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8. Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Author

Bjornsdottir, G. Stefansdottir, L. Thorleifsson, G. Sulem, P. Norland, K. Ferkingstad, E. Oddsson, A. Zink, F. Lund, S.H. Nawaz, M.S. Bragi Walters, G. Skuladottir, A.T. Gudjonsson, S.A. Einarsson, G. Halldorsson, G.H. Bjarnadottir, V. Sveinbjornsson, G. Helgadottir, A. Styrkarsdottir, U. Gudmundsson, L.J. Pedersen, O.B. Hansen, T.F. Werge, T. Banasik, K. Troelsen, A. Skou, S.T. Thørner, L.W. Erikstrup, C. Nielsen, K.R. Mikkelsen, S. Andersen, S. Brunak, S. Burgdorf, K. Hjalgrim, H. Jemec, G. Jennum, P. Johansson, P.I. Nielsen, K.R. Nyegaard, M. Bruun, M.T. Pedersen, O.B. Dinh, K.M. Sørensen, E. Ostrowski, S. Johansson, P.I. Gudbjartsson, D. Stefánsson, H. Þorsteinsdóttir, U. Larsen, M.A.H. Didriksen, M. Sækmose, S. Zeggini, E. Hatzikotoulas, K. Southam, L. Gilly, A. Barysenka, A. van Meurs, J.B.J. Boer, C.G. Uitterlinden, A.G. Styrkársdóttir, U. Stefánsdóttir, L. Jonsson, H. Ingvarsson, T. Esko, T. Mägi, R. Teder-Laving, M. Ikegawa, S. Terao, C. Takuwa, H. Meulenbelt, I. Coutinho de Almeida, R. Kloppenburg, M. Tuerlings, M. Slagboom, P.E. Nelissen, R.R.G.H.H. Valdes, A.M. Mangino, M. Tsezou, A. Zengini, E. Alexiadis, G. Babis, G.C. Cheah, K.S.E. Wu, T.T. Samartzis, D. Cheung, J.P.Y. Sham, P.C. Kraft, P. Kang, J.H. Hveem, K. Zwart, J.-A. Luetge, A. Skogholt, A.H. Johnsen, M.B. Thomas, L.F. Winsvold, B. Gabrielsen, M.E. Lee, M.T.M. Zhang, Y. Lietman, S.A. Shivakumar, M. Smith, G.D. Tobias, J.H. Hartley, A. Gaunt, T.R. Zheng, J. Wilkinson, J.M. Steinberg, J. Morris, A.P. Jonsdottir, I. Bjornsson, A. Olafsson, I.H. Ulfarsson, E. Blondal, J. Vikingsson, A. Brunak, S. Ostrowski, S.R. Ullum, H. Thorsteinsdottir, U. Stefansson, H. Gudbjartsson, D.F. Thorgeirsson, T.E. Stefansson, K. DBDS Genetic Consortium GO Consortium

Abstract

Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (ORIDD = 0.92, P = 1.6 × 10−39; ORdorsalgia = 0.92, P = 7.2 × 10−15) is with a 3’UTR variant (rs1871452-T) in CHST3, encoding a sulfotransferase enzyme expressed in intervertebral discs. The largest effects on IDD are conferred by rare (MAF = 0.07 − 0.32%) loss-of-function (LoF) variants in SLC13A1, encoding a sodium-sulfate co-transporter (LoF burden OR = 1.44, P = 3.1 × 10−11); variants that also associate with reduced serum sulfate. Genes implicated by this study are involved in cartilage and bone biology, as well as neurological and inflammatory processes. © 2022, The Author(s).

Published
2022

9. DNA Extraction Method for Insects From Sticky Traps: Targeting a Low Abundance Pest, Phthorimaea absoluta (Lepidoptera: Gelechiidae), in Mixed Species Communities.

