7 results on '"Zsuzsa Marka"'
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2. Enabling Real-time Multi-messenger Astrophysics Discoveries with Deep Learning
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E A Huerta, Gabrielle Allen, Igor Andreoni, Javier M Antelis, Etienne Bachelet, G Bruce Berriman, Federica B Bianco, Rahul Biswas, Matias Carrasco Kind, Kyle Chard, Minsik Cho, Philip S Cowperthwaite, Zacariah B Etienne, Maya Fishbach, Francisco Forster, Daniel George, Tom Gibbs, Matthew Graham, William Gropp, Robert Gruendl, Anushri Gupta, Roland Haas, Sarah Habib, Elise Jennings, Margaret W G Johnson, Erik Katsavounidis, Daniel S Katz, Asad Khan, Volodymyr Kindratenko, William T C Kramer, Xin Liu, Ashish Mahabal, Zsuzsa Marka, Kenton McHenry, J M Miller, Claudia Moreno, M S Neubauer, Steve Oberlin, Alexander Rolivas Jr, Donald Petravick, Adam Rebei, Shawn Rosofsky, Milton Ruiz, Aaron Saxton, Bernard F Schutz, Alex Schwing, Ed Seidel, Stuart L Shapiro, Hongyu Shen, Yue Shen, Leo P Singer, Brigitta M Sipocz, Lunan Sun, John Towns, Antonios Tsokaros, Wei Wei, Jack Wells, Timothy J Williams, Jinjun Xiong, and Zhizhen Zhao
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Astrophysics - Abstract
Multi-messenger astrophysics is a fast-growing, interdisciplinary field that combines data, which vary in volume and speed of data processing, from many different instruments that probe the Universe using different cosmic messengers: electromagnetic waves, cosmic rays, gravitational waves and neutrinos. In this Expert Recommendation, we review the key challenges of real-time observations of gravitational wave sources and their electromagnetic and astroparticle counterparts, and make a number of recommendations to maximize their potential for scientific discovery. These recommendations refer to the design of scalable and computationally efficient machine learning algorithms; the cyber-infrastructure to numerically simulate astrophysical sources, and to process and interpret multi-messenger astrophysics data; the management of gravitational wave detections to trigger real-time alerts for electromagnetic and astroparticle follow-ups; a vision to harness future developments of machine learning and cyber-infrastructure resources to cope with the big-data requirements; and the need to build a community of experts to realize the goals of multi-messenger astrophysics.
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- 2019
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3. High-Energy and Ultra-High-Energy Neutrinos: A Snowmass White Paper
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Markus Ackermann, Mauricio Bustamante, Lu Lu, Nepomuk Otte, Mary Hall Reno, Stephanie Wissel, Sanjib K. Agarwalla, Jaime Alvarez-Muñiz, Rafael Alves Batista, Carlos A. Argüelles, Brian A. Clark, Austin Cummings, Sudipta Das, Valentin Decoene, Peter B. Denton, Damien Dornic, Zhan-Arys Dzhilkibaev, Yasaman Farzan, Alfonso Garcia, Maria Vittoria Garzelli, Christian Glaser, Aart Heijboer, Jörg R. Hörandel, Giulia Illuminati, Yu Seon Jeong, John L. Kelley, Kevin J. Kelly, Ali Kheirandish, Spencer R. Klein, John F. Krizmanic, Michael J. Larson, Kohta Murase, Ashish Narang, Remy L. Prechelt, Steven Prohira, Elisa Resconi, Marcos Santander, Victor B. Valera, Justin Vandenbroucke, Olga Vasil'evna Suvorova, Lawrence Wiencke, Shigeru Yoshida, Tianlu Yuan, Enrique Zas, Pavel Zhelnin, Bei Zhou, Luis A. Anchordoqui, Yosuke Ashida, Mahdi Bagheri, Aswathi Balagopal, Vedant Basu, James Beatty, Keith Bechtol, Nicole Bell, Abigail Bishop, Julia Book, Anthony Brown, Alexander Burgman, Michael Campana, Nhan Chau, Thomas Y. Chen, Alan Coleman, Amy Connolly, Janet M. Conrad, Pablo Correa, Cyril Creque-Sarbinowski, Zachary