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2. Genotypic and Phenotypic Characterization of Some psms Hypervirulent Clinical Isolates of Staphylococcus aureus in a Tertiary Hospital in Hefei, Anhui

Author

Cao J, Zhang H, He Z, Piao Z, Zong X, and Sun B

Subjects
staphylococcus aureus, virulence factors, qrt-pcr, next-generation sequencing, psm, Infectious and parasitic diseases, RC109-216
Abstract

Jiaxin Cao,1,2 Huimin Zhang,1,2 Zhien He,2 Zhongwan Piao,1 Xianchun Zong,1 Baolin Sun1,2 1College of Life Science and Technology, Mudanjiang Normal University, Mudanjiang, People’s Republic of China; 2School of Life Science and Medicine, University of Science and Technology of China, Hefei, People’s Republic of ChinaCorrespondence: Baolin Sun; Zhongwan Piao, Email sunb@ustc.edu.cn; jwcpzw@126.comBackground: Staphylococcus aureus is a highly successful pathogen that can cause various infectious diseases, from relatively mild skin infections to life-threatening severe systemic diseases. The widespread pathogenicity of S. aureus is mainly due to its ability to produce many virulence factors that help destroy various host cells, causing disease. Our primary goal in this study was to explore the genes of highly virulent strains, to identify genes closely associated with high virulence, and to provide ideas for the treatment of infection by highly virulent clinical strains.Results: This study collected 221 clinical strains from The First Affiliated Hospital Of The University of Science and Technology of China (USTC); their hemolytic abilities were tested. Eight isolates were selected based on their highly hemolytic ability and tested their hemolytic activity again; their phenotypes and gene sequences were also explored. Whole-genome sequencing (WGS) showed six plasmids (pN315, pNE131, pSJH901, pSJH101, SAP106B, and MSSA476), eight antibiotic resistance genes [blaR1, blaI, blaZ, mecA, erm(C), erm(T), tet(38), and fosB-Saur] and seventy-two virulence related genes. Three highly virulent strains, namely X21111206, 21092239, and 21112607, were found according the Galleria mellonella infection model. Therefore, we selected 10 representative virulence genes for qRT-PCR: psmα, psmβ, hlgA, hlgB, hlgC, hla, clfA, clfB, spa, and sak. Among them, the expression levels of psmα and psmβ, the three isolates, were significantly higher than the positive control NCTC8325.Conclusion: Significant differences appear in the expression of virulence genes in the highly virulent strains, particularly the psmα and psmβ, It may be that the high expression of psm gene is the cause of the high virulence of Staphylococcus aureus. We can reduce the pathogenicity of Staphylococcus aureus by inhibiting the expression of psm gene, which may provide a strong basis for psm as a new target for clinical treatment of S. aureus infection.Keywords: Staphylococcus aureus, virulence factors, qRT-PCR, next-generation sequencing, psm

Published
2023

3. Molecular Epidemiology of Staphylococcus aureus in a Tertiary Hospital in Anhui, China: ST59 Remains a Serious Threat

Author

Zhang H, Cao J, He Z, Zong X, and Sun B

Subjects
staphylococcus aureus, epidemiological analysis, multilocus sequence typing, phenotype, hemolytic, Infectious and parasitic diseases, RC109-216
Abstract

Huimin Zhang,1 Jiaxin Cao,1 Zhien He,2,3 Xianchun Zong,1 Baolin Sun2,3 1College of Life Science and Technology, Mudanjiang Normal University, Mudanjiang, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital, University of Science and Technology of China, Hefei, People’s Republic of China; 3School of Life Science and Medicine, University of Science and Technology of China, Hefei, People’s Republic of ChinaCorrespondence: Baolin Sun, Email sunb@ustc.edu.cnPurpose: This study aimed to investigate the molecular characteristics, antimicrobial resistance and hemolytic phenotype of Staphylococcus aureus isolated from Anhui, China.Results: From August 2021 to January 2022, 214 S. aureus isolates were collected from the Anhui Provincial Hospital. This study identified 117 methicillin-resistant S. aureus and 97 methicillin-sensitive S. aureus isolates, and the detection rate of methicillin-resistant isolates was 1.8-fold higher than the average isolates reported in China (53.9% vs 30.5%). S. aureus isolates share identity at five or more of the seven MLST-based housekeeping loci, referred to as the clonal complex (CC). Forty ST types were found in 214 clinical S. aureus isolates, with the most extensive distribution of ST59 and ST6697 typing numbers and higher CC5 detection rates than any other clonal group. (The ST typing is the result of the MLST typing website query.) To detect the virulence of ST types of S. aureus, hemolysis experiments were performed on 214 clinical isolates, and it was concluded that ST59 had a relatively robust hemolytic capacity.Conclusion: Anhui S. aureus isolates have unique molecular and antibiotic resistance profiles. The antibiotic resistance profile may be related to the random use of antibiotics.Keywords: Staphylococcus aureus, epidemiological analysis, multilocus sequence typing, phenotype, hemolytic

Published
2023

4. First measurement of unpolarized SIDIS cross section and cross section ratios from a $^3$He target

Author

Yan, X., Allada, K., Aniol, K., Annand, J. R. M., Averett, T., Benmokhtar, F., Bertozzi, W., Bradshaw, P. C., Bosted, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chen, W., Chirapatpimol, K., Chudakov, E., Cisbani, E., Cornejo, J. C., Cusanno, F., Dalton, M. M., Deconinck, W., de Jager, C. W., De Leo, R., Deng, X., Deur, A., Ding, H., Dolph, P. A. M., Dutta, C., Dutta, D., Fassi, L. El, Frullani, S., Gao, H., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Guo, L., Hamilton, D., Hansen, O., Higinbotham, D. W., Holmstrom, T., Huang, J., Huang, M., Ibrahim, H. F, Iodice, M., Jiang, X., Jin, G., Jones, M. K., Katich, J., Kelleher, A., Kim, W., Kolarkar, A., Korsch, W., LeRose, J. J., Li, X., Li, Y., Lindgren, R., Liu, T., Liyanage, N., Long, E., Lu, H. -J., Margaziotis, D. J., Markowitz, P., Marrone, S., McNulty, D., Meziani, Z. -E., Michaels, R., Moffit, B., Camacho, C. Munoz, Nanda, S., Narayan, A., Nelyubin, V., Norum, B., Oh, Y., Osipenko, M., Parno, D., Peng, J. -C., Phillips, S. K., Posik, M., Puckett, A. J. R., Qian, X., Qiang, Y., Rakhman, A., Ransome, R., Riordan, S., Saha, A., Sawatzky, B., Schulte, E., Shahinyan, A., Shabestari, M. H., Sirca, S., Stepanyan, S., Subedi, R., Sulkosky, V., Tang, L. -G., Tobias, W. A., Urciuoli, G. M., Vilardi, I., Wang, K., Wojtsekhowski, B., Wang, Y., Yao, H., Ye, Y., Ye, Z., Yuan, L., Zhan, X., Zhang, Y., Zhang, Y. -W., Zhao, B., Zhao, Y. X., Zheng, X., Zhu, L., Zhu, X., and Zong, X.

Subjects
Nuclear Experiment
Abstract

The unpolarized semi-inclusive deep-inelastic scattering (SIDIS) differential cross sections in $^3$He($e,e^{\prime}\pi^{\pm}$)$X$ have been measured for the first time in Jefferson Lab experiment E06-010 performed with a $5.9\,$GeV $e^-$ beam on a $^3$He target. The experiment focuses on the valence quark region, covering a kinematic range $0.12 < x_{bj} < 0.45$, $1 < Q^2 < 4 \, \textrm{(GeV/c)}^2$, $0.45 < z_{h} < 0.65$, and $0.05 < P_t < 0.55 \, \textrm{GeV/c}$. The extracted SIDIS differential cross sections of $\pi^{\pm}$ production are compared with existing phenomenological models while the $^3$He nucleus approximated as two protons and one neutron in a plane wave picture, in multi-dimensional bins. Within the experimental uncertainties, the azimuthal modulations of the cross sections are found to be consistent with zero.

