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3. Update of the BIPM comparison BIPM.RI(II)-K1.I-131 of activity measurements of the radionuclide 131I to include the 2015 results of the BEV (Austria) and the POLATOM (Poland), the 2017 result of the NMISA (South Africa), and to link the CCRI(II)-S6.I-131 comparison

Author

Michotte, C, primary, Courte, S, additional, Coulon, R, additional, Nonis, M, additional, Ratel, G, additional, Maringer, F J, additional, Brettner-Messler, R, additional, Dziel, T, additional, Listkowska, A, additional, Rooy, M W van, additional, Staden, M J van, additional, Lubbe, J, additional, and Zimmerman, B, additional

Published
2023
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6. An analysis-ready and quality controlled resource for pediatric brain white-matter research

Author

Richie-Halford, A., Cieslak, M., Ai, L., Caffarra, S., Covitz, S., Franco, A., Karipidis, I., Kruper, J., Milham, M., Avelar-Pereira, B., Roy, E., Sydnor, V., Yeatman, J., Abbott, N., Anderson, J., Gagana, B., Bleile, M., Bloomfield, P., Bottom, V., Bourque, J., Boyle, R., Brynildsen, J., Calarco, N., Castrellon, J., Chaku, N., Chen, B., Chopra, S., Coffey, E., Colenbier, N., Cox, D., Crippen, J., Crouse, J., David, S., Leener, B., Delap, G., Deng, Z., Dugre, J., Eklund, A., Ellis, K., Ered, A., Farmer, H., Faskowitz, J., Finch, J., Flandin, G., Flounders, M., Fonville, L., Frandsen, S., Garic, D., Garrido-Vásquez, P., Gonzalez-Escamilla, G., Grogans, S., Grotheer, M., Gruskin, D., Guberman, G., Haggerty, E., Hahn, Y., Hall, E., Hanson, J., Harel, Y., Vieira, B., Hettwer, M., Hobday, H., Horien, C., Huang, F., Huque, Z., James, A., Kahhale, I., Kamhout, S., Keller, A., Khera, H., Kiar, G., Kirk, P., Kohl, S., Korenic, S., Korponay, C., Kozlowski, A., Kraljevic, N., Lazari, A., Leavitt, M., Li, Z., Liberati, G., Lorenc, E., Lossin, A., Lotter, L., Lydon-Staley, D., Madan, C., Magielse, N., Marusak, H., Mayor, J., McGowan, A., Mehta, K., Meisler, S., Michael, C., Mitchell, M., Morand-Beaulieu, S., Newman, B., Nielsen, J., O’Mara, S., Ojha, A., Omary, A., Özarslan, E., Parkes, L., Peterson, M., Pines, A., Pisanu, C., Rich, R., Sahoo, A., Samara, A., Sayed, F., Schneider, J., Shaffer, L., Shatalina, E., Sims, S., Sinclair, S., Song, J., Hogrogian, G., Tooley, U., Tripathi, V., Turker, H., Valk, S., https://orcid.org/0000-0003-2998-6849, Wall, M., Walther, C., Wang, Y., Wegmann, B., Welton, T., Wiesman, A., Wiesman, M., Winters, D., Yuan, R., Zacharek, S., Zajner, C., Zakharov, I., Zammarchi, G., Zhou, D., Zimmerman, B., Zoner, K., Satterthwaite, T., Rokem, A., and Fibr Community Science Consortium

Subjects
Statistics and Probability, Brain, Neuroimaging, Library and Information Sciences, White Matter, Computer Science Applications, Education, Diffusion Magnetic Resonance Imaging, Image Processing, Computer-Assisted, Humans, Radiologi och bildbehandling, Statistics, Probability and Uncertainty, Child, Information Systems, Radiology, Nuclear Medicine and Medical Imaging
Abstract