Curtis-Ginsberg, Paramita Dasgupta, Simon De Kockere, Krijn de Vries, Cosmin Deaconu, Abhishek Desai, Tyce DeYoung, Armando di Matteo, Dominik Elsaesser, Phillip Fürst, Kwok Lung Fan, Anatoli Fedynitch, Derek Fox, Erik Ganster, Martin Ha Minh, Christian Haack, Steffen Hallman, Francis Halzen, Andreas Haungs, Aya Ishihara, Eleanor Judd, Timo Karg, Albrecht Karle, Teppei Katori, Alina Kochocki, Claudio Kopper, Marek Kowalski, Ilya Kravchenko, Naoko Kurahashi, Mathieu Lamoureux, Hermes León Vargas, Massimiliano Lincetto, Qinrui Liu, Jim Madsen, Yuya Makino, Joseph Mammo, Zsuzsa Marka, Eric Mayotte, Kevin Meagher, Maximilian Meier, Lino Miramonti, Marjon Moulai, Katharine Mulrey, Marco Muzio, Richard Naab, Anna Nelles, William Nichols, Alisa Nozdrina, Erin O'Sullivan, Vivian OD́ell, Jesse Osborne, Vishvas Pandey, Ek Narayan Paudel, Alex Pizzuto, Mattias Plum, Carlos Pobes Aranda, Lilly Pyras, Christoph Raab, Zoe Rechav, Juan Rojo, Oscar Romero Matamala, Pierpaolo Savina, Frank Schroeder, Lisa Schumacher, Sergio Sciutto, Stephen Sclafani, Mohammad Ful Hossain Seikh, Manuel Silva, Rajeev Singh, Daniel Smith, Samuel Timothy Spencer, Robert Wayne Springer, Juliana Stachurska, Olga Suvorova, Ignacio Taboada, Simona Toscano, Matias Tueros, Jean Pierre Twagirayezu, Nick van Eijndhoven, Péter Veres, Abigail Vieregg, Winnie Wang, Nathan Whitehorn, Walter Winter, Emre Yildizci, Shiqi Yu, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Faculty of Sciences and Bioengineering Sciences, Elementary Particle Physics, and Physics
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Astrophysics and Astronomy ,neutrino: energy: high ,Astronomy ,Astrophysics::High Energy Astrophysical Phenomena ,Baikal ,WIMP: dark matter ,neutrino: flux ,IceCube ,neutrino: decay ,neutrino: energy ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,neutrino: supernova ,numerical calculations ,KM3NeT ,Particle Physics - Phenomenology ,astro-ph.HE ,new physics ,hep-ex ,ANITA ,Astronomy and Astrophysics ,hep-ph ,neutrino: UHE ,neutrino: propagation ,neutrino: detector ,Space and Planetary Science ,[PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph] ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Particle Physics - Experiment - Abstract
Astrophysical neutrinos are excellent probes of astroparticle physics and high-energy physics. With energies far beyond solar, supernovae, atmospheric, and accelerator neutrinos, high-energy and ultra-high-energy neutrinos probe fundamental physics from the TeV scale to the EeV scale and beyond. They are sensitive to physics both within and beyond the Standard Model through their production mechanisms and in their propagation over cosmological distances. They carry unique information about their extreme non-thermal sources by giving insight into regions that are opaque to electromagnetic radiation. This white paper describes the opportunities astrophysical neutrino observations offer for astrophysics and high-energy physics, today and in coming years. Astrophysical neutrinos are excellent probes of astroparticle physics and high-energy physics. With energies far beyond solar, supernovae, atmospheric, and accelerator neutrinos, high-energy and ultra-high-energy neutrinos probe fundamental physics from the TeV scale to the EeV scale and beyond. They are sensitive to physics both within and beyond the Standard Model through their production mechanisms and in their propagation over cosmological distances. They carry unique information about their extreme non-thermal sources by giving insight into regions that are opaque to electromagnetic radiation. This white paper describes the opportunities astrophysical neutrino observations offer for astrophysics and high-energy physics, today and in coming years.