Published
2016
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5. Prevalence and Risk Factors Associated with Insomnia Symptoms Among the Chinese General Public After the Coronavirus Disease 2019 Epidemic Was Initially Controlled

Author

Guo J, Yang L, Xu Y, Zhang C, Luo X, Liu S, Yao L, Bai H, Zong X, Zhang J, Liu Z, and Zhang B

Subjects
insomnia symptoms, prevalence, covid-19, under control, general public, china, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Junlong Guo,1,2 Lulu Yang,1,2 Yan Xu,1,2 Chenxi Zhang,1,2 Xian Luo,1,2 Shuai Liu,1– 3 Lihua Yao,4 Hanping Bai,4 Xiaofen Zong,4 Jihui Zhang,5 Zhongchun Liu,4 Bin Zhang1,2 1Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Guangdong Mental Health Center, Guangdong Provincial People’s Hospital, Guangzhou, People’s Republic of China; 3Department of Psychiatry, The Third People’s Hospital of Qinghai Province, Xining, People’s Republic of China; 4Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China; 5Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Bin ZhangDepartment of Psychiatry, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People’s Republic of ChinaTel +86-20-62786731Email zhang73bin@hotmail.comZhongchun LiuDepartment of Psychiatry, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, People’s Republic of ChinaEmail zcliu6@whu.edu.cnIntroduction: The prevalence rate and related factors of insomnia remained unknown after the COVID-19 epidemic had been under control. Therefore, we conducted this survey to investigate the prevalence rate and related factors of insomnia symptoms in the Chinese general public after the COVID-19 had been initially control.Methods: An online survey was conducted among Chinese citizens through the JD Health APP. The questionnaire was used for collecting demographic data and self-designed questions related to the COVID-19 outbreak. Insomnia Severity Index, Patient Health Questionnaire-9, Somatic Symptom Scale-8 and Impact of Events Scale-Revised were used for measuring psychological symptoms. To examine the associations of sociodemographic and psychological factors with insomnia symptoms, a binary logistic regression was used.Results: In total, there were 14,894 eligible participants, and 4601 (30.9%) participants were found to have insomnia symptoms. The regression model revealed that a higher risk of insomnia symptoms was associated with being over the age of 40 years, having history of psychiatric disorders, smoking, having infected friends or colleagues, having depressive or somatic symptoms, experiencing psychological distress and feeling estranged from family members. Meanwhile a lower risk of insomnia symptoms was associated with being female, having closer family relationships, not feeling alienated from others and being satisfied with the available information.Conclusion: In our study, 30.9% of the participants in the general public reported insomnia symptoms after the COVID-19 epidemic had been initially controlled. When providing precise interventions for insomnia, extra attention should be paid to the individuals who are male, elderly and smokers, and those with psychiatric disorder history, with infected friends or colleagues, with psychological symptoms and with poor social support.Keywords: insomnia symptoms, prevalence, COVID-19, under control, general public, China

Published
2021

6. Double Spin Asymmetries of Inclusive Hadron Electroproductions from a Transversely Polarized $^3\rm{He}$ Target

Author

The Jefferson Lab Hall A Collaboration, Zhao, Y. X., Allada, K., Aniol, K., Annand, J. R. M., Averett, T., Benmokhtar, F., Bertozzi, W., Bradshaw, P. C., Bosted, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chen, W., Chirapatpimol, K., Chudakov, E., Cisbani, E., Cornejo, J. C., Cusanno, F., Dalton, M., Deconinck, W., de Jager, C. W., De Leo, R., Deng, X., Deur, A., Ding, H., Dolph, P. A. M., Dutta, C., Dutta, D., Fassi, L. El, Frullani, S., Gao, H., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Guo, L., Hamilton, D., Hansen, O., Higinbotham, D. W., Holmstrom, T., Huang, J., Huang, M., Ibrahim, H. F, Iodice, M., Jiang, X., Jin, G., Jones, M. K., Katich, J., Kelleher, A., Kim, W., Kolarkar, A., Korsch, W., LeRose, J. J., Li, X., Li, Y., Lindgren, R., Liyanage, N., Long, E., Lu, H. -J., Margaziotis, D. J., Markowitz, P., Marrone, S., McNulty, D., Meziani, Z. -E., Michaels, R., Moffit, B., Camacho, C. Muñoz, Nanda, S., Narayan, A., Nelyubin, V., Norum, B., Oh, Y., Osipenko, M., Parno, D., Peng, J. -C., Phillips, S. K., Posik, M., Puckett, A. J. R., Qian, X., Qiang, Y., Rakhman, A., Ransome, R., Riordan, S., Saha, A., Sawatzky, B., Schulte, E., Shahinyan, A., Shabestari, M. H., Širca, S., Stepanyan, S., Subedi, R., Sulkosky, V., Tang, L. -G., Tobias, W. A., Urciuoli, G. M., Vilardi, I., Wang, K., Wojtsekhowski, B., Wang, Y., Yan, X., Yao, H., Ye, Y., Ye, Z., Yuan, L., Zhan, X., Zhang, Y., Zhang, Y. -W., Zhao, B., Zheng, X., Zhu, L., Zhu, X., and Zong, X.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We report the measurement of beam-target double-spin asymmetries ($A_\text{LT}$) in the inclusive production of identified hadrons, $\vec{e}~$+$~^3\text{He}^{\uparrow}\rightarrow h+X$, using a longitudinally polarized 5.9 GeV electron beam and a transversely polarized $^3\rm{He}$ target. Hadrons ($\pi^{\pm}$, $K^{\pm}$ and proton) were detected at 16$^{\circ}$ with an average momentum $<$$P_h$$>$=2.35 GeV/c and a transverse momentum ($p_{T}$) coverage from 0.60 to 0.68 GeV/c. Asymmetries from the $^3\text{He}$ target were observed to be non-zero for $\pi^{\pm}$ production when the target was polarized transversely in the horizontal plane. The $\pi^{+}$ and $\pi^{-}$ asymmetries have opposite signs, analogous to the behavior of $A_\text{LT}$ in semi-inclusive deep-inelastic scattering., Comment: Published in PRC (92.015207), nuclear experiment, high-energy experiment

Published
2015
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7. Single Spin Asymmetries in Charged Kaon Production from Semi-Inclusive Deep Inelastic Scattering on a Transversely Polarized $^3{\rm{He}}$ Target

Author

Zhao, Y. X., Wang, Y., Allada, K., Aniol, K., Annand, J. R. M., Averett, T., Benmokhtar, F., Bertozzi, W., Bradshaw, P. C., Bosted, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chen, W., Chirapatpimol, K., Chudakov, E., Cisbani, E., Cornejo, J. C., Cusanno, F., Dalton, M. M., Deconinck, W., de Jager, C. W., De Leo, R., Deng, X., Deur, A., Ding, H., Dolph, P. A. M., Dutta, C., Dutta, D., Fassi, L. El, Frullani, S., Gao, H., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Guo, L., Hamilton, D., Hansen, O., Higinbotham, D. W., Holmstrom, T., Huang, J., Huang, M., Ibrahim, H. F, Iodice, M., Jiang, X., Jin, G., Jones, M. K., Katich, J., Kelleher, A., Kim, W., Kolarkar, A., Korsch, W., LeRose, J. J., Li, X., Li, Y., Lindgren, R., Liyanage, N., Long, E., Lu, H. -J., Margaziotis, D. J., Markowitz, P., Marrone, S., McNulty, D., Meziani, Z. -E., Michaels, R., Moffit, B., Camacho, C. Muñoz, Nanda, S., Narayan, A., Nelyubin, V., Norum, B., Oh, Y., Osipenko, M., Parno, D., Peng, J. -C., Phillips, S. K., Posik, M., Puckett, A. J. R., Qian, X., Qiang, Y., Rakhman, A., Ransome, R., Riordan, S., Saha, A., Sawatzky, B., Schulte, E., Shahinyan, A., Shabestari, M. H., Širca, S., Stepanyan, S., Subedi, R., Sulkosky, V., Tang, L. -G., Tobias, A., Urciuoli, G. M., Vilardi, I., Wang, K., Wojtsekhowski, B., Yan, X., Yao, H., Ye, Y., Ye, Z., Yuan, L., Zhan, X., Zhang, Y., Zhang, Y. -W., Zhao, B., Zheng, X., Zhu, L., Zhu, X., and Zong, X.

Subjects
Nuclear Experiment
Abstract

We report the first measurement of target single spin asymmetries of charged kaons produced in semi-inclusive deep inelastic scattering of electrons off a transversely polarized $^3{\rm{He}}$ target. Both the Collins and Sivers moments, which are related to the nucleon transversity and Sivers distributions, respectively, are extracted over the kinematic range of 0.1$<$$x_{bj}$$<$0.4 for $K^{+}$ and $K^{-}$ production. While the Collins and Sivers moments for $K^{+}$ are consistent with zero within the experimental uncertainties, both moments for $K^{-}$ favor negative values. The Sivers moments are compared to the theoretical prediction from a phenomenological fit to the world data. While the $K^{+}$ Sivers moments are consistent with the prediction, the $K^{-}$ results differ from the prediction at the 2-sigma level., Comment: 6 pages, 3 figures

Published
2014
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8. Can Anti-Müllerian Hormone Be a Reliable Biomarker for Assessing Ovarian Function in Women Postchemotherapy?

