Search

Your search keyword '"Zuk, Samantha M"' showing total 50 results
Start Over Author "Zuk, Samantha M"
50 results on '"Zuk, Samantha M"'

2. Prevalence and Heterogeneity of Cerebrovascular Disease Imaging Lesions

Author

Graff-Radford, Jonathan, Aakre, Jeremiah A., Knopman, David S., Schwarz, Christopher G., Flemming, Kelly D., Rabinstein, Alejandro A., Gunter, Jeffrey L., Ward, Chadwick P., Zuk, Samantha M., Spychalla, A.J., Preboske, Gregory M., Petersen, Ronald C., Kantarci, Kejal, Huston, John, III, Jack, Clifford R., Jr., Mielke, Michelle M., and Vemuri, Prashanthi

Published
2020
Full Text
View/download PDF

3. Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease

Author

Vemuri, Prashanthi, Senjem, Matthew L, Gunter, Jeffrey L, Lundt, Emily S, Tosakulwong, Nirubol, Weigand, Stephen D, Borowski, Bret J, Bernstein, Matt A, Zuk, Samantha M, Lowe, Val J, Knopman, David S, Petersen, Ronald C, Fox, Nick C, Thompson, Paul M, Weiner, Michael W, Jack, Clifford R, and Initiative, For the Alzheimer's Disease Neuroimaging

Subjects
Allied Health and Rehabilitation Science, Health Sciences, Neurodegenerative, Dementia, Aging, Brain Disorders, Acquired Cognitive Impairment, Biomedical Imaging, Bioengineering, Clinical Research, Neurosciences, Clinical Trials and Supportive Activities, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aged, Aged, 80 and over, Algorithms, Alzheimer Disease, Artificial Intelligence, Brain Mapping, Cognitive Dysfunction, Datasets as Topic, Diffusion Tensor Imaging, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuroimaging, Quality Control, Alzheimer's Disease Neuroimaging Initiative, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveOur primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD).MethodsWe identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) and AD subjects from all available Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects with usable pairs of accelerated and unaccelerated scans. There were a total of 696 subjects with baseline and 3 month scans, 628 subjects with baseline and 6 month scans and 464 subjects with baseline and 12 month scans available. We employed the Symmetric Diffeomorphic Image Normalization method (SyN) for normalization of the serial scans to obtain tensor based morphometry (TBM) maps which indicate the structural changes between pairs of scans. We computed a TBM-SyN summary score of annualized structural changes over 31 regions of interest (ROIs) that are characteristically affected in AD. TBM-SyN scores were computed using accelerated and unaccelerated scan pairs and compared in terms of agreement, group-wise discrimination, and sample size estimates for a hypothetical therapeutic trial.ResultsWe observed a number of systematic differences between TBM-SyN scores computed from accelerated and unaccelerated pairs of scans. TBM-SyN scores computed from accelerated scans tended to have overall higher estimated values than those from unaccelerated scans. However, the performance of accelerated scans was comparable to unaccelerated scans in terms of discrimination between clinical groups and sample sizes required in each clinical group for a therapeutic trial. We also found that the quality of both accelerated vs. unaccelerated scans were similar.ConclusionsAccelerated scanning protocols reduce scan time considerably. Their group-wise discrimination and sample size estimates were comparable to those obtained with unaccelerated scans. The two protocols did not produce interchangeable TBM-SyN estimates, so it is arguably important to use either accelerated pairs of scans or unaccelerated pairs of scans throughout the study duration.

Published
2015

5. An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

Author

Sarro, Lidia, Tosakulwong, Nirubol, Schwarz, Christopher G., Graff-Radford, Jonathan, Przybelski, Scott A., Lesnick, Timothy G., Zuk, Samantha M., Reid, Robert I., Raman, Mekala R., Boeve, Bradley F., Ferman, Tanis J., Knopman, David S., Comi, Giancarlo, Filippi, Massimo, Murray, Melissa E., Parisi, Joseph E., Dickson, Dennis W., Petersen, Ronald C., Jack, Clifford R., Jr., and Kantarci, Kejal