We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated the HBN dMRI data (N = 2747) into the Brain Imaging Data Structure and preprocessed it according to best-practices, including denoising and correcting for motion effects, susceptibility-related distortions, and eddy currents. Preprocessed, analysis-ready data was made openly available. Data quality plays a key role in the analysis of dMRI. To optimize QC and scale it to this large dataset, we trained a neural network through the combination of a small data subset scored by experts and a larger set scored by community scientists. The network performs QC highly concordant with that of experts on a held out set (ROC-AUC = 0.947). A further analysis of the neural network demonstrates that it relies on image features with relevance to QC. Altogether, this work both delivers resources to advance transdiagnostic research in brain connectivity and pediatric mental health, and establishes a novel paradigm for automated QC of large datasets., Scientific Data, 9 (1), ISSN:2052-4463

Published
2022

7. Wilderness protected areas : management guidelines for IUCN category 1b protected areas

Author

Locke, H., additional, Ghosh, S., additional, Carver, S., additional, McDonald, T., additional, Sloan, S.S., additional, Merculieff, I., additional, Hendee, J., additional, Dawson, C., additional, Moore, S., additional, Newsome, D., additional, McCool, S., additional, Semler, R., additional, Martin, S., additional, Dvorak, R., additional, Armatas, C., additional, Swain, R., additional, Barr, B., additional, Krause, D., additional, Whittington-Evans, N., additional, Hamilton, L.S., additional, Holtrop, J., additional, Tricker, J., additional, Landres, P., additional, Mejicano, E., additional, Gilbert, T., additional, Mackey, B., additional, Aykroyd,, T., additional, Zimmerman, B., additional, and Thomas, J., additional

Published
2016
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8. Masses and Proton Separation Energies Obtained from Q α and Q p Measurements

Author

Davids, C. N., Woods, P. J., Batchelder, J. C., Bingham, C. R., Blumenthal, D. J., Brown, L. T., Busse, B. C., Carpenter, M. P., Conticchio, L. F., Davinson, T., Deboer, J., Freeman, S. J., Hamada, S., Henderson, D. J., Irvine, R. J., Janssens, R. V. F., Maier, H. J., Müller, L., Page, R. D., Penttilä, H. T., Poli, G. L., Seweryniak, D., Soramel, F., Toth, K. S., Walters, W. B., Zimmerman, B. E., Lunney, David, editor, Audi, Georges, editor, and Kluge, H.-Jürgen, editor

Published
2001
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9. Democratic research: Setting up a research commons for a qualitative, comparative, longitudinal interview study during the COVID-19 pandemic

Author

Zimmerman, B., Wagenaar, H., Kieslich, K., Prainsack, B., Meyers, G., Buyx, A., El-Sayed, S., Fiske, A., Galasso, I., Greiger, S., Hangel, N., Horn, R., Johnson, S., Sharon, T., Siffels, L., Zimmerman, B., Wagenaar, H., Kieslich, K., Prainsack, B., Meyers, G., Buyx, A., El-Sayed, S., Fiske, A., Galasso, I., Greiger, S., Hangel, N., Horn, R., Johnson, S., Sharon, T., and Siffels, L.

Abstract

Item does not contain fulltext

Published
2022

10. Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants.

Author

Egbuna, O., Zimmerman, B., Manos, G., Fortier, A., Chirieac, M. C., Dakin, L. A., Friedman, D. J., Bramham, K., Campbell, K., Knebelmann, B., Barisoni, L., Falk, R. J., Gipson, D. S., Lipkowitz, M. S., Ojo, A., Bunnage, M. E., Pollak, M. R., Altshuler, D., and Chertow, G. M.