Author

Li X, Liu S, Ma L, Chen X, Weng H, Huang R, Yu Y, and Zong X

Subjects
anti-müllerian hormone, ovarian function, cyclophosphamide, breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Xiaolin Li,1,2,* Sixuan Liu,1,* Lisi Ma,1 Xuan Chen,1 Huaiyu Weng,1 Run Huang,1 Yang Yu,2 Xiangyun Zong1 1Department of Breast Surgery, Shanghai Jiao Tong University Affiliated Shanghai Sixth People’s Hospital, Shanghai 200233, People’s Republic of China; 2Institute of Cancer and Basic Medicine, Cancer Hospital of the University of Chinese Academy of Science (Zhejiang Cancer Hospital), Hangzhou 310022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiangyun ZongDepartment of Breast Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of ChinaTel +86 21 24058549Email tigerzong@msn.comPurpose: The predictive value of anti-Müllerian hormone (AMH) for ovarian dysfunction postchemotherapy is controversial. This study aimed to evaluate the value of serum AMH levels clinically and theoretically.Patients, Animals, and Methods: We detected the serum estradiol, follicular stimulating hormone (FSH), luteinizing hormone (LH), and AMH levels in 144 premenopausal women with breast cancer receiving cyclophosphamide-based chemotherapy. The hormone levels before and postchemotherapy were compared; the correlations among the hormones and amenorrhea and menstrual recovery were analyzed. In addition, the serum AMH levels were detected randomly in 177 normal healthy women and 36 normal female C57BL/6J mice of different ages; meanwhile, the status of ovarian follicles was also examined. Furthermore, 72 Balb/c nude mice with breast cancer were randomly assigned to three groups that received different doses of cyclophosphamide (CTX) (control, 100 mg/kg, and 200 mg/kg), and the alterations in serum AMH levels and ovarian follicles were recorded and analyzed.Results: Chemotherapy-induced amenorrhea was associated with prechemotherapy AMH levels, E2 levels, and FSH levels (P < 0.0001). The recovery of menstruation was associated with prechemotherapy AMH levels (P < 0.0001), but not with E2 and FSH levels (P > 0.05). In patients with breast cancer treated with chemotherapy, the serum AMH levels did not differ significantly between the pre- and post-chemotherapy periods in patients aged < 35 years (P > 0.05), whereas a dramatic reduction was detected in patients aged > 35 years (P < 0.0001). In healthy women, the serum AMH levels declined sharply after 35 years of age (P < 0.0001) and remained relatively stable at a younger age. Similar results were obtained in experiments using normal mice. The cancer-bearing mice exposed to 200 mg/kg CTX exhibited a significant decline in AMH levels and a remarkable decrease in the number of primordial and growing follicles (P < 0.0001).Conclusion: Our results indicate that AMH is an efficient marker for predicting postchemotherapy ovarian function exclusively in premenopausal female patients with breast cancer aged > 35 years.Keywords: anti-Müllerian hormone, ovarian function, cyclophosphamide, breast cancer

Published
2020

9. Transverse-energy distributions at midrapidity in $p$$+$$p$, $d$$+$Au, and Au$+$Au collisions at $\sqrt{s_{_{NN}}}=62.4$--200~GeV and implications for particle-production models

Author

Adler, S. S., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Al-Jamel, A., Alexander, J., Aoki, K., Aphecetche, L., Armendariz, R., Aronson, S. H., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Baldisseri, A., Barish, K. N., Barnes, P. D., Bassalleck, B., Bathe, S., Batsouli, S., Baublis, V., Bauer, F., Bazilevsky, A., Belikov, S., Bennett, R., Berdnikov, Y., Bjorndal, M. T., Boissevain, J. G., Borel, H., Boyle, K., Brooks, M. L., Brown, D. S., Bruner, N., Bucher, D., Buesching, H., Bumazhnov, V., Bunce, G., Burward-Hoy, J. M., Butsyk, S., Camard, X., Campbell, S., Chai, J. -S., Chand, P., Chang, W. C., Chernichenko, S., Chi, C. Y., Chiba, J., Chiu, M., Choi, I. J., Choudhury, R. K., Chujo, T., Cianciolo, V., Cleven, C. R., Cobigo, Y., Cole, B. A., Comets, M. P., Constantin, P., Csanád, M., Csörgő, T., Cussonneau, J. P., Dahms, T., Das, K., David, G., Deák, F., Delagrange, H., Denisov, A., d'Enterria, D., Deshpande, A., Desmond, E. J., Devismes, A., Dietzsch, O., Dion, A., Drachenberg, J. L., Drapier, O., Drees, A., Dubey, A. K., Durum, A., Dutta, D., Dzhordzhadze, V., Efremenko, Y. V., Egdemir, J., Enokizono, A., En'yo, H., Espagnon, B., Esumi, S., Fields, D. E., Finck, C., Fleuret, F., Fokin, S. L., Forestier, B., Fox, B. D., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fung, S. -Y., Gadrat, S., Gastineau, F., Germain, M., Glenn, A., Gonin, M., Gosset, J., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Gustafsson, H. -Å., Hachiya, T., Henni, A. Hadj, Haggerty, J. S., Hagiwara, M. N., Hamagaki, H., Hansen, A. G., Harada, H., Hartouni, E. P., Haruna, K., Harvey, M., Haslum, E., Hasuko, K., Hayano, R., He, X., Heffner, M., Hemmick, T. K., Heuser, J. M., Hidas, P., Hiejima, H., Hill, J. C., Hobbs, R., Holmes, M., Holzmann, W., Homma, K., Hong, B., Hoover, A., Horaguchi, T., Hur, M. G., Ichihara, T., Iinuma, H., Ikonnikov, V. V., Imai, K., Inaba, M., Inuzuka, M., Isenhower, D., Isenhower, L., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Jacak, B. V., Jia, J., Jin, J., Jinnouchi, O., Johnson, B. M., Johnson, S. C., Joo, K. S., Jouan, D., Kajihara, F., Kametani, S., Kamihara, N., Kaneta, M., Kang, J. H., Katou, K., Kawabata, T., Kawagishi, T., Kazantsev, A. V., Kelly, S., Khachaturov, B., Khanzadeev, A., Kikuchi, J., Kim, D. J., Kim, E., Kim, E. J., Kim, G. -B., Kim, H. J., Kim, Y. -S., Kinney, E., Kiss, Á., Kistenev, E., Kiyomichi, A., Klein-Boesing, C., Kobayashi, H., Kochenda, L., Kochetkov, V., Kohara, R., Komkov, B., Konno, M., Kotchetkov, D., Kozlov, A., Kroon, P. J., Kuberg, C. H., Kunde, G. J., Kurihara, N., Kurita, K., Kweon, M. J., Kwon, Y., Kyle, G. S., Lacey, R., Lajoie, J. G., Lebedev, A., Bornec, Y. Le, Leckey, S., Lee, D. M., Lee, M. K., Leitch, M. J., Leite, M. A. L., Li, X. H., Lim, H., Litvinenko, A., Liu, M. X., Maguire, C. F., Makdisi, Y. I., Malakhov, A., Malik, M. D., Manko, V. I., Mao, Y., Martinez, G., Masui, H., Matathias, F., Matsumoto, T., McCain, M. C., McGaughey, P. L., Miake, Y., Miller, T. E., Milov, A., Mioduszewski, S., Mishra, G. C., Mitchell, J. T., Mohanty, A. K., Morrison, D. P., Moss, J. M., Moukhanova, T. V., Mukhopadhyay, D., Muniruzzaman, M., Murata, J., Nagamiya, S., Nagata, Y., Nagle, J. L., Naglis, M., Nakamura, T., Newby, J., Nguyen, M., Norman, B. E., Nyanin, A. S., Nystrand, J., O'Brien, E., Ogilvie, C. A., Ohnishi, H., Ojha, I. D., Okada, K., Omiwade, O. O., Oskarsson, A., Otterlund, I., Oyama, K., Ozawa, K., Pal, D., Palounek, A. P. T., Pantuev, V., Papavassiliou, V., Park, J., Park, W. J., Pate, S. F., Pei, H., Penev, V., Peng, J. -C., Pereira, H., Peresedov, V., Peressounko, D. Yu., Pierson, A., Pinkenburg, C., Pisani, R. P., Purschke, M. L., Purwar, A. K., Qu, H., Qualls, J. M., Rak, J., Ravinovich, I., Read, K. F., Reuter, M., Reygers, K., Riabov, V., Riabov, Y., Roche, G., Romana, A., Rosati, M., Rosendahl, S. S. E., Rosnet, P., Rukoyatkin, P., Rykov, V. L., Ryu, S. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakai, S., Samsonov, V., Sanfratello, L., Santo, R., Sato, H. D., Sato, S., Sawada, S., Schutz, Y., Semenov, V., Seto, R., Sharma, D., Shea, T. K., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shohjoh, T., Shoji, K., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, C. P., Singh, V., Skutnik, S., Smith, W. C., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Staley, F., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Suire, C., Sullivan, J. P., Sziklai, J., Tabaru, T., Takagi, S., Takagui, E. M., Taketani, A., Tanaka, K. H., Tanaka, Y., Tanida, K., Tannenbaum, M. J., Taranenko, A., Tarján, P., Thomas, T. L., Togawa, M., Tojo, J., Torii, H., Towell, R. S., Tram, V-N., Tserruya, I., Tsuchimoto, Y., Tuli, S. K., Tydesjö, H., Tyurin, N., Uam, T. J., Vale, C., Valle, H., van Hecke, H. W., Velkovska, J., Velkovsky, M., Vértesi, R., Veszprémi, V., Vinogradov, A. A., Volkov, M. A., Vznuzdaev, E., Wagner, M., Wang, X. R., Watanabe, Y., Wessels, J., White, S. N., Willis, N., Winter, D., Wohn, F. K., Woody, C. L., Wysocki, M., Xie, W., Yanovich, A., Yokkaichi, S., Young, G. R., Younus, I., Yushmanov, I. E., Zajc, W. A., Zaudtke, O., Zhang, C., Zhou, S., Zimányi, J., Zolin, L., and Zong, X.

