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Abstract Background Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacological treatment. The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing. However, the toxicity of the strong hyperoxic hit precludes a longer-term follow-up due to high mortality after the first week of life. This study aimed to extend the preterm rabbit model to postnatal day (PND) 14 to mimic the evolving phase of BPD and enable the investigation of therapeutic interventions at later and more relevant time points. Methods Preterm rabbit pups delivered on the 28th day of gestation were either exposed to room air or different degrees of hyperoxia (50% and 70% O2) for 14 days. Single (immediately after birth) or double (at birth and at PND5) intratracheal lipopolysaccharide (LPS) administrations were also tested in combination with 50% O2. Age-matched rabbits delivered vaginally at term were used as controls. Survival, weight gain, lung function, pulmonary artery micro-ultrasound Doppler analysis, lung histology (alveolarization, lung injury score, and design-based stereology), and longitudinal micro-CT imaging were used to compare the outcomes at PND14. Results Premature birth itself, without any other BPD hit, was associated with lung function deficits, delayed lung development, and cardiovascular abnormalities. The BPD-like lung phenotype was enhanced by 70% O2 but not by 50% O2 hyperoxia. Intratracheal LPS delivered immediately after birth was associated with significantly higher lung injury scores at PND14 and increased tissue damping, a marker of parenchymal air resistance. Conclusion Several strategies are feasible to extend the preterm rabbit model of BPD to PND14. Preterm birth at the saccular phase itself, even in the absence of other postnatal BPD hits, was associated with lung function deficits, delayed lung development, and cardiovascular abnormalities compared with age-matched term rabbit pups. Enhanced BPD-like phenotypes can be further achieved by continued exposure to moderate hyperoxia (70% O2) and the intratracheal administration of LPS.

Este ensaio busca interpelar a educação do corpo através das práticas corporais ligadas ao esporte de rendimento mediadas pelos dispositivos de gênero. Sob esta mirada, tem como objetivo tensionar algumas questões ligadas aos usos políticos do corpo no que tange a regulamentação da participação de atletas trans e intersexo em competições esportivas. O texto faz uma crítica a tais regulamentos que ficam presos a uma ontologia onde o corpo é reduzido à sua natureza biológica e transcendental. As fronteiras das definições anatômico-sexuais, tradicionalmente impostas nas competições esportivas, sempre expurgaram do território de tais práticas os corpos trans e intersexo, pois estes borram o binarismo de gênero que o esporte sustenta. Conclui-se que a biologia do corpo de atletas trans e intersexo não deveriam ser colocadas como totalizantes nas marcações identitárias desses corpos, e assim, faz-se necessário superar tais “prisões” ontológicas.

The present study proposes an advanced multi-field modeling approach to optimize in silico subcutaneous insulin release. We introduce a generalized fluid-pharmacokinetics framework, integrating syringe injection and subcutaneous permeability, thus advancing a first-of-its-kind computational model of insulin delivery port. The proposed theoretical framework comprises three main elements: (1) a realistic geometry model of a commercial port device and the surrounding subcutaneous tissues; (2) a staggered fluid dynamics model of syringe injection coupled with a multi-compartmental model of insulin absorption within a porous medium; (3) a computational-based device optimization to minimize the onset of lipodystrophies due to multiple injection procedures. A novel tissue lesion model is advanced, linking local subcutaneous pressure levels to altered permeability that comprise accumulation effects due to repeated injections. The computational framework was fine-tuned according to state-of-the-art experimental evidence, and extensive numerical analyses predicted unexplored insulin port devices behaviors thus allowing comparison of computed haematic insulin profiles with those obtained clinically. Accordingly, a vast parametric analysis was performed to identify the optimal conditions that minimize tissue lesions and support prolonged device usage.

Abstract The interface between pediatric palliative care (PPC) and inborn metabolic diseases (IMD) remains incipient, though these conditions fill the state of art of complex chronic diseases, eligible to this health approach. We analyzed the medical records of PPC clinic during the years 2001 to 2021 and the IMD outpatients. We established a parallel with the world scientific literature concerning the epidemiology of PPC and IMD. Among outpatients, 14% were diagnosed with IMD, which were referred to the PPC service earlier compared to Non‐IMD cases. The Group 3 (complex molecules) was the most frequent (64.7%), following by Group 1 representing by small molecules (21.6%), the latter having a lower median age at diagnosis when compared to the former (0.7 vs. 5.2 years, p = 0.001). The sphingolipidoses were the pathologies most frequent in our cohort, in line with what was observed in the literature. There were no differences between IMD groups in terms of diagnosis and PPC referral age, however in Non‐IMD conditions, the age of diagnosis were earlier than IMD. Nevertheless, IMD group showed lower age of referral to PPC. The IMD comprises large fraction of outpatients in the PPC setting, thus further studies are needed in this field.

