375 results on '"Zili Xie"'
Search Results
2. High Bandwidth Semi-Polar InGaN/GaN Micro-LEDs With Low Current Injection for Visible Light Communication
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Feifan Xu, Pengjiang Qiu, Tao Tao, Pengfei Tian, Xiaoyan Liu, Ting Zhi, Zili Xie, Bin Liu, and Rong Zhang
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Light-emitting diodes (LEDs) ,modulation bandwidth ,semi-polar InGaN/GaN MQWs ,visible light communication (VLC) ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
Micro-light-emitting diodes (micro-LEDs) with high modulation rates and low power consumption could attract growing attention as visible light communication (VLC) technology advances. The designed and fabricated semi-polar micro-LEDs have achieved high bandwidth at low current injection due to the reduced quantum-confined Stark effect (QCSE), which was significantly greater than that of typical c-plane at the same current injection. Semi-polar green micro-LEDs got a −3 dB bandwidth that surpasses 500 MHz and 1 GHz at low current densities of 43.8 A/cm2 and 120.6 A/cm2, while blue micro-LEDs exceed 500 MHz at low current densities of 76.6 A/cm2, respectively. Additionally, the free space VLC system has shown semi-polar blue and green micro-LED transmission data rates of 3.495 Gbps (433 A/cm2) and 3.483 Gbps (402 A/cm2) respectively. Semi-polar micro-LEDs, which can achieve low power consumption and high bandwidth, are anticipated to play a significant role in the development of energy-efficient VLC in the future.
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- 2023
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3. Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters
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Weiwei Yu, Zhen Wang, Xiafei Yu, Yonghui Zhao, Zili Xie, Kailian Zhang, Zhexu Chi, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Yuxian Guo, Xuyan Yang, Xue Zhang, Yingliang Wu, Wei Yang, and Di Wang
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Science - Abstract
Potassium channels and membrane potential may influence macrophage function during inflammation. Here the authors show that the Kir2.1 potassium channel affects macrophage metabolism by altering cell surface retention of nutrient transporters and subsequently regulates inflammatory disease responses.
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- 2022
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4. A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain
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Xueming Hu, Lixia Du, Shenbin Liu, Zhou Lan, Kaikai Zang, Jing Feng, Yonghui Zhao, Xingliang Yang, Zili Xie, Peter L. Wang, Aaron M. Ver Heul, Lvyi Chen, Vijay K. Samineni, Yan-Qing Wang, Kory J. Lavine, Robert W. Gereau IV, Gregory F. Wu, and Hongzhen Hu
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Neuroscience ,Medicine - Abstract
Microglia, resident macrophages of the CNS, are essential to brain development, homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS diseases, including neuropathic pain. However, molecular mechanisms that govern the spinal neuroimmune axis in the setting of neuropathic pain remain incompletely understood. Here, we show that genetic ablation or pharmacological blockade of transient receptor potential vanilloid type 4 (TRPV4) markedly attenuated neuropathic pain-like behaviors in a mouse model of spared nerve injury. Mechanistically, microglia-expressed TRPV4 mediated microglial activation and proliferation and promoted functional and structural plasticity of excitatory spinal neurons through release of lipocalin-2. Our results suggest that microglial TRPV4 channels reside at the center of the neuroimmune axis in the spinal cord, which transforms peripheral nerve injury into central sensitization and neuropathic pain, thereby identifying TRPV4 as a potential new target for the treatment of chronic pain.
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- 2023
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5. How should we define a nociceptor in the gut-brain axis?
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Nick J. Spencer, Tim Hibberd, Zili Xie, and Hongzhen Hu
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pain ,nociception ,spinal afferent ,visceral pain ,colon ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
In the past few years, there has been extraordinary interest in how the gut communicates with the brain. This is because substantial and gathering data has emerged to suggest that sensory nerve pathways between the gut and brain may contribute much more widely in heath and disease, than was originally presumed. In the skin, the different types of sensory nerve endings have been thoroughly characterized, including the morphology of different nerve endings and the sensory modalities they encode. This knowledge is lacking for most types of visceral afferents, particularly spinal afferents that innervate abdominal organs, like the gut. In fact, only recently have the nerve endings of spinal afferents in any visceral organ been identified. What is clear is that spinal afferents play the major role in pain perception from the gut to the brain. Perhaps surprisingly, the majority of spinal afferent nerve endings in the gut express the ion channel TRPV1, which is often considered to be a marker of “nociceptive” neurons. And, a majority of gut-projecting spinal afferent neurons expressing TRPV1 are activated at low thresholds, in the “normal” physiological range, well below the normal threshold for detection of painful sensations. This introduces a major conundrum regarding visceral nociception. How should we define a “nociceptor” in the gut? We discuss the notion that nociception from the gut wall maybe a process encrypted into multiple different morphological types of spinal afferent nerve ending, rather than a single class of sensory ending, like free-endings, suggested to underlie nociception in skin.
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- 2022
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6. H-Terminated Diamond MOSFETs on High-Quality Diamond Film Grown by MPCVD
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Wenxiao Hu, Xinxin Yu, Tao Tao, Kai Chen, Yucong Ye, Jianjun Zhou, Zili Xie, Yu Yan, Bin Liu, and Rong Zhang
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single-crystal ,diamond ,MPCVD ,H-diamond ,MOSFET ,Crystallography ,QD901-999 - Abstract
Diamond-based transistors have been considered as one of the best choices due to the numerous advantages of diamond. However, difficulty in the growth and fabrication of diamond needs to be addressed. In this paper, high quality diamond film with an atomically flat surface was grown by microwave plasma chemical vapor deposition. High growth rate, as much as 7 μm/h, has been acquired without nitrogen doping, and the root mean square (RMS) of the surface roughness was reduced from 0.92 nm to 0.18 nm by using a pre-etched process. H-terminated diamond MOSFETs were fabricated on a high-quality epitaxial diamond layer, of which the saturated current density was enhanced. The hysteresis of the transfer curve and the shift of the threshold voltage were significantly reduced as well.
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- 2023
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7. A Simulation of Thermal Management Using a Diamond Substrate with Nanostructures
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Tingting Liu, Kaiwen Zheng, Tao Tao, Wenxiao Hu, Kai Chen, Ting Zhi, Yucong Ye, Zili Xie, Yu Yan, Bin Liu, and Rong Zhang
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diamond ,nanostructures ,thermal management ,comsol ,simulation ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
In recent years, the rapid progress in the field of GaN-based power devices has led to a smaller chip size and increased power usage. However, this has given rise to increasing heat aggregation, which affects the reliability and stability of these devices. To address this issue, diamond substrates with nanostructures were designed and investigated in this paper. The simulation results confirmed the enhanced performance of the device with diamond nanostructures, and the fabrication of a diamond substrate with nanostructures is demonstrated herein. The diamond substrate with square nanopillars 2000 nm in height exhibited optimal heat dissipation performance. Nanostructures can effectively decrease heat accumulation, resulting in a reduction in temperature from 121 °C to 114 °C. Overall, the simulation and experimental results in this work may provide guidelines and help in the development of the advanced thermal management of GaN devices using diamond micro/nanostructured substrates.