Abstract

BACKGROUND Persons with toxic gain-of-function variants in the gene encoding apolipoprotein LI (AP0L1) are at greater risk for the development of rapidly progressive, proteinuric nephropathy. Despite the known genetic cause, therapies targeting proteinuric kidney disease in persons with two APOL1 variants (G1 or G2) are lacking. METHODS We used tetracycline-inducible APOL1 human embryonic kidney (HEK293) cells to assess the ability of a small-molecule compound, inaxaplin, to inhibit APOL1 channel function. An APOL1 G2-homologous transgenic mouse model of proteinuric kidney disease was used to assess inaxaplin treatment for proteinuria. We then conducted a single-group, open-label, phase 2a clinical study in which inaxaplin was administered to participants who had two APOL1 variants, biopsy-proven focal segmental glomerulosclerosis, and proteinuria (urinary protein-to-creatinine ratio of ≥0.7 to <10 [with protein and creatinine both measured in grams] and an estimated glomerular filtration rate of ≥27 ml per minute per 1.73 m² of body-surface area). Participants received inaxaplin daily for 13 weeks (15 mg for 2 weeks and 45 mg for 11 weeks) along with standard care. The primary outcome was the percent change from the baseline urinary protein-to-creatinine ratio at week 13 in participants who had at least 80% adherence to inaxaplin therapy. Safety was also assessed. RESULTS In preclinical studies, inaxaplin selectively inhibited APOL1 channel function in vitro and reduced proteinuria in the mouse model. Sixteen participants were enrolled in the phase 2a study. Among the 13 participants who were treated with inaxaplin and met the adherence threshold, the mean change from the baseline urinary protein-to-creatinine ratio at week 13 was -47.6% (95% confidence interval, -60.0 to -31.3). In an analysis that included all the participants regardless of adherence to inaxaplin therapy, reductions similar to those in the primary analysis were observed in all but 1 participant. Adverse events were mild or moderate in severity; none led to study discontinuation. CONCLUSIONS Targeted inhibition of APOL1 channel function with inaxaplin reduced proteinuria in participants with two APOL1 variants and focal segmental glomerulosclerosis. (Funded by Vertex Pharmaceuticals; VX19-147-101 ClinicalTrials.gov number, NCT04340362.) [ABSTRACT FROM AUTHOR]

Published
2023
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11. Update of the BIPM comparison BIPM.RI(II)-K1.Co-57 of activity measurements of the radionuclide 57Co to include the 2013 result of the POLATOM (Poland), the 2015 result of the NMISA (South Africa), the 2021 result of the CMI (Czech Republic), and to link the CCRI(II)-S6.Co-57 comparison

Author

Michotte, C, primary, Courte, S, additional, Nonis, M, additional, Coulon, R, additional, Ratel, G, additional, Zimmerman, B, additional, Dziel, T, additional, Muklanowicz, A, additional, Ziemek, T, additional, Staden, M J van, additional, Rooy, M W van, additional, Lubbe, J, additional, Sochorová, J, additional, and Auerbach, P, additional

Published
2022
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17. Normative positions towards COVID-19 contact-tracing apps: Findings from a large-scale qualitative study in nine European countries

Author

Lucivero, F., Marelli, L., Zimmerman, B., Prainsack, B., Galasso, I., Horn, R., Kieslich, K., Lanzing, M., Ongolly, F., Lievevrouw, E., Samuel, G., Sharon, T., Siffels, L.E., Stendahl, E., Van Hoyweghen, I., Lucivero, F., Marelli, L., Zimmerman, B., Prainsack, B., Galasso, I., Horn, R., Kieslich, K., Lanzing, M., Ongolly, F., Lievevrouw, E., Samuel, G., Sharon, T., Siffels, L.E., Stendahl, E., and Van Hoyweghen, I.

