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234 results on '"Zinellu, Elisabetta"'

3. Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study

Author

Zinellu, Angelo, primary, Zoroddu, Stefano, additional, Fois, Simona, additional, Mellino, Sabrina, additional, Scala, Chiara, additional, Virdis, Erika, additional, Zinellu, Elisabetta, additional, Sotgia, Salvatore, additional, Paliogiannis, Panagiotis, additional, Mangoni, Arduino A., additional, Carru, Ciriaco, additional, Pirina, Pietro, additional, and Fois, Alessandro G., additional

Published
2024
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4. Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis

Author

Zinellu, Angelo, Paliogiannis, Panagiotis, Sotgiu, Elisabetta, Mellino, Sabrina, Mangoni, Arduino A., Zinellu, Elisabetta, and Negri, Silvia

Subjects
Inflammation -- Care and treatment, Pulmonary fibrosis -- Care and treatment, Lymphocytes, Medical colleges, Health
Abstract

Purpose Inflammation and immunity play a pivotal but yet unclear role in idiopathic pulmonary fibrosis (IPF), a chronic disorder characterized by progressive damage of lung parenchyma and severe loss of lung function despite optimal treatment. However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain. Methods Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included in this cross-sectional study. Results We found significant differences in neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) between IPF patients and healthy controls. In logistic regression, all combined blood inflammation indexes, barring PLR, were independently associated with the presence of IPF after adjusting for age, gender, body mass index and smoking status. Furthermore, significant associations between FVC% and NLR, LMR, SIRI and AISI, and between DLCO% and NLR, dNLR, LMR, SIRI and AISI, were observed. Conclusions In conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation in IPF., Author(s): Angelo Zinellu [sup.1], Panagiotis Paliogiannis [sup.2], Elisabetta Sotgiu [sup.1], Sabrina Mellino [sup.1], Arduino A. Mangoni [sup.4], Elisabetta Zinellu [sup.3], Silvia Negri [sup.2] [sup.3], Claudia Collu [sup.2] [sup.3], Gianfranco Pintus [...]

Published
2020
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5. Evaluation of Inflammation and Oxidative Stress Markers in Patients with Obstructive Sleep Apnea (OSA)

Author

Pau, Maria Carmina, primary, Zinellu, Angelo, additional, Mangoni, Arduino A., additional, Paliogiannis, Panagiotis, additional, Lacana, Maria Roberta, additional, Fois, Sara Solveig, additional, Mellino, Sabrina, additional, Fois, Alessandro G., additional, Carru, Ciriaco, additional, Zinellu, Elisabetta, additional, and Pirina, Pietro, additional

Published
2023
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9. Prevalence and management of COPD and heart failure comorbidity in the general practitioner setting

Author

Pais, A., Cosseddu, S., Dessì, M.A., Accardo, G., Frau, D., Peruzzu, I., Uda, F., Idda, G., Sini, C., Piro, S., Muscas, A., Arno, P., Manca, A., Serra, F., Deiana, G., Pintori, G., Canu, M.G., Fanari, G., Setzu, S., Vaccargiu, A.M., Vincis, B., Schirru, M.T., Maureddu, P.P., Dall'Acqua, P., Contini, R., Meloni, M., Martinetti, M., Granara, A.R., Massa, S., Cadeddu, M.G., Mariani, B., Urru, C., Ambu, R., Meloni, M.C., Puddu, S., Spano, F., Musa, S., Corona, M., Pirina, Pietro, Martinetti, Marco, Spada, Claudia, Zinellu, Elisabetta, Pes, Rosanna, Chessa, Efisio, Fois, Alessandro Giuseppe, and Miravitlles, Marc

Published
2017
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15. IC4: a new combined predictive index of mortality in idiopathic pulmonary fibrosis

Author

ZINELLU, Angelo, primary, COLLU, Claudia, additional, ZINELLU, Elisabetta, additional, AHMAD, Kaïs, additional, NASSER, Mouhamad, additional, TRACLET, Julie, additional, SOTGIU, Elisabetta, additional, MELLINO, Sabrina, additional, MANGONI, Arduino A., additional, CARRU, Ciriaco, additional, PIRINA, Pietro, additional, COTTIN, Vincent, additional, and FOIS, Alessandro G., additional

Published
2022
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22. The Aggregate Index of Systemic Inflammation (AISI): A Novel Prognostic Biomarker in Idiopathic Pulmonary Fibrosis

Author

Zinellu, Angelo, primary, Collu, Claudia, additional, Nasser, Mouhamad, additional, Paliogiannis, Panagiotis, additional, Mellino, Sabrina, additional, Zinellu, Elisabetta, additional, Traclet, Julie, additional, Ahmad, Kais, additional, Mangoni, Arduino Aleksander, additional, Carru, Ciriaco, additional, Pirina, Pietro, additional, Fois, Alessandro Giuseppe, additional, and Cottin, Vincent, additional

Published
2021
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24. Vaccination Status and Number of Vaccine Doses Are Independently Associated with the PaO 2 /FiO 2 Ratio on Admission in Hospitalized COVID-19 Patients.