Subjects
Nuclear Experiment
Abstract

Measurements of the midrapidity transverse energy distribution, $d\Et/d\eta$, are presented for $p$$+$$p$, $d$$+$Au, and Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV and additionally for Au$+$Au collisions at $\sqrt{s_{_{NN}}}=62.4$ and 130 GeV. The $d\Et/d\eta$ distributions are first compared with the number of nucleon participants $N_{\rm part}$, number of binary collisions $N_{\rm coll}$, and number of constituent-quark participants $N_{qp}$ calculated from a Glauber model based on the nuclear geometry. For Au$+$Au, $\mean{d\Et/d\eta}/N_{\rm part}$ increases with $N_{\rm part}$, while $\mean{d\Et/d\eta}/N_{qp}$ is approximately constant for all three energies. This indicates that the two component ansatz, $dE_{T}/d\eta \propto (1-x) N_{\rm part}/2 + x N_{\rm coll}$, which has been used to represent $E_T$ distributions, is simply a proxy for $N_{qp}$, and that the $N_{\rm coll}$ term does not represent a hard-scattering component in $E_T$ distributions. The $dE_{T}/d\eta$ distributions of Au$+$Au and $d$$+$Au are then calculated from the measured $p$$+$$p$ $E_T$ distribution using two models that both reproduce the Au$+$Au data. However, while the number-of-constituent-quark-participant model agrees well with the $d$$+$Au data, the additive-quark model does not., Comment: 391 authors, 24 pages, 19 figures, and 15 Tables. Submitted to Phys. Rev. C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are publicly available at http://www.phenix.bnl.gov/papers.html

Published
2013
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10. Measurement of pretzelosity asymmetry of charged pion production in Semi-Inclusive Deep Inelastic Scattering on a polarized $^3$He target

Author

Zhang, Y., Qian, X., Allada, K., Dutta, C., Huang, J., Katich, J., Wang, Y., Aniol, K., Annand, J. R. M., Averett, T., Benmokhtar, F., Bertozzi, W., Bradshaw, P. C., Bosted, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chen, W., Chirapatpimol, K., Chudakov, E., Cisbani, E., Cornejo, J. C., Cusanno, F., Dalton, M. M., Deconinck, W., de Jager, C. W., De Leo, R., Deng, X., Deur, A., Ding, H., Dolph, P. A. M., Dutta, D., Fassi, L. El, Frullani, S., Gao, H., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Guo, L., Hamilton, D., Hansen, O., Higinbotham, D. W., Holmstrom, T., Huang, M., Ibrahim, H. F., Iodice, M., Jiang, X., Jin, G., Jones, M. K., Kelleher, A., Kim, W., Kolarkar, A., Korsch, W., LeRose, J. J., Li, X., Li, Y., Lindgren, R., Liyanage, N., Long, E., Lu, H. -J., Margaziotis, D. J., Markowitz, P., Marrone, S., McNulty, D., Meziani, Z. -E., Michaels, R., Moffit, B., Camacho, C. Muñoz, Nanda, S., Narayan, A., Nelyubin, V., Norum, B., Oh, Y., Osipenko, M., Parno, D., Peng, J. C., Phillips, S. K., Posik, M., Puckett, A. J. R., Qiang, Y., Rakhman, A., Ransome, R. D., Riordan, S., Saha, A., Sawatzky, B., Schulte, E., Shahinyan, A., Shabestari, M. H., Sirca, S., Stepanyan, S., Subedi, R., Sulkosky, V., Tang, L. -G., Tobias, W. A., Urciuoli, G. M., Vilardi, I., Wang, K., Wojtsekhowski, B., Yan, X., Yao, H., Ye, Y., Ye, Z., Yuan, L., Zhan, X., Zhang, Y. -W., Zhao, B., Zheng, X., Zhu, L., Zhu, X., and Zong, X.

Subjects
Nuclear Experiment
Abstract

An experiment to measure single-spin asymmetries in semi-inclusive production of charged pions in deep-inelastic scattering on a transversely polarized $^3$He target was performed at Jefferson Lab in the kinematic region of $0.16

Published
2013
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11. Single Spin Asymmetries of Inclusive Hadrons Produced in Electron Scattering from a Transversely Polarized $^3$He Target

Author

Allada, K., Zhao, Y. X., Aniol, K., Annand, J. R. M., Averett, T., Benmokhtar, F., Bertozzi, W., Bradshaw, P. C., Bosted, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chen, W., Chirapatpimol, K., Chudakov, E., Cisbani, E., Cornejo, J. C., Cusanno, F., Dalton, M., Deconinck, W., de Jager, C. W., De Leo, R., Deng, X., Deur, A., Ding, H., Dolph, P. A. M., Dutta, C., Dutta, D., Fassi, L. El, Frullani, S., Gao, H., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Guo, L., Hamilton, D., Hansen, O., Higinbotham, D. W., Holmstrom, T., Huang, J., Huang, M., Ibrahim, H. F, Iodice, M., Jiang, X., Jin, G., Jones, M. K., Katich, J., Kelleher, A., Kim, W., Kolarkar, A., Korsch, W., LeRose, J. J., Li, X., Li, Y., Lindgren, R., Liyanage, N., Long, E., Lu, H. -J., Margaziotis, D. J., Markowitz, P., Marrone, S., McNulty, D., Meziani, Z. -E., Michaels, R., Moffit, B., Camacho, C. Munoz, Nanda, S., Narayan, A., Nelyubin, V., Norum, B., Oh, Y., Osipenko, M., Parno, D., Peng, J. -C., Phillips, S. K., Posik, M., Puckett, A. J. R., Qian, X., Qiang, Y., Rakhman, A., Ransome, R., Riordan, S., Saha, A., Sawatzky, B., Schulte, E., Shahinyan, A., Shabestari, M. H., Sirca, S., Stepanyan, S., Subedi, R., Sulkosky, V., Tang, L. -G., Tobias, A., Urciuoli, G. M., Vilardi, I., Wang, K., Wang, Y., Wojtsekhowski, B., Yan, X., Yao, H., Ye, Y., Ye, Z., Yuan, L., Zhan, X., Zhang, Y., Zhang, Y. -W., Zhao, B., Zheng, X., Zhu, L., Zhu, X., and Zong, X.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

We report the first measurement of target single-spin asymmetries (A$_N$) in the inclusive hadron production reaction, $e~$+$~^3\text{He}^{\uparrow}\rightarrow h+X$, using a transversely polarized $^3$He target. The experiment was conducted at Jefferson Lab in Hall A using a 5.9-GeV electron beam. Three types of hadrons ($\pi^{\pm}$, $\text{K}^{\pm}$ and proton) were detected in the transverse hadron momentum range 0.54 $

Published
2013
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12. Measurement of the Target-Normal Single-Spin Asymmetry in Deep-Inelastic Scattering from the Reaction $^{3}\mathrm{He}^{\uparrow}(e,e')X$

