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The neighbourhood is a basic unit in police work in the city. Throughout the twentieth and twenty-first centuries, theories of crime and place conceptualized the neighbourhood differently; some emphasized sociological aspects, while others focused on physical aspects. Each theory offers different practices for crime reduction and police action strategies in neighbourhoods. This paper shows how the police implement different strategies in a neighbourhood in South Tel Aviv. It argues that the diversity of approaches increases the range and areas of police intervention in the neighbourhood and empowers their control and effect on place. It indicates the dominance of physical and microgeographical approaches over sociological approaches. Methodologically, this paper uses a three-pronged approach: 1. In-depth interviews with police officers and other dominant actors in space; 2. Ethnographic work with the urban police; and 3. Spatial analysis of policework in the neighbourhood. The conclusion discusses the consequences and shortcomings of the current paradigm in policing and suggests three directions as departure points for new thinking on crime and neighbourhoods: rethinking scale; reassessing the subject of concern; and readdressing the entanglement between crime and space. [ABSTRACT FROM AUTHOR]

Prior research reveals the interrelations between gentrification and policing, yet this paper introduces the unheard perspective of the of police on their role in gentrification. The study focuses on South Tel Aviv, which houses immigrants, drug addicts, prostitution and houselessness. It is undergoing massive urban renewal and has become the most policed area in the city. Methodology includes interviews with police officers (N-15), ethnography with urban police and spatial analysis of urban renewal. The paper argues that: 1. Gentrifying a high-crime neighborhood triggers a collision of urban forces and spatial negotiations amid users, institutions, and areas in the city. 2. Police play a significant role in this process and must operate intensive borderwork on various scales, with technology becoming a tool for internal, microgeographical social borderwork. 3. Policing gentrification raises reflexivity among officers regarding their profession, social obligation and position in urban politics. The paper concludes with the concept of policing temporality to describe the role of police in gentrification. [ABSTRACT FROM AUTHOR]

Aims: Due to the lack of tools evaluating participation of children with ASD in the educational setting, this study aimed to adapt the Structured Preschool Participation Observation (SPO), which assess the participation of preschool children attending mainstream-educational settings to children with ASD attending non-inclusive special education (content validity), to measure its initial psychometric properties (internal reliability, inter-rater reliability), and to describe children's participation characteristics, creating an effective tool to fill this gap. Methods: Content validity was evaluated by 21 experts using questionnaires. Thirty-five children with ASD were observed in their educational setting using the adapted tool (SPO-ASD). Results: Content validity was satisfactory regarding the items and their classification into occupational areas. Moderate to excellent internal consistency (α =.73–.92) and inter-rater reliability (ICC =.61–.95, p<.05) were found for all scales and most areas. Children's participation frequency was high in learning and activities of daily living (ADL), low in play and social participation. Performance level was low in social participation. Enjoyment level was low, and needed assistance in ADL was high. Conclusions: Based on our initial evaluation, the SPO-ASD may be suitable for assessing participation of children with ASD attending special education preschools. Additional studies are needed to more securely establish its psychometric properties. [ABSTRACT FROM AUTHOR]

Motivation: Dozens of studies in recent years have demonstrated that codon usage encodes various aspects related to all stages of gene expression regulation. When relevant high-quality large-scale gene expression data are available, it is possible to statistically infer and model these signals, enabling analysing and engineering gene expression. However, when these data are not available, it is impossible to infer and validate such models. Results: In this current study, we suggest Chimera--an unsupervised computationally efficient approach for exploiting hidden high-dimensional information related to the way gene expression is encoded in the open reading frame (ORF), based solely on the genome of the analysed organism. One version of the approach, named Chimera Average Repetitive Substring (ChimeraARS), estimates the adaptability of an ORF to the intracellular gene expression machinery of a genome (host), by computing its tendency to include long substrings that appear in its coding sequences; the second version, named ChimeraMap, engineers the codons of a protein such that it will include long substrings of codons that appear in the host coding sequences, improving its adaptation to a new host's gene expression machinery. We demonstrate the applicability of the new approach for analysing and engineering heterologous genes and for analysing endogenous genes. Specifically, focusing on Escherichia coli, we show that it can exploit information that cannot be detected by conventional approaches (e.g. the CAI--Codon Adaptation Index), which only consider single codon distributions; for example, we report correlations of up to 0.67 for the ChimeraARS measure with heterologous gene expression, when the CAI yielded no correlation. [ABSTRACT FROM AUTHOR]

One of the open questions in regulatory genomics is how the efficiency of gene translation is encoded in the coding sequence. Here we analyse recently generated measurements of folding energy in Saccharomyces cerevisiae, showing that genes with high protein abundance tend to have strong mRNA folding (mF; R=0.68). mF strength also strongly correlates with ribosomal density and mRNA levels, suggesting that this relation at least partially pertains to the efficiency of translation elongation, presumably by preventing aggregation of mRNA molecules. [ABSTRACT FROM AUTHOR]

The codon composition of the coding sequence's (ORF) 5' end first few dozen codons is known to be distinct to that of the rest of the ORF. Various explanations for the unusual codon distribution in this region have been proposed in recent years, and include, among others, novel regulatory mechanisms of translation initiation and elongation. However, due to the fact that many overlapping regulatory signals are suggested to be associated with this relatively short region, its research is challenging. Here, we review the currently known signals that appear in this region, the theories related to the way they regulate translation and affect the organismal fitness, and the debates they provoke., (© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.)