Abstract

Item does not contain fulltext

Published
2021

20. CtDNA as a predictor of outcome in patients treated with neoadjuvant atezolizumab in muscle invasive urothelial cancer

Author

Powles, T, primary, Szabados, B, additional, Castellano, D, additional, Rodriguez-Vida, A, additional, Valderrama, B, additional, Crabb, S, additional, Van Der Heijden, M, additional, Pous, AF, additional, Prendergast, A, additional, Gravis, G, additional, Herranz, UA, additional, Sharma, S, additional, Ravauld, A, additional, Sethi, H, additional, Zimmerman, B, additional, Aleshin, A, additional, Kockx, M, additional, Banchereau, R, additional, Mariathasan, S, additional, and Assaf, ZJ, additional

Published
2020
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21. Providing operational analysis to a peace support operation: the Kosovo experience

Author

Neighbour, MR, Bailey, P, Hawthorn, M, Lensing, C, Robson, H, Smith, S, and Zimmerman, B

Subjects
Operations research -- Analysis, Peace -- Research, Business, Business, general
Abstract

The Operational Analysis (OA) Branch of the HQ ARRC deployed into Kosovo concurrently with the withdrawal of Serbian forces. The authors, all members of the Operational Analysis Branch, were responsible for providing general scientific, and more specifically Operational Research, advice to General Jackson, Commander of the Kosovo Force. This paper outlines the work done by OA Branch leading up to, and during the challenging period from the first deployment of troops into Kosovo in June 1999 to October 1999. The work of the branch was in two major sections; the first, support to returning Kosovo to normality and the second, to monitor the compliance of the Kosovo Liberation Army (UCK) with the undertaking to demilitarise. OA Branch provided not only the military with work to quantify the return to normality, but also worked with and provided data to aid agencies. The work ranged from assessments of damage to the infrastructure of Kosovo, particularly the housing, through to the monitoring of crime. The population estimates produced by the branch corrected the emotive image being produced in the media, and became the subject of an international press conference. OA Branch's weekly Compliance Monitoring report was the authoritative document for checking on the progress of the UCK towards demilitarisation; this coupled with work on trends in violence were regularly briefed to the KFOR Commander. Journal of the Operational Research Society (2002) 53, 523-543. DOI: 10.1057/palgrave/jors/2601328 Keywords: peace support operations; compliance monitoring; campaign monitoring; damage assessment; Kosovo

Published
2002

23. BIPM comparison BIPM.RI(II)-K1.Ge-68 of activity measurements of the radionuclide 68Ge for the LNMRI/IRD, NIST, NIM, IRA-METAS, LNE-LNHB and the TAEK, and the linked 2015 CCRI(II)-K2.Ge-68 comparison

Author

Michotte, C, primary, Ratel, G, additional, Courte, S, additional, Nonis, M, additional, Iwahara, A, additional, Da Silva, C J, additional, Fitzgerald, R, additional, Bergeron, D E, additional, Cessna, J T, additional, Laureano-Pérez, L, additional, Pibida, L, additional, Zimmerman, B E, additional, Zhang, M, additional, Liang, J, additional, Liu, H, additional, Juget, F, additional, Nedjadi, Y, additional, Fréchou, C, additional, Bobin, C, additional, Yeltepe, E, additional, and Dirican, A, additional

Published
2020
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39. Masses and Proton Separation Energies Obtained from Qα and Qp Measurements*

Author

Davids, C. N., Woods, P. J., Batchelder, J. C., Bingham, C. R., Blumenthal, D. J., Brown, L. T., Busse, B. C., Carpenter, M. P., Conticchio, L. F., Davinson, T., Deboer, J., Freeman, S. J., Hamada, S., Henderson, D. J., Irvine, R. J., Janssens, R. V. F., Maier, H. J., MüLler, L., Page, R. D., Penttilä, H. T., Poli, G. L., Seweryniak, D., Soramel, F., Toth, K. S., Walters, W. B., and Zimmerman, B. E.