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- 2023
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8. The Study on the Lasing Modes Modulated by the Dislocation Distribution in the GaN-Based Microrod Cavities
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Yuyin Li, Peng Chen, Xianfei Zhang, Ziwen Yan, Tong Xu, Zili Xie, Xiangqian Xiu, Dunjun Chen, Hong Zhao, Yi Shi, Rong Zhang, and Youdou Zheng
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GaN ,microrod cavity ,low-threshold ,dislocation ,whispering gallery mode ,Chemistry ,QD1-999 - Abstract
Low-threshold lasing under pulsed optical pumping is demonstrated in GaN-based microrod cavities at room temperature, which are fabricated on the patterned sapphire substrates (PSS). Because the distribution of threading dislocations (TDs) is different at different locations, a confocal micro-photoluminescence spectroscopy (μ-PL) was performed to analyze the lasing properties of the different diameter microrods at the top of the triangle islands and between the triangle islands of the PSS substrates, respectively. The μ-PL results show that the 2 μm-diameter microrod cavity has a minimum threshold of about 0.3 kW/cm2. Whispering gallery modes (WGMs) in the microrod cavities are investigated by finite-difference time-domain simulation. Combined with the dislocation distribution in the GaN on the PSS substrates, it is found that the distribution of the strongest lasing WGMs always moves to the region with fewer TDs. This work reveals the connection between the lasing modes and the dislocation distribution, and can contribute to the development of low-threshold and high-efficiency GaN-based micro-lasers.
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- 2023
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9. Progress on AlGaN-based solar-blind ultraviolet photodetectors and focal plane arrays
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Qing Cai, Haifan You, Hui Guo, Jin Wang, Bin Liu, Zili Xie, Dunjun Chen, Hai Lu, Youdou Zheng, and Rong Zhang
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Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
Abstract Solar-blind ultraviolet (UV) photodetectors (PDs) have attracted tremendous attention in the environmental, industrial, military, and biological fields. As a representative III-nitride material, AlGaN alloys have broad development prospects in the field of solar-blind detection due to their superior properties, such as tunable wide bandgaps for intrinsic UV detection. In recent decades, a variety of AlGaN-based PDs have been developed to achieve high-precision solar-blind UV detection. As integrated optoelectronic technology advances, AlGaN-based focal plane arrays (FPAs) are manufactured and exhibit outstanding solar-blind imaging capability. Considering the rapid development of AlGaN detection techniques, this paper comprehensively reviews the progress on AlGaN-based solar-blind UV PDs and FPAs. First, the basic physical properties of AlGaN are presented. The epitaxy and p-type doping problems of AlGaN alloys are then discussed. Diverse PDs, including photoconductors and Schottky, metal–semiconductor–metal (MSM), p-i-n, and avalanche photodiodes (APDs), are demonstrated, and the physical mechanisms are analyzed to improve device performance. Additionally, this paper summarizes imaging technologies used with AlGaN FPAs in recent years. Benefiting from the development of AlGaN materials and optoelectronic devices, solar-blind UV detection technology is greeted with significant revolutions. Summarizing recent advances in the processing and properties of AlGaN-based solar-blind UV PDs and FPAs as well as AlGaN growth and doping techniques.
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- 2021
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10. Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
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William R. Arnold, Lauren N. Carnevale, Zili Xie, Javier L. Baylon, Emad Tajkhorshid, Hongzhen Hu, and Aditi Das
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Science - Abstract
Endocannabinoids are ligands of cannabinoid receptors and a promising target for pain management. Here, the authors report a class of lipids formed by the epoxidation of N-arachidonoyl dopamine and N-arachidonoyl serotonin by cytochrome P450 epoxygenases, which reciprocally regulate canabinoid receptors and display anti-inflammatory activity.
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- 2021
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11. High Performance Wide Angle DBR Design for Optoelectronic Devices
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Ting Zhi, Tao Tao, Bin Liu, Yu Yan, Zili Xie, Hong Zhao, and Dunjun Chen
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Distributed Bragg Reflector (DBR) mirror ,SiO2/TI3O5 ,light emitting diodes ,PEC ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
To improve the performance of optoelectronic devices, a high performance wide angle SiO2/Ti3O5 Distributed Bragg Reflector (DBR) mirror was designed and fabricated on double polished sapphire substrate. 17-pairs gradually varied DBR structure was applied in order to acquire a broad stopband reflectivity over 95% from 400 nm to 800 nm, covering the whole visible light region. The DBR mirrors deposited at the backside of optoelectronics devices are also demonstrated to remain a high reflectivity at wide incident angles, which improves the emission efficiency of LEDs and light absorption efficiency of InGaN/GaN photoelectrochemical cell (PEC).
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- 2021
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12. Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain
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Zili Xie, Jing Feng, Tao Cai, Ronald McCarthy, Mark D. Eschbach II, Yuhui Wang, Yonghui Zhao, Zhihua Yi, Kaikai Zang, Yi Yuan, Xueming Hu, Fengxian Li, Qin Liu, Aditi Das, Sarah K. England, and Hongzhen Hu
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Neuroscience ,Medicine - Abstract
Pain emanating from the female reproductive tract is notoriously difficult to treat, and the prevalence of transient pelvic pain has been placed as high as 70%–80% in women surveyed. Although sex hormones, especially estrogen, are thought to underlie enhanced pain perception in females, the underlying molecular and cellular mechanisms are not completely understood. Here, we showed that the pain-initiating TRPA1 channel was required for pain-related behaviors in a mouse model of estrogen-induced uterine pain in ovariectomized female mice. Surprisingly, 2- and 4-hydroxylated estrogen metabolites (2- and 4-HEMs) in the estrogen hydroxylation pathway, but not estrone, estradiol, or 16-HEMs, directly increased nociceptor hyperactivity through TRPA1 and TRPV1 channels, and picomolar concentrations of 2- and 4-hydroxylation estrone (2- or 4-OHE1) could sensitize TRPA1 channel function. Moreover, both TRPA1 and TRPV1 were expressed in uterine-innervating primary nociceptors, and their expression was increased in the estrogen-induced uterine pain model. Importantly, pretreatment with 2- or 4-OHE1 recapitulated estrogen-induced uterine pain-like behaviors, and intraplantar injections of 2- and 4-OHE1 directly produced a TRPA1-dependent mechanical hypersensitivity. Our findings demonstrated that TRPA1 is critically involved in estrogen-induced uterine pain-like behaviors, which may provide a potential drug target for treating female reproductive tract pain.
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- 2022
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13. 1.4-kV Quasi-Vertical GaN Schottky Barrier Diode With Reverse p-n Junction Termination
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Ru Xu, Peng Chen, Menghan Liu, Jing Zhou, Yunfei Yang, Yimeng Li, Cheng Ge, Haocheng Peng, Bin Liu, Dunjun Chen, Zili Xie, Rong Zhang, and Youdou Zheng
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Vertical GaN-on-Sapphire Schottky barrier diode ,reverse p-n GaN junction ,breakdown voltage ,power FOM ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
In this paper, we demonstrate high-performance quasi-vertical GaN-on-Sapphire Schottky barrier diodes (SBD) with a reverse GaN p-n junction termination (RPN). The SBD has a current output of 1 kA/cm2 at $V_{F}=2.5$ V, a low $V_{on}$ of 0.66 V ± 0.017 V, a low $R_{on,sp}$ of 1.4 $\text{m}\Omega \cdot $ cm2, current ON/OFF ratio of over $10^{9}$ (−3 V~3 V). By introducing the RPN, the breakdown voltage can boost from 459 V to 1419 V, and power figure-of-merit (FOM) can reach 1438 MV/cm2. It is shown that the presence of the RPN with a suitable anode recess depth can generate an electric field (EF) opposite to the built-in EF at the center of the second top p-n junction, which can decrease the EF peak intensity and make the electric field more uniformly distributed inside the device. Finally, the leakage current of the SBD is inhibited and the breakdown voltage is increased.