Author

Katich, J., Qian, X., Zhao, Y. X., Allada, K., Aniol, K., Annand, J. R. M., Averett, T., Benmokhtar, F., Bertozzi, W., Bradshaw, P. C., Bosted, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chen, W., Chirapatpimol, K., Chudakov, E., Cisbani, E., Cornejo, J. C., Cusanno, F., Dalton, M. M., Deconinck, W., de Jager, C. W., De Leo, R., Deng, X., Deur, A., Ding, H., Dolph, P. A. M., Dutta, C., Dutta, D., Fassi, L. El, Frullani, S., Gao, H., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Guo, L., Hamilton, D., Hansen, O., Higinbotham, D. W., Holmstrom, T., Huang, J., Huang, M., Ibrahim, H. F., Iodice, M., Jiang, X., Jin, G., Jones, M. K., Kelleher, A., Kim, W., Kolarkar, A., Korsch, W., LeRose, J. J., Li, X., Li, Y., Lindgren, R., Liyanage, N., Long, E., Lu, H. -J., Margaziotis, D. J., Markowitz, P., Marrone, S., McNulty, D., Meziani, Z. -E., Michaels, R., Moffit, B., Camacho, C. Muńoz, Nanda, S., Narayan, A., Nelyubin, V., Norum, B., Oh, Y., Osipenko, M., Parno, D., Peng, J. C., Phillips, S. K., Posik, M., Puckett, A. J. R., Qiang, Y., Rakhman, A., Ransome, R. D., Riordan, S., Saha, A., Sawatzky, B., Schulte, E., Shahinyan, A., Shabestari, M. H., Širca, S., Stepanyan, S., Subedi, R., Sulkosky, V., Tang, L. -G., Tobias, A., Urciuoli, G. M., Vilardi, I., Wang, K., Wang, Y., Wojtsekhowski, B., Yan, X., Yao, H., Ye, Y., Ye, Z., Yuan, L., Zhan, X., Zhang, Y., Zhang, Y. -W., Zhao, B., Zheng, X., Zhu, L., Zhu, X., and Zong, X.

Subjects
Nuclear Experiment
Abstract

We report the first measurement of the target-normal single-spin asymmetry in deep-inelastic scattering from the inclusive reaction $^3$He$^{\uparrow}\left(e,e' \right)X$ on a polarized $^3$He gas target. Assuming time-reversal invariance, this asymmetry is strictly zero in the Born approximation but can be non-zero if two-photon-exchange contributions are included. The experiment, conducted at Jefferson Lab using a 5.89 GeV electron beam, covers a range of $1.7 < W < 2.9$ GeV, $1.02$ GeV, which is non-zero at the $2.89\sigma$ level. Our measured asymmetry agrees both in sign and magnitude with a two-photon-exchange model prediction that uses input from the Sivers transverse momentum distribution obtained from semi-inclusive deep-inelastic scattering., Comment: This is the final edited version as published in PRL

Published
2013
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13. Direct photon production in d+Au collisions at sqrt(s_NN)=200 GeV

Author

Adare, A., Adler, S. S., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Al-Bataineh, H., Al-Jamel, A., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aphecetche, L., Aramaki, Y., Armendariz, R., Aronson, S. H., Asai, J., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Baldisseri, A., Barish, K. N., Barnes, P. D., Bassalleck, B., Basye, A. T., Bathe, S., Batsouli, S., Baublis, V., Bauer, F., Baumann, C., Bazilevsky, A., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bhom, J. H., Bickley, A. A., Bjorndal, M. T., Blau, D. S., Boissevain, J. G., Bok, J. S., Borel, H., Boyle, K., Brooks, M. L., Brown, D. S., Bruner, N., Bucher, D., Buesching, H., Bumazhnov, V., Bunce, G., Burward-Hoy, J. M., Butsyk, S., Camacho, C. M., Camard, X., Campbell, S., Caringi, A., Chand, P., Chang, B. S., Chang, W. C., Charvet, J. -L., Chen, C. -H., Chernichenko, S., Chi, C. Y., Chiba, J., Chiu, M., Choi, I. J., Choi, J. B., Choudhury, R. K., Christiansen, P., Chujo, T., Chung, P., Churyn, A., Chvala, O., Cianciolo, V., Citron, Z., Cobigo, Y., Cole, B. A., Comets, M. P., del Valle, Z. Conesa, Connors, M., Constantin, P., Csanád, M., Csörgő, T., Cussonneau, J. P., Dahms, T., Dairaku, S., Danchev, I., Das, K., Datta, A., David, G., Dayananda, M. K., Deák, F., Delagrange, H., Denisov, A., d'Enterria, D., Deshpande, A., Desmond, E. J., Devismes, A., Dharmawardane, K. V., Dietzsch, O., Dion, A., Donadelli, M., Drachenberg, J. L., Drapier, O., Drees, A., Drees, K. A., Dubey, A. K., Durham, J. M., Durum, A., Dutta, D., Dzhordzhadze, V., D'Orazio, L., Edwards, S., Efremenko, Y. V., Ellinghaus, F., Engelmore, T., Enokizono, A., En'yo, H., Espagnon, B., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finck, C., Finger, M., Finger Jr, M., Fleuret, F., Fokin, S. L., Fox, B. D., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fung, S. -Y., Fusayasu, T., Gadrat, S., Garishvili, I., Germain, M., Glenn, A., Gong, H., Gonin, M., Gosset, J., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Grim, G., Perdekamp, M. Grosse, Gunji, T., Gustafsson, H. -Å., Hachiya, T., Henni, A. Hadj, Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamblen, J., Han, R., Hanks, J., Hansen, A. G., Hartouni, E. P., Haruna, K., Harvey, M., Haslum, E., Hasuko, K., Hayano, R., He, X., Heffner, M., Hemmick, T. K., Hester, T., Heuser, J. M., Hidas, P., Hiejima, H., Hill, J. C., Hobbs, R., Hohlmann, M., Holzmann, W., Homma, K., Hong, B., Hoover, A., Horaguchi, T., Hornback, D., Huang, S., Ichihara, T., Ichimiya, R., Iinuma, H., Ikeda, Y., Ikonnikov, V. V., Imai, K., Imrek, J., Inaba, M., Inuzuka, M., Isenhower, D., Isenhower, L., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Ivanischev, D., Iwanaga, Y., Jacak, B. V., Jia, J., Jiang, X., Jin, J., Jinnouchi, O., Johnson, B. M., Johnson, S. C., Jones, T., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kaneta, M., Kang, J. H., Kapustinsky, J., Karatsu, K., Kasai, M., Katou, K., Kawabata, T., Kawall, D., Kawashima, M., Kazantsev, A. V., Kelly, S., Kempel, T., Khachaturov, B., Khanzadeev, A., Kijima, K. M., Kikuchi, J., Kim, A., Kim, B. I., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, E. J., Kim, G. -B., Kim, H. J., Kim, S. H., Kim, Y. -J., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Kiyomichi, A., Klay, J., Klein-Boesing, C., Kleinjan, D., Kobayashi, H., Kochenda, L., Kochetkov, V., Kohara, R., Komkov, B., Konno, M., Koster, J., Kotchetkov, D., Kozlov, A., Král, A., Kravitz, A., Kroon, P. J., Kuberg, C. H., Kunde, G. J., Kurita, K., Kurosawa, M., Kweon, M. J., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Layton, D., Lebedev, A., Bornec, Y. Le, Leckey, S., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, T., Leitch, M. J., Leite, M. A. L., Lenzi, B., Li, X., Li, X. H., Lichtenwalner, P., Liebing, P., Lim, H., Levy, L. A. Linden, Liška, T., Litvinenko, A., Liu, H., Liu, M. X., Love, B., Lynch, D., Maguire, C. F., Makdisi, Y. I., Malakhov, A., Malik, M. D., Manko, V. I., Mannel, E., Mao, Y., Martinez, G., Mašek, L., Masui, H., Matathias, F., Matsumoto, T., McCain, M. C., McCumber, M., McGaughey, P. L., Means, N., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Mikeš, P., Miki, K., Miller, T. E., Milov, A., Mioduszewski, S., Mishra, G. C., Mishra, M., Mitchell, J. T., Mohanty, A. K., Moon, H. J., Morino, Y., Morreale, A., Morrison, D. P., Moss, J. M., Moukhanova, T. V., Mukhopadhyay, D., Muniruzzaman, M., Murakami, T., Murata, J., Nagamiya, S., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nam, S., Newby, J., Nguyen, M., Nihashi, M., Niita, T., Nouicer, R., Nyanin, A. S., Nystrand, J., Oakley, C., O'Brien, E., Oda, S. X., Ogilvie, C. A., Ohnishi, H., Ojha, I. D., Oka, M., Okada, K., Onuki, Y., Oskarsson, A., Otterlund, I., Ouchida, M., Oyama, K., Ozawa, K., Pak, R., Pal, D., Palounek, A. P. T., Pantuev, V., Papavassiliou, V., Park, I. H., Park, J., Park, S. K., Park, W. J., Pate, S. F., Pei, H., Penev, V., Peng, J. -C., Pereira, H., Peresedov, V., Peressounko, D. Yu., Petti, R., Pierson, A., Pinkenburg, C., Pisani, R. P., Proissl, M., Purschke, M. L., Purwar, A. K., Qu, H., Qualls, J. M., Rak, J., Rakotozafindrabe, A., Ravinovich, I., Read, K. F., Rembeczki, S., Reuter, M., Reygers, K., Riabov, V., Riabov, Y., Richardson, E., Roach, D., Roche, G., Rolnick, S. D., Romana, A., Rosati, M., Rosen, C. A., Rosendahl, S. S. E., Rosnet, P., Rukoyatkin, P., Ružička, P., Rykov, V. L., Ryu, S. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakai, S., Sakashita, K., Samsonov, V., Sanfratello, L., Sano, S., Santo, R., Sato, H. D., Sato, S., Sato, T., Sawada, S., Schutz, Y., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Semenov, V., Seto, R., Sharma, D., Shea, T. K., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Staley, F., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Suire, C., Sukhanov, A., Sullivan, J. P., Sziklai, J., Takagi, S., Takagui, E. M., Taketani, A., Tanabe, R., Tanaka, K. H., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Themann, H., Thomas, D., Thomas, T. L., Togawa, M., Toia, A., Tojo, J., Tomášek, L., Tomita, Y., Torii, H., Towell, R. S., Tram, V-N., Tserruya, I., Tsuchimoto, Y., Tydesjö, H., Tyurin, N., Uam, T. J., Vale, C., Valle, H., van Hecke, H. W., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Velkovsky, M., Vértesi, R., Veszprémi, V., Vinogradov, A. A., Virius, M., Volkov, M. A., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Wei, F., Wei, R., Wessels, J., White, S. N., Willis, N., Winter, D., Wohn, F. K., Woody, C. L., Wright, R. M., Wysocki, M., Xie, W., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., You, Z., Young, G. R., Younus, I., Yushmanov, I. E., Zajc, W. A., Zaudtke, O., Zhang, C., Zhou, S., Zimányi, J., Zolin, L., and Zong, X.