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- 2022
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4. Low-Latency Algorithm for Multi-messenger Astrophysics (LLAMA) search for common sources of gravitational waves and high-energy neutrinos
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Doga Veske, Szabolcs Marka, Stefan Countryman, Zsuzsa Marka, Imre Bartos, and Yasmeen Asali
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Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Instrumentation and Methods for Astrophysics - Abstract
For more than a decade, searches for common sources of gravitational-waves (GWs) and astrophysical neutrinos have returned null results. With the open public alerts of LIGO-Virgo during their third observing run O3 in 2019-2020, search for high energy neutrinos continued in realtime with IceCube. Here, we describe our analysis with Low-Latency Algorithm for Multi-messenger Astrophysics (LLAMA) which incorporates a Bayesian formalism with astrophysical priors to use the distance information from the 3D localization of GW detections for higher statistical power. Finally, we summarize our results during O3.
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- 2020
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5. The transient gravitational-wave sky
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Nils, A, John, B, Krzystof, B, Sebastiano, B, Emanuele, B, Laura, C, Pablo Cerdá, D, James, C, Marc, F, Lee Samuel, F, Chris, F, Giacomazzo, B, Jose Antonio, G, Martin, H, Ik Siong, H, Stefan, H, Nathan Johnson, M, Peter, K, Sergei, K, Shiho, K, Kostas, K, Pablo, L, Luis, L, Janna, L, Steve, L, Andrew, M, Ilya, M, Szabolcs, M, Zsuzsa, M, David, N, Paul, O, Rosalba, P, Jocelyn, R, Christian, R, Carl, R, Max, R, Erik, S, Antony, S, Peter, S, Deirdre, S, Alicia, S, Ulrich, S, Patrick, S, Nial, T, Michal, W, Stan, W, Nils Andersson, John Baker, Krzystof Belczynski, Sebastiano Bernuzzi, Emanuele Berti, Laura Cadonati, Pablo Cerdá Durán, James Clark, Marc Favata, Lee Samuel Finn, Chris Fryer, Giacomazzo, Bruno, Jose Antonio González, Martin Hendry, Ik Siong Heng, Stefan Hild, Nathan Johnson McDaniel, Peter Kalmus, Sergei Klimenko, Shiho Kobayashi, Kostas Kokkotas, Pablo Laguna, Luis Lehner, Janna Levin, Steve Liebling, Andrew MacFadyen, Ilya Mandel, Szabolcs Marka, Zsuzsa Marka, David Neilsen, Paul O'Brien, Rosalba Perna, Jocelyn Read, Christian Reisswig, Carl Rodriguez, Max Ruffert, Erik Schnetter, Antony Searle, Peter Shawhan, Deirdre Shoemaker, Alicia Soderberg, Ulrich Sperhake, Patrick Sutton, Nial Tanvir, Michal Was, Stan Whitcomb, Nils, A, John, B, Krzystof, B, Sebastiano, B, Emanuele, B, Laura, C, Pablo Cerdá, D, James, C, Marc, F, Lee Samuel, F, Chris, F, Giacomazzo, B, Jose Antonio, G, Martin, H, Ik Siong, H, Stefan, H, Nathan Johnson, M, Peter, K, Sergei, K, Shiho, K, Kostas, K, Pablo, L, Luis, L, Janna, L, Steve, L, Andrew, M, Ilya, M, Szabolcs, M, Zsuzsa, M, David, N, Paul, O, Rosalba, P, Jocelyn, R, Christian, R, Carl, R, Max, R, Erik, S, Antony, S, Peter, S, Deirdre, S, Alicia, S, Ulrich, S, Patrick, S, Nial, T, Michal, W, Stan, W, Nils Andersson, John Baker, Krzystof Belczynski, Sebastiano Bernuzzi, Emanuele Berti, Laura Cadonati, Pablo Cerdá Durán, James Clark, Marc Favata, Lee Samuel Finn, Chris Fryer, Giacomazzo, Bruno, Jose Antonio González, Martin Hendry, Ik Siong Heng, Stefan Hild, Nathan Johnson McDaniel, Peter Kalmus, Sergei Klimenko, Shiho Kobayashi, Kostas Kokkotas, Pablo Laguna, Luis Lehner, Janna Levin, Steve Liebling, Andrew MacFadyen, Ilya Mandel, Szabolcs Marka, Zsuzsa Marka, David Neilsen, Paul O'Brien, Rosalba Perna, Jocelyn Read, Christian Reisswig, Carl Rodriguez, Max Ruffert, Erik Schnetter, Antony Searle, Peter Shawhan, Deirdre Shoemaker, Alicia Soderberg, Ulrich Sperhake, Patrick Sutton, Nial Tanvir, Michal Was, and Stan Whitcomb