Author

Butterwort, V, Dansby, H, Zink, F A, Tembrock, L R, Gilligan, T M, Godoy, A, Braswell, W E, and Kawahara, A Y

Subjects
NUCLEIC acid isolation methods, GELECHIIDAE, LEPIDOPTERA, INTRODUCED insects, INSECTS, BIOLOGICAL invasions, BIODIVERSITY
Abstract

Invasive insects can cause catastrophic damage to ecosystems and cost billions of dollars each year due to management expenses and lost revenue. Rapid detection is an important step to prevent invasive insects from spreading, but improvements in detection capabilities are needed for bulk collections like those from sticky traps. Here we present a bulk DNA extraction method designed for the detection of Phthorimaea absoluta Meyrick (Lepidoptera: Gelechiidae), an invasive moth that can decimate tomato crops. We test the extraction method for insect specimens on sticky traps, subjected to different temperature and humidity conditions, and among mock insect communities left in the field for up to 21 d. We find that the extraction method yielded high success (>92%) in recovering target DNA across field and lab trials, without a decline in recovery after three weeks, across all treatments. These results may have a large impact on tomato growing regions where P. absoluta is in the early stages of invasion or not yet present. The extraction method can also be used to improve detection capabilities for other bulk insect collections, especially those using sticky traps, to the benefit of pest surveys and biodiversity studies. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Publisher Correction: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures (Nature Communications, (2019), 10, 1, (2054), 10.1038/s41467-019-09860-0)

Author

Styrkarsdottir, U, Stefansson, OA, Gunnarsdottir, K, Thorleifsson, G, Lund, SH, Stefansdottir, L, Juliusson, K, Agustsdottir, AB, Zink, F, Halldorsson, GH, Ivarsdottir, EV, Benonisdottir, S, Jonsson, H, Gylfason, A, Norland, K, Trajanoska, K, Boer, CG, Southam, L, Leung, JCS, Tang, NLS, Kwok, TCY, Lee, JSW, Ho, SC, Byrjalsen, I, Center, JR, Lee, SH, Koh, JM, Lohmander, LS, Ho-Pham, LT, Nguyen, TV, Eisman, JA, Woo, J, Leung, PC, Loughlin, J, Zeggini, E, Christiansen, C, Rivadeneira, F, van Meurs, J, Uitterlinden, AG, Mogensen, B, Ingvarsson, T, Sigurdsson, G, Benediktsson, R, Sulem, P, Jonsdottir, I, Masson, G, Holm, H, Norddahl, GL, Thorsteinsdottir, U, Gudbjartsson, DF, and Stefansson, K

Abstract

© 2019, The Author(s). The original HTML version of this Article was updated shortly after publication to add links to the Peer Review file. In addition, affiliations 16 and 17 incorrectly read ‘School of Medicine Sydney, University of Notre Dame Australia, Sydney, WA, 6160, Australia’ and ‘St Vincent’s Clinical School, University of New South Wales Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.’ This has now been corrected in both the PDF and HTML versions of the Article.

Published
2019

13. A DNA Extraction Method for Insects From Sticky Traps: Targeting a Low Abundance Pest, Phthorimaea absoluta(Lepidoptera: Gelechiidae), in Mixed Species Communities

Author

Butterwort, V, Dansby, H, Zink, F A, Tembrock, L R, Gilligan, T M, Godoy, A, Braswell, W E, and Kawahara, A Y

Abstract

Invasive insects can cause catastrophic damage to ecosystems and cost billions of dollars each year due to management expenses and lost revenue. Rapid detection is an important step to prevent invasive insects from spreading, but improvements in detection capabilities are needed for bulk collections like those from sticky traps. Here we present a bulk DNA extraction method designed for the detection of Phthorimaea absolutaMeyrick (Lepidoptera: Gelechiidae), an invasive moth that can decimate tomato crops. We test the extraction method for insect specimens on sticky traps, subjected to different temperature and humidity conditions, and among mock insect communities left in the field for up to 21 d. We find that the extraction method yielded high success (>92%) in recovering target DNA across field and lab trials, without a decline in recovery after three weeks, across all treatments. These results may have a large impact on tomato growing regions where P. absolutais in the early stages of invasion or not yet present. The extraction method can also be used to improve detection capabilities for other bulk insect collections, especially those using sticky traps, to the benefit of pest surveys and biodiversity studies.