Subjects
Nuclear Experiment
Abstract

Direct photons have been measured in sqrt(s_NN)=200 GeV d+Au collisions at midrapidity. A wide p_T range is covered by measurements of nearly-real virtual photons (1

Published
2012
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14. Beam-Target Double Spin Asymmetry A_LT in Charged Pion Production from Deep Inelastic Scattering on a Transversely Polarized He-3 Target at 1.4<Q^2<2.7 GeV^2

Author

Huang, J., Allada, K., Dutta, C., Katich, J., Qian, X., Wang, Y., Zhang, Y., Aniol, K., Annand, J. R. M., Averett, T., Benmokhtar, F., Bertozzi, W., Bradshaw, P. C., Bosted, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chen, W., Chirapatpimol, K., Chudakov, E., Cisbani, E., Cornejo, J. C., Cusanno, F., Dalton, M. M., Deconinck, W., de Jager, C. W., De Leo, R., Deng, X., Deur, A., Ding, H., Dolph, P. A. M., Dutta, D., Fassi, L. El, Frullani, S., Gao, H., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Guo, L., Hamilton, D., Hansen, O., Higinbotham, D. W., Holmstrom, T., Huang, M., Ibrahim, H. F., Iodice, M., Jiang, X., Jin, G., Jones, M. K., Kelleher, A., Kim, W., Kolarkar, A., Korsch, W., LeRose, J. J., Li, X., Li, Y., Lindgren, R., Liyanage, N., Long, E., Lu, H. -J., Margaziotis, D. J., Markowitz, P., Marrone, S., McNulty, D., Meziani, Z. -E., Michaels, R., Moffit, B., Camacho, C. Muñoz, Nanda, S., Narayan, A., Nelyubin, V., Norum, B., Oh, Y., Osipenko, M., Parno, D., Peng, J. C., Phillips, S. K., Posik, M., Puckett, A. J. R., Qiang, Y., Rakhman, A., Ransome, R. D., Riordan, S., Saha, A., Sawatzky, B., Schulte, E., Shahinyan, A., Shabestari, M. H., Širca, S., Stepanyan, S., Subedi, R., Sulkosky, V., Tang, L. -G., Tobias, A., Urciuoli, G. M., Vilardi, I., Wang, K., Wojtsekhowski, B., Yan, X., Yao, H., Ye, Y., Ye, Z., Yuan, L., Zhan, X., Zhang, Y. -W., Zhao, B., Zheng, X., Zhu, L., Zhu, X., and Zong, X.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

We report the first measurement of the double-spin asymmetry $A_{LT}$ for charged pion electroproduction in semi\nobreakdash-inclusive deep\nobreakdash-inelastic electron scattering on a transversely polarized $^{3}$He target. The kinematics focused on the valence quark region, $0.16

Published
2011
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15. Single Spin Asymmetries in Charged Pion Production from Semi-Inclusive Deep Inelastic Scattering on a Transversely Polarized $^3$He Target

Author

Qian, X., Allada, K., Dutta, C., Huang, J., Katich, J., Wang, Y., Zhang, Y., Aniol, K., Annand, J. R. M., Averett, T., Benmokhtar, F., Bertozzi, W., Bradshaw, P. C., Bosted, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chen, W., Chirapatpimol, K., Chudakov, E., Cisbani, E., Cornejo, J. C., Cusanno, F., Dalton, M. M., Deconinck, W., de Jager, C. W., De Leo, R., Deng, X., Deur, A., Ding, H., Dolph, P. A. M., Dutta, D., Fassi, L. El, Frullani, S., Gao, H., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Guo, L., Hamilton, D., Hansen, O., Higinbotham, D. W., Holmstrom, T., Huang, M., Ibrahim, H. F., Iodice, M., Jiang, X., Jin, G., Jones, M. K., Kelleher, A., Kim, W., Kolarkar, A., Korsch, W., LeRose, J. J., Li, X., Li, Y., Lindgren, R., Liyanage, N., Long, E., Lu, H. -J., Margaziotis, D. J., Markowitz, P., Marrone, S., McNulty, D., Meziani, Z. -E., Michaels, R., Moffit, B., Camacho, C. Munoz, Nanda, S., Narayan, A., Nelyubin, V., Norum, B., Oh, Y., Osipenko, M., Parno, D., Peng, J. C., Phillips, S. K., Posik, M., Puckett, A. J. R., Qiang, Y., Rakhman, A., Ransome, R. D., Riordan, S., Saha, A., Sawatzky, B., Schulte, E., Shahinyan, A., Shabestari, M. H., Širca, S., Stepanyan, S., Subedi, R., Sulkosky, V., Tang, L. -G., Tobias, A., Urciuoli, G. M., Vilardi, I., Wang, K., Wojtsekhowski, B., Yan, X., Yao, H., Ye, Y., Ye, Z., Yuan, L., Zhan, X., Zhang, Y. -W., Zhao, B., Zheng, X., Zhu, L., Zhu, X., and Zong, X.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

We report the first measurement of target single spin asymmetries in the semi-inclusive $^3{He}(e,e'\pi^\pm)X$ reaction on a transversely polarized target. The experiment, conducted at Jefferson Lab using a 5.9 GeV electron beam, covers a range of 0.14 $< x <$ 0.34 with 1.3 $

Published
2011
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16. A High-Pressure Polarized $^3$He Gas Target for Nuclear Physics Experiments Using A Polarized Photon Beam

Author

Ye, Q., Laskaris, G., Gao, H., Chen, W., Zheng, W., Zong, X., Averett, T., Cates, G. D., and Tobias, W. A.