- Abstract
Interferometric detectors will very soon give us an unprecedented view of the gravitational-wave sky, and in particular of the explosive and transient Universe. Now is the time to challenge our theoretical understanding of short-duration gravitational-wave signatures from cataclysmic events, their connection to more traditional electromagnetic and particle astrophysics, and the data analysis techniques that will make the observations a reality. This paper summarizes the state of the art, future science opportunities, and current challenges in understanding gravitational-wave transients.
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- 2013
6. Potential COVID-19 therapeutics from a rare disease: weaponizing lipid dysregulation to combat viral infectivity
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Stephen L. Sturley, Tamayanthi Rajakumar, Natalie Hammond, Katsumi Higaki, Zsuzsa Márka, Szabolcs Márka, and Andrew B. Munkacsi
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severe acute respiratory syndrome coronavirus 2 ,cholesterol ,cholesterol trafficking ,lysosomal storage disease ,Niemann-Pick disease ,dyslipidemias ,Biochemistry ,QD415-436 - Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has resulted in the death of more than 328,000 persons worldwide in the first 5 months of 2020. Herculean efforts to rapidly design and produce vaccines and other antiviral interventions are ongoing. However, newly evolving viral mutations, the prospect of only temporary immunity, and a long path to regulatory approval pose significant challenges and call for a common, readily available, and inexpensive treatment. Strategic drug repurposing combined with rapid testing of established molecular targets could provide a pause in disease progression. SARS-CoV-2 shares extensive structural and functional conservation with SARS-CoV-1, including engagement of the same host cell receptor (angiotensin-converting enzyme 2) localized in cholesterol-rich microdomains. These lipid-enveloped viruses encounter the endosomal/lysosomal host compartment in a critical step of infection and maturation. Niemann-Pick type C (NP-C) disease is a rare monogenic neurodegenerative disease caused by deficient efflux of lipids from the late endosome/lysosome (LE/L). The NP-C disease-causing gene (NPC1) has been strongly associated with viral infection, both as a filovirus receptor (e.g., Ebola) and through LE/L lipid trafficking. This suggests that NPC1 inhibitors or NP-C disease mimetics could serve as anti-SARS-CoV-2 agents. Fortunately, there are such clinically approved molecules that elicit antiviral activity in preclinical studies, without causing NP-C disease. Inhibition of NPC1 may impair viral SARS-CoV-2 infectivity via several lipid-dependent mechanisms, which disturb the microenvironment optimum for viral infectivity. We suggest that known mechanistic information on NPC1 could be utilized to identify existing and future drugs to treat COVID-19.