Published
2001

41. Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study

Author

Tang, W.H. Wilson, primary, McGee, Paula, additional, Lachin, John M., additional, Li, Daniel Y., additional, Hoogwerf, Byron, additional, Hazen, Stanley L., additional, Nathan, D.M., additional, Zinman, B., additional, Crofford, O., additional, Genuth, S., additional, Brown‐Friday, J., additional, Crandall, J., additional, Engel, H., additional, Engel, S., additional, Martinez, H., additional, Phillips, M., additional, Reid, M., additional, Shamoon, H., additional, Sheindlin, J., additional, Gubitosi‐Klug, R., additional, Mayer, L., additional, Pendegast, S., additional, Zegarra, H., additional, Miller, D., additional, Singerman, L., additional, Smith‐Brewer, S., additional, Novak, M., additional, Quin, J., additional, Genuth, Saul, additional, Palmert, M., additional, Brown, E., additional, McConnell, J., additional, Pugsley, P., additional, Crawford, P., additional, Dahms, W., additional, Gregory, N.S., additional, Lackaye, M.E., additional, Kiss, S., additional, Chan, R., additional, Orlin, A., additional, Rubin, M., additional, Brillon, D., additional, Reppucci, V., additional, Lee, T., additional, Heinemann, M., additional, Chang, S., additional, Levy, B., additional, Jovanovic, L., additional, Richardson, M., additional, Bosco, B., additional, Dwoskin, A., additional, Hanna, R., additional, Barron, S., additional, Campbell, R., additional, Bhan, A., additional, Kruger, D., additional, Jones, J.K., additional, Edwards, P.A., additional, Carey, J.D., additional, Angus, E., additional, Thomas, A., additional, Galprin, A., additional, McLellan, M., additional, Whitehouse, F., additional, Bergenstal, R., additional, Johnson, M., additional, Gunyou, K., additional, Thomas, L., additional, Laechelt, J., additional, Hollander, P., additional, Spencer, M., additional, Kendall, D., additional, Cuddihy, R., additional, Callahan, P., additional, List, S., additional, Gott, J., additional, Rude, N., additional, Olson, B., additional, Franz, M., additional, Castle, G., additional, Birk, R., additional, Nelson, J., additional, Freking, D., additional, Gill, L., additional, Mestrezat, W., additional, Etzwiler, D., additional, Morgan, K., additional, Aiello, L.P., additional, Golden, E., additional, Arrigg, P., additional, Asuquo, V., additional, Beaser, R., additional, Bestourous, L., additional, Cavallerano, J., additional, Cavicchi, R., additional, Ganda, O., additional, Hamdy, O., additional, Kirby, R., additional, Murtha, T., additional, Schlossman, D, additional, Shah, S., additional, Sharuk, G., additional, Silva, P., additional, Silver, P., additional, Stockman, M., additional, Sun, J., additional, Weimann, E., additional, Wolpert, H., additional, Aiello, L.M., additional, Jacobson, A., additional, Rand, L., additional, Rosenzwieg, J., additional, Larkin, M.E., additional, Christofi, M., additional, Folino, K., additional, Godine, J., additional, Lou, P., additional, Stevens, C., additional, Anderson, E., additional, Bode, H., additional, Brink, S., additional, Cornish, C., additional, Cros, D., additional, Delahanty, L., additional, eManbey, ., additional, Haggan, C., additional, Lynch, J., additional, McKitrick, C., additional, Norman, D., additional, Moore, D., additional, Ong, M., additional, Taylor, C., additional, Zimbler, D., additional, Crowell, S., additional, Fritz, S., additional, Hansen, K., additional, Gauthier‐Kelly, C., additional, Service, F.J., additional, Ziegler, G., additional, Barkmeier, A., additional, Schmidt, L., additional, French, B., additional, Woodwick, R., additional, Rizza, R., additional, Schwenk, W.F., additional, Haymond, M., additional, Pach, J., additional, Mortenson, J., additional, Zimmerman, B., additional, Lucas, A., additional, Colligan, R., additional, Luttrell, L., additional, Lopes‐Virella, M., additional, Caulder, S., additional, Pittman, C., additional, Patel, N., additional, Lee, K., additional, Nutaitis, M., additional, Fernandes, J., additional, Hermayer, K., additional, Kwon, S., additional, Blevins, A, additional, Parker, J., additional, Colwell, J., additional, Lee, D., additional, Soule, J., additional, Lindsey, P., additional, Bracey, M., additional, Farr, A., additional, Elsing, S., additional, Thompson, T., additional, Selby, J., additional, Lyons, T., additional, Yacoub‐Wasef, S., additional, Szpiech, M., additional, Wood, D., additional, Mayfield, R., additional, Molitch, M., additional, Adelman, D., additional, Colson, S., additional, Jampol, L., additional, Lyon, A., additional, Gill, M., additional, Strugula, Z., additional, Kaminski, L., additional, Mirza, R., additional, Simjanoski, E., additional, Ryan, D., additional, Johnson, C., additional, Wallia, A., additional, Ajroud‐Driss, S., additional, Astelford, P., additional, Leloudes, N., additional, Degillio, A., additional, Schaefer, B., additional, Mudaliar, S., additional, Lorenzi, G, additional, Goldbaum, M., additional, Jones, K., additional, Prince, M., additional, Swenson, M., additional, Grant, I., additional, Reed, R., additional, Lyon, R., additional, Kolterman, O., additional, Giotta, M., additional, Clark, T., additional, Friedenberg, G., additional, Sivitz, W.I., additional, Vittetoe, B., additional, Kramer, J., additional, Bayless, M., additional, Zeitler, R., additional, Schrott, H., additional, Olson, N., additional, Snetselaar, L., additional, Hoffman, R., additional, MacIndoe, J., additional, Weingeist, T., additional, Fountain, C., additional, Miller, R., additional, Johnsonbaugh, S., additional, Patronas, M., additional, Carney, M., additional, Mendley, S., additional, Salemi, P., additional, Liss, R., additional, Hebdon, M., additional, Counts, D., additional, Donner, T., additional, Gordon, J., additional, Hemady, R., additional, Kowarski, A., additional, Ostrowski, D., additional, Steidl, S., additional, Jones, B., additional, Herman, W.H., additional, Martin, C.L., additional, Pop‐Busui, R., additional, Greene, D.A., additional, Stevens, M.J., additional, Burkhart, N., additional, Sandford, T., additional, Floyd, J., additional, Bantle, J., additional, Flaherty, N., additional, Terry, J., additional, Koozekanani, D., additional, Montezuma, S., additional, Wimmergren, N., additional, Rogness, B., additional, Mech, M., additional, Strand, T., additional, Olson, J., additional, McKenzie, L., additional, Kwong, C., additional, Goetz, F., additional, Warhol, R., additional, Hainsworth, D., additional, Goldstein, D., additional, Hitt, S., additional, Giangiacomo, J., additional, Schade, D.S, additional, Canady, J.L., additional, Burge, M.R., additional, Das, A., additional, Avery, R.B., additional, Ketai, L.H., additional, Chapin, J.E., additional, Schluter, M.L., additional, Rich, J., additional, Johannes, C., additional, Hornbeck, D., additional, Schutta, M., additional, Bourne, P.A., additional, Brucker, A., additional, Braunstein, S., additional, Schwartz, S., additional, Maschak‐Carey, B.J., additional, Baker, L., additional, Orchard, T., additional, Cimino, L., additional, Songer, T., additional, Doft, B., additional, Olson, S., additional, Becker, D., additional, Rubinstein, D., additional, Bergren, R.L., additional, Fruit, J., additional, Hyre, R., additional, Palmer, C., additional, Silvers, N., additional, Lobes, L., additional, Rath, P. Paczan, additional, Conrad, P.W., additional, Yalamanchi, S., additional, Wesche, J., additional, Bratkowksi, M., additional, Arslanian, S., additional, Rinkoff, J., additional, Warnicki, J., additional, Curtin, D., additional, Steinberg, D., additional, Vagstad, G., additional, Harris, R., additional, Steranchak, L., additional, Arch, J., additional, Kelly, K., additional, Ostrosaka, P., additional, Guiliani, M., additional, Good, M., additional, Williams, T., additional, Olsen, K., additional, Campbell, A., additional, Shipe, C., additional, Conwit, R., additional, Finegold, D., additional, Zaucha, M., additional, Drash, A., additional, Morrison, A., additional, Malone, J.I., additional, Bernal, M.L., additional, Pavan, P.R., additional, Grove, N., additional, Tanaka, E.A., additional, McMillan, D., additional, Vaccaro‐Kish, J., additional, Babbione, L., additional, Solc, H., additional, DeClue, T.J., additional, Dagogo‐Jack, S., additional, Wigley, C., additional, Ricks, H., additional