Published
2022
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14. GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures

Author

Styrkarsdottir, U, Stefansson, O A, Gunnarsdottir, K, Thorleifsson, G, Lund, SH, Stefansdottir, L, Juliusson, K, Agustsdottir, AB, Zink, F, Halldorsson, GH, Ivarsdottir, EV, Benonisdottir, S, Jonsson, H, Gylfason, A, Norland, K, Trajanoska, Katerina, Boer, Cindy, Southam, L, Leung, JCS, Tang, NLS, Kwok, TCY, Lee, JSW, Ho, SC, Byrjalsen, I, Center, JR, Lee, SH, Koh, JM, Lohmander, LS, Ho-Pham, LT, Nguyen, TV, Eisman, JA, Woo, J, Leung, PC, Loughlin, J, Zeggini, E, Christiansen, C, Rivadeneira, Fernando, van Meurs, Joyce, Uitterlinden, André, Mogensen, B, Ingvarsson, T, Sigurdsson, G, Benediktsson, R, Sulem, P, Jonsdottir, I, Masson, G, Holm, H, Norddahl, GL, Thorsteinsdottir, U, Gudbjartsson, DF, Stefansson, K, Styrkarsdottir, U, Stefansson, O A, Gunnarsdottir, K, Thorleifsson, G, Lund, SH, Stefansdottir, L, Juliusson, K, Agustsdottir, AB, Zink, F, Halldorsson, GH, Ivarsdottir, EV, Benonisdottir, S, Jonsson, H, Gylfason, A, Norland, K, Trajanoska, Katerina, Boer, Cindy, Southam, L, Leung, JCS, Tang, NLS, Kwok, TCY, Lee, JSW, Ho, SC, Byrjalsen, I, Center, JR, Lee, SH, Koh, JM, Lohmander, LS, Ho-Pham, LT, Nguyen, TV, Eisman, JA, Woo, J, Leung, PC, Loughlin, J, Zeggini, E, Christiansen, C, Rivadeneira, Fernando, van Meurs, Joyce, Uitterlinden, André, Mogensen, B, Ingvarsson, T, Sigurdsson, G, Benediktsson, R, Sulem, P, Jonsdottir, I, Masson, G, Holm, H, Norddahl, GL, Thorsteinsdottir, U, Gudbjartsson, DF, and Stefansson, K

Published
2019

30. Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis

Author

Styrkarsdottir, U., Helgason, H., Sigurdsson, A., Norddahl, G.L., Agustsdottir, A.B., Reynard, L.N., Villalvilla, A., Halldorsson, G.H., Jonasdottir, A., Magnusdottir, A., Oddson, A., Sulem, G., Zink, F., Sveinbjornsson, G., Helgason, A., Johannsdottir, H.S., Helgadottir, A., Stefansson, H., Gretarsdottir, S., Rafnar, T., Almdahl, I.S., Braekhus, A., Fladby, T., Selbaek, G., Hosseinpanah, F., Azizi, F., Koh, J.M., Tang, N.L., Daneshpour, M.S., Mayordomo, J.I., Welt, C., Braund, P.S., Samani, N.J., Kiemeney, L.A.L.M., Lohmander, L.S., Christiansen, C., Andreassen, O.A., Magnusson, O., Masson, G., Kong, A., Jonsdottir, I., Gudbjartsson, D., Sulem, P., Jonsson, H., Loughlin, J., Ingvarsson, T., Thorsteinsdottir, U., Stefansson, K., Styrkarsdottir, U., Helgason, H., Sigurdsson, A., Norddahl, G.L., Agustsdottir, A.B., Reynard, L.N., Villalvilla, A., Halldorsson, G.H., Jonasdottir, A., Magnusdottir, A., Oddson, A., Sulem, G., Zink, F., Sveinbjornsson, G., Helgason, A., Johannsdottir, H.S., Helgadottir, A., Stefansson, H., Gretarsdottir, S., Rafnar, T., Almdahl, I.S., Braekhus, A., Fladby, T., Selbaek, G., Hosseinpanah, F., Azizi, F., Koh, J.M., Tang, N.L., Daneshpour, M.S., Mayordomo, J.I., Welt, C., Braund, P.S., Samani, N.J., Kiemeney, L.A.L.M., Lohmander, L.S., Christiansen, C., Andreassen, O.A., Magnusson, O., Masson, G., Kong, A., Jonsdottir, I., Gudbjartsson, D., Sulem, P., Jonsson, H., Loughlin, J., Ingvarsson, T., Thorsteinsdottir, U., and Stefansson, K.

