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11 results on '"Zolezzi, Carola"'

5. Lipid peroxidation and antioxidant status in adults receiving lipid-based home parenteral nutrition

Author

Pironi, Loris, Ruggeri, Enrico, Zolezzi, Carola, Savarino, Lucia, Incasa, Elena, Belluzzi, Andrea, Munarini, Alessandra, Piazzi, Sandro, Tolomelli, Maurizio, Pizzoferrato, Arturo, and Miglioli, Mario

Subjects
Lipid peroxidation -- Causes of, Parenteral feeding -- Physiological aspects, Antioxidants -- Physiological aspects, Food/cooking/nutrition, Health
Abstract

Background: Infusion of lipid emulsions rich in polyunsaturated fatty acids (PUFAs) may increase lipid peroxidation, which is counteracted mainly by superoxide dismutase (SOD) (a zinc-, copper-, and manganese-dependent enzyme), selenium-dependent glutathione peroxidase (Se-GSHPx), and [Alpha]-tocopherol. Objective: We investigated lipid peroxidation and antioxidant status in patients receiving home parenteral nutrition (HPN) providing variable amounts of a lipid emulsion rich in PUFAs, and [Alpha]-tocopherol, zinc, copper, and manganese as recommended by the American Medical Association, and no selenium. Design: Serum malondialdehyde, plasma [Alpha]-tocopherol, selenium, Se-GSHPx, PUFAs, and red blood cell Se-GSHPx and SOD were evaluated in 12 patients and in 25 healthy control subjects. Malondialdehyde was also assessed in a group of 40 healthy control subjects. Results: Patients had significantly higher concentrations of malondialdehyde and SOD and lower [Alpha]-tocopherol concentrations and selenium nutritional status. Linear regression analysis showed that malondialdehyde was associated with the daily PUFA load (r = 0.69, P [is less than] 0.03) and with plasma [Alpha]-tocopherol (r = -0.59, P [is less than] 0.05), but stepwise multiple regression analysis confirmed only the association between malondialdehyde and [Alpha]-tocopherol; plasma [Alpha]-tocopherol was associated with the daily PUFA load (r = -0.65, P [is less than] 0.04) and with the duration of HPN (r = -0.74, P [is less than] 0.02). Conclusions: In HPN patients, the peroxidative stress due to lipid emulsions rich in PUFAs is counteracted primarily by [Alpha]-tocopherol. The dosages of [Alpha]-tocopherol, zinc, copper, and manganese Recommended by the American Medical Association appear sufficient to sustain SOD activity but inadequate to maintain [Alpha]-tocopherol nutritional status. HPN formulations should be supplemented with selenium. Am J Clin Nutr 1998;68:888-93.

Published
1998

11. Vitamin A and vitamin E isoforms stability and peroxidation potential of all-in-one admixtures for parenteral nutrition.

Author

Guidetti M, Sforzini A, Bersani G, Corsini C, Grossi G, Zolezzi C, Fasano C, and Pironi L

Subjects
Analysis of Variance, Chromatography, Liquid, Diterpenes, Drug Stability, Fat Emulsions, Intravenous metabolism, Fatty Acids, Unsaturated chemistry, Malondialdehyde chemistry, Olive Oil, Plant Oils chemistry, Retinyl Esters, Soybean Oil chemistry, Time Factors, Tocopherols chemistry, Triglycerides chemistry, Vitamin A analogs & derivatives, Lipid Peroxidation, Parenteral Nutrition methods, Vitamin A chemistry, Vitamin E chemistry, Vitamins chemistry
Abstract

Background: In all-in-one admixtures (AIOs), vitamins can be degraded and lipid can be peroxidized by light exposure, oxygen action, and multiple chemical interactions., Aim: We investigated the impact of three commercial lipid emulsions and two multivitamin preparations on vitamin A and vitamin E chemical stability and lipid peroxidation potential of AIOs., Methods: A soybean oil (Soy), soybean/medium-chain triacylglycerol oil (MCT), and olive/soybean oil (Olive)-based emulsion (all 20%), and a lyophilized (Lyo) and emulsified (Emu) multivitamin compounds, were tested. Two AIOs for each lipid emulsion were prepared, the former with Lyo and the latter with Emu. The concentrations of retinol palmitate, alpha-gamma-delta-tocopherol, and malondialdehyde were analyzed in AIOs, immediately (T0) and 24 hours (T24) after compounding., Results: Retinol palmitate, and alpha- and gamma-tocopherol were more stable in MCT-AIOs than in both Soy-AIOs and Olive-AIOs (p < 0.013; p < 0.001 respectively). Furthermore alpha-tocopherol was more stable in Lyo-AIOs than in Emu-AIOs (p < 0.004). Malondialdehyde (MDA) increased differently among the admixtures; however the concentrations were similar in all AIOs at T24., Conclusions: The differences in retinol palmitate stability were due both to lipid emulsions per se and to interaction between lipid emulsions and multivitamin preparations. The alpha-gamma-tocopherol stability depended on both lipid emulsions and multivitamin preparations. In tested AIOs there was a different degradation rate of fat-soluble vitamins to keep the same lipid peroxidation level, since MDA concentrations at T24 were similar among AIOs.

Published
2008
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