Published
2017
Full Text
View/download PDF

10. Higher systolic and diastolic blood pressures are associated with loss of white matter integrity in postmenopausal women of the KEEPS Continuation Study

Author

Kara, Firat, primary, Reid, Robert I., additional, Schwarz, Christopher G., additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Zuk, Samantha M., additional, Kendall‐Thomas, June, additional, Thostenson, Kaely, additional, Reyes, Denise A., additional, Fields, Julie A., additional, Senjem, Matthew L., additional, Min, Hoon‐Ki, additional, Lowe, Val J., additional, Jack, Clifford R., additional, Bailey, Kent R., additional, James, Taryn T., additional, Lobo, Rogerio A., additional, Manson, JoAnn E., additional, Pal, Lubna, additional, Hammers, Dustin B., additional, Malek‐Ahmadi, Michael H., additional, Cedars, Marcelle I., additional, Naftolin, Frederick, additional, Miller, Virginia M., additional, Harman, Sherman M., additional, Dowling, N. Maritza, additional, Gleason, Carey E., additional, and Kantarci, Kejal, additional

Published
2021
Full Text
View/download PDF

13. Study of Symptomatic vs. Silent Brain Infarctions on MRI in Elderly Subjects

Author

Raghavan, Sheelakumari, primary, Graff-Radford, Jonathan, additional, Scharf, Eugene, additional, Przybelski, Scott A., additional, Lesnick, Timothy G., additional, Gregg, Brian, additional, Schwarz, Christopher G., additional, Gunter, Jeffrey L., additional, Zuk, Samantha M., additional, Rabinstein, Alejandro, additional, Mielke, Michelle M., additional, Petersen, Ronald C., additional, Knopman, David S., additional, Kantarci, Kejal, additional, Jack, Clifford R., additional, and Vemuri, Prashanthi, additional

Published
2021
Full Text
View/download PDF

14. Utility of DTI as a prognostic biomarker in MCI: Beyond AD biomarkers

Author

Pillai, Sheela Kumari Raghavan, primary, Przybelski, Scott A., additional, Reid, Robert I., additional, Graff‐Radford, Jonathan, additional, Lesnick, Timothy G., additional, Zuk, Samantha M., additional, Knopman, David S., additional, Machulda, Mary M., additional, Mielke, Michelle M., additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, and Vemuri, Prashanthi, additional

Published
2020
Full Text
View/download PDF

15. Preservation of white matter integrity on DTI 3 years after early menopausal hormone therapies

Author

Kara, Firat, primary, Chen, Qin, additional, Reid, Robert I., additional, Schwarz, Christopher G., additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Zuk, Samantha M., additional, Lowe, Val J., additional, Fields, Julie A., additional, Gleason, Carey E., additional, Shuster, Lynne T., additional, Bailey, Kent R., additional, Jack, Clifford R., additional, Rocca, Walter A., additional, Miller, Virginia M., additional, and Kantarci, Kejal, additional

Published
2020
Full Text
View/download PDF

16. Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging

Author

Vemuri, Prashanthi, primary, Lesnick, Timothy G., additional, Przybelski, Scott A., additional, Graff‐Radford, Jonathan, additional, Reid, Robert I., additional, Lowe, Val J., additional, Zuk, Samantha M., additional, Senjem, Matthew L., additional, Schwarz, Christopher G., additional, Gunter, Jeffrey L., additional, Kantarci, Kejal, additional, Machulda, Mary M., additional, Mielke, Michelle M., additional, Petersen, Ronald C., additional, Knopman, David S., additional, and Jack, Clifford R., additional

Published
2018
Full Text
View/download PDF

17. Brain structure and cognition 3 years after the end of an early menopausal hormone therapy trial

Author

Kantarci, Kejal, primary, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Zuk, Samantha M., additional, Lowe, Val J., additional, Fields, Julie A., additional, Gunter, Jeffrey L., additional, Senjem, Matthew L., additional, Settell, Megan L., additional, Gleason, Carey E., additional, Shuster, Lynne T., additional, Bailey, Kent R., additional, Dowling, N. Maritza, additional, Asthana, Sanjay, additional, Jack, Clifford R., additional, Rocca, Walter A., additional, and Miller, Virginia M., additional