Author

Zinellu, Elisabetta, Zinellu, Angelo, Merella, Michela, Mangoni, Arduino A., Pau, Maria Carmina, Fois, Sara S., Fois, Alessandro G., Carru, Ciriaco, and Pirina, Pietro

Subjects
VACCINATION status, COVID-19, HOSPITAL patients, VACCINATION, COVID-19 testing
Abstract

Introduction: Coronavirus Disease-19 (COVID-19) vaccines reduce the risk of severe disease and mortality. However, the association between vaccination status and number of doses and the PaO2/FiO2 ratio, a clinical measure of hypoxemia associated with an increased risk of intensive care treatment and mortality, has not been investigated. Methods: We retrospectively assessed a consecutive series of 116 patients admitted to hospital with a primary diagnosis of COVID-19 between January and April 2022. Demographic, clinical, and laboratory data were collected within 24 h from admission. Results: There was a significant positive relationship between the number of vaccine doses and the PaO2/FiO2 ratio (r = 0.223, p = 0.012). This association remained significant after adjusting for confounders. Vaccinated patients had significantly higher PaO2/FiO2 ratios than the unvaccinated (median: 250; IQR: 195–309 vs. 200; IQR: 156–257, p = 0.013). Conclusion: These results highlight the importance of the number of vaccine doses received in reducing the degree of hypoxia on admission in hospitalized COVID-19 patients. [ABSTRACT FROM AUTHOR]

Published
2022
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30. The The PaO2/FiO2 ratio on admission is independently associated with prolonged hospitalization in COVID-19 patients

Author

Zinellu, Angelo, primary, De Vito, Andrea, additional, Scano, Valentina, additional, Paliogiannis, Panagiotis, additional, Fiore, Vito, additional, Madeddu, Giordano, additional, Maida, Ivana, additional, Zinellu, Elisabetta, additional, Mangoni, Arduino Aleksander, additional, Arru, Luigi Benedetto, additional, Carru, Ciriaco, additional, Babudieri, Sergio, additional, Pirina, Pietro, additional, and Fois, Alessandro Giuseppe, additional

Published
2021
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34. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients

Author

Fois, Alessandro G., primary, Paliogiannis, Panagiotis, additional, Scano, Valentina, additional, Cau, Stefania, additional, Babudieri, Sergio, additional, Perra, Roberto, additional, Ruzzittu, Giulia, additional, Zinellu, Elisabetta, additional, Pirina, Pietro, additional, Carru, Ciriaco, additional, Arru, Luigi B., additional, Fancellu, Alessandro, additional, Mondoni, Michele, additional, Mangoni, Arduino A., additional, and Zinellu, Angelo, additional

Published
2020
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36. Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease

Author

Zinellu, Elisabetta, Zinellu, Angelo, Fois, Alessandro G., Fois, Sara S., Piras, Barbara, Carru, Ciriaco, and Pirina, Pietro

Subjects
Article Subject
Abstract

Introduction. Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that is not fully reversible after inhaled bronchodilator use associated with an abnormal inflammatory condition. The biggest risk factor for COPD is cigarette smoking. The exposure to noxious chemicals contained within tobacco smoke is known to cause airway epithelial injury through oxidative stress, which in turn has the ability to elicit an inflammatory response. In fact, the disruption of the delicate balance between oxidant and antioxidant defenses leads to an oxidative burden that has long been held responsible to play a pivotal role in the pathogenesis of COPD. There are currently several biomarkers of oxidative stress in COPD that have been evaluated in a variety of biological samples. The aim of this review is to identify the best studied molecules by summarizing the key literature findings, thus shedding some light on the subject. Methods. We searched for relevant case-control studies examining oxidative stress biomarkers in stable COPD, taking into account the analytical method of detection as an influence factor. Results. Many oxidative stress biomarkers have been evaluated in several biological matrices, mostly in the blood. Some of them consistently differ between the cases and controls even when allowing different analytical methods of detection. Conclusions. The present review provides an overview of the oxidative stress biomarkers that have been evaluated in patients with COPD, bringing focus on those molecules whose reliability has been confirmed by the use of different analytical methods.