Subjects
Nuclear Experiment
Abstract

Following the first experiment on three-body photodisintegration of polarized $^3$He utilizing circularly polarized photons from High Intensity Gamma Source (HI$\gamma$S) at Duke Free Electron Laser Laboratory (DFELL), a new high-pressure polarized $^3$He target cell made of pyrex glass coated with a thin layer of sol-gel doped with aluminum nitrate nonahydrate has been built in order to reduce the photon beam induced background. The target is based on the technique of spin-exchange optical pumping of hybrid rubidium and potassium and the highest polarization achieved is $\sim$62% determined from both NMR-AFP and EPR polarimetry. The $X$ parameter is estimated to be $\sim0.06$ and the performance of the target is in good agreement with theoretical predictions. We also present beam test results from this new target cell and the comparison with the GE180 $^3$He target cell used previously at HI$\gamma$S. This is the first time that sol-gel coating technique has been used in a polarized $^3$He target for nuclear physics experiments., Comment: 8 pages, 3 figures

Published
2009
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17. Clinicopathological Characteristics and Treatment Outcomes of Pregnancy Complicated by Malignant Ovarian Germ Cell Tumors

Author

Zong X, Yang JX, Zhang Y, Cao DY, and Shen K

Subjects
pregnancy, germ cell tumor, expectant management, retrospective studies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Xuan Zong, Jia-Xin Yang, Ying Zhang, Dong-Yan Cao, Keng Shen Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Jia-Xin YangDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, People’s Republic of ChinaTel +86 10 6915 4022Fax +86 10 6915 5635Email yangjiaxin_2017@163.comPurpose: This study aimed to analyze the clinicopathological features, treatment, and feto-maternal outcomes of pregnancy complicated by malignant ovarian germ cell tumors (MOGCTs), to increase the awareness on this condition.Patients and Methods: We retrospectively reviewed the medical records of patients diagnosed with MOGCTs during pregnancy, who were treated and followed-up at Peking Union Medical College Hospital from January 2000 to December 2017. The demographic characteristics, pathological features, treatment and prognosis were analyzed.Results: The histological subtypes varied in 14 patients (dysgerminoma, n=1; immature teratoma, n=4; yolk sac tumor, n=6; and mixed germ cell tumors, n=3). Ten (71.4%) patients, including three who opted for conservative therapy until childbirth, one who only received salvage chemotherapy during pregnancy, and six who underwent cystectomy or unilateral salpingo-oophorectomy during pregnancy, desired fetal preservation. After undergoing surgery, four patients chose surveillance instead of timely adjuvant chemotherapy. Eight patients delivered their babies, and the preterm delivery rate was 50.0%. One newborn died of premature birth. The median follow-up period was 44 (range: 13 to 86) months. During the current study period, 12 patients had survived and did not report any diseases. However, two died due to disease progression.Conclusion: Pregnant women with MOGCTs had favorable outcomes. However, when a malignant tumor is suspected, surgery cannot be avoided. Thus, instead of timely postoperative adjuvant chemotherapy, close surveillance may be an acceptable alternative for pregnant women with low-risk MOGCTs.Keywords: pregnancy, germ cell tumor, expectant management, retrospective studies

Published
2020

21. ^{7}Li NMR Study of Heavy Fermion LiV2O4 Containing Magnetic Defects

Author

Zong, X., Das, S., Borsa, F., Vannette, M. D., Prozorov, R., Schmalian, J., and Johnston, D. C.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

We present a systematic study of the variations of the ^{7}Li NMR properties versus magnetic defect concentration up to 0.83 mol% within the spinel structure of polycrystalline powder samples and a collection of small single crystals of LiV2O4 in the temperature range from 0.5 to 4.2 K. We also report static magnetization measurements and ac magnetic susceptibility measurements at 14 MHz on the samples at low temperatures. Both the NMR spectrum and nuclear spin-lattice relaxation rate are inhomogeneous in the presence of the magnetic defects. The NMR data for the powders are well explained by assuming that (i) there is a random distribution of magnetic point defects, (ii) the same heavy Fermi liquid is present in the samples containing the magnetic defects as in magnetically pure LiV2O4, and (iii) the influences of the magnetic defects and of the Fermi liquid on the magnetization and NMR properties are separable. In the single crystals, somewhat different behaviors are observed. Remarkably, the magnetic defects in the powder samples show evidence of spin freezing below T ~ 1.0 K, whereas in the single crystals with similar magnetic defect concentration no spin freezing was found down to 0.5 K. Thus different types of magnetic defects and/or interactions between them appear to arise in the powders versus the crystals, possibly due to the substantially different synthesis conditions of the powders and crystals., Comment: 18 pages typeset in 2 columns, 16 figures; submitted to PRB

Published
2008
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22. Crystallography, magnetic susceptibility, heat capacity, and electrical resistivity of heavy fermion LiV$_2$O$_4$ single crystals grown using a self-flux technique

Author

Das, S., Zong, X., Niazi, A., Ellern, A., Yan, J. Q., and Johnston, D. C.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Magnetically pure spinel compound ${\rm LiV_2O_4}$ is a rare $d$-electron heavy fermion. Measurements on single crystals are needed to clarify the mechanism for the heavy fermion behavior in the pure material. In addition, it is known that small concentrations ($< 1$ mol%) of magnetic defects in the structure strongly affect the properties, and measurements on single crystals containing magnetic defects would help to understand the latter behaviors. Herein, we report flux growth of ${\rm LiV_2O_4}$ and preliminary measurements to help resolve these questions. The magnetic susceptibility of some as-grown crystals show a Curie-like upturn at low temperatures, showing the presence of magnetic defects within the spinel structure. The magnetic defects could be removed in some of the crystals by annealing them at 700 $^\circ$C\@. A very high specific heat coefficient $\gamma$ = 450 mJ/(mol K${^2}$\@) was obtained at a temperature of 1.8 K for a crystal containing a magnetic defect concentration $n$${\rm_{defect}}$ = 0.5 mol%. A crystal with $n$${\rm _{defect}}$ = 0.01 mol% showed a residual resistivity ratio of 50., Comment: 6 pages, 7 figures, Title modified

Published
2007
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23. ^{17}O and ^{51}V NMR for the zigzag spin-1 chain compound CaV2O4

Author

Zong, X., Suh, B. J., Niazi, A., Yan, J. Q., Schlagel, D. L., Lograsso, T. A., and Johnston, D. C.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

$^{51}$V NMR studies on CaV2O4 single crystals and $^{17}$O NMR studies on $^{17}$O-enriched powder samples are reported. The temperature dependences of the $^{17}$O NMR line width and nuclear spin-lattice relaxation rate give strong evidence for a long-range antiferromagnetic transition at Tn = 78 K in the powder. Magnetic susceptibility measurements show that Tn = 69 K in the crystals. A zero-field $^{51}$V NMR signal was observed at low temperatures (f $\approx$ 237 MHz at 4.2 K) in the crystals. The field swept spectra with the field in different directions suggest the presence of two antiferromagnetic substructures. Each substructure is collinear, with the easy axes of the two substructures separated by an angle of 19(1) degree, and with their average direction pointing approximately along the b-axis of the crystal structure. The two spin substructures contain equal number of spins. The temperature dependence of the ordered moment, measured up to 45 K, shows the presence of an energy gap Eg in the antiferromagnetic spin wave excitation spectrum. Antiferromagnetic spin wave theory suggests that Eg lies between 64 and 98 K., Comment: 11 pages, 14 figures. v2: 2 new figures; version published in Phys. Rev. B

Published
2007
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24. Phase Relations in the Li2O-V2O3-V2O5 System at 700 C: Correlations with Magnetic Defect Concentration in Heavy Fermion LiV2O4

Author

Das, S., Ma, X., Zong, X., Niazi, A., and Johnston, D. C.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

The phase relations in the Li2O-V2O3-V2O5 ternary system at 700 C for compositions in equilibrium with LiV2O4 are reported. This study clarified the synthesis conditions under which low and high magnetic defect concentrations can be obtained within the spinel structure of LiV2O4. We confirmed that the LiV2O4 phase can be obtained containing low (0.006 mol%) to high (0.83 mol%) magnetic defect concentrations n{defect} and with consistently high magnetic defect spin S values between 3 and 6.5. The high n{defect} values were obtained in the LiV2O4 phase in equilibrium with V2O3, Li3VO4, or LiVO2 and the low values in the LiV2O4 phase in equilibrium with V3O5. A model is suggested to explain this correlation., Comment: 6 pages, 7 figures; Phys. Rev. B (accepted)

Published
2006
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25. Relaxation of Spin Polarized $^3$He in Mixtures of $^3$He and $^4$He Below the $^4$He Lambda Point

Author

Ye, Q., Dutta, D., Gao, H., Kramer, K., Qian, X., Zong, X., Hannelius, L., McKeown, R. D., Heyburn, B., Singer, S., Golub, R., and Korobkina, E.