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- 2020
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14. Modification of Neurogenic Colonic Motor Behaviours by Chemogenetic Ablation of Calretinin Neurons
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Jing Feng, Tim J. Hibberd, Jialie Luo, Pu Yang, Zili Xie, Lee Travis, Nick J. Spencer, and Hongzhen Hu
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colonic motor complex ,IPAN ,enteric nervous system ,large intestine ,colon ,sensory neuron ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
How the enteric nervous system determines the pacing and propagation direction of neurogenic contractions along the colon remains largely unknown. We used a chemogenetic strategy to ablate enteric neurons expressing calretinin (CAL). Mice expressing human diphtheria toxin receptor (DTR) in CAL neurons were generated by crossing CAL-ires-Cre mice with Cre-dependent ROSA26-DTR mice. Immunohistochemical analysis revealed treatment with diphtheria toxin incurred a 42% reduction in counts of Hu-expressing colonic myenteric neurons (P = 0.036), and 57% loss of CAL neurons (comprising ∼25% of all Hu neurons; P = 0.004) compared to control. As proportions of Hu-expressing neurons, CAL neurons that contained nitric oxide synthase (NOS) were relatively spared (control: 15 ± 2%, CAL-DTR: 13 ± 1%; P = 0.145), while calretinin neurons lacking NOS were significantly reduced (control: 26 ± 2%, CAL-DTR: 18 ± 5%; P = 0.010). Colonic length and pellet sizes were significantly reduced without overt inflammation or changes in ganglionic density. Interestingly, colonic motor complexes (CMCs) persisted with increased frequency (mid-colon interval 111 ± 19 vs. 189 ± 24 s, CAL-DTR vs. control, respectively, P < 0.001), decreased contraction size (mid-colon AUC 26 ± 24 vs. 59 ± 13 gram/seconds, CAL-DTR vs. control, respectively, P < 0.001), and lacked preferential anterograde migration (P < 0.001). The functional effects of modest calretinin neuron ablation, particularly increased neurogenic motor activity frequencies, differ from models that incur general enteric neuron loss, and suggest calretinin neurons may contribute to pacing, force, and polarity of CMCs in the large bowel.
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- 2022
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15. Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis
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Yu Wang, Yan Yue, Ruoyang Jia, Xinyi Liu, Zhiqing Cheng, Yongfeng Cheng, Yinxiang Xu, Zili Xie, and Hongmei Xia
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paeonol ,thermosensitive gel ,liposome–hydrogel ,antioxidant ,atopic dermatitis ,Science ,Chemistry ,QD1-999 ,Inorganic chemistry ,QD146-197 ,General. Including alchemy ,QD1-65 - Abstract
Paeonol (PAE) is a hydrophobic drug. In this study, we encapsulated paeonol in a lipid bilayer of liposomes (PAE-L), which delayed drug release and increased drug solubility. When PAE-L was dispersed in gels (PAE-L-G) based on a poloxamer matrix material for local transdermal delivery, we observed amphiphilicity, reversible thermal responsiveness, and micellar self-assembly behavior. These gels can be used for atopic dermatitis (AD), an inflammatory skin disease, to change the surface temperature of the skin. In this study, we prepared PAE-L-G at an appropriate temperature for the treatment of AD. We then assessed the gel’s relevant physicochemical properties, in vitro cumulative drug release, and antioxidant properties. We found that PAE-loaded liposomes could be designed to increase the drug effect of thermoreversible gels. At 32 °C, PAE-L-G could change from solution state to gelatinous state at 31.70 ± 0.42 s, while the viscosity was 136.98 ± 0.78 MPa.S and the free radical scavenging rates on DPPH and H2O2 were 92.24 ± 5.57% and 92.12 ± 2.71%, respectively. Drug release across the extracorporeal dialysis membrane reached 41.76 ± 3.78%. In AD-like mice, PAE-L-G could also relieve skin damage by the 12th day. In summary, PAE-L-G could play an antioxidant role and relieve inflammation caused by oxidative stress in AD.
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- 2023
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16. Simulation Study on the Structure Design of p-GaN/AlGaN/GaN HEMT-Based Ultraviolet Phototransistors
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Haiping Wang, Haifan You, Jiangui Yang, Minqiang Yang, Lu Wang, Hong Zhao, Zili Xie, and Dunjun Chen
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ultraviolet (UV) ,phototransistors (PTs) ,p-GaN/AGaN/GaN ,HEMTs ,Silvaco ,simulation ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
This work investigates the impacts of structural parameters on the performances of p-GaN/AlGaN/GaN HEMT-based ultraviolet (UV) phototransistors (PTs) using Silvaco Atlas. The simulation results show that a larger Al content or greater thickness for the AlGaN barrier layer can induce a higher two-dimensional electron gas (2DEG) density and produce a larger photocurrent. However, they may also lead to a larger dark current due to the incomplete depletion of the GaN channel layer. The depletion conditions with various Al contents and thicknesses of the AlGaN layer are investigated in detail, and a borderline between full depletion and incomplete depletion was drawn. An optimized structure with an Al content of 0.23 and a thickness of 14 nm is achieved for UV-PT, which exhibits a high photocurrent density of 92.11 mA/mm, a low dark current density of 7.68 × 10−10 mA/mm, and a large photo-to-dark-current ratio of over 1011 at a drain voltage of 5 V. In addition, the effects of other structural parameters, such as the thickness and hole concentration of the p-GaN layer as well as the thickness of the GaN channel layer, on the performances of the UV-PTs are also studied in this work.
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- 2022
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17. Improved Optical and Electrical Characteristics of GaN-Based Micro-LEDs by Optimized Sidewall Passivation
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Zhifang Zhu, Tao Tao, Bin Liu, Ting Zhi, Yang Chen, Junchi Yu, Di Jiang, Feifan Xu, Yimeng Sang, Yu Yan, Zili Xie, and Rong Zhang
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Micro-LED ,sidewall damage ,passivation process ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
GaN-based Micro-LED has been widely regarded as the most promising candidate for next generation of revolutionary display technology due to its advantages of high efficiency, high brightness and high stability. However, the typical micro-fabrication process would leave a great number of damages on the sidewalls of LED pixels, especially for Micro-LEDs, thus reducing the light emitting efficiency. In this paper, sidewall passivation methods were optimized by using acid-base wet etching and SiO2 layer passivation. The optical and electrical characteristics of optimized Micro-LEDs were measured and analyzed. The internal quantum efficiency (IQE) of Micro-LED was increased to 85.4%, and the reverse leakage current was reduced down to 10−13 A at −5 V. Optimized sidewall passivation can significantly reduce the non-radiative recombination centers, improving the device performance and supporting the development of high-resolution Micro-LED display.