Published
2018
Full Text
View/download PDF

20. CHANGES IN BRAIN STRUCTURE THREE YEARS AFTER THE END OF MENOPAUSAL HORMONE THERAPIES IN A RANDOMIZED CONTROLLED TRIAL

Author

Kantarci, Kejal, primary, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Zuk, Samantha M., additional, Gunter, Jeffrey L., additional, Senjem, Matthew L., additional, Settell, Megan L., additional, Gleason, Carey E., additional, Dowling, Maritza, additional, Shuster, Lynne T., additional, Bailey, Kent R., additional, Jack, Clifford R., additional, Rocca, Walter, additional, and Miller, Virginia M., additional

Published
2017
Full Text
View/download PDF

21. Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis

Author

Zeydan, Burcu, primary, Lowe, Val J, additional, Schwarz, Christopher G, additional, Przybelski, Scott A, additional, Tosakulwong, Nirubol, additional, Zuk, Samantha M, additional, Senjem, Matthew L, additional, Gunter, Jeffrey L, additional, Roberts, Rosebud O, additional, Mielke, Michelle M, additional, Benarroch, Eduardo E, additional, Rodriguez, Moses, additional, Machulda, Mary M, additional, Lesnick, Timothy G, additional, Knopman, David S, additional, Petersen, Ronald C, additional, Jack, Clifford R, additional, Kantarci, Kejal, additional, and Kantarci, Orhun H, additional

Published
2017
Full Text
View/download PDF

22. Pittsburgh compound-B PET and MRI biomarkers of cognition in aging MS patients (P4.347)

Author

Zeydan, Burcu, primary, Lowe, Val J., additional, Przybelski, Scott A., additional, Schwarz, Christopher G., additional, Tosakulwong, Nirubol, additional, Zuk, Samantha M., additional, Senjem, Matthew L., additional, Gunter, Jeffery L., additional, Roberts, Rosebud O., additional, Mielke, Michelle M., additional, Benarroch, Eduardo E., additional, Rodriguez, Moses, additional, Machulda, Mary M., additional, Lesnick, Timothy G., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, Kantarci, Kejal, additional, and Kantarci, Orhun H., additional

Published
2017
Full Text
View/download PDF

23. White Matter Integrity on DTI, Amyloid Load, and Neurodegeneration in Non-demented Elderly

Author

Kantarci, Kejal, Schwarz, Christopher G., Reid, Robert, Przybelski, Scott A., Lesnick, Timothy, Zuk, Samantha M., Senjem, Matthew L., Gunter, Jeffrey L., Lowe, Val, Machulda, Mary M., Knopman, David S., Petersen, Ronald C., and Jack, Clifford R.

Subjects
Aged, 80 and over, Male, Amyloid beta-Peptides, Neurodegenerative Diseases, White Matter, Article, Diffusion Tensor Imaging, Positron-Emission Tomography, Anisotropy, Humans, Cognitive Dysfunction, Female, Longitudinal Studies, Gray Matter, Biomarkers, Aged
Abstract

Pathophysiologic mechanisms leading to loss of white matter integrity and the temporal positioning of biomarkers of white matter integrity relative to the biomarkers of gray matter neurodegeneration and amyloid load in the course of Alzheimer disease (AD) are poorly understood.To investigate the effects of AD-related gray matter neurodegeneration and high β-amyloid on white matter microstructure in older adults without dementia.A population-based, longitudinal cohort study was conducted. Participants included in the Mayo Clinic Study of Aging (N = 701) who underwent magnetic resonance imaging, diffusion tensor imaging (DTI), and positron emission tomography studies with diagnoses of cognitively normal ([CN] n = 570) or mild cognitive impairment ([MCI] n = 131) were included. Both groups were divided into biomarker-negative, amyloid-positive-only, neurodegeneration-positive-only, and amyloid plus neurodegeneration-positive groups based on their amyloid load shown on carbon 11-labeled Pittsburgh Compound B positron emission tomography, AD hypometabolic pattern shown on fludeoxyglucose F 18 positron emission tomography, and/or hippocampal atrophy shown on magnetic resonance imaging.Fractional anisotropy (FA) determined using DTI.No FA alterations were observed in biomarker-negative MCI and amyloid-positive-only CN and MCI groups compared with biomarker-negative CN participants on voxel-based analysis (P.05; familywise error corrected). Conversely, the neurodegeneration-positive-only and amyloid plus neurodegeneration-positive CN and MCI groups consistently had decreased FA in the fornix, which correlated with cognitive performance (ρ = 0.38; P.001). Patients with MCI had more extensive white matter involvement than did those with CN, and the greatest FA decreases were observed in the amyloid plus neurodegeneration-positive MCI group (P.05; familywise error corrected).A high amyloid load does not influence diffusion tensor imaging-based measures of white matter integrity in the absence of coexistent gray matter neurodegeneration in older adults without dementia.