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- 2020
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7. 8th Edoardo Amaldi Conference on Gravitational Waves
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Szabolcs Marka and Zsuzsa Marka
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History ,Engineering ,Gravitational-wave observatory ,Operations research ,biology ,business.industry ,Gravitational wave ,Miller ,Columbia university ,Library science ,biology.organism_classification ,Session (web analytics) ,Computer Science Applications ,Education ,Outreach ,Pathfinder ,business ,Inclusion (education) - Abstract
(The attached PDF contains select pictures from the Amaldi8 Conference) At Amaldi7 in Sydney in 2007 the Gravitational Wave International Committee (GWIC), which oversees the Amaldi meetings, decided to hold the 8th Edoardo Amaldi Conference on Gravitational Waves at Columbia University in the City of New York. With this decision, Amaldi returned to North America after a decade. The previous two years have seen many advances in the field of gravitational wave detection. By the summer of 2009 the km-scale ground based interferometric detectors in the US and Europe were preparing for a second long-term scientific run as a worldwide detector network. The advanced or second generation detectors had well-developed plans and were ready for the production phase or started construction. The European-American space mission, LISA Pathfinder, was progressing towards deployment in the foreseeable future and it is expected to pave the ground towards gravitational wave detection in the milliHertz regime with LISA. Plans were developed for an additional gravitational wave detector in Australia and in Japan (in this case underground) to extend the worldwide network of detectors for the advanced detector era. Japanese colleagues also presented plans for a space mission, DECIGO, that would bridge the gap between the LISA and ground-based interferometer frequency range. Compared to previous Amaldi meetings, Amaldi8 had new elements representing emerging trends in the field. For example, with the inclusion of pulsar timing collaborations to the GWIC, gravitational wave detection using pulsar timing arrays was recognized as one of the prominent directions in the field and was represented at Amaldi8 as a separate session. By 2009, searches for gravitational waves based on external triggers received from electromagnetic observations were already producing significant scientific results and plans existed for pointing telescopes by utilizing gravitational wave trigger events. Such multimessenger approaches to gravitational wave detection also received special attention at the meeting. For the first time in the history of Amaldi conferences, plenary and contributed sessions were held to transfer ideas and experience gained with gravitational wave science inspired education and outreach projects. Additionally, Columbia University faculties working in frontier fields, which currently may not have direct connection to the field of gravitational wave science, gave enthralling presentations in the form of a 'wake-up' lecture series. The meeting also facilitated the exchange of scientific results and new ideas among all members of gravitational wave experiment collaborations and the gravitational wave theory community. Additionally, future directions in gravitational wave detection were discussed in a special session dedicated to the Gravitational Wave International Committee Roadmap. A highly entertaining and inspiring public talk titled Songs from Space: Black Holes and the Big Bang in Audio was given by Janna Levin and it attracted over 300 young and old science enthusiasts from and around New York City. This special issue of Classical and Quantum Gravity (Volume 27, Number 8, 2010) is published as the proceedings of Amaldi8. It contains the overview articles by invited plenary speakers, and some of the highlights of the meeting as selected by session chairs and organizers. Other Amaldi8 talks and posters appear in the refereed issue of the electronic Journal of Physics: Conference Series. This issue of CQG and the JPCS issue are electronically linked. The conference organizers gratefully acknowledge the financial support of Columbia University in the City of New York, the International Union of Pure and Applied Physics and the United States National Science Foundation. We would like to thank the Gravitational Wave International Committee for the scientific oversight, the Local Organizing Committee for the program selection, and the session chairs for the thoughtful delivery of conference goals and enabling many lively discussions that are much needed for the development of our frontier field. We would also like to thank the hard work of Columbia University Physics Department administrators for handling some of the practical aspects of the organization. Finally, a team of students (Jonathan Berliner, Rutu Das, David Fierroz, Alyssa Miller, David Murphy and Keith Redwine) provided assistance behind the scene. Their hard work, practical ideas, and dedication are greatly appreciated. We are also grateful for Keith Redwine for his help in organizing the JPCS proceedings articles. Finally, we would like to thank the over 310 participants for their interesting and lively contributions that ultimately made the conference a success. Zsuzsa Marka Local Organizing Committee Szabolcs Marka Chair, Local Organizing Committee Columbia Astrophysics Laboratory and Physics Department, Columbia University Guest Editors
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- 2010
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