Published
2020
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38. Effects of Pirfenidone and Nintedanib on Markers of Systemic Oxidative Stress and Inflammation in Patients with Idiopathic Pulmonary Fibrosis: A Preliminary Report

Author

Fois, Alessandro G., primary, Sotgiu, Elisabetta, additional, Scano, Valentina, additional, Negri, Silvia, additional, Mellino, Sabrina, additional, Zinellu, Elisabetta, additional, Pirina, Pietro, additional, Pintus, Gianfranco, additional, Carru, Ciriaco, additional, Mangoni, Arduino A., additional, and Zinellu, Angelo, additional

Published
2020
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39. The De Ritis ratio as prognostic biomarker of in‐hospital mortality in COVID‐19 patients

Author

Zinellu, Angelo, primary, Arru, Francesco, additional, De Vito, Andrea, additional, Sassu, Alessandro, additional, Valdes, Giovanni, additional, Scano, Valentina, additional, Zinellu, Elisabetta, additional, Perra, Roberto, additional, Madeddu, Giordano, additional, Carru, Ciriaco, additional, Pirina, Pietro, additional, Mangoni, Arduino A., additional, Babudieri, Sergio, additional, and Fois, Alessandro G., additional

Published
2020
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40. Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases

Author

Chamitava, Liliya, primary, Cazzoletti, Lucia, additional, Ferrari, Marcello, additional, Garcia-Larsen, Vanessa, additional, Jalil, Aneza, additional, Degan, Paolo, additional, Fois, Alessandro G., additional, Zinellu, Elisabetta, additional, Fois, Sara S., additional, Fratta Pasini, Anna Maria, additional, Nicolis, Morena, additional, Olivieri, Mario, additional, Corsico, Angelo, additional, Bono, Roberto, additional, Pirina, Pietro, additional, and Zanolin, Maria Elisabetta, additional

Published
2020
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41. Systemic transsulfuration pathway thiol concentrations in chronic obstructive pulmonary disease patients

Author

Zinellu, Angelo, primary, Zinellu, Elisabetta, additional, Sotgiu, Elisabetta, additional, Fois, Alessandro G., additional, Paliogiannis, Panagiotis, additional, Scano, Valentina, additional, Piras, Barbara, additional, Sotgia, Salvatore, additional, Mangoni, Arduino A., additional, Carru, Ciriaco, additional, and Pirina, Pietro, additional

Published
2020
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46. The De Ritis ratio as prognostic biomarker of in‐hospital mortality in COVID‐19 patients.

Author

Zinellu, Angelo, Arru, Francesco, De Vito, Andrea, Sassu, Alessandro, Valdes, Giovanni, Scano, Valentina, Zinellu, Elisabetta, Perra, Roberto, Madeddu, Giordano, Carru, Ciriaco, Pirina, Pietro, Mangoni, Arduino A., Babudieri, Sergio, and Fois, Alessandro G.

Subjects
HOSPITAL mortality, COVID-19, BIOMARKERS, LOG-rank test, SURVIVAL analysis (Biometry)
Abstract

Increased concentrations of serum aspartate transaminase (AST) and alanine transaminase (ALT) are common in COVID‐19 patients. However, their capacity to predict mortality, particularly the AST/ALT ratio, commonly referred to as the De Ritis ratio, is unknown. We investigated the association between the De Ritis ratio on admission and in‐hospital mortality in 105 consecutive patients with coronavirus disease of 2019 (COVID‐19) admitted to three COVID‐19 referral centres in Sardinia, Italy. The De Ritis ratio was significantly lower in survivors than nonsurvivors (median: 1.25; IQR: 0.91‐1.64 vs 1.67; IQR: 1.38‐1.97, P =.002) whilst there were no significant between‐group differences in ALT and AST concentrations. In ROC curve analysis, the AUC value of the De Ritis ratio was 0.701 (95% CI 0.603‐0.787, P =.0006) with sensitivity and specificity of 74% and 70%, respectively. Kaplan‐Meier survival curves showed a significant association between the De Ritis ratio and mortality (logrank test P =.014). By contrast, no associations were observed between the ALT and AST concentrations and mortality (logrank test P =.83 and P =.62, respectively). In multivariate Cox regression analysis, the HR in patients with De Ritis ratios ≥1.63 (upper tertile of this parameter) remained significant after adjusting for age, gender, smoking status, cardiovascular disease, intensity of care, diabetes, respiratory diseases, malignancies and kidney disease (HR: 2.46, 95% CI 1.05‐5.73, P =.037). Therefore, the De Ritis ratio on admission was significantly associated with in‐hospital mortality in COVID‐19 patients. Larger studies are required to confirm the capacity of this parameter to independently predict mortality in this group. [ABSTRACT FROM AUTHOR]

Published
2021
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