Published
2014

24. Association of Kidney Function Biomarkers with Brain MRI Findings: The BRINK Study

Author

Vemuri, Prashanthi, primary, Knopman, David S., additional, Jack, Clifford R., additional, Lundt, Emily S., additional, Weigand, Stephen D., additional, Zuk, Samantha M., additional, Thostenson, Kaely B., additional, Reid, Robert I., additional, Kantarci, Kejal, additional, Slinin, Yelena, additional, Lakshminarayan, Kamakshi, additional, Davey, Cynthia S., additional, and Murray, Anne, additional

Published
2016
Full Text
View/download PDF

25. An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

Author

Sarro, Lidia, primary, Tosakulwong, Nirubol, additional, Schwarz, Christopher G., additional, Graff-Radford, Jonathan, additional, Przybelski, Scott A., additional, Lesnick, Timothy G., additional, Zuk, Samantha M., additional, Reid, Robert I., additional, Raman, Mekala R., additional, Boeve, Bradley F., additional, Ferman, Tanis J., additional, Knopman, David S., additional, Comi, Giancarlo, additional, Filippi, Massimo, additional, Murray, Melissa E., additional, Parisi, Joseph E., additional, Dickson, Dennis W., additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, and Kantarci, Kejal, additional

Published
2016
Full Text
View/download PDF

26. Effects of hormone therapy on brain structure

Author

Kantarci, Kejal, primary, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Zuk, Samantha M., additional, Gunter, Jeffrey L., additional, Gleason, Carey E., additional, Wharton, Whitney, additional, Dowling, N. Maritza, additional, Vemuri, Prashanthi, additional, Senjem, Matthew L., additional, Shuster, Lynne T., additional, Bailey, Kent R., additional, Rocca, Walter A., additional, Jack, Clifford R., additional, Asthana, Sanjay, additional, and Miller, Virginia M., additional

Published
2016
Full Text
View/download PDF

27. Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition

Author

Kantarci, Kejal, primary, Lowe, Val J., additional, Lesnick, Timothy G., additional, Tosakulwong, Nirubol, additional, Bailey, Kent R., additional, Fields, Julie A., additional, Shuster, Lynne T., additional, Zuk, Samantha M., additional, Senjem, Matthew L., additional, Mielke, Michelle M., additional, Gleason, Carey, additional, Jack, Clifford R., additional, Rocca, Walter A., additional, and Miller, Virginia M., additional

Published
2016
Full Text
View/download PDF

29. Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis.

Author

Zeydan, Burcu, Lowe, Val J., Schwarz, Christopher G., Przybelski, Scott A., Tosakulwong, Nirubol, Zuk, Samantha M., Senjem, Matthew L., Gunter, Jeffrey L., Roberts, Rosebud O., Mielke, Michelle M., Benarroch, Eduardo E., Rodriguez, Moses, Machulda, Mary M., Lesnick, Timothy G., Knopman, David S., Petersen, Ronald C., Jack, Clifford R., Kantarci, Kejal, and Kantarci, Orhun H.