Background: Infective endocarditis is a life-threatening disease with diverse clinical presentations, making diagnosis challenging and requiring a range of complementary tests. The level of suspicion, based on clinical judgment, guides decisions regarding the initiation of empirical treatment and the selection of appropriate diagnostic tools. This study aimed to develop and validate the EndoPredict-Dx score for early prediction of infective endocarditis diagnosis. Methods: Patients admitted to a specialized cardiovascular hospital emergency department with suspected infective endocarditis between January 2011 and January 2020 were included. The primary outcome was left-sided infective endocarditis according to the Duke criteria. Logistic regression was used to derive the scoring system, with internal validation performed through bootstrapping. Candidate variables were obtained from the admission medical history, physical examination, and laboratory parameters. Results: Of the 805 individuals with suspected infective endocarditis (median age 56 years (40–73); 58.6% men), 530 confirmed the diagnosis based on the Duke criteria. The EndoPredict-Dx assigned points for male sex, previous endocarditis, petechiae, heart murmur, suspected embolism, symptoms lasting 14 or more days at the time of admission, hemoglobin level ≤ 12 g/dL, leukocyte level ≥ 10 × 109/L, C-reactive protein level ≥ 20 mg/L, and urine red blood cells ≥ 20,000 cells/mL. Patients were divided into three risk groups. The AUROC was 0.78 (95% CI 0.75–0.81) for the derivation cohort and 0.77 for the internal validation. Conclusions: The EndoPredict-Dx score accurately predicted the likelihood of infective endocarditis using clinical and laboratory data collected at admission.

Este estudo tem como objetivo analisar o modo como os atos de currículo da Educação Física (EF) legitimam as práticas corporais no âmbito de três escolas de Ensino Médio (EM) de Simão Dias – Sergipe. A pesquisa foi feita a partir de uma abordagem qualitativa, do tipo documental. Os respectivos Projetos Político-Pedagógicos e Planos de Ensino do componente foram submetidos à análise de conteúdo de Bardin. Notamos que as limitações dos espaços físicos condicionam a vivência de práticas legitimadas na escola. Percebemos forte influência dos Parâmetros Curriculares Nacionais, assim como a vivência exaustiva dos esportes euroamericanos.

O escrito tem como objetivo interpelar o fascismo propagado no filme “Raça” (2016), tensionando-o a partir de questões ligadas à raça, à eugenia, ao dispositivo da imunidade e às políticas do corpo e da vida como formas de regulação. A partir de trechos do filme, discutem-se os modos pelos quais os argumentos científicos embasam as possibilidades de eliminação de uns em detrimento da valoração da vida de outros. Os mecanismos fascistas descritos e analisados no filme operam como práticas biopolíticas por meio de dispositivos diversos. Entende-se que isso conforma práticas políticas de regulação sobre os corpos na direção da manutenção ou supressão da vida, de acordo com as características que são atribuídas, arbitrariamente, aos indivíduos e à população. Considera-se que o filme é retrato de um contexto em que tais práticas foram exacerbadas ao limite, e que o esporte olímpico e os Jogos Olímpicos são arenas privilegiadas paras esses ensaios sociais

ABSTRACT Objective: To describe the newborn population with Patau (T13) and Edwards Syndrome (T18) with congenital heart diseases that stayed in the Intensive Care Unit (ICU) of a quaternary care hospital complex, regarding surgical and non-surgical medical procedures, palliative care, and outcomes. Methods: Descriptive case series conducted from January/2014 to December/2018 through analysis of records of patients with positive karyotype for T13 or T18 who stayed in the ICU of a quaternary hospital. Descriptive statistics analysis was applied. Results: 33 records of eligible patients were identified: 27 with T18 (82%), and 6 T13 (18%); 64% female and 36% male. Eight were preterm infants with gestational age between 30–36 weeks (24%), and only 4 among the 33 infants had a birth weight >2500 g (12%). Four patients underwent heart surgery and one of them died. Intrahospital mortality was 83% for T13, and 59% for T18. The majority had other malformations and underwent other surgical procedures. Palliative care was offered to 54% of the patients. The median hospitalization time for T18 and T13 was 29 days (range: 2–304) and 25 days (13–58), respectively. Conclusions: Patients with T13 and T18 have high morbidity and mortality, and long hospital and ICU stays. Multicentric studies are needed to allow the analysis of important aspects for creating protocols that, seeking therapeutic proportionality, may bring better quality of life for patients and their families.

O objetivo deste trabalho é refletir sobre a evolução epistemológica do Racionalismo Crítico e a cientificidade da Administração. Para alcançá-lo, empregou-se a pesquisa bibliográfica para recuperar materiais sobre Karl Popper, Imre Lakatos e demais autores, além de perpassar pelos principais pesquisadores brasileiros tangente à cientificidade da Administração. As discussões evidenciam que o Racionalismo Crítico foi influenciado pelos convencionalistas, como Henri Poincaré e Pierre Duhem, além disso, dentro dos marcadores popperianos e lakatianos, a Administração pode ser considerada uma ciência, embora algumas pesquisas possam carecer de rigor metodológico. Por fim, considera-se que essa área do saber ainda tem muito a evoluir, contudo, é a única capaz de investigar com afinco seu objeto principal: as organizações.

O ensaio objetiva demonstrar as formas de presença do animal e da animalidade que fazem do esporte uma expressão desse “mais-que-humano” do humano. Parte-se do pressuposto que o esporte é uma manifestação potente da animalidade do humano, e não uma fronteira que os coloca em oposição. Tensiona-se o conceito de território para interpelar a relação “animal/humano” no esporte a fim de pensar os processos cartográficos intermediado por poderes: o poder dos dispositivos que os atravessam e a potência do poder desses corpos de afetar e serem afetados. Conclui-se que o esporte é um fenômeno da vida, ou do continuum da vida, ao expressar sempre o “mais-que-humano” do humano. Por ser um argumento de ordem política, entende-se que as análises sobre o esporte não podem se furtar de repensá-lo desde uma chave ontológica distinta daquela que separa os seres e os classifica a partir de uma relação de superioridade e inferioridade.