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16 results on '"Zlobinskaya, Olga"'

9. Proton Minibeam Radiation Therapy Reduces Side Effects in an In Vivo Mouse Ear Model

Author

Girst, Stefanie, primary, Greubel, Christoph, additional, Reindl, Judith, additional, Siebenwirth, Christian, additional, Zlobinskaya, Olga, additional, Walsh, Dietrich W.M., additional, Ilicic, Katarina, additional, Aichler, Michaela, additional, Walch, Axel, additional, Wilkens, Jan J., additional, Multhoff, Gabriele, additional, Dollinger, Günther, additional, and Schmid, Thomas E., additional

Published
2016
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11. A laser-driven nanosecond proton source for radiobiological studies

Author

Bin, Jianhui, primary, Allinger, Klaus, additional, Assmann, Walter, additional, Dollinger, Günther, additional, Drexler, Guido A., additional, Friedl, Anna A., additional, Habs, Dieter, additional, Hilz, Peter, additional, Hoerlein, Rainer, additional, Humble, Nicole, additional, Karsch, Stefan, additional, Khrennikov, Konstantin, additional, Kiefer, Daniel, additional, Krausz, Ferenc, additional, Ma, Wenjun, additional, Michalski, Dörte, additional, Molls, Michael, additional, Raith, Sebastian, additional, Reinhardt, Sabine, additional, Röper, Barbara, additional, Schmid, Thomas E., additional, Tajima, Toshiki, additional, Wenz, Johannes, additional, Zlobinskaya, Olga, additional, Schreiber, Joerg, additional, and Wilkens, Jan J., additional

Published
2012
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13. Cigarette smoke‐induced transgenerational alterations in genome stability in cord blood of human F1 offspring

Author

Laubenthal, Julian, primary, Zlobinskaya, Olga, additional, Poterlowicz, Krzysztof, additional, Baumgartner, Adolf, additional, Gdula, Michal R., additional, Fthenou, Eleni, additional, Keramarou, Maria, additional, Hepworth, Sarah J., additional, Kleinjans, Jos C. S., additional, Schooten, Frederik‐Jan, additional, Brunborg, Gunnar, additional, Godschalk, Roger W., additional, Schmid, Thomas E., additional, and Anderson, Diana, additional

Published
2012
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15. Laser driven ion source from ultrathin foils and its biomedical application.

Author

Bin, Jianhui, Ma, Wenjun, Allinger, Klaus, Kiefer, Daniel, Hilz, Peter, Reinhardt, Sabine, Assmann, Walter, Habs, Dieter, Schreiber, Joerg, Drexler, Guido A., Friedl, Anna A., Humble, Nicole, Michalski, Dorte, Molls, Michael, Schmid, Thomas E., Zlobinskaya, Olga, and Wilkens, Jan J.

Abstract

Laser driven ion acceleration has attracted considerable attention due to its potential practical applications, such as in ion cancer therapy, proton imaging and fast ignition. Utilization of nanometer thin targets and ultrahigh contrast laser pulses has enabled a quantum leap in laser particle acceleration, offering much improved ion pulses as compared to plasma expansion schemes such as target normal sheath acceleration. Moreover, such nano-targets offer the possibility to control the ion beam by the laser parameters. We present the observation of well-collimated proton beams with a divergence as low as 1–2 degree and energies up to 8 MeV with a laser pulse of 0.4 J and 30 fs duration irradiating ultrathin DLC foils. The divergence strongly depends on the focal size of the laser and the highest energetic protons are generated even with moderate laser intensity as low as 3×1018 W/cm2. These remarkable features enabled us to irradiate living cells with a single shot dose of up to 7 Gray in one nanosecond for the first time, utilizing MPQ's table top ATLAS laser system. Although many issues still remain to solve, our demonstration of the feasibility of a very compact laser-driven beam line for proton acceleration, transport and delivery bolsters future applications such as laser driven hadron therapy. [ABSTRACT FROM PUBLISHER]

Published
2012
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16. Differences in Phosphorylated Histone H2AX Foci Formation and Removal of Cells Exposed to Low and High Linear Energy Transfer Radiation.

Author

Schmid TE, Zlobinskaya O, and Multhoff G

Abstract

The use of particle ion beams in cancer radiotherapy has a long history. Today, beams of protons or heavy ions, predominantly carbon ions, can be accelerated to precisely calculated energies which can be accurately targeted to tumors. This particle therapy works by damaging the DNA of tissue cells, ultimately causing their death. Among the different types of DNA lesions, the formation of DNA double strand breaks is considered to be the most relevant of deleterious damages of ionizing radiation in cells. It is well-known that the extremely large localized energy deposition can lead to complex types of DNA double strand breaks. These effects can lead to cell death, mutations, genomic instability, or carcinogenesis. Complex double strand breaks can increase the probability of mis-rejoining by NHEJ. As a consequence differences in the repair kinetics following high and low LET irradiation qualities are attributed mainly to quantitative differences in their contributions of the fast and slow repair component. In general, there is a higher contribution of the slow component of DNA double strand repair after exposure to high LET radiation, which is thought to reflect the increased amount of complex DNA double strand breaks. These can be accurately measured by the γ-H2AX assay, because the number of phosphorylated H2AX foci correlates well with the number of double strand breaks induced by low or / and high LET radiation.

Published
2012
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