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5. A Study on the Effect of Different Charge Structures on the Permeability Enhancement of Coal Seam Blasting.

Author

Zuo, Yunfei, Zhang, Jianyu, Yang, Lidong, Wang, Feiran, and Wang, Zhengang

Subjects
BLAST effect, GAS well drilling, GAS extraction, COAL gas, BLASTING
Abstract

With the increasing depth of coal mining, the ground stress of coal seams rises, the gas content rises, and the permeability decreases, which is unfavorable to gas extraction and increases the possibility of gas accidents in coal mines. Blasting technology is often used to improve the permeability of coal seams and increase the effect of gas extraction, but it is difficult to control the blasting effect of ordinary flux coils, and the direction of the fissure and the degree of development of randomness, so it is important to study the effect of different flux coil structures on the blasting of coal seams to increase the permeability of the coal seam, in this paper, first of all, through the numerical simulation to analyze the effect of the blasting of the ordinary structure flux coils and the fissure change in the polygonal structure flux coils, and then make the experimental module. Then, we make the test module, build the test platform, and analyze the effect of blasting penetration of different drug coil structures by comparing the strain after blasting and the change in resistivity before and after blasting of two kinds of drug coil structures, and the results show that the polymerized drug coil can play the role of directional fracturing, and compared with the ordinary structure of the drug coil, the polymerized drug shows a better effect of fracturing and penetration increase. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Dynamic Transition between Monomer and Excimer Phosphorescence in Organic Near‐Infrared Phosphorescent Crystals

Author

Deng, Zihao, primary, Zhang, Jianyu, additional, Zhou, Jiaming, additional, Shen, Wei, additional, Zuo, Yunfei, additional, Wang, Jin, additional, Yang, Shengyi, additional, Liu, Junkai, additional, Chen, Yuyang, additional, Chen, Chun‐Chao, additional, Jia, Guocheng, additional, Alam, Parvej, additional, Lam, Jacky W. Y., additional, and Tang, Ben Zhong, additional

Published
2024
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11. CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR‐212‐5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway

Author

Yuan, Menglang, primary, Zhang, Xinsheng, additional, Yue, Fangxia, additional, Zhang, Feifan, additional, Jiang, Sufen, additional, Zhou, Xu, additional, Lv, Jinjuan, additional, Zhang, Zhenyu, additional, Sun, Yuzhu, additional, Chen, Zihao, additional, Wu, Han, additional, Liu, Xiaoqian, additional, Yu, Xiaoqi, additional, Wei, Bowen, additional, Jiang, Kexin, additional, Lin, Fang, additional, Zuo, Yunfei, additional, and Ren, Shuangyi, additional

Published
2023
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14. Aggregation-Induced Emission Macromolecular Materials for Antibacterial Applications

Author

Zuo, Yunfei, Kwok, Ryan Tsz Kin, Sun, Jianwei, Lam, Wing Yip, Tang, Benzhong, Zuo, Yunfei, Kwok, Ryan Tsz Kin, Sun, Jianwei, Lam, Wing Yip, and Tang, Benzhong

Abstract

Recent advancements in aggregation-induced emission (AIE) macromolecular materials have brought their attention as potential antibacterial solutions, these materials offer new approaches to cure multidrug-resistant infections and biofilms in bacterial infections as well as real-time monitoring and specific targeting of bacteria. This review provides an overview of the three main categories of AIE macromolecular materials with antibacterial properties; namely AIE-active polymers, AIEgen@polymer complexes, and clusterization-triggered emission (CTE) based polymers. The mechanisms and applications of these materials in antibacterial treatment, wound care, and protective equipment are also discussed. The potential for future developments and application directions of AIE-based antimicrobial materials are finally highlighted.

