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2. Left ventricular diastolic function in atrial fibrillation: Methodological implications and clinical considerations.

Author

Palmiero, Pasquale, Caretto, Pierpaolo, Zito, Annapaola, Ciccone, Marco Matteo, Pelliccia, Francesco, and Maiello, Maria

Subjects
LEFT heart ventricle, VENTRICULAR ejection fraction, HEART physiology, HEART failure, ATRIAL fibrillation, ECHOCARDIOGRAPHY, DISEASE progression
Abstract

The assessment of LVDDis routinely included in echocardiographic evaluation because it correlates with cardiac disease progression and its prognostic value. Classic parameters used for assessing LVdiastolic function correlate well with invasive measurements which remains the gold standard. Nevertheless, no one echocardiographic parameter alone can completely evaluate LVDD. LV diastolic function evaluation in atrial fibrillation is still challenging, since the E/A ratio, one of the most used parameters in echocardiographic evaluation, cannot be feasible. This is not a good reason to give up measurement. In this review, we analyze the different methods for estimating LV diastolic function in atrial fibrillation, including measurement not dependent on atrial systole and some novel methods that are promising, but not ever available during clinical practice highlighting that this assessment is mandatory for a complete clinical evaluation of the patients. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Identification of cardiac organ damage in arterial hypertension: insights by echocardiography for a comprehensive assessment

Author

Cameli, Matteo, Lembo, Maria, Sciaccaluga, Carlotta, Bandera, Francesco, Ciccone, Marco M., D’Andrea, Antonello, D’Ascenzi, Flavio, Esposito, Roberta, Evola, Vincenzo, Liga, Riccardo, Mandoli, Giulia E., Palmiero, Pasquale, Santoro, Ciro, Scicchitano, Pietro, Sorrentino, Regina, Zito, Annapaola, Pedrinelli, Roberto, Mondillo, Sergio, Mattioli, Anna V., and Galderisi, Maurizio

Published
2020
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8. Mediterranean diet impact on cardiovascular diseases: a narrative review

Author

Mattioli, Anna V., Palmiero, Pasquale, Manfrini, Olivia, Puddu, Paolo E., Nodari, Savina, Dei Cas, Alessandra, Mercuro, Giuseppe, Scrutinio, Domenico, Palermo, Pietro, Sciomer, Susanna, Di Francesco, Simona, Novo, Giuseppina, Novo, Salvatore, Pedretti, Roberto F.E., Zito, Annapaola, Parati, Gianfranco, Pedrinelli, Roberto, Farinetti, Alberto, Maiello, Maria, Moscucci, Federica, Tenaglia, Raffaele L., Sucato, Vincenzo, Triggiani, Marco, Cugusi, Lucia, Scicchitano, Pietro, Saba, Pier S., and Ciccone, Marco M.

Published
2017
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15. Survival Benefits of Invasive Versus Conservative Strategies in Heart Failure in Patients With Reduced Ejection Fraction and Coronary Artery Disease: A Meta-Analysis

Author

Wolff, Georg, Dimitroulis, Dimitrios, Andreotti, Felicita, Kołodziejczak, Michalina, Jung, Christian, Scicchitano, Pietro, Devito, Fiorella, Zito, Annapaola, Occhipinti, Michele, Castiglioni, Battistina, Calveri, Giuseppe, Maisano, Francesco, Ciccone, Marco M., De Servi, Stefano, and Navarese, Eliano P.

Published
2017
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19. The Prognostic Role of ST2L and sST2 in Patients Who Underwent Carotid Plaque Endarterectomy: A Five-Year Follow-Up Study

Author

Scicchitano, Pietro, primary, Marzullo, Andrea, additional, Santoro, Annarita, additional, Zito, Annapaola, additional, Cortese, Francesca, additional, Galeandro, Cristina, additional, Ciccone, Andrea Sebastiano, additional, Angiletta, Domenico, additional, Manca, Fabio, additional, Pulli, Raffaele, additional, Navarese, Eliano Pio, additional, Gurbel, Paul A., additional, and Ciccone, Marco Matteo, additional

Published
2022
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26. Low-dose aspirin for primary prevention of cardiovascular events in postmenopausal women with type-2 diabetes: The prescriptive approach in the real world

Author

Maiello, Maria, Cecere, Annagrazia, Zito, Annapaola, Ciccone, Marco Matteo, and Palmiero, Pasquale

