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3 results on '"Zoe M. Mandese"'

1. Evidence of transmission from fully vaccinated individuals in a large outbreak of the SARS-CoV-2 Delta variant in Provincetown, Massachusetts

Author

Pardis C. Sabeti, Erika Buzby, Stacey Gabriel, Hanna Shephard, Clare Bernard, Petra L. Schubert, Deirdre Arvidson, Anthony A. Philippakis, Stephanie Baez, Christopher Tomkins-Tinch, Faye L. Reagan, Corey M. Nolet, Matthew Defelice, Catherine M. Brown, Kyle Vernest, Lydia A. Krasilnikova, Gabrielle Gionet, Seana Cofsky, John Beauchamp, Nicholas A. Fitzgerald, Maurice Melchiono, Timelia Fink, Taylor Brock-Fisher, Niall J. Lennon, Jessica Brown, Andrew S. Lang, Bradford P. Taylor, Katelyn S. Messer, Nikolaos Barkas, Sushma Chaluvadi, Selina Clancy, William P. Hanage, Katherine C. DeRuff, Vaira Harik, Bryn Loftness, Gordon Adams, Glen R. Gallagher, Christine Loreth, Brendan Blumenstiel, Lisa M. Anderson, Hillary Johnson, Zoe M. Mandese, Gage K. Moreno, Sabrina T. Dobbins, James Meldrim, Amanda Kearns, Heather M. Rooke, Scott Hennigan, Jacob E. Lemieux, Bronwyn MacInnis, Marissa E. Fisher, Rachel Harrington, Joshua Hall, Maesha A. Ulcena, Sandra Smole, Gina Vicente, Matthew D. Lee, Natasha L. Smith, Sean E. English, Stephen F. Schaffner, Luc Gagne, Michelle Cipicchio, Matthew Doucette, Scott Anderson, Daniel J. Park, Stephanie Ash, Ivan Specht, Lawrence C. Madoff, Steven K. Reilly, Theresa Covell, Katie Larkin, Marianne C. Ray, Sarah D. Slack, Megan E. Vodzak, Jillian Silbert, Johanna Vostok, Beau Schaeffer, Jonna Grimsby, Molly Dunn, and Katherine J. Siddle

Subjects
Delta, Adult, Male, medicine.medical_specialty, Adolescent, Population, Genome, Viral, Disease cluster, Article, law.invention, Disease Outbreaks, Young Adult, law, Epidemiology, medicine, Humans, education, Child, Phylogeny, Aged, Aged, 80 and over, education.field_of_study, Molecular Epidemiology, Whole Genome Sequencing, SARS-CoV-2, Public health, Vaccination, Infant, Newborn, Outbreak, COVID-19, Infant, Middle Aged, Geography, Transmission (mechanics), Massachusetts, Child, Preschool, Female, Contact Tracing, Demography
Abstract

Multiple summer events, including large indoor gatherings, in Provincetown, Massachusetts (MA), in July 2021 contributed to an outbreak of over one thousand COVID-19 cases among residents and visitors. Most cases were fully vaccinated, many of whom were also symptomatic, prompting a comprehensive public health response, motivating changes to national masking recommendations, and raising questions about infection and transmission among vaccinated individuals. To characterize the outbreak and the viral population underlying it, we combined genomic and epidemiological data from 467 individuals, including 40% of known outbreak-associated cases. The Delta variant accounted for 99% of sequenced outbreak-associated cases. Phylogenetic analysis suggests over 40 sources of Delta in the dataset, with one responsible for a single cluster containing 83% of outbreak-associated genomes. This cluster was likely not the result of extensive spread at a single site, but rather transmission from a common source across multiple settings over a short time. Genomic and epidemiological data combined provide strong support for 25 transmission events from, including many between, fully vaccinated individuals; genomic data alone provides evidence for an additional 64. Together, genomic epidemiology provides a high-resolution picture of the Provincetown outbreak, revealing multiple cases of transmission of Delta from fully vaccinated individuals. However, despite its magnitude, the outbreak was restricted in its onward impact in MA and the US, likely due to high vaccination rates and a robust public health response.