Abstract

Contains fulltext : 174179.pdf (publisher's version ) (Closed access), We performed a genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, which included 4,657 Icelandic patients and 207,514 population controls. We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P = 4.0 x 10-12, odds ratio (OR) = 16.7) and a frameshift mutation, rs532464664 (p.Val330Glyfs*106), in the CHADL gene that associates through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 x 10-18, OR = 7.71). On average, c.1141G>C heterozygotes and individuals homozygous for rs532464664 had their hip replacement operation 13.5 years and 4.9 years earlier than others (P = 0.0020 and P = 0.0026), respectively. We show that the full-length CHADL transcript is expressed in cartilage. Furthermore, the premature stop codon introduced by the CHADL frameshift mutation results in nonsense-mediated decay of the mutant transcripts.

Published
2017

31. Selection against variants in the genome associated with educational attainment

Author

Kong, A. (Augustine), Frigge, M.L. (Michael), Thorleifsson, G. (Gudmar), Stefansson, H. (Hreinn), Young, A.I. (Alexander I.), Zink, F. (Florian), Jonsdottir, G.A. (Gudrun A.), Okbay, A. (Aysu), Sulem, P. (Patrick), Masson, G. (Gisli), Gudbjartsson, D.F. (Daniel), Helgason, A. (Agnar), Bjornsdottir, G. (Gyda), Thorsteinsdottir, U. (Unnur), Zwart, J-A. (John-Anker), Kong, A. (Augustine), Frigge, M.L. (Michael), Thorleifsson, G. (Gudmar), Stefansson, H. (Hreinn), Young, A.I. (Alexander I.), Zink, F. (Florian), Jonsdottir, G.A. (Gudrun A.), Okbay, A. (Aysu), Sulem, P. (Patrick), Masson, G. (Gisli), Gudbjartsson, D.F. (Daniel), Helgason, A. (Agnar), Bjornsdottir, G. (Gyda), Thorsteinsdottir, U. (Unnur), and Zwart, J-A. (John-Anker)

Abstract

Epidemiological and genetic association studies show that genetics play an important role in the attainment of education. Here, we investigate the effect of this genetic component on the reproductive history of 109,120 Icelanders and the consequent impact on the gene pool over time. We show that an educational attainment polygenic score, POLYEDU, constructed from results of a recent study is associated with delayed reproduction (P < 10-100) and fewer children overall. The effect is stronger for women and remains highly significant after adjusting for educational attainment. Based on 129,808 Icelanders born between 1910 and 1990, we find that the average POLYEDU has been declining at a rate of ∼0.010 standard units per decade, which is substantial on an evolutionary timescale. Most importantly, because POLYEDU only captures a fraction of the overall underlying genetic component the latter could be declining at a rate that is two to three times faster.

Published
2017
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32. A rare splice donor mutation in the haptoglobin gene associates with blood lipid levels and coronary artery disease.

Author

Bjornsson, E., Helgason, H., Halldorsson, G., Helgadottir, A., Gylfason, A, Kehr, B., Jonasdottir, A., Sigurdsson, A., Oddsson, A., Thorleifsson, G., Magnusson, O.T., Gretarsdottir, S., Zink, F., Kristjansson, R.P., Asgeirsdottir, M., Swinkels, D.W., Kiemeney, L.A., Eyjolfsson, G.I., Sigurdardottir, O., Masson, G., Olafsson, I., Thorgeirsson, G., Holm, H., Thorsteinsdottir, U., Gudbjartsson, D.F., Sulem, P., Stefansson, K., Bjornsson, E., Helgason, H., Halldorsson, G., Helgadottir, A., Gylfason, A, Kehr, B., Jonasdottir, A., Sigurdsson, A., Oddsson, A., Thorleifsson, G., Magnusson, O.T., Gretarsdottir, S., Zink, F., Kristjansson, R.P., Asgeirsdottir, M., Swinkels, D.W., Kiemeney, L.A., Eyjolfsson, G.I., Sigurdardottir, O., Masson, G., Olafsson, I., Thorgeirsson, G., Holm, H., Thorsteinsdottir, U., Gudbjartsson, D.F., Sulem, P., and Stefansson, K.