Subjects
Cardiovascular events, low-dose aspirin, postmenopausal women, primary prevention, type-2 diabetes, Medicine, Original Article
Abstract

Background: The long-term efficacy of low-dose aspirin for primary prevention of cardiovascular (CV) events in postmenopausal women with type-2 diabetes is controversial. Therefore, it is recommended only on an individual basis, recommendation of grade C. Methods: We enrolled 275 consecutive postmenopausal women with type-2 diabetes, without an increased bleeding risk and without preexisting CV disease as coronary artery disease, stroke, and peripheral vascular disease, but with a high risk assessed by score >10%, aged 60–69 years. All were receiving aspirin (75–100 mg daily), aspirin group (AG). 170 postmenopausal women with type-2 diabetes and without preexisting cardiovascular (CV) disease, but not on aspirin treatment, despite a high risk assessed by score >10%, were control group (CG). Mean age was 66 ± 4 years for AG and 65 ± 7 years for CG. Our goal was to identify the prevalence of low-dose aspirin prescriptions in these populations according to different clinical conditions. Results: Women with only high risk were 41/275 (15%) on AG and 72/170 (42.3%) on CG, Chi-squared 41, Odds ratio 0.2, c.i. 95%, P < 0.0001. Women affected by metabolic syndrome were 105/275 (38.1%) on AG and 47/170 (27.6%) on CG, Chi-squared 5.1, Odds ratio 1.6, c.i. 95%, P < 0.02. Women affected by metabolic cardiomyopathy were 111/275 (40.3%) on AG and 44/170 (25.9%) on CG, Chi-squared 8, Odds ratio 1.8, c.i. 95%, P < 0.004. Women affected by diabetic cardiomyopathy were 18/275 (6.6%) on AG and 7/170 (4.2%) on CG, Chi-squared 1.2, Odds ratio 16, c.i. 95%, P < 0.2 n.s. Conclusions: Low-dose aspirin in our population is prescribed preferentially in postmenopausal women with type-2 diabetes when affected by metabolic syndrome or metabolic cardiomyopathy, at the opposite women with only high risk have lower chance to receive aspirin.

Published
2021

34. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19

Author

Carpagnano, Giovanna Elisiana, primary, Lecce, Valentina Di, additional, Quaranta, Vitaliano Nicola, additional, Zito, Annapaola, additional, Buonamico, Enrico, additional, Capozza, Elena, additional, Palumbo, Alessandro, additional, Gioia, Giuseppe Di, additional, Valerio, Vincenzo Nicola, additional, and Resta, Onofrio, additional

Published
2020
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35. When should cardiovascular prevention begin? The importance of antenatal, perinatal and primordial prevention

Author

D’Ascenzi, Flavio, primary, Sciaccaluga, Carlotta, additional, Cameli, Matteo, additional, Cecere, Annagrazia, additional, Ciccone, Marco M, additional, Di Francesco, Simona, additional, Ganau, Antonello, additional, Imbalzano, Egidio, additional, Liga, Riccardo, additional, Palermo, Pietro, additional, Palmiero, Pasquale, additional, Parati, Gianfranco, additional, Pedrinelli, Roberto, additional, Scicchitano, Piero, additional, Zito, Annapaola, additional, and Mattioli, Anna V, additional

Published
2019
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38. Correlation between coronary artery disease severity, left ventricular mass index and carotid intima media thickness, assessed by radio-frequency

Author

Ciccone Marco M, Scicchitano Pietro, Zito Annapaola, Agati Luciano, Gesualdo Michele, Mandolesi Sandro, Carbonara Rosa, Ciciarello Francesco, and Fedele Francesco