Published
2021

2. Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA

Author

Rebecca Earnest, Rockib Uddin, Nicholas Matluk, Nicholas Renzette, Sarah E. Turbett, Katherine J. Siddle, Christine Loreth, Gordon Adams, Christopher H. Tomkins-Tinch, Mary E. Petrone, Jessica E. Rothman, Mallery I. Breban, Robert Tobias Koch, Kendall Billig, Joseph R. Fauver, Chantal B.F. Vogels, Kaya Bilguvar, Bony De Kumar, Marie L. Landry, David R. Peaper, Kevin Kelly, Greg Omerza, Heather Grieser, Sim Meak, John Martha, Hannah B. Dewey, Susan Kales, Daniel Berenzy, Kristin Carpenter-Azevedo, Ewa King, Richard C. Huard, Vlad Novitsky, Mark Howison, Josephine Darpolor, Akarsh Manne, Rami Kantor, Sandra C. Smole, Catherine M. Brown, Timelia Fink, Andrew S. Lang, Glen R. Gallagher, Virginia E. Pitzer, Pardis C. Sabeti, Stacey Gabriel, Bronwyn L. MacInnis, Ryan Tewhey, Mark D. Adams, Daniel J. Park, Jacob E. Lemieux, Nathan D. Grubaugh, Ahmad Altajar, Alexandra DeJesus, Anderson Brito, Anne E. Watkins, Anthony Muyombwe, Brendan S. Blumenstiel, Caleb Neal, Chaney C. Kalinich, Chen Liu, Christopher Castaldi, Claire Pearson, Clare Bernard, Corey M. Nolet, David Ferguson, Erika Buzby, Eva Laszlo, Faye L. Reagan, Gina Vicente, Heather M. Rooke, Heidi Munger, Hillary Johnson, Irina R. Tikhonova, Isabel M. Ott, Jafar Razeq, James C. Meldrim, Jessica Brown, Jianhui Wang, Johanna Vostok, John P. Beauchamp, Jonna L. Grimsby, Joshua Hall, Katelyn S. Messer, Katie L. Larkin, Kyle Vernest, Lawrence C. Madoff, Lisa M. Green, Lori Webber, Luc Gagne, Maesha A. Ulcena, Marianne C. Ray, Marissa E. Fisher, Mary Barter, Matthew D. Lee, Matthew T. DeFelice, Michelle C. Cipicchio, Natasha L. Smith, Niall J. Lennon, Nicholas A. Fitzgerald, Nicholas Kerantzas, Pei Hui, Rachel Harrington, Randy Downing, Rashida Haye, Ryan Lynch, Scott E. Anderson, Scott Hennigan, Sean English, Seana Cofsky, Selina Clancy, Shrikant Mane, Stephanie Ash, Stephanie Baez, Steve Fleming, Steven Murphy, Sushma Chaluvadi, Tara Alpert, Trevor Rivard, Wade Schulz, Zoe M. Mandese, and Acibadem University Dspace

Subjects
Delta, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Alpha (ethology), COVID-19, Biology, Transmissibility (vibration), General Biochemistry, Genetics and Molecular Biology, Article, New england, New England, Humans, Viral rna, Public Health, Demography
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant quickly rose to dominance in mid-2021, displacing other variants, including Alpha. Studies using data from the United Kingdom and India estimated that Delta was 40-80% more transmissible than Alpha, allowing Delta to become the globally dominant variant. However, it was unclear if the ostensible difference in relative transmissibility was due mostly to innate properties of Delta’s infectiousness or differences in the study populations. To investigate, we formed a partnership with SARS-CoV-2 genomic surveillance programs from all six New England US states. By comparing logistic growth rates, we found that Delta emerged 37-163% faster than Alpha in early 2021 (37% Massachusetts, 75% New Hampshire, 95% Maine, 98% Rhode Island, 151% Connecticut, and 163% Vermont). We next computed variant-specific effective reproductive numbers and estimated that Delta was 58-120% more transmissible than Alpha across New England (58% New Hampshire, 68% Massachusetts, 76% Connecticut, 85% Rhode Island, 98% Maine, and 120% Vermont). Finally, using RT-PCR data, we estimated that Delta infections generate on average ∼6 times more viral RNA copies per mL than Alpha infections. Overall, our evidence indicates that Delta’s enhanced transmissibility could be attributed to its innate ability to increase infectiousness, but its epidemiological dynamics may vary depending on the underlying immunity and behavior of distinct populations.