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- 2022
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18. Electrically Injected Hybrid Organic/Inorganic III-Nitride White Light-Emitting Diodes Based on Rubrene/(InGaN/GaN) Multiple-Quantum-Wells P-N Junction
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Danbei Wang, Bin Liu, Hongmei Zhang, Hong Zhao, Tao Tao, Zili Xie, Rong Zhang, and Youdou Zheng
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III-nitrides ,organic materials ,p-n junction ,light emitting diodes ,white electroluminescence ,hole transport layer ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
It is known that the commercialized white light-emitting diodes (WLEDs) depend on phosphor conversion, which is limited by the unbalanced carrier injection in multiple quantum wells (MQWs) and low down-conversion efficiency. To solve these problems, hybrid organic/inorganic III-nitride WLEDs were designed and fabricated based on Rubrene/(InGaN/GaN) MQWs p-n junction. In such new structure, Rubrene can act as yellow-red emitter and play an important role in hole transport layer owing to its high carrier mobility. By optimizing the hybrid LED structure, the charge balance and recombination zone in radiative region were significantly improved. In this work, the optimal hybrid WLED with color coordinates of (0.31, 0.33) shows a maximum current efficiency of 15.22 cd/A with excellent long lifetime stability. The hybrid WLEDs based on organic/inorganic p-n junction were demonstrated with a good performance, which provides an attractive route to achieve high performance phosphor-free WLED sources for microdisplay or large-area WLED applications.
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- 2019
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19. The Fabrication of Docetaxel-Containing Emulsion for Drug Release Kinetics and Lipid Peroxidation
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Yifang Wu, Mengmeng Wang, Yufan Li, Hongmei Xia, Yongfeng Cheng, Chang Liu, Ying Xia, Yu Wang, Yan Yue, Xiaoman Cheng, and Zili Xie
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docetaxel ,emulsion ,drug release ,lipid peroxidation ,Pharmacy and materia medica ,RS1-441 - Abstract
Docetaxel (DTX)-based formulation development is still confronted with significant challenges, due to its refractory solubility and side effects on normal tissues. Inspired by the application of the transdermal drug delivery model to topical treatment, we developed a biocompatible and slow-release DTX-containing emulsion via self-assembly prepared by a high-speed electric stirring method and optimized the formulation. The results of accelerated the emulsion stability experiment showed that the emulsion prepared at 10,000 rpm/min had a stability of 89.15 ± 2.05%. The ADME, skin irritation, skin toxicity and molecular interaction between DTX and excipients were predicted via Discovery Studio 2016 software. In addition, DTX addition in oil or water phases of the emulsion showed different release rates in vitro and ex vivo. The DTX release ex vivo of the DTX/O-containing emulsion and the DTX/W-containing emulsion were 45.07 ± 5.41% and 96.48 ± 4.54%, respectively. In vitro antioxidant assays and anti-lipid peroxidation models revealed the antioxidant potential of DTX. However, DTX-containing emulsions could maintain and even enhance the antioxidant effect, both scavenging free radicals in vitro and inhibiting the process of lipid peroxidation.
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- 2022
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20. AlGaN Quantum Disk Nanorods with Efficient UV-B Emission Grown on Si(111) Using Molecular Beam Epitaxy
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Dongqi Zhang, Tao Tao, Haiding Sun, Siqi Li, Hongfeng Jia, Huabin Yu, Pengfei Shao, Zhenhua Li, Yaozheng Wu, Zili Xie, Ke Wang, Shibing Long, Bin Liu, Rong Zhang, and Youdou Zheng
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molecular beam epitaxy ,nanorods ,AlGaN ,quantum disks ,Chemistry ,QD1-999 - Abstract
AlGaN nanorods have attracted increasing amounts of attention for use in ultraviolet (UV) optoelectronic devices. Here, self-assembled AlGaN nanorods with embedding quantum disks (Qdisks) were grown on Si(111) using plasma-assisted molecular beam epitaxy (PA-MBE). The morphology and quantum construction of the nanorods were investigated and well-oriented and nearly defect-free nanorods were shown to have a high density of about 2 × 1010 cm−2. By controlling the substrate temperature and Al/Ga ratio, the emission wavelengths of the nanorods could be adjusted from 276 nm to 330 nm. By optimizing the structures and growth parameters of the Qdisks, a high internal quantum efficiency (IQE) of the AlGaN Qdisk nanorods of up to 77% was obtained at 305 nm, which also exhibited a shift in the small emission wavelength peak with respect to the increasing temperatures during the PL measurements.
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- 2022
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21. Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome
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Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, and Colin G. Nichols
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Gastroenterology ,Muscle biology ,Medicine - Abstract
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we describe 1 CS patient who required an implanted intestinal irrigation system for successful stooling. We used gene-modified mice to assess the underlying KATP channel subunits in gut smooth muscle and to model the consequences of altered KATP channels in CS gut. We show that Kir6.1/SUR2 subunits underlie smooth muscle KATP channels throughout the small intestine and colon. Knockin mice, carrying human KCNJ8 and ABCC9 CS mutations in the endogenous loci, exhibited reduced intrinsic contractility throughout the intestine, resulting in death when weaned onto solid food in the most severely affected animals. Death was avoided by weaning onto a liquid gel diet, implicating intestinal insufficiency and bowel impaction as the underlying cause, and GI transit was normalized by treatment with the KATP inhibitor glibenclamide. We thus define the molecular basis of intestinal KATP channel activity, the mechanism by which overactivity results in GI insufficiency, and a viable approach to therapy.
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- 2020
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22. The Sign of Exciton-Photon Coupling in GaN-Based Triangular-like Ridge Cavity
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Jing Zhou, Peng Chen, Zili Xie, Xiangqian Xiu, Dunjun Chen, Ping Han, Yi Shi, Rong Zhang, and Youdou Zheng
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exciton ,cavity ,InGaN ,exciton-photon coupling ,Crystallography ,QD901-999 - Abstract
In this paper, the behavior of exciton radiative recombination in a GaN-based triangular-like ridge cavity is studied at room-temperature. The triangular-like ridge cavity is fabricated on a standard-blue-LED epitaxial wafer grown on a sapphire substrate. Through the photoluminescence (PL) and time-resolved photoluminescence (TR-PL) measurements, a clear modulation of the original spontaneous emission is found in the microcavity, a new transition channel is observed, and the effect is angle-dependent. Furthermore, by changing the tilt angle during angle-resolution photoluminescence (AR-PL), it is found that the coupling between excitons and photons in the cavity is the strongest when tilted at 10°. By simulation, the strong localization of photons in the top of the cavity can be confirmed. The PL, TR-PL, and AR-PL results showed the sign of the exciton-photon coupling in the triangular-like ridge cavity.