Subjects
WHITE matter (Nerve tissue), BRAIN imaging, MULTIPLE sclerosis, POSITRON emission tomography, LOGISTIC regression analysis
Abstract

Background: There is growing interest in white matter (WM) imaging with positron emission tomography (PET). Objectives: We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding. Methods: In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences. Results: MS patients had lower memory (p = 0.03) and language (p = 0.02) performance; smaller thalamic volumes (p = 0.003); and thinner temporal (p = 0.001) and frontal (p = 0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls (p = 0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS (p = 0.0002). Reduced PiB uptake in both the areas of WM hyperintensities (r = 0.65; p = 0.02) and NAWM (r = 0.69; p = 0.01) was associated with decreased visuospatial performance in MS. Conclusion: PiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures’ integrity such as those involved in visuospatial performance. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

30. IC‐P‐146: Arterial stiffness and white matter hyperintensity load in normotensive postmenopausal women

Author

Barnes, Jill N., primary, Harvey, Ronee E., additional, Zuk, Samantha M., additional, Lundt, Emily S., additional, Lesnick, Timothy G., additional, Gunter, Jeffrey L., additional, Senjem, Matthew L., additional, Miller, Virginia M., additional, Jack, Clifford R., additional, Joyner, Michael J., additional, and Kantarci, Kejal, additional

Published
2015
Full Text
View/download PDF

31. O2-10-06: Frequency and distribution of cerebral microbleeds in dementia with lewy bodies

Author

Sarro, Lidia, primary, Gungor, Ipek, additional, Radford, Jonathan Graff, additional, Zuk, Samantha M., additional, Tosakulwong, Nirubol, additional, Przybelski, Scott A., additional, Boeve, Bradley, additional, Ferman, Tanis J., additional, Smith, Glenn E., additional, Knopman, David S., additional, Filippi, Massimo, additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, and Kantarci, Kejal, additional

Published
2015
Full Text
View/download PDF

32. O3-01-03: Effects of hormone therapy on brain structure in recently postmenopausal women: A randomized controlled trial

Author

Kantarci, Kejal, primary, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Zuk, Samantha M., additional, Gunter, Jeffrey L., additional, Gleason, Carey E., additional, Wharton, Whitney, additional, Dowling, N. Maritza, additional, Vemuri, Prashanthi, additional, Senjem, Matthew L., additional, Shuster, Lynne T., additional, Bailey, Kent R., additional, Rocca, Walter, additional, Jack, Clifford R., additional, Asthana, Sanjay, additional, and Miller, Virginia M., additional

Published
2015
Full Text
View/download PDF

34. P1-178: Frequency of cerebral infarcts in probable dementia with lewy bodies

Author

Sarro, Lidia, primary, Radford, Jonathan Graff, additional, Zuk, Samantha M., additional, Tosakulwong, Nirubol, additional, Przybelski, Scott A., additional, Boeve, Bradley, additional, Ferman, Tanis J., additional, Smith, Glenn E., additional, Knopman, David S., additional, Filippi, Massimo, additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, and Kantarci, Kejal, additional

Published
2015
Full Text
View/download PDF

36. IC-P-060: Frequency of cerebral infarcts in probable dementia with lewy bodies

Author

Sarro, Lidia, primary, Radford, Jonathan Graff, additional, Zuk, Samantha M., additional, Tosakulwong, Nirubol, additional, Przybelski, Scott A., additional, Boeve, Bradley, additional, Ferman, Tanis J., additional, Smith, Glenn E., additional, Knopman, David S., additional, Filippi, Massimo, additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, and Kantarci, Kejal, additional

Published
2015
Full Text
View/download PDF

37. IC-P-061: Frequency and distribution of cerebral microbleeds in dementia with lewy bodies

Author

Sarro, Lidia, primary, Gungor, Ipek, additional, Radford, Jonathan Graff, additional, Zuk, Samantha M., additional, Tosakulwong, Nirubol, additional, Przybelski, Scott A., additional, Boeve, Bradley, additional, Ferman, Tanis J., additional, Smith, Glenn E., additional, Knopman, David S., additional, Filippi, Massimo, additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, and Kantarci, Kejal, additional

Published
2015
Full Text
View/download PDF

38. Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease

Author

Vemuri, Prashanthi, primary, Senjem, Matthew L., additional, Gunter, Jeffrey L., additional, Lundt, Emily S., additional, Tosakulwong, Nirubol, additional, Weigand, Stephen D., additional, Borowski, Bret J., additional, Bernstein, Matt A., additional, Zuk, Samantha M., additional, Lowe, Val J., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Fox, Nick C., additional, Thompson, Paul M., additional, Weiner, Michael W., additional, and Jack, Clifford R., additional