Subjects
Physics - Atomic Physics, Nuclear Experiment
Abstract

We report the first study of the depolarization behavior of spin polarized 3He in a mixture of 3He-4He at a temperature below the 4He Lambda point in a deuterated TetraPhenyl Butadiene-doped deuterated PolyStyrene (dTPB-dPS) coated acrylic cell. In our experiment the measured 3He relaxation time is due to the convolution of the 3He longitudinal relaxation time, T1, and the diffusion time constant of 3He in superfluid 4He since depolarization takes place on the walls. We have obtained a 3He relaxation time ~3000 seconds at a temperature around 1.9K. We have shown that it's possible to achieve values of wall depolarization probability on the order of (1-2)x10^-7 for polarized 3He in the superfluid 4He from a dTPB-dPS coated acrylic surface., Comment: The Model used to interpret the data has been changed

Published
2006
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26. Dynamics of Magnetic Defects in Heavy Fermion LiV2O4 from Stretched Exponential 7Li NMR Relaxation

Author

Johnston, D. C., Baek, S. -H., Zong, X., Borsa, F., Schmalian, J., and Kondo, S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

7Li NMR measurements on LiV2O4 from 0.5 to 4.2 K are reported. A small concentration of magnetic defects within the structure drastically changes the 7Li nuclear magnetization relaxation versus time from a pure exponential as in pure LiV2O4 to a stretched exponential, indicating glassy behavior of the magnetic defects. The stretched exponential function is described as arising from a distribution of 7Li nuclear spin-lattice relaxation rates and we present a model for the distribution in terms of the dynamics of the magnetic defects. Our results explain the origin of recent puzzling 7Li NMR literature data on LiV2O4 and our model is likely applicable to other glassy systems., Comment: Four typeset pages including four figures

Published
2005
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27. Identification of key genes, pathways and miRNA/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis

Author

Ma K, Zhang HX, Wei GH, Dong ZF, Zhao HJ, Han XC, Song XB, Zhang HL, Zong X, Baloch Z, and Wang SJ

Subjects
stress, depression, nucleus accumbens, miRNA/mRNA, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Ke Ma,1 Hongxiu Zhang,2 Guohui Wei,1 Zhenfei Dong,1 Haijun Zhao,1 Xiaochun Han,1 Xiaobin Song,1 Huiling Zhang,1 Xin Zong,1 Zulqarnain Baloch,3 Shijun Wang1 1Shandong Co-Innovation Center of Classic TCM formula, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, People’s Republic of China; 2Institute of Virology, Jinan Center for Disease Control and Prevention, Jinan 250021, People’s Republic of China; 3College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, People’s Republic of China Introduction: Major depressive disorder (MDD) is a recurrent, devastating mental disorder, which affects >350 million people worldwide, and exerts substantial public health and financial costs to society. Thus, there is a significant need to discover innovative therapeutics to treat depression efficiently. Stress-induced dysfunction in the subtype of neuronal cells and the change of synaptic plasticity and structural plasticity of nucleus accumbens (NAc) are implicated in depression symptomology. However, the molecular and epigenetic mechanisms and stresses to the NAc pathological changes in depression remain elusive. Materials and methods: In this study, treatment group mice were treated continually with the chronic unpredictable mild stress (CUMS) until expression of depression-like behaviors were found. Depression was confirmed with sucrose preference, novelty-suppressed feeding, forced swimming, and tail suspension tests. We applied high-throughput RNA sequencing to assess microRNA expression and transcriptional profiles in the NAc tissue from depression-like behaviors mice and control mice. The regulatory network of miRNAs/mRNAs was constructed based on the high-throughput RNA sequence and bioinformatics software predictions. Results: A total of 17 miRNAs and 10 mRNAs were significantly upregulated in the NAc of CUMS-induced mice with depression-like behaviors, and 12 miRNAs and 29 mRNAs were downregulated. A series of bioinformatics analyses showed that these altered miRNAs predicted target mRNA and differentially expressed mRNAs were significantly enriched in the MAPK signaling pathway, GABAergic synapse, dopaminergic synapse, cytokine–cytokine receptor interaction, axon guidance, regulation of autophagy, and so on. Furthermore, dual luciferase report assay and qRT-PCR results validated the miRNA/mRNA regulatory network. Conclusion: The deteriorations of GABAergic synapses, dopaminergic synapses, neurotransmitter synthesis, as well as autophagy-associated apoptotic pathway are associated with the molecular pathological mechanism of CUMS-induced depression. Keywords: stress, depression, nucleus accumbens, miRNA, mRNA

Published
2019

30. PRELIMINARY DATA FROM A FIRST‐IN HUMAN PHASE II STUDY OF SEQUENTIAL USE OF SELINEXOR AND CD19 CART THERAPY IN PATIENTS WITH RELAPSED OR REFRACTORY B‐CELL NON‐HODGKIN LYMPHOMA

Author

Zhang, Y., primary, Zong, X., additional, Jia, S., additional, Li, J., additional, Geng, H., additional, Zeng, L., additional, Yang, Q., additional, Cai, W., additional, Liu, S., additional, Lu, Y., additional, Yu, L., additional, Li, C., additional, and Wu, D., additional

Published
2023
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32. Faba Bean

Author

Redden, R., Paull, J., Zong, X., Sass, O., Yang, T., Ling, Li, Singh, Mohar, editor, Bisht, Ishwari Singh, editor, and Dutta, Manoranjan, editor

Published
2014
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41. Structure and function of cyclic nucleotide-gated channels

Author

Biel, M., Zong, X., Ludwig, A., Sautter, A., Hofmann, F., Blaustein, M. P., editor, Greger, R., editor, Grunicke, H., editor, Jahn, R., editor, Lederer, W. J., editor, Mendell, L. M., editor, Miyajima, A., editor, Pette, D., editor, Schultz, G., editor, and Schweiger, M., editor

Published
1999
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43. Improved pea reference genome and pan-genome highlight genomic features and evolutionary characteristics

Author

Yang, T., Liu, R., Luo, Y., Hu, S., Wang, D., Wang, C., Pandey, M.K., Ge, S., Xu, Q., Li, N., Li, G., Huang, Y., Saxena, R.K., Ji, Y., Li, M., Yan, X., He, Y., Liu, Y., Wang, X., Xiang, C., Varshney, R.K., Ding, H., Gao, S., Zong, X., Yang, T., Liu, R., Luo, Y., Hu, S., Wang, D., Wang, C., Pandey, M.K., Ge, S., Xu, Q., Li, N., Li, G., Huang, Y., Saxena, R.K., Ji, Y., Li, M., Yan, X., He, Y., Liu, Y., Wang, X., Xiang, C., Varshney, R.K., Ding, H., Gao, S., and Zong, X.

Abstract

Complete and accurate reference genomes and annotations provide fundamental resources for functional genomics and crop breeding. Here we report a de novo assembly and annotation of a pea cultivar ZW6 with contig N50 of 8.98 Mb, which features a 243-fold increase in contig length and evident improvements in the continuity and quality of sequence in complex repeat regions compared with the existing one. Genome diversity of 118 cultivated and wild pea demonstrated that Pisum abyssinicum is a separate species different from P. fulvum and P. sativum within Pisum. Quantitative trait locus analyses uncovered two known Mendel’s genes related to stem length (Le/le) and seed shape (R/r) as well as some candidate genes for pod form studied by Mendel. A pan-genome of 116 pea accessions was constructed, and pan-genes preferred in P. abyssinicum and P. fulvum showed distinct functional enrichment, indicating the potential value of them as pea breeding resources in the future.

Published
2022

44. Development of an Agrobacterium-mediated CRISPR/Cas9 system in pea (Pisum sativum L.)

Author

Li, G., Liu, R., Xu, R., Varshney, R.K., Ding, H., Li, M., Yan, X., Huang, S., Li, J., Wang, D., Ji, Y., Wang, C., He, J., Luo, Y., Gao, S., Wei, P., Zong, X., Yang, T., Li, G., Liu, R., Xu, R., Varshney, R.K., Ding, H., Li, M., Yan, X., Huang, S., Li, J., Wang, D., Ji, Y., Wang, C., He, J., Luo, Y., Gao, S., Wei, P., Zong, X., and Yang, T.

Abstract

Pea (Pisum sativum L.) is an annual cool-season legume crop. Owing to its role in sustainable agriculture as both a rotation and a cash crop, its global market is expanding and increased production is urgently needed. For both technical and regulatory reasons, neither conventional nor transgenic breeding techniques can keep pace with the demand for increased production. In answer to this challenge, CRISPR/Cas9 genome editing technology has been gaining traction in plant biology and crop breeding in recent years. However, there are currently no reports of the successful application of the CRISPR/Cas9 genome editing technology in pea. We developed a transient transformation system of hairy roots, mediated by Agrobacterium rhizogenes strain K599, to validate the efficiency of a CRISPR/Cas9 system. Further optimization resulted in an efficient vector, PsU6.3-tRNA-PsPDS3-en35S-PsCas9. We used this optimized CRISPR/Cas9 system to edit the pea phytoene desaturase (PsPDS) gene, causing albinism, by Agrobacterium-mediated genetic transformation. This is the first report of successful generation of gene-edited pea plants by this route.

Published
2022

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