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- 2022
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23. Hybrid Cyan Nitride/Red Phosphors White Light-Emitting Diodes With Micro-Hole Structures
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Tao Tao, Ting Zhi, Xu Cen, Bin Liu, Qi Wang, Zili Xie, Peng Chen, Dunjun Chen, Yugang Zhou, Youdou Zheng, and Rong Zhang
- Subjects
— ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
Hybrid white light emitting diodes (LEDs) have been developed utilizing micro-LEDs radiatively pumping down-conversion phosphor materials. The cyan InGaN/GaN multiple quantum wells LEDs with 95 μm in square are fabricated into 4 × 4 pixels as one unit in 4 in wafer by photolithography and inductively coupled plasma etching techniques. The relatively low turn on voltage and low leakage of cyan micro-LEDs indicate good electrical performance. A significant reduction in the efficiency droop characteristics of cyan micro-LED has been observed in comparison with that of standard green LED. Finally, based on a systemic optimization for white emission indexes, high-quality hybrid white light emission has been demonstrated by the combination of blue and cyan micro-LEDs with two types of phosphors, which have a high color rendering index up to 87 at the correlated color temperatures of 6500 K. It also demonstrates a way to adjust the color component by modifying the output power of cyan micro-LED in hybrid LED, showing a promising candidate in a large range of applications including micro-displays, bioinstrumentation, photolithography, and lab-on-chip systems in the future.
- Published
- 2018
- Full Text
- View/download PDF
24. The Study on the Droop Effect in the InGaN/AlGaInN MQWs With Lattice-Matched AlGaN/InGaN Superlattices Barrier by Highly Excited Photoluminescence Measurement
- Author
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Fulong Jiang, Yaying Liu, Menghan Liu, Ningze Zhuo, Peng Gao, Huajie Fang, Peng Chen, Bin Liu, Xiangqian Xiu, Zili Xie, Ping Han, Yi Shi, Rong Zhang, and Youdou Zheng
- Subjects
InGaN ,Multiple Quantum Wells ,polarization ,efficiency droop. ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
We have fabricated the InGaN/AlGaInN multiple quantum wells with lattice-matched AlGaN/InGaN superlattices barriers (SL-MQWs). The lattice-matched superlattices promote the formation of the high-quality MQWs and eliminate the large polarization electric field. Highly excited photoluminescence measurement is performed by Ti-sapphire pulse laser with the maximal carrier density of 1020 cm-3. Under such high carrier density, the conventional InGaN/GaN MQWs (C-MQWs) have an additional nonradiative loss of carriers and suffer from the efficiency droop effect, while slight droop behavior is observed in the SL-MQWs sample. The results show that the substitution of AlGaN/InGaN superlattices as quantum barriers can effectively suppress the droop behavior at highly excited condition.
- Published
- 2018
- Full Text
- View/download PDF
25. A Selective Etching Route for Large-Scale Fabrication of β-Ga2O3 Micro-/Nanotube Arrays
- Author
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Shan Ding, Liying Zhang, Yuewen Li, Xiangqian Xiu, Zili Xie, Tao Tao, Bin Liu, Peng Chen, Rong Zhang, and Youdou Zheng
- Subjects
β-Ga2O3 ,micro-/nanotubes ,GaN template ,ICP etching ,Chemistry ,QD1-999 - Abstract
In this paper, based on the different etching characteristics between GaN and Ga2O3, large-scale and vertically aligned β-Ga2O3 nanotube (NT) and microtube (MT) arrays were fabricated on the GaN template by a facile and feasible selective etching method. GaN micro-/nanowire arrays were prepared first by inductively coupled plasma (ICP) etching using self-organized or patterning nickel masks as the etching masks, and then the Ga2O3 shell layer converted from GaN was formed by thermal oxidation, resulting in GaN@Ga2O3 micro-/nanowire arrays. After the GaN core of GaN@Ga2O3 micro-/nanowire arrays was removed by ICP etching, hollow Ga2O3 tubes were obtained successfully. The micro-/nanotubes have uniform morphology and controllable size, and the wall thickness can also be controlled with the thermal oxidation conditions. These vertical β-Ga2O3 micro-/nanotube arrays could be used as new materials for novel optoelectronic devices.
- Published
- 2021
- Full Text
- View/download PDF
26. Author Correction: Progress on AlGaN-based solar-blind ultraviolet photodetectors and focal plane arrays
- Author
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Qing Cai, Haifan You, Hui Guo, Jin Wang, Bin Liu, Zili Xie, Dunjun Chen, Hai Lu, Youdou Zheng, and Rong Zhang
- Subjects
Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Published
- 2021
- Full Text
- View/download PDF
27. Investigations of Sidewall Passivation Technology on the Optical Performance for Smaller Size GaN-Based Micro-LEDs
- Author
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Junchi Yu, Tao Tao, Bin Liu, Feifan Xu, Yao Zheng, Xuan Wang, Yimeng Sang, Yu Yan, Zili Xie, Shihao Liang, Dunjun Chen, Peng Chen, Xiangqian Xiu, Youdou Zheng, and Rong Zhang
- Subjects
Micro-LED ,passivation ,edge effect ,Crystallography ,QD901-999 - Abstract
Micro-light emitting diodes (Micro-LEDs) based on III-nitride semiconductors have become a research hotspot in the field of high-resolution display due to its unique advantages. However, the edge effect caused by inductively coupled plasma (ICP) dry etching in Micro-LEDs become significant with respect to the decreased chip size, resulting in a great reduction in device performance. In this article, sector-shaped GaN-based blue Micro-LEDs are designed and fabricated. Additionally, the device performance of different size Micro-LEDs with passivation are investigated with respect to those without passivation. Several methods have been applied to minimize the etching damage near the edge, including acid-base wet etching and SiO2 passivation layer growth. The room temperature photoluminescence (PL) results demonstrate that the light emission intensity of Micro-LEDs can be significantly enhanced by optimized passivation process. PL mapping images show that the overall luminescence of properly passivated Micro-LEDs is enhanced, the uniformity is improved, and the effective luminescence area is increased. The recombination lifetime of carriers in Micro-LEDs are increased by the usage of passivation process, which proves the reduction in non-radiative recombination centers in Micro-LEDs and improved luminescence efficiency. As a result, the internal quantum efficiency (IQE) is improved from 14.9% to 37.6% for 10 μm Micro-LEDs, and from 18.3% to 26.9% for 5 μm Micro-LEDs.
- Published
- 2021
- Full Text
- View/download PDF
28. Reverse Leakage Current Characteristics of GaN/InGaN Multiple Quantum-Wells Blue and Green Light-Emitting Diodes
- Author
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Ting Zhi, Tao Tao, Bin Liu, Zili Xie, Peng Chen, and Rong Zhang
- Subjects
GaN-based light-emitting diodes (LEDs) ,multiple quantum wells (MQWs) ,(I–V) current-voltage characteristics ,reverse leakage current ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
The mechanisms of reverse leakage in InGaN/GaN multiple-quantum-wells (MQWs) blue and green light-emitting diodes (LEDs) were studied through analyzing the current-voltage (I-V) characteristics with the temperature ranging from 50 to 350 K. When the reverse bias V is below 12 V, the leakage current is dominated by the variable-range hopping conduction (T250K), respectively. As the reverse bias increases (|V|>12V), the space-charge-limited conduction mechanism is responsible for the leakage current. It is found that the leakage current is highly associated with the defects density, as well as the trapping capacity of deep level centers; therefore, the lower leakage current of blue LED is mainly attributed to higher thermal activation energy Ea due to less deep level centers within GaN/InGaN MQWs structures.