, Kitabchi, A., additional, Chaum, E., additional, Murphy, M.B., additional, Moser, S., additional, Meyer, D., additional, Iannacone, A., additional, Yoser, S., additional, Bryer‐Ash, M., additional, Schussler, S., additional, Lambeth, H., additional, Raskin, P., additional, Strowig, S., additional, Basco, M., additional, Cercone, S., additional, Barnie, A., additional, Devenyi, R., additional, Mandelcorn, M., additional, Brent, M., additional, Rogers, S., additional, Gordon, A., additional, Bakshi, N., additional, Perkins, B., additional, Tuason, L., additional, Perdikaris, F., additional, Ehrlich, R., additional, Daneman, D., additional, Perlman, K., additional, Ferguson, S, additional, Palmer, J., additional, Fahlstrom, R., additional, de Boer, I.H., additional, Kinyoun, J., additional, Van Ottingham, L., additional, Catton, S., additional, Ginsberg, J., additional, McDonald, C., additional, Harth, J., additional, Driscoll, M., additional, Sheidow, T., additional, Mahon, J., additional, Canny, C., additional, Nicolle, D., additional, Colby, P., additional, Dupre, J., additional, Hramiak, I., additional, Rodger, N.W., additional, Jenner, M., additional, Smith, T., additional, Brown, W., additional, May, M., additional, Lipps Hagan, J., additional, Agarwal, A., additional, Adkins, T., additional, Lorenz, R., additional, Feman, S., additional, Survant, L., additional, White, N.H., additional, Levandoski, L., additional, Grand, G., additional, Thomas, M., additional, Joseph, D., additional, Blinder, K., additional, Shah, G., additional, Burgess, D., additional, Boniuk, I., additional, Santiago, J., additional, Tamborlane, W., additional, Gatcomb, P., additional, Stoessel, K., additional, Ramos, P., additional, Fong, K., additional, Ossorio, P., additional, Ahern, J., additional, Meadema‐Mayer, L., additional, Beck, C., additional, Farrell, K., additional, Quin, J, additional, Gaston, P., additional, Trail, R., additional, Lachin, J., additional, Backlund, J., additional, Bebu, I., additional, Braffett, B., additional, Diminick, L., additional, Gao, X., additional, Hsu, W., additional, Klumpp, K., additional, Pan, H., additional, Trapani, V., additional, Cleary, P., additional, McGee, P., additional, Sun, W., additional, Villavicencio, S., additional, Anderson, K., additional, Dews, L., additional, Younes, Naji, additional, Rutledge, B., additional, Chan, K., additional, Rosenberg, D., additional, Petty, B., additional, Determan, A., additional, Kenny, D., additional, Williams, C., additional, Cowie, C., additional, Siebert, C., additional, Steffes, M., additional, Arends, V., additional, Bucksa, J., additional, Nowicki, M., additional, Chavers, B., additional, O'Leary, D., additional, Polak, J., additional, Harrington, A., additional, Funk, L., additional, Crow, R, additional, Gloeb, B., additional, Thomas, S., additional, O'Donnell, C., additional, Soliman, E.Z., additional, Zhang, Z.M., additional, Li, Y., additional, Campbell, C., additional, Keasler, L., additional, Hensley, S., additional, Hu, J., additional, Barr, M., additional, Taylor, T., additional, Prineas, R., additional, Feldman, E.L., additional, Albers, J.W., additional, Low, P., additional, Sommer, C., additional, Nickander, K., additional, Speigelberg, T., additional, Pfiefer, M., additional, Schumer, M., additional, Moran, M., additional, Farquhar, J., additional, Ryan, C., additional, Sandstrom, D., additional, Geckle, M., additional, Cupelli, E., additional, Thoma, F., additional, Burzuk, B., additional, Woodfill, T., additional, Danis, R., additional, Blodi, B., additional, Lawrence, D., additional, Wabers, H., additional, Gangaputra, S., additional, Neill, S., additional, Burger, M., additional, Dingledine, J., additional, Gama, V., additional, Sussman, R., additional, Davis, M., additional, Hubbard, L., additional, Budoff, M., additional, Darabian, S., additional, Rezaeian, P., additional, Wong, N., additional, Fox, M., additional, Oudiz, R., 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Published
2018
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46. Autoimmune pancreatitis in children: working guidelines for diagnosis and management.