Abstract

Contains fulltext : 174137.pdf (publisher's version ) (Closed access)

Published
2017

33. Pharmacogenomics study of glucocorticoid sensitive and resistant asthma predicts glucocorticoid responsiveness with high accuracy

Author

Hakonarson, H., Bjornsdottir, U.S., Halapi, E., Zink, F., Helgadottir, H., Bjarkarson, I., Arnason, T., Thorarinsson, F., Gudmundsdottir, A.S., Ingvarsson, S., Amundadottir, L., Andresdottir, M., Adalsteinsdottir, E.A., Gislason, D., Gislason, T., Gurney, M., Gulcher, J., and Stefansson, K.

Subjects
Human genetics -- Research, Corticosteroids -- Genetic aspects, Asthma -- Genetic aspects, Biological sciences
Published
2001

34. Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer

Author

Stacey, S.N., Kehr, B., Gudmundsson, J., Zink, F., Jonasdottir, A., Gudjonsson, S.A., Sigurdsson, A., Halldorsson, B.V., Agnarsson, B.A., Benediktsdottir, K.R., Aben, K.K.H., Vermeulen, S.H., Cremers, R.G., Panadero, A., Helfand, B.T., Cooper, P.R., Donovan, J.L., Hamdy, F.C., Jinga, V., Okamoto, I., Jonasson, J.G., Tryggvadottir, L., Johannsdottir, H., Kristinsdottir, A.M., Masson, G., Magnusson, O.T., Iordache, P.D., Helgason, A., Helgason, H., Sulem, P., Gudbjartsson, D.F., Kong, A., Jonsson, E., Barkardottir, R.B., Einarsson, G.V., Rafnar, T., Thorsteinsdottir, U., Mates, I.N., Neal, D.E., Catalona, W.J., Mayordomo, J.I., Kiemeney, L.A., Thorleifsson, G., Stefansson, K., Stacey, S.N., Kehr, B., Gudmundsson, J., Zink, F., Jonasdottir, A., Gudjonsson, S.A., Sigurdsson, A., Halldorsson, B.V., Agnarsson, B.A., Benediktsdottir, K.R., Aben, K.K.H., Vermeulen, S.H., Cremers, R.G., Panadero, A., Helfand, B.T., Cooper, P.R., Donovan, J.L., Hamdy, F.C., Jinga, V., Okamoto, I., Jonasson, J.G., Tryggvadottir, L., Johannsdottir, H., Kristinsdottir, A.M., Masson, G., Magnusson, O.T., Iordache, P.D., Helgason, A., Helgason, H., Sulem, P., Gudbjartsson, D.F., Kong, A., Jonsson, E., Barkardottir, R.B., Einarsson, G.V., Rafnar, T., Thorsteinsdottir, U., Mates, I.N., Neal, D.E., Catalona, W.J., Mayordomo, J.I., Kiemeney, L.A., Thorleifsson, G., and Stefansson, K.

Abstract

Contains fulltext : 172827.pdf (publisher's version ) (Open Access), Transcriptional and splicing anomalies have been observed in intron 8 of the CASP8 gene (encoding procaspase-8) in association with cutaneous basal-cell carcinoma (BCC) and linked to a germline SNP rs700635. Here, we show that the rs700635[C] allele, which is associated with increased risk of BCC and breast cancer, is protective against prostate cancer [odds ratio (OR) = 0.91, P = 1.0 x 10(-6)]. rs700635[C] is also associated with failures to correctly splice out CASP8 intron 8 in breast and prostate tumours and in corresponding normal tissues. Investigation of rs700635[C] carriers revealed that they have a human-specific short interspersed element-variable number of tandem repeat-Alu (SINE-VNTR-Alu), subfamily-E retrotransposon (SVA-E) inserted into CASP8 intron 8. The SVA-E shows evidence of prior activity, because it has transduced some CASP8 sequences during subsequent retrotransposition events. Whole-genome sequence (WGS) data were used to tag the SVA-E with a surrogate SNP rs1035142[T] (r(2) = 0.999), which showed associations with both the splicing anomalies (P = 6.5 x 10(-32)) and with protection against prostate cancer (OR = 0.91, P = 3.8 x 10(-7)).