- Published
- 2016
- Full Text
- View/download PDF
29. Plectasin, First Animal Toxin-Like Fungal Defensin Blocking Potassium Channels through Recognizing Channel Pore Region
- Author
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Fang Xiang, Zili Xie, Jing Feng, Weishan Yang, Zhijian Cao, Wenxin Li, Zongyun Chen, and Yingliang Wu
- Subjects
plectasin ,defensin ,potassium channels ,Kv1.3 channel ,molecular mechanism ,functional evolution ,Medicine - Abstract
The potassium channels were recently found to be inhibited by animal toxin-like human β-defensin 2 (hBD2), the first defensin blocker of potassium channels. Whether there are other defensin blockers from different organisms remains an open question. Here, we reported the potassium channel-blocking plectasin, the first defensin blocker from a fungus. Based on the similar cysteine-stabilized alpha-beta (CSαβ) structure between plectasin and scorpion toxins acting on potassium channels, we found that plectasin could dose-dependently block Kv1.3 channel currents through electrophysiological experiments. Besides Kv1.3 channel, plectasin could less inhibit Kv1.1, Kv1.2, IKCa, SKCa3, hERG and KCNQ channels at the concentration of 1 μΜ. Using mutagenesis and channel activation experiments, we found that outer pore region of Kv1.3 channel was the binding site of plectasin, which is similar to the interacting site of Kv1.3 channel recognized by animal toxin blockers. Together, these findings not only highlight the novel function of plectasin as a potassium channel inhibitor, but also imply that defensins from different organisms functionally evolve to be a novel kind of potassium channel inhibitors.
- Published
- 2015
- Full Text
- View/download PDF
30. Peptidomimetic Star Polymers for Targeting Biological Ion Channels.
- Author
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Rong Chen, Derong Lu, Zili Xie, Jing Feng, Zhongfan Jia, Junming Ho, Michelle L Coote, Yingliang Wu, Michael J Monteiro, and Shin-Ho Chung
- Subjects
Medicine ,Science - Abstract
Four end-functionalized star polymers that could attenuate the flow of ionic currents across biological ion channels were first de novo designed computationally, then synthesized and tested experimentally on mammalian K+ channels. The 4-arm ethylene glycol conjugate star polymers with lysine or a tripeptide attached to the end of each arm were specifically designed to mimic the action of scorpion toxins on K+ channels. Molecular dynamics simulations showed that the lysine side chain of the polymers physically occludes the pore of Kv1.3, a target for immuno-suppression therapy. Two of the compounds tested were potent inhibitors of Kv1.3. The dissociation constants of these two compounds were computed to be 0.1 μM and 0.7 μM, respectively, within 3-fold to the values derived from subsequent experiments. These results demonstrate the power of computational methods in molecular design and the potential of star polymers as a new infinitely modifiable platform for ion channel drug discovery.
- Published
- 2016
- Full Text
- View/download PDF
31. TRP Channels as Drug Targets to Relieve Itch
- Author
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Zili Xie and Hongzhen Hu
- Subjects
TRP channels ,itch ,pain ,TRPA1 ,TRPV1 ,TRPV3 ,TRPV4 ,TRPM8 ,TRPC4 ,agonists ,antagonists ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Although acute itch has a protective role by removing irritants to avoid further damage, chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a considerable amount of stimulating research has been carried out to delineate mechanisms of itch at the molecular, cellular, and circuit levels. There is growing evidence that transient receptor potential (TRP) channels play important roles in itch signaling. The purpose of this review is to summarize our current knowledge about the role of TRP channels in the generation of itch under both physiological and pathological conditions, thereby identifying them as potential drug targets for effective anti-itch therapies.
- Published
- 2018
- Full Text
- View/download PDF
32. Asymmetric tunneling model of forward leakage current in GaN/InGaN light emitting diodes
- Author
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Ting Zhi, Tao Tao, Bin Liu, Yi Li, Zhe Zhuang, Guogang Zhang, Zili Xie, Rong Zhang, and Youdou Zheng
- Subjects
Physics ,QC1-999 - Abstract
Through investigating the temperature dependent current-voltage (T-I-V) properties of GaN based blue and green LEDs in this study, we propose an asymmetric tunneling model to understand the leakage current below turn-on voltage (V < 3.2 V): At the forward bias within 1.5 V ∼ 2.1 V (region 1), the leakage current is main attributed to electrons tunneling from the conduction band of n-type GaN layer to the valence band of p-type GaN layer via defect states in space-charge region (SCR); While, at the forward bias within 2 V ∼ 2.4 V (region 2), heavy holes tunneling gradually becomes dominant at low temperature (T < 200K) as long as they can overcome the energy barrier height. The tunneling barrier for heavy holes is estimated to be lower than that for electrons, indicating the heavy holes might only tunnel to the defect states. This asymmetric tunneling model shows a novel carrier transport process, which provides better understanding of the leakage characteristics and is vital for future device improvements.
- Published
- 2015
- Full Text
- View/download PDF
33. The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases
- Author
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Fang Ye, Youtian Hu, Weiwei Yu, Zili Xie, Jun Hu, Zhijian Cao, Wenxin Li, and Yingliang Wu
- Subjects
Kv1.3 channel ,BmKTX ,scorpion toxin ,BmKTX-D33H ,ion channel selectivity ,autoimmune diseases ,Medicine - Abstract
The Kv1.3 channel-acting scorpion toxins usually adopt the conserved anti-parallel β-sheet domain as the binding interface, but it remains challenging to discover some highly selective Kv1.3 channel-acting toxins. In this work, we investigated the pharmacological profile of the Kv1.3 channel-acting BmKTX-D33H, a structural analogue of the BmKTX scorpion toxin. Interestingly, BmKTX-D33H, with its conserved anti-parallel β-sheet domain as a Kv1.3 channel-interacting interface, exhibited more than 1000-fold selectivity towards the Kv1.3 channel as compared to other K+ channels (including Kv1.1, Kv1.2, Kv1.7, Kv11.1, KCa2.2, KCa2.3, and KCa3.1). As expected, BmKTX-D33H was found to inhibit the cytokine production and proliferation of both Jurkat cells and human T cells in vitro. It also significantly improved the delayed-type hypersensitivity (DTH) responses, an autoreactive T cell-mediated inflammation in rats. Amino acid sequence alignment and structural analysis strongly suggest that the “evolutionary” Gly11 residue of BmKTX-D33H interacts with the turret domain of Kv1 channels; it appears to be a pivotal amino acid residue with regard to the selectivity of BmKTX-D33H towards the Kv1.3 channel (in comparison with the highly homologous scorpion toxins). Together, our data indicate that BmKTX-D33H is a Kv1.3 channel–specific blocker. Finally, the remarkable selectivity of BmKTX-D33H highlights the great potential of evolutionary-guided peptide drug design in future studies.
- Published
- 2016
- Full Text
- View/download PDF
34. Measurement and Prediction of the Adsorption of Binary Mixtures of Organic Vapours on Activated Carbon
- Author
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Jufang Wu, Zili Xie, Kunmin Guo, and Ola Claesson
- Subjects
Physical and theoretical chemistry ,QD450-801 - Abstract
This paper describes a modified headspace method for measuring the adsorption equilibrium of mixtures of organic vapours. The advantage of the method relative to the ordinary headspace method is the shorter time needed to reach adsorption equilibrium. The adsorption isotherms of benzene, hexane and pentane on activated carbons were acquired quickly and easily using this method. The method has also been used to measure the binary equilibrium data of benzene–hexane, benzene–pentane and hexane–pentane mixtures on three types of activated carbon. The ‘Ideal Adsorbed Solution Theory’ (IAST) was used to predict the binary adsorption equilibria from the adsorption isotherms for the single components. Good agreement was obtained between prediction and measurement for the total amount of components adsorbed, as well as for the ratio of compounds in the adsorbed phase. The small deviation noted was probably a result of using the Freundlich adsorption isotherm in IAST modelling.