Published
2015
Full Text
View/download PDF

39. IC‐01‐06: AORTIC BLOOD PRESSURE IS ASSOCIATED WITH WHITE MATTER HYPERINTENSITY FRACTION IN POSTMENOPAUSAL WOMEN WITH NORMAL BLOOD PRESSURE

Author

Barnes, Jill N., primary, Harvey, Ronée E., additional, Zuk, Samantha M., additional, Lundt, Emily S., additional, Lesnick, Timothy G., additional, Gunter, Jeffrey L., additional, Senjem, Matthew L., additional, Miller, Virginia M., additional, Jack, Clifford R., additional, Joyner, Michael J., additional, and Kantarci, Kejal, additional

Published
2014
Full Text
View/download PDF

41. P3-194: AORTIC BLOOD PRESSURE IS ASSOCIATED WITH WHITE MATTER HYPERINTENSITY FRACTION IN POSTMENOPAUSAL WOMEN WITH NORMAL BLOOD PRESSURE

Author

Barnes, Jill N., primary, Harvey, Ronée E., additional, Zuk, Samantha M., additional, Lundt, Emily S., additional, Lesnick, Timothy G., additional, Gunter, Jeffrey, additional, Senjem, Matthew L., additional, Miller, Virginia M., additional, Jack, Clifford R., additional, Joyner, Michael J., additional, and Kantarci, Kejal, additional

Published
2014
Full Text
View/download PDF

43. Association of Kidney Function Biomarkers with Brain MRI Findings: The BRINK Study.

Author

Vemuri, Prashanthi, Jack Jr, Clifford R., Zuk, Samantha M., Thostenson, Kaely B., Reid, Robert I., Kantarci, Kejal, Knopman, David S., Lundt, Emily S., Weigand, Stephen D., Slinin, Yelena, Lakshminarayan, Kamakshi, Davey, Cynthia S., Murray, Anne M., Jack, Clifford R, Murray, Anne, and Jack, Clifford R Jr

Subjects
KIDNEY function tests, MAGNETIC resonance imaging, BRAIN diseases, CEREBROVASCULAR disease, DISEASES in older people, BRAIN, CHRONIC kidney failure, GLOMERULAR filtration rate, HEMORRHAGE, DIGITAL image processing, INFARCTION, LONGITUDINAL method, REGRESSION analysis, RESEARCH funding
Abstract

Background: Chronic kidney disease (CKD) studies have reported variable prevalence of brain pathologies, in part due to low inclusion of participants with moderate to severe CKD.Objective: To measure the association between kidney function biomarkers and brain MRI findings in CKD.Methods: In the BRINK (BRain IN Kidney Disease) study, MRI was used to measure gray matter volumes, cerebrovascular pathologies (white matter hyperintensity (WMH), infarctions, microhemorrhages), and microstructural changes using diffusion tensor imaging (DTI). We performed regression analyses with estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR) as primary predictors, and joint models that included both predictors, adjusted for vascular risk factors.Results: We obtained 240 baseline MRI scans (150 CKD with eGFR <45 in ml/min/1.73 m2; 16 mild CKD: eGFR 45-59; 74 controls: eGFR≥60). Lower eGFR was associated with greater WMH burden, increased odds of cortical infarctions, and worsening diffusion changes throughout the brain. In eGFR models adjusted for UACR, only cortical infarction associations persisted. However, after adjusting for eGFR, higher UACR provided additional information related to temporal lobe atrophy, increased WMH, and whole brain microstructural changes as measured by increased DTI mean diffusivity.Conclusions: Biomarkers of kidney disease (eGFR and UACR) were associated with MRI brain changes, even after accounting for vascular risk factors. UACR adds unique additional information to eGFR regarding brain structural and diffusion biomarkers. There was a greater impact of kidney function biomarkers on cerebrovascular pathologies and microstructural brain changes, suggesting that cerebrovascular etiology may be the primary driver of cognitive impairment in CKD. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results