Published
2023

15. ARID1A downregulation promotes cell proliferation and migration of colon cancer via VIM activation and CDH1 suppression

Author

Baldi, Salem, primary, Zhang, Qianshi, additional, Zhang, Zhenyu, additional, Safi, Mohammed, additional, Khamgan, Hassan, additional, Wu, Han, additional, Zhang, Mengyan, additional, Qian, Yuanyuan, additional, Gao, Yina, additional, Shopit, Abdullah, additional, Al‐Danakh, Abdullah, additional, Alradhi, Mohammed, additional, Al‐Nusaif, Murad, additional, and Zuo, Yunfei, additional

Published
2022
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16. Aggregation-Induced Emission Luminogens for Cell Death Research

Author

Zuo, Yunfei, Shen, Hanchen, Sun, Feiyi, Li, Pei, Sun, Jianwei, Kwok, Tsz Kin, Lam, Wing Yip, Tang, Benzhong, Zuo, Yunfei, Shen, Hanchen, Sun, Feiyi, Li, Pei, Sun, Jianwei, Kwok, Tsz Kin, Lam, Wing Yip, and Tang, Benzhong

Abstract

Cell death is closely related to various diseases, and monitoring and controlling cell death is a promising strategy to develop efficient therapy. Aggregation-induced emission luminogens (AIEgens) are ideal candidates for developing novel theranostic agents because of their intriguing properties in the aggregate state. The rational application of AIE materials in cell death-related research is still in its infancy but has shown great clinical potential. This review discussed the research frontier and our understanding of AIE materials in various subroutines of cell death, including apoptosis, necrosis, immunogenic cell death, pyroptosis, autophagy, lysosome-dependent cell death, and ferroptosis. We hope that the new insights can be offered to this growing field and attract more researchers to provide valuable contributions.

Published
2022

22. Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in non-Hodgkin lymphoma and significant correlations with lactic acid dehydrogenase and β2-microglobulin

Author

Zhang, Zhuqing, Chen, Kai, Yan, Longchao, Yang, Ziyi, Zhu, Zhanmeng, Chen, Chunlin, Zeng, Jia, Wei, Wei, Qi, Xia, Ren, Shuangyi, and Zuo, Yunfei

Subjects
Gene expression -- Research, Non-Hodgkin's lymphomas -- Physiological aspects, Lactic acid -- Physiological aspects -- Health aspects, Cell adhesion -- Research, Dendritic cells -- Physiological aspects -- Health aspects, Globulin -- Physiological aspects -- Health aspects, Biological sciences
Abstract

Dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein (DC-SIGNR), a type II integral membrane protein and a member of the C-type lectins, has been reported to bind various strains of HIV-1, HIV-2, and simian immunodeficiency virus. Serum DC-SIGNR is not currently available for the detection of non-Hodgkin lymphoma (NHL). Using an enzyme-linked immunosorbent assay (ELISA), we assessed the serum levels of DC-SIGNR in 70 cancer patients and 100 healthy controls. Additionally, using immunohistochemistry, we determined the expression of DC-SIGNR in the lymph nodes. Using the ELISA, low serum levels of DC-SIGNR were detected in the patients (median, 4.513 ng x [L.sup.-1]; range, 1.066-9.232 ng x [L.sup.-1]; p = 0.0003). Serum concentrations of DC-SIGNR correlated significantly with age (p = 0.0077) and lactic acid dehydrogenase (p = 0.0046) and [β.sub.2]-microglobulin (p = 0.0491) levels. However, we found no statistically significant correlation between serum DC-SIGNR levels and clinical data such as sex, Ann Arbor stage, B symptoms, and histologic subtypes. Moreover, NHL patients with a lower level of serum DC-SIGNR expression in lymphatic endothelial cells also showed negative immunostaining levels. These results suggest that DC-SIGNR is a biological molecule that may be potentially useful in NHL clinical settings. Key words: DC-SIGNR, non-Hodgkin lymphoma, expression. On rapporte que DC-SIGNR, une proteine membranaire integrale de type II membre des lectines de type C, se lie a differentes souches de VIH-1, VIH-2 et de virus d'immunodeficience simienne. La DC-SIGNR serique n'est pas actuellement utilisee pour detecter les lymphomes non-hodgkiniens (LNH). Nous avons evalue a l'aide d'un dosage ELISA les niveaux seriques de DC-SIGNR chez 70 patients atteints de cancer de meme que chez 100 sujets sains. En outre, nous avons determine par immunohistochimie l'expression de DC-SIGNR dans les ganglions lymphatiques. En ce qui concerne l'ELISA, de faibles niveaux de DC-SIGNR serique etaient detectes chez les patients (mediane, 4.513 ng/L ; limites, 1.066 a 9.232 ng/L ; p = 0.0003). Les concentrations seriques de DC-SIGNR etaient correlees de maniere significative avec l'age (p = 0.0077) et les niveaux de LDH (p = 0.0046) et de [β.sub.2]-microglobuline (p = 0.0491). Toutefois, nous n'avons pas trouve de correlation statistiquement significative en les niveaux de DC-SIGNR serique et les donnees cliniques comme le genre, le stade de Ann Arbor, les symptomes B et les sous-types histologiques. Qui plus est, les patients atteints de LNH qui presentaient de niveaux d'expression plus faibles de CD-SIGNR serique dans les cellules endotheliales des ganglions lymphatiques montraient aussi une immunocoloration negative. Ces resultats suggerent que la DC-SIGNR est une molecule biologique qui pourrait eventuellement etre utile dans le suivi clinique des LNH. [Traduit par la redaction] Mots-cles: DC-SIGNR, lymphome non-Hodgkinien, expression., Introduction Non-Hodgkin lymphoma (NHL) is a multifactorial heterogeneous malignancy that accounts for 5.1% of all cancer cases and 2.7% of all cancer deaths (Boffetta 2011; Wang et al. 2007) Likewise, [...]

Published
2013
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33. Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium-binding protein A8 and P-glycoprotein.

Author

Yang, Liu, Li, Duo, Tang, Peiyan, and Zuo, Yunfei

Subjects
CALCIUM-binding proteins, CURCUMIN, CHRONIC myeloid leukemia, SMALL interfering RNA, MULTIDRUG resistance, P-glycoprotein
Abstract

The development of multidrug resistance (MDR) has seriously impeded the efficacy of drug treatment of chronic myeloid leukemia (CML). Recent studies have indicated that S100 calcium-binding protein A8 (S100A8) is associated with the occurrence and development of MDR. Traditional Chinese medicine may provide drugs with the potential to be used as multidrug resistance reversal agents with low toxicity and multi-target characteristics. The present study selected K562/DOX cells, a CML drug-resistant cell line, as a research model, and aimed to examine whether curcumin was able to reverse the resistance to doxorubicin (DOX), and elucidate the underlying molecular mechanisms. An MTT cytotoxicity assay indicated that curcumin at 0.5–2 µM reversed DOX resistance with a reversal index of 1.3–9.3. Western blot analysis revealed that curcumin treatment caused a downregulation of the expression of P-glycoprotein (P-gp) and S100A8 in a dose- and time-dependent manner. To study the internal association between S100A8 and P-gp, and the S100A8 role in drug resistance reversal, an RNA knockdown assay was conducted; however, S100A8 did not regulate the expression of P-gp or vice versa. After inhibiting the expression of S100A8 with specific small interfering RNA (si-S100A8), the sensitivity of K562/DOX cells to DOX was enhanced. In addition, si-S100A8 did not increase the intracellular accumulation of DOX, but increased the intracellular free calcium ion content, and the expression and activity of apoptosis-associated proteins, thereby inducing apoptosis. In conclusion, the present study suggested that inhibition of S100A8 expression increased DOX-induced apoptosis, and curcumin acted independently on S100A8 and P-gp to exert its drug resistance reversal effects [ABSTRACT FROM AUTHOR]

Published
2020
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