- Published
- 2001
- Full Text
- View/download PDF
35. An Intelligent Marshalling Model for Enterprise Station Freight Railway.
- Author
-
Junxia Guo, Gang Lu, Zili Xie, Jiawei Wen, and Nanshan Xu
- Published
- 2020
- Full Text
- View/download PDF
36. Gallium Nitride Blue/Green Micro-LEDs for High Brightness and Transparency Display
- Author
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Junchi Yu, Feifan Xu, Tao Tao, Bin Liu, Bin Wang, Yimeng Sang, Shihao Liang, Yang Chen, Meixin Feng, Zhe Zhuang, Zili Xie, Xiaojuan Sun, Youdou Zheng, Kai Huang, and Rong Zhang
- Subjects
Electrical and Electronic Engineering ,Electronic, Optical and Magnetic Materials - Published
- 2023
- Full Text
- View/download PDF
37. Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity
- Author
-
Mengmeng Wang, Hongmei Xia, Xinying Yang, Qin Zhang, Yufan Li, Yu Wang, Ying Xia, and Zili Xie
- Subjects
General Pharmacology, Toxicology and Pharmaceutics - Published
- 2023
- Full Text
- View/download PDF
38. InGaN/GaN Nanorod Arrays for a Hybrid Nanolaser
- Author
-
Di Jiang, Penggang Li, Bin Liu, Kai Huang, Tao Tao, Ting Zhi, Yu Yan, Zili Xie, Junyong Kang, Youdou Zheng, and Rong Zhang
- Subjects
General Materials Science - Published
- 2022
- Full Text
- View/download PDF
39. Self-Powered Solar-Blind Photodetectors Based on Vertically Aligned GaN@Ga2O3 Core–Shell Nanowire Arrays
- Author
-
Shan Ding, Kai Chen, Xiangqian Xiu, Yuewen Li, Liying Zhang, Pengfei Shao, Zili Xie, Tao Tao, Bin Liu, Peng Chen, Dunjun Chen, Rong Zhang, and Youdou Zheng
- Subjects
General Materials Science - Published
- 2022
- Full Text
- View/download PDF
40. Quantification of CGRP‐immunoreactive myenteric neurons in mouse colon
- Author
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Timothy J. Hibberd, Wai Ping Yew, Kelsi N. Dodds, Zili Xie, Lee Travis, Simon J. Brookes, Marcello Costa, Hongzhen Hu, and Nick J. Spencer
- Subjects
Neurons ,Mice ,Colon ,Calcitonin Gene-Related Peptide ,General Neuroscience ,Peripherins ,Animals ,Myenteric Plexus ,Nitric Oxide Synthase ,Colchicine - Abstract
Quantitative data of biological systems provide valuable baseline information for understanding pathology, experimental perturbations, and computational modeling. In mouse colon, calcitonin gene-related peptide (CGRP) is expressed by myenteric neurons with multiaxonal (Dogiel type II) morphology, characteristic of intrinsic primary afferent neurons (IPANs). Analogous neurons in other species and gut regions represent 5-35% of myenteric neurons. We aimed to quantify proportions of CGRP-immunopositive (CGRP+) myenteric neurons. Colchicine-treated wholemount preparations of proximal, mid, and distal colon were labeled for HuC/D, CGRP, nitric oxide synthase (NOS), and peripherin (Per). The pan-neuronal markers (Hu+/Per+) co-labeled 94% of neurons. Hu+/Per- neurons comprised ∼6%, but Hu-/Per+ cells were rare. Thus, quantification was based on Hu+ myenteric neurons (8576 total; 1225 ± 239 per animal, n = 7). CGRP+ cell bodies were significantly larger than the average of all Hu+ neurons (329 ± 13 vs. 261 ± 12 μm
- Published
- 2022
- Full Text
- View/download PDF
41. C-Plane Blue Micro-LED With 1.53 GHz Bandwidth for High-Speed Visible Light Communication
- Author
-
Feifan Xu, Zuxin Jin, Tao Tao, Pengfei Tian, Guobin Wang, Xiaoyan Liu, Ting Zhi, Qi-ang Yan, Danfeng Pan, Zili Xie, Ke Xu, Bin Liu, and Rong Zhang
- Subjects
Electrical and Electronic Engineering ,Electronic, Optical and Magnetic Materials - Published
- 2022
- Full Text
- View/download PDF
42. 3-D Simulation Study of a Normally-OFF GaN Lateral Multi-Channel JFET With Optimized Electrical Field Transfer Terminal Structure
- Author
-
Hui Guo, Haineng Bai, Zi-Hui Zhang, Zili Xie, Dunjun Chen, Hai Lu, Rong Zhang, and Youdou Zheng
- Subjects
Electrical and Electronic Engineering ,Electronic, Optical and Magnetic Materials - Published
- 2022
- Full Text
- View/download PDF
43. Gate-Controlled NiO/Graphene/4H-SiC Double Schottky Barrier Heterojunction Based on a Metal-Oxide-Semiconductor Structure for Dual-Mode and Wide Range Ultraviolet Detection
- Author
-
Yimeng Li, Peng Chen, Xiufang Chen, Hehe Gong, Xiaobo Hu, Yan Peng, Xiangang Xu, Zili Xie, Xiangqian Xiu, Dunjun Chen, Jiandong Ye, Ping Han, Yi Shi, Rong Zhang, and Youdou Zheng
- Subjects
Materials Chemistry ,Electrochemistry ,Electronic, Optical and Magnetic Materials - Published
- 2022
- Full Text
- View/download PDF
44. Highly responsive and selective ppb-level NO2 gas sensor based on porous Pd-functionalized CuO/rGO at room temperature
- Author
-
Haineng Bai, Hui Guo, Cheng Feng, Jin Wang, Bin Liu, Zili Xie, Fuqiang Guo, Dunjun Chen, Rong Zhang, and Youdou Zheng
- Subjects
Materials Chemistry ,General Chemistry - Abstract
Notably, the Pd–CuO/rGO sensor exhibits the highest response compared to the other three sensors (including the CuO, Pd–CuO and CuO/rGO sensors).
- Published
- 2022
- Full Text
- View/download PDF
45. Growth and nitridation of β-Ga2O3 thin films by Sol-Gel spin-coating epitaxy with post-annealing process
- Author
-
Zili Xie, Xiangqian Xiu, Bin Liu, Peng Chen, Li Yuewen, Fei Cheng, Rong Zhang, Yuxia Zhu, Tao Tao, and Youdou Zheng
- Subjects
Spin coating ,Materials science ,General Chemistry ,Condensed Matter Physics ,Epitaxy ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Crystal ,Crystallinity ,Materials Chemistry ,Ceramics and Composites ,Sapphire ,Composite material ,Thin film ,Porosity ,Sol-gel - Abstract
β-Ga2O3 thin films have been successfully prepared on (0001) sapphire substrate by simple and effective sol-gel spin-coating method with post-annealing process (SSP). The effects of different preheating temperatures on the crystal quality and surface morphology of β-Ga2O3 films have been systematically investigated. The β-Ga2O3 thin films exhibit good crystallinity with ( $$\bar 2$$ 01) preferred orientation and smooth surface morphology. The results showed that β-Ga2O3 thin films directly grown on (0001) sapphire by SSP method have comparable or better crystal quality compared with other epitaxial methods. The β-Ga2O3 thin films annealed at 1000 °C with the preheating temperature of 300 °C and above have smooth and crack-free surface morphology. The single-domain-growth mode of β-Ga2O3 thin film prepared on ~7° off-angled (0001) sapphire substrate toward plane has been confirmed by SSP method, and the porous GaN layers have been obtained by the nitridation of the Sol-Gel grown β-Ga2O3 thin films for future applications in high-quality free-standing GaN substrates.