Subjects
RFQIMT, LVMI, coronary stenosis, CAD, cardiovascular risk, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Intima-media thickness of the common carotid artery (CCA-IMT) is a validated marker of systemic atherosclerosis process. The aim of this study was to evaluate the association between coronary artery disease (CAD), left ventricular hypertrophy (LVH) and CCA-IMT, assessed by Radio Frequency-Quality Intima Media Thickness (RFQIMT) method, the next generation of IMT real-time measurement, based on the direct analysis of the radiofrequency signal and endowed with high accuracy and reproducibility in early detection of arterial wall thickness. Methods 115 patients (76 men, mean age: 65.1 ± 12 years) referred to our department and shown significant (≥ 70% luminal obstruction) stenosis at least in one major epicardial coronary artery were studied. Coronary angiograms were divided for severity and extent of the disease: 79 patients (69%) had one, 24 patients (21%) two, 12 patients (10%) three major epicardial coronary arteries with ≥ 70% stenosis. All patients underwent echocardiography and carotid ultrasound examination, assessed by RF. Results Dividing RFQIMT data in tertiles, dyslipidaemia (31 patients with IMT ≥ 1.20 mm vs 16 with IMT = 0.91-1.19 vs 25 with IMT ≤ 0.9, p = 0.004), LVMI (153.5 ± 20.6 g/m2 in IMT ≥ 1.20 mm vs 131.2 ± 8.4 g/m2 in IMT = 0.91-1.19 mm vs 114.3 ± 11.1 g/m2 in IMT ≤ 0.9 mm, P < 0.001) and number of high stenosed coronary arteries (IMT ≥ 1.20 mm population more often showed three vessel diseases than IMT ≤ 0.90 mm one, P < 0.001) seemed to be significantly related to CCA-IMT increases. Furthermore, LVMI is positively related to IMT (r = 0.91; P < 0.001). In a multivariate regression model (R2 = 0.88), RFQIMT remained significantly associated with the dyslipidemia (regression coefficient ± standard error [SE]: 0.057 ± 0.023; p = 0.017), LVMI (regression coefficient ± SE: 0.01 ± 0.001; P < 0.0001) and number of damaged coronaries (regression coefficient ± SE: 0.0174 ± 0.028; P < 0.0001). Conclusions RFQIMT is a sophisticated method for carotid ultrasound evaluation. Its evaluation in patients with at least one important major epicardial coronary vessel stenosis would help the accuracy in the general assessment of the number of coronary lesions in these patients.

Published
2011
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40. Echocolor Doppler morpho-functional study of the jugulo-subclavian confluence in chronic cerebro-spinal venous insufficiency and multiple sclerosis patients

Author

Mandolesi, Sandro, D Alessandro, Aldo, Desogus, Antonello Ignazio, Ciccone, Marco Matteo, Zito, Annapaola, Stammegna, Immacolata, Tarcisio Niglio, Orsini, Augusto, Mandolesi, Dimitri, D Alessandro, Alessandro, and Revelli, Luca

Subjects
Adult, Male, Jugulo-Subclavian Confluence Diameter, Multiple Sclerosis, CCSVI, Valsalva Maneuver, Settore MED/18 - CHIRURGIA GENERALE, EchoColorDoppler Map, Middle Aged, Subclavian Vein, Severity of Illness Index, Disability Evaluation, Young Adult, Venous Insufficiency, Cerebrovascular Circulation, Hemorheology, Humans, Female, Jugular Veins, Ultrasonography, Doppler, Color, Aged
Abstract

