: In einem orthotopen humanen Magenkarzinomtumormodell[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
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20. PGK1: ein Schlüsselmolekül für die Entstehung der Peritonealkarzinose beim Magenkarzinom

Author

Zieker, D., Königsrainer, I., Traub, F., Beckert, S., Nieselt, K., Northoff, H., Brücher, B., and Königsrainer, A.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Ausbildung einer Peritonealkarzinose beim diffusen Magenkarzinom ist prognostisch ein limitierender Prognosefaktor. Die Überexprimierung von PGK1 und seinen Signalmolekülen CXCR4 und CXCL12 bei peritoneal metastasierten diffusen Magenkarzinomen, deutet darauf hin, dass dieser[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009

21. Preoperative FDG-PET-CT correlates with intraoperative findings in patients with peritoneal carcinomatosis

Author

Königsrainer, I., Zieker, D., Aschoff, P., Beckert, S., Hartmann, J., Pfannenberg, C., Fend, F., Brücher, B.L., and Königsrainer, A.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Peritoneal carcinomatosis until recently were considered incurable. Interdisciplinary multimodal therapy including extensive cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) offers significant survival benefit. So far, no radiomorphological imaging can[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009

22. Einfluss des IDO2-Blockers D-1MT auf die IDO-Aktivität humaner Tumoren und dendritischer Zellen

Author

Löb, S., Terness, P., Zieker, D., Schäfer, R., Brücher, B., Rammensee, H.G., and Königsrainer, A.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Clinical phase-I-trials with cancer patients have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine-2,3-dioxygenase (IDO) with the IDO2-inhibitor dextro-1-methyl-tryptophan (D-1MT). In this study we analyzed IDO2- and IDO1-expression[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009

23. Identifizierung von Progressionsgenen bei Patienten mit GERD, Barrett-Ösophagus und Ösophaguskarzinomen mittels MicroArray-Technologie

Author

Zieker, D., Traub, F., Nieselt, K., Northoff, H., Königsrainer, A., and Brücher, B.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Bei dem Großteil der Patienten mit Adenokarzinomen des Ösophagus geht der Tumor aus einem sog. Barrett-Ösophagus hervor. Dieser kann wiederum aus einem gastroösophagealen Reflux (GERD) entstehen. Allerdings entwickeln nur etwa 10% der GERD-Patienten einen Barrett[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009

24. Aberrant Expression of Checkpoint-Kinases in pancreatic carcinomas

Author

Traub, F., Gaedcke, J., Zieker, D., Kupka, S., Zug, C., Ghadimi, M., Brücher, B.L.D.M., and Königsrainer, A.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Over the past two decades, research aimed at understanding and fighting the complex mechanisms of cellular transformation which lead to tumor development and helped to improve the detection and treatment of many cancers. However, some tumors have not benefited from these advances. Among[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009

25. Fresh mesothelial lesions highly attract free floating intraperitoneal colorectal tumour cells in a rat model

Author

Königsrainer, I, Zieker, D, Beckert, S, Weyhern von, C, Löb, S, Falch, C, Brücher, BL, Königsrainer, A, and Glatzle, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Intraperitoneal free cancer cells are associated with a higher risk of recurrence and a poorer prognosis in colorectal surgery. Tumour recurrence may occur early after surgery. One potential mechanism is the ability of peritoneal lesions to attract tumour cells. Material and methods:[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009
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26. Laktat stimuliert Kollagensynthese, VEGF Expression und Migration von Endothelzellen durch Produktion von Sauerstoffradikalen

Author

Zieker, D, Küper, M, Löffler, M, Northoff, H, Königsrainer, A, Hunt, TK, and Beckert, S

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Wunden sind biochemisch durch hohe Laktatspiegel im Gewebe charakterisiert. Die Substanz Laktat wurde dabei lange Zeit lediglich als Abfallprodukt anaerober Stoffwechselvorgänge angesehen. In der Vergangenheit konnten jedoch zahlreiche positive Effekte von Laktat auf die Wundheilung[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009
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33. Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer

Author

Zieker, D, Königsrainer, I, Tritschler, I, Löffler, M, Beckert, S, Traub, F, Nieselt, K, Bühler, S, Weller, M, Gaedcke, J, Taichman, R S, Northoff, H, Brücher, B L D M, Königsrainer, A, Zieker, D, Königsrainer, I, Tritschler, I, Löffler, M, Beckert, S, Traub, F, Nieselt, K, Bühler, S, Weller, M, Gaedcke, J, Taichman, R S, Northoff, H, Brücher, B L D M, and Königsrainer, A

Abstract

Peritoneal carcinomatosis is a frequent finding in gastric cancer associated with a poor prognosis. The features that enable gastric tumors to disseminate are poorly understood until now. Previously, we showed elevated mRNA levels of phosphoglycerate kinase 1 (PGK1), an ATP-generating enzyme in the glycolytic pathway, the chemokine receptor 4 (CXCR4), the corresponding chemokine ligand 12 (CXCL12) and beta-catenin in specimens from gastric cancer patients with peritoneal carcinomatosis. In this study the influence of PGK1 on CXCR4 and beta-catenin was assessed as well as the invasiveness of PGK1 overexpressing cancer cells. In this current study we found that PGK1 regulates the expression of CXCR4 and beta-catenin at the mRNA and protein levels. On the other hand, CXCR4 regulates the expression of PGK1. Plasmid-mediated overexpression of PGK1 dramatically increased the invasiveness of gastric cancer cells. Interestingly, inhibition of CXCR4 in cells overexpressing PGK1 produced only a moderate reduction of invasiveness, suggesting that PGK1 itself has a critical role in tumor invasiveness. Immunohistochemistry in specimens from diffuse gastric cancer patients also revealed an overexpression of PGK1 in patients with development of peritoneal carcinomatosis. Therefore, PGK1 may be a crucial enzyme in peritoneal dissemination. Together these findings suggest that the enhanced expression of PGK1 and its signaling targets CXCR4 and beta-catenin in gastric cancer cells promote peritoneal carcinomatosis. Thus, PGK1 may serve as prognostic marker and/or be a potential therapeutic target to prevent dissemination of gastric carcinoma cells into the peritoneum. (c) 2009 UICC.

Published
2010

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