Published
2021

3. Transmission from vaccinated individuals in a large SARS-CoV-2 Delta variant outbreak

Author

Katherine J. Siddle, Lydia A. Krasilnikova, Gage K. Moreno, Stephen F. Schaffner, Johanna Vostok, Nicholas A. Fitzgerald, Jacob E. Lemieux, Nikolaos Barkas, Christine Loreth, Ivan Specht, Christopher H. Tomkins-Tinch, Jillian S. Paull, Beau Schaeffer, Bradford P. Taylor, Bryn Loftness, Hillary Johnson, Petra L. Schubert, Hanna M. Shephard, Matthew Doucette, Timelia Fink, Andrew S. Lang, Stephanie Baez, John Beauchamp, Scott Hennigan, Erika Buzby, Stephanie Ash, Jessica Brown, Selina Clancy, Seana Cofsky, Luc Gagne, Joshua Hall, Rachel Harrington, Gabrielle L. Gionet, Katherine C. DeRuff, Megan E. Vodzak, Gordon C. Adams, Sabrina T. Dobbins, Sarah D. Slack, Steven K. Reilly, Lisa M. Anderson, Michelle C. Cipicchio, Matthew T. DeFelice, Jonna L. Grimsby, Scott E. Anderson, Brendan S. Blumenstiel, James C. Meldrim, Heather M. Rooke, Gina Vicente, Natasha L. Smith, Katelyn S. Messer, Faye L. Reagan, Zoe M. Mandese, Matthew D. Lee, Marianne C. Ray, Marissa E. Fisher, Maesha A. Ulcena, Corey M. Nolet, Sean E. English, Katie L. Larkin, Kyle Vernest, Sushma Chaluvadi, Deirdre Arvidson, Maurice Melchiono, Theresa Covell, Vaira Harik, Taylor Brock-Fisher, Molly Dunn, Amanda Kearns, William P. Hanage, Clare Bernard, Anthony Philippakis, Niall J. Lennon, Stacey B. Gabriel, Glen R. Gallagher, Sandra Smole, Lawrence C. Madoff, Catherine M. Brown, Daniel J. Park, Bronwyn L. MacInnis, and Pardis C. Sabeti

Subjects
Article, General Biochemistry, Genetics and Molecular Biology
Abstract

An outbreak of over one thousand COVID-19 cases in Provincetown, Massachusetts, in July 2021—the first large outbreak mostly in vaccinated individuals in the US—prompted a comprehensive public health response, motivating changes to national masking recommendations and raising questions about infection and transmission among vaccinated individuals. To address these questions, we combined genomic and epidemiological data from 467 individuals, including 40% of known outbreak-associated cases. The Delta variant accounted for 99% of outbreak-associated cases in this dataset; it was introduced from at least 40 sources, but 83% of cases derived from a single source, likely through transmission across multiple settings over a short time rather than a single event. Genomic and epidemiological data supported multiple transmissions of Delta from and between fully vaccinated individuals. However, despite its magnitude, the outbreak had limited onward impact in MA and the US, likely due to high vaccination rates and a robust public health response., Rapid integration of epidemiological and genomic data helped to support public health measures during a recent large outbreak of the SARS-CoV-2 Delta variant. This outbreak stemmed primarily from a single source that spread the virus at multiple locations and frequent transmission between vaccinated individuals was observed and contained with robust intervention and community engagement.

Published
2022

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