Published
2016

39. Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

Author

University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, Hancock, D. B., Reginsson, G. W., Gaddis, N. C., Chen, X., Saccone, N. L., Lutz, S. M., Qaiser, Beenish, Sherva, R., Steinberg, S., Zink, F., Stacey, S. N., Glasheen, C., Chen, J., Gu, F., Frederiksen, B. N., Loukola, A., Gudbjartsson, D. F., Brueske, I., Landi, M. T., Bickeboeller, H., Madden, P., Farrer, L., Kaprio, J., Kranzler, H. R., Gelernter, J., Baker, T. B., Kraft, P., Amos, C. I., Caporaso, N. E., Hokanson, J. E., Bierut, L. J., Thorgeirsson, T. E., Johnson, E. O., Stefansson, K., University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, Hancock, D. B., Reginsson, G. W., Gaddis, N. C., Chen, X., Saccone, N. L., Lutz, S. M., Qaiser, Beenish, Sherva, R., Steinberg, S., Zink, F., Stacey, S. N., Glasheen, C., Chen, J., Gu, F., Frederiksen, B. N., Loukola, A., Gudbjartsson, D. F., Brueske, I., Landi, M. T., Bickeboeller, H., Madden, P., Farrer, L., Kaprio, J., Kranzler, H. R., Gelernter, J., Baker, T. B., Kraft, P., Amos, C. I., Caporaso, N. E., Hokanson, J. E., Bierut, L. J., Thorgeirsson, T. E., Johnson, E. O., and Stefansson, K.

Abstract

We conducted a 1000 Genomes-imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerstrom Test for Nicotine Dependence in 17 074 ever smokers from five European-ancestry samples. We followed up novel variants in 7469 ever smokers from five independent European-ancestry samples. We identified genome-wide significant association in the alpha-4 nicotinic receptor subunit (CHRNA4) gene on chromosome 20q13: lowest P = 8.0 x 10(-9) across all the samples for rs2273500-C (frequency = 0.15; odds ratio = 1.12 and 95% confidence interval = 1.08-1.17 for severe vs mild dependence). rs2273500-C, a splice site acceptor variant resulting in an alternate CHRNA4 transcript predicted to be targeted for nonsense-mediated decay, was associated with decreased CHRNA4 expression in physiologically normal human brains (lowest P = 7.3 x 10(-4)). Importantly, rs2273500-C was associated with increased lung cancer risk (N = 28 998, odds ratio = 1.06 and 95% confidence interval = 1.00-1.12), likely through its effect on smoking, as rs2273500-C was no longer associated with lung cancer after adjustment for smoking. Using criteria for smoking behavior that encompass more than the single 'cigarettes per day' item, we identified a common CHRNA4 variant with important regulatory properties that contributes to nicotine dependence and smoking-related consequences.

Published
2015

40. Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

Author

Hancock, D B, primary, Reginsson, G W, additional, Gaddis, N C, additional, Chen, X, additional, Saccone, N L, additional, Lutz, S M, additional, Qaiser, B, additional, Sherva, R, additional, Steinberg, S, additional, Zink, F, additional, Stacey, S N, additional, Glasheen, C, additional, Chen, J, additional, Gu, F, additional, Frederiksen, B N, additional, Loukola, A, additional, Gudbjartsson, D F, additional, Brüske, I, additional, Landi, M T, additional, Bickeböller, H, additional, Madden, P, additional, Farrer, L, additional, Kaprio, J, additional, Kranzler, H R, additional, Gelernter, J, additional, Baker, T B, additional, Kraft, P, additional, Amos, C I, additional, Caporaso, N E, additional, Hokanson, J E, additional, Bierut, L J, additional, Thorgeirsson, T E, additional, Johnson, E O, additional, and Stefansson, K, additional

Published
2015
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