The aim of this work is to measure the mean diameter of the confluence jugulo- subclavian, the impact of different types of jugular confluences and the correlation between the types of confluences and the Valsalva maneuver (jugular reflux) in subjects with Chronic Cerebro-Spinal Venous Insufficiency (CCSVI) and Multiple Sclerosis.We investigated by Echo-Color-Doppler (ECD) 103 subjects (67 F 36M) of mean age 45 ± 12 years (a minimum of 22 to a maximum of 79 years, with a median of 44 and a modal value 42 years), mean EDSS of 4.7 and average disease duration of 12 years.The 103 right jugular veins investigated had an average diameter of 8.4 ± 2.4 mm (minimum 4.0, maximum 14.9 mm; median 7.9; modal value 7.6 mm). Three form types were found: 56 cylindrical, 29 conical and 18 funnel. Valsalva maneuver was positive in 30 patients. The 103 left jugular investigated had an average diameter of 8.9 ± 2.4 mm (minimum 2.8, maximum 14.4 mm; median of 8.8; modal value 8.7 mm). The form types were found: 42 cylindrical, 45 conical and 16 funnel. Valsalva maneuver was positive in 30 patients.The mean diameter of the jugular veins was 8.7 mm. Internal jugular veins with cylindrical morphology have a diameter smaller than other forms; this difference is statistically significant. The different morphology of the jugular vein confluence does not increase the possibility of a reflux because the positive Valsalva maneuvers are not statistically significant when compared to the various types.CCSVI, EchoColorDoppler Map, Jugulo-Subclavian Confluence Diameter.Lo scopo di questo lavoro è quello di misurare il diametro medio della confluenza della Giugulare interna nella succlavia, l’incidenza delle diversi tipologie di confluenza e la correlazione tra queste e la manovra di Valsalva (reflusso in giugulare) in soggetti con insufficienza venosa cronica cerebro spinale (CCSVI) e la Sclerosi Multipla.Abbiamo studiato con Echo-Color-Doppler (ECD) 103 soggetti (67 F 36M) di età media 45 ± 12 anni (da un minimo di 22 ad un massimo di 79 anni, con una mediana di 44 e un valore modale 42 anni ), media di edss 4.7 e media durata della malattia di 12 anni. RISULTATI: le 103 vene giugulari destre avevano un diametro medio di 8,4 ± 2,4 millimetri (minimo 4,0, massimo 14,9 millimetri; mediana 7,9; valore modale 7,6 millimetri). Le tipologie trovate sono state: 56 cilindrica, 29 conica e 18 imbuto. La manovra di Valsalva è stata positiva in 30 pazienti. Le 103 giugulari sinistre avevano un diametro medio di 8,9 ± 2,4 millimetri (minimo 2,8, massimo 14,4 millimetri; mediana di 8,8; valore modale 8,7 millimetri). Le tipologie trovate sono state: 42 cilindrica, 45 conica e 16 imbuto. Manovra di Valsalva è stata positiva in 30 pazienti. La differenza di forme cilindriche su quelle coniche tra destra e sinistra è statisticamente significativa con Chi-quadro = 4.74 ep = 0,0294277. Nei maschi i diametri medi delle vene giugulari destre erano più grandi rispetto ai pazienti di sesso femminile e statisticamente significativi con Chiquadro = 5.04 ep = 0,0248.Il diametro medio delle vene giugulari interne alla confluenza è di 8,7 mm. Le giugulari interne con sbocco cilindrico hanno un diametro più piccolo statisticamente significativo rispetto alle altre forme. La differente morfologia della confluenza della vena giugulare non aumenta la possibilità di un reflusso in quanto le manovre di Valsalva positive non sono statisticamente significative rispetto ai vari tipi.

Published
2017

42. Idarucizumab: What Should We Know?

Author

Cortese, Francesca, primary, Calculli, Giacinto, additional, Gesualdo, Michele, additional, Cecere, Annagrazia, additional, Zito, Annapaola, additional, De Vito, Fiorella, additional, Carbonara, Rossella, additional, Carbonara, Santa, additional, Cortese, Anna Maria, additional, and Ciccone, Marco Matteo, additional

Published
2018
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43. Evaluation of endothelial function and cardiovascular risk in non-obese patients with slight degree of obstructive sleep apnea syndrome

Author

Devito, Fiorella, primary, Zito, Annapaola, additional, Dragonieri, Silvano, additional, Carratù, Pierluigi, additional, Quaranta, Vitaliano N., additional, Vitale, Francesco, additional, Quaranta, Nicola, additional, Panza, Francesco, additional, Logroscino, Giancarlo, additional, Cameli, Matteo, additional, Resta, Onofrio, additional, and Ciccone, Marco Matteo, additional

Published
2017
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44. When should cardiovascular prevention begin? The importance of antenatal, perinatal and primordial prevention

Author

D’Ascenzi, Flavio, Sciaccaluga, Carlotta, Cameli, Matteo, Cecere, Annagrazia, Ciccone, Marco M, Di Francesco, Simona, Ganau, Antonello, Imbalzano, Egidio, Liga, Riccardo, Palermo, Pietro, Palmiero, Pasquale, Parati, Gianfranco, Pedrinelli, Roberto, Scicchitano, Piero, Zito, Annapaola, and Mattioli, Anna V

Abstract

Cardiovascular diseases represent a major health problem, being one of the leading causes of morbidity and mortality worldwide. Therefore, in this scenario, cardiovascular prevention plays an essential role although it is difficult to establish when promoting and implementing preventive strategies. However, there is growing evidence that prevention should start even before birth, during pregnancy, aiming to avoid the onset of cardiovascular risk factors, since events that occur early in life have a great impact on the cardiovascular risk profile of an adult. The two pillars of this early preventive strategy are nutrition and physical exercise, together with prevention of cardio-metabolic diseases during pregnancy. This review attempts to gather the growing evidence of the benefits of antenatal, perinatal and primordial prevention, discussing also the possibility to reverse or to mitigate the cardiovascular profile developed in the initial stages of life. This could pave the way for future research, investigating the optimal time and duration of these preventing measures, their duration and maintenance in adulthood, and the most effective interventions according to the different age and guiding in the next years, the best clinical practice and the political strategies to cope with cardiovascular disease.