Author

UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, Scheers, Isabelle, Palermo, J., Friedman, S., Wilsschanski, M., Shah, U., Abu-El-Haija, M., Barth, B, Fishman, D., Gariepy, C., Giefer, M., Heyman, M., Himes, R., Husain, S, Lin, T., Liu, Q., Lowe, M., Mascarenhas, M., Morinville, V., Ooi, C., Perito, E., Piccoli, D., Pohl, J., Schwarzenberg, S, Troendle, D, Werlin, S., Zimmerman, B., Uc, A., Gonska, T., 45th Edition BVK/SBP Congress, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, Scheers, Isabelle, Palermo, J., Friedman, S., Wilsschanski, M., Shah, U., Abu-El-Haija, M., Barth, B, Fishman, D., Gariepy, C., Giefer, M., Heyman, M., Himes, R., Husain, S, Lin, T., Liu, Q., Lowe, M., Mascarenhas, M., Morinville, V., Ooi, C., Perito, E., Piccoli, D., Pohl, J., Schwarzenberg, S, Troendle, D, Werlin, S., Zimmerman, B., Uc, A., Gonska, T., and 45th Edition BVK/SBP Congress

Abstract

Introduction Autoimmune pancreatitis (AIP) is an increasingly recognized disease entity, but data in children are limited. Pediatric gastroenterologists relied on adult AIP guidelines but disease presentation and outcome of AIP in children might differ from the adult experience. Aim We aim to develop a working definition and diagnostic approach for AIP in children. Methods Clinical data, imaging, histology, and treatment modalities were collected using 2 different approaches: (1) a systematic literature search and (2) children with an AIP diagnosis from the largest multicenter study of chronic pancreatitis in children (INSPPIRE) and from Cliniques St-Luc (CUSL). We then sought expert opinion from pediatric pancreatologists. Results We identified 44 AIP cases, 26 from literature review, 14 from the INSPPIRE and 4 from CUSL cohort. The median age at diagnosis was 13.2 years. Abdominal pain (39/44, 87%) and/or obstructive jaundice (20/44, 45%) were the most reported symptoms at diagnosis. Elevated IgG4 levels was seen in only 8/38 (21%). Cross-sectional imaging was abnormal in all children mainly showing hypointense global or focal gland enlargement (35/43, 81%), irregularity of the main pancreatic duct (29/43, 67%) and common bile duct stricture (25/43, 58%). Lymphoplasmacytic inflammation, pancreas fibrosis and ductal granulocyte infiltration were the main histologic findings (18/25, 72%). Children with AIP had a prompt clinical response to steroids. Complications of AIP included impaired exocrine (4/25,16%) and/or endocrine (3/27,11%) function. Conclusions AIP in children is a distinct subtype of pancreatitis. Based on these observations, we established working guidelines to help identification and management of children with AIP and pave the way for future studies.

Published
2017

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