- Published
- 2021
- Full Text
- View/download PDF
46. Percutaneous Electroosmosis of Berberine-Loaded Ca
- Author
-
Yinyin, Liu, Si, Shen, Yifang, Wu, Mengmeng, Wang, Yongfeng, Cheng, Hongmei, Xia, Ruoyang, Jia, Chang, Liu, Yu, Wang, Ying, Xia, Xiaoman, Cheng, Yan, Yue, and Zili, Xie
- Abstract
Flexible conductive hydrogel has been driven by scientific breakthroughs and offers a wide variety of applications, including sensors, electronic skins, biomedicine, energy storage, etc. Based on the mixed-ion crosslinking method, gelatin and sodium alginate (Gel-Alg) composite hydrogels were successfully prepared using Ca
- Published
- 2022
47. Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle
- Author
-
Jing Feng, Yonghui Zhao, Zili Xie, Kaikai Zang, Sanja Sviben, Xueming Hu, James A. J. Fitzpatrick, Lu Wen, Yifei Liu, Ting Wang, Katy Lawson, Qin Liu, Yan Yan, Xinzhong Dong, Liang Han, Gregory F. Wu, Brian S. Kim, and Hongzhen Hu
- Subjects
Nerve Fibers, Unmyelinated ,Sensory Receptor Cells ,Pruritus ,Humans ,General Medicine ,Article ,Merkel Cells ,Skin - Abstract
Itch sensation provokes the scratch reflex to protect us from harmful stimuli in the skin. Although scratching transiently relieves acute itch through activation of mechanoreceptors, it propagates the vicious itch-scratch cycle in chronic itch by further aggravating itch over time. Although well recognized clinically, the peripheral mechanisms underlying the itch-scratch cycle remain poorly understood. Here, we show that mechanical stimulation of the skin results in activation of the Piezo2 channels on Merkel cells that pathologically promotes spontaneous itch in experimental dry skin. Three-dimensional reconstruction and immunoelectron microscopy revealed structural alteration of MRGPRA3 + pruriceptor nerve endings directed toward Merkel cells in the setting of dry skin. Our results uncover a functional miswiring mechanism under pathologic conditions, resulting in touch receptors triggering the firing of pruriceptors in the skin to drive the itch-scratch cycle.
- Published
- 2022
48. Self-Assembly Nanopillar/Superlattice Hierarchical Structure: Boosting AlGaN Crystalline Quality and Achieving High-Performance Ultraviolet Avalanche Photodetector
- Author
-
Qing Cai, Haifan You, Qianyu Hou, Tao Tao, Zili Xie, Xun Cao, Bin Liu, Dunjun Chen, Hai Lu, Rong Zhang, and Youdou Zheng
- Subjects
General Materials Science - Abstract
As a burgeoning wide-band gap semiconductor material, Al
- Published
- 2022
49. Enhanced Stability and Sensitivity of AlGaN/GaN-HEMTs pH Sensor by Reference Device
- Author
-
Youdou Zheng, Hui Guo, Lei Jianming, Seung-Hyeon Kang, Yan Dong, Jeong-Gil Kim, Quan Dai, Rui Wang, Dunjun Chen, Yanli Liu, Rong Zhang, Chul-Ho Won, Jung-Hee Lee, and Zili Xie
- Subjects
Materials science ,Equivalent series resistance ,business.industry ,010401 analytical chemistry ,Transistor ,Gallium nitride ,High-electron-mobility transistor ,01 natural sciences ,Signal ,0104 chemical sciences ,law.invention ,Capacitor ,chemistry.chemical_compound ,chemistry ,law ,Optoelectronics ,Equivalent circuit ,Electrical and Electronic Engineering ,business ,Instrumentation ,Sensitivity (electronics) - Abstract
To improve the stability and sensitivity of pH sensors based on AlGaN/GaN high electron mobility transistors (HEMTs), we proposed a modified sensing structure by integrating a reference HEMT device. This structural pH sensor exhibits a typical Nernstian behavior with a sensitivity of 54.38 mV/pH, which is higher than the value of 49.43mV/pH derived from the AlGaN/GaN HEMT-based sensor without integrating the reference HEMTs device. Furthermore, the stability of the new structural sensor is enhanced by approximately 19.2% in comparison with that of its traditional counterpart. The improved performances are analyzed using an electrical double-layer model together with an equivalent circuit model, and we find that the new sensor structure has a larger capacitor and exhibits a better rectification effect, hence decreasing the electrical noise and enhancing the stability of the testing signal. Meanwhile, the new sensor structure displays a smaller equivalent resistance and results in a larger available output current, hence exhibiting a higher sensitivity.
- Published
- 2021
- Full Text
- View/download PDF
50. High density polarization-induced 2D hole gas enabled by elevating Al composition in GaN/AlGaN heterostructures
- Author
-
Pengfei Shao, Xing Fan, Siqi Li, Songlin Chen, Hui Zhou, Huan Liu, Hui Guo, Weizong Xu, Tao Tao, Zili Xie, Hong Lu, Ke Wang, Bin Liu, Dunjun Chen, Youdou Zheng, and Rong Zhang
- Subjects
Physics and Astronomy (miscellaneous) - Abstract
A two-dimensional hole gas (2DHG) induced by polarization charges at the GaN/AlGaN hetero-interface is attracting much attention because of its potential to develop p-channel transistors required for GaN complementary logic integrated circuits. This platform is compatible with commercial AlGaN/GaN n-channel electronics, but the performance of GaN p-channel transistors has been far behind. In this work, 2DHGs in GaN/AlGaN/GaN heterostructures grown by plasma-assisted molecular beam epitaxy have been investigated. The Al composition of the AlGaN barrier has been pushed as high as possible without obvious strain relaxation, and the record high 2DHG sheet density and conductivity on the GaN/AlGaN/GaN platform have been obtained. By adopting a parallel conduction model, a dependent relationship of the 2DHG density on temperature has been extracted. The temperature dependent Hall-effect results have demonstrated that the 2DHG density boosts by 75 times and 46 times at room temperature and 77 K, respectively, when the Al composition is pushed from 0.18 to 0.45 for the AlGaN barriers. The 2DHG sheet density reaches 3.6 × 1013 and 2.1 × 1013 cm−2 at room temperature and 77 K, respectively, and the lowest sheet resistance is 8.9 kΩ/□ at 77 K. Such a 2DHG is beneficial for fabrication of p-channel GaN transistors with lower on-resistance on the already-industrialized platform.
- Published
- 2023
- Full Text
- View/download PDF
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