Published
2021
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45. Evaluation of endothelial function and cardiovascular risk in non-obese patients with slight degree of obstructive sleep apnea syndrome

Author

Devito, Fiorella, Zito, Annapaola, Dragonieri, Silvano, Carratu, Pierluigi, Quaranta, Vitaliano N., Vitale, Francesco, Quaranta, Nicola, Panza, Francesco, Logroscino, Giancarlo, Cameli, Matteo, Resta, Onofrio, Ciccone, Marco M., Devito, Fiorella, Zito, Annapaola, Dragonieri, Silvano, Carratu, Pierluigi, Quaranta, Vitaliano N., Vitale, Francesco, Quaranta, Nicola, Panza, Francesco, Logroscino, Giancarlo, Cameli, Matteo, Resta, Onofrio, and Ciccone, Marco M.

Abstract

Recently, it has been clearly described an independent relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk, with underlying mechanisms also including endothelial dysfunction. We enrolled 32 consecutive non-obese patients (mean age of 39.5 +/- 11.5 years), of which 16 with mild OSAS and 16 snoring without OSAS. Mild OSAS is defined by an AHI index between 5 and 15. We have investigated if whether there was a relationship between mild OSAS, endothelial function and carotid intima-media thickness (C-IMT). The population was divided into two groups: Group 1 (16 simple snorer patients with an average age of 39.4 +/- 12.1 years) and Group 2 (16 subjects with mild OSAS with an average age of 39.6 +/- 11.2 years). Each group underwent cardiovascular investigation including measurement of flow-mediated dilation (FMD) of the brachial artery and C-IMT. Both groups comprised non-obese subjects. Patients with mild OSAS had serum total cholesterol values statistically significantly higher than simple snores patients (178.6 +/- 24.9 vs 159.2 +/- 25.3; p=0.038). OSAS patients had also a trend towards higher values of maximum C-IMT compared to simple snorer patients (0.70 +/- 0.15 vs 0.65 +/- 0.16), although below the level of significance. Between the two groups, no difference was found for FMD values. The present results on mild OSAS strengthen the importance of a diagnosis of OSAS as soon as possible, in order to encourage all primary prevention interventions to correct risk factors responsible for disease progression and the occurrence of cardiovascular diseases, not excluding the use of therapies of non-invasive ventilation even in the early stages of the disease.

Published
2017
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47. MO014A LOW-SODIUM BREAD IMPROVES THE ADHERENCE TO A LOW-SODIUM DIET IN HYPERTENSIVE SUBJECTS

Author

Cosola, Carmela, primary, Maranzano, Valentina, additional, Zito, Annapaola, additional, Montemurno, Eustacchio, additional, Dalfino, Giuseppe, additional, Pompa, Giovanni, additional, Pertosa, Giovanni Battista, additional, Manno, Carlo, additional, Ciccone, Marco Matteo, additional, Grandaliano, Giuseppe, additional, and Gesualdo, Loreto, additional

Published
2017
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48. Evaluation of body composition with bioimpedence. A comparison between athletic and non‐athletic children

Author

Meleleo, Domenico, primary, Bartolomeo, Nicola, additional, Cassano, Liliana, additional, Nitti, Alessandro, additional, Susca, Giovanna, additional, Mastrototaro, Giuseppina, additional, Armenise, Umberto, additional, Zito, Annapaola, additional, Devito, Fiorella, additional, Scicchitano, Pietro, additional, and Ciccone, Marco Matteo, additional

Published
2017
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50. Non-alcoholic fatty liver disease is associated with early left ventricular dysfunction in childhood acute lymphoblastic leukaemia survivors

Author

Delvecchio, Maurizio, primary, Muggeo, Paola, additional, Monteduro, Mariantonietta, additional, Lassandro, Giuseppe, additional, Novielli, Chiara, additional, Valente, Federica, additional, Salinaro, Emanuela, additional, Zito, Annapaola, additional, Ciccone, Marco Matteo, additional, Miniello, Vito Leonardo, additional, Santoro, Nicola, additional, Giordano, Paola, additional, and Faienza, Maria Felicia, additional

Published
2017
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