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2. Packing theory derived from phyllotaxis and products of linear forms 0

Author

Zurita, S. E. Graiff, Kane, B., and Oishi-Tomiyasu, R.

Subjects
Mathematics - Number Theory, 52C15, 52C17 (primary), 11J70, 11J06, 35Q92 (secondary)
Abstract

\textit{Parastichies} are spiral patterns observed in plants and numerical patterns generated using golden angle method. We generalize this method by using Markoff theory and the theory of product of linear forms, to obtain a theory for packing of Riemannian manifolds of general dimensions $n$ with a locally diagonalizable metric, including the Euclidean spaces. For example, packings in a plane with logarithmic spirals and in a 3D ball (3D analogue of the Vogel spiral) are newly obtained. Using this method, we prove that it is possible to generate almost uniformly distributed point sets on any real analytic Riemannian surfaces in a local sense. We also discuss how to extend the packing to the whole manifold in some special cases including the Vogel spiral. The packing density is bounded below by approximately 0.7 for surfaces and 0.38 for 3-manifolds under the most general assumption.

Published
2021

3. Denoising Atmospheric Temperature Measurements Taken by the Mars Science Laboratory on the Martian Surface

Author

Zurita-Zurita, S., Escribano, Francisco J., Sáez-Landete, J., and Rodríguez-Manfredi, J. A.

Subjects
Electrical Engineering and Systems Science - Signal Processing, Astrophysics - Earth and Planetary Astrophysics, Computer Science - Information Retrieval, Physics - Data Analysis, Statistics and Probability
Abstract

In the present article we analyze data from two temperature sensors of the Mars Science Laboratory, which has been active in Mars since August 2012. Temperature measurements received from the rover are noisy and must be processed and validated before being delivered to the scientific community. Currently, a simple Moving Average (MA) filter is used to perform signal denoising. The application of this basic method relies on the assumption that the noise is stationary and statistically independent from the underlying structure of the signal, an arguable assumption in this kind of harsh environment. In this paper, we analyze the application of two alternative methods to process the temperature sensor measurements: the Discrete Wavelet Transform (DWT) and the Hilbert-Huang Transform (HHT). We consider two different datasets, one belonging to the current Martian measurement campaigns, and the other to the Thermal Vacuum Tests. The processing of these datasets allows to separate the random noise from the interference created by other systems. The experiments show that the MA filter may provide useful results under given circumstances. However, the proposed methods allow a better fitting for all the realistic scenarios, while providing the possibility to identify and analyze other interesting signal features and artifacts that could be later studied and classified. The large amount of data to be processed makes computational efficiency an important requirement in this mission. Considering the computational cost and the filtering performance, we propose the method based on DWT as more suitable for this application., Comment: 10 pages, 7 figures, accepted for publication at IEEE Transactions on Instrumentation and Measurement

Published
2020
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4. The diverse meteorology of Jezero crater over the first 250 sols of Perseverance on Mars

Author

Rodriguez-Manfredi, J. A., de la Torre Juarez, M., Sanchez-Lavega, A., Hueso, R., Martinez, G., Lemmon, M. T., Newman, C. E., Munguira, A., Hieta, M., Tamppari, L. K., Polkko, J., Toledo, D., Sebastian, E., Smith, M. D., Jaakonaho, I., Genzer, M., De Vicente-Retortillo, A., Viudez-Moreiras, D., Ramos, M., Saiz-Lopez, A., Lepinette, A., Wolff, M., Sullivan, R. J., Gomez-Elvira, J., Apestigue, V., Conrad, P. G., Del Rio-Gaztelurrutia, T., Murdoch, N., Arruego, I., Banfield, D., Boland, J., Brown, A. J., Ceballos, J., Dominguez-Pumar, M., Espejo, S., Fairén, A. G., Ferrandiz, R., Fischer, E., Garcia-Villadangos, M., Gimenez, S., Gomez-Gomez, F., Guzewich, S. D., Harri, A.-M., Jimenez, J. J., Jimenez, V., Makinen, T., Marin, M., Martin, C., Martin-Soler, J., Molina, A., Mora-Sotomayor, L., Navarro, S., Peinado, V., Perez-Grande, I., Pla-Garcia, J., Postigo, M., Prieto-Ballesteros, O., Rafkin, S. C. R., Richardson, M. I., Romeral, J., Romero, C., Savijärvi, H., Schofield, J. T., Torres, J., Urqui, R., and Zurita, S.

Published
2023
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5. The Mars Environmental Dynamics Analyzer, MEDA. A Suite of Environmental Sensors for the Mars 2020 Mission

Author

Rodriguez-Manfredi, J. A., de la Torre Juárez, M., Alonso, A., Apéstigue, V., Arruego, I., Atienza, T., Banfield, D., Boland, J., Carrera, M. A., Castañer, L., Ceballos, J., Chen-Chen, H., Cobos, A., Conrad, P. G., Cordoba, E., del Río-Gaztelurrutia, T., de Vicente-Retortillo, A., Domínguez-Pumar, M., Espejo, S., Fairen, A. G., Fernández-Palma, A., Ferrándiz, R., Ferri, F., Fischer, E., García-Manchado, A., García-Villadangos, M., Genzer, M., Giménez, S., Gómez-Elvira, J., Gómez, F., Guzewich, S. D., Harri, A.-M., Hernández, C. D., Hieta, M., Hueso, R., Jaakonaho, I., Jiménez, J. J., Jiménez, V., Larman, A., Leiter, R., Lepinette, A., Lemmon, M. T., López, G., Madsen, S. N., Mäkinen, T., Marín, M., Martín-Soler, J., Martínez, G., Molina, A., Mora-Sotomayor, L., Moreno-Álvarez, J. F., Navarro, S., Newman, C. E., Ortega, C., Parrondo, M. C., Peinado, V., Peña, A., Pérez-Grande, I., Pérez-Hoyos, S., Pla-García, J., Polkko, J., Postigo, M., Prieto-Ballesteros, O., Rafkin, S. C. R., Ramos, M., Richardson, M. I., Romeral, J., Romero, C., Runyon, K. D., Saiz-Lopez, A., Sánchez-Lavega, A., Sard, I., Schofield, J. T., Sebastian, E., Smith, M. D., Sullivan, R. J., Tamppari, L. K., Thompson, A. D., Toledo, D., Torrero, F., Torres, J., Urquí, R., Velasco, T., Viúdez-Moreiras, D., and Zurita, S.

Published
2021
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8. The Diverse Meteorology of Jezero Crater over the First 250 Sols of Perseverance on Mars

Author

Universidad de Sevilla. Departamento de Electrónica y Electromagnetismo, Ministerio de Economía y Competitividad (MINECO). España, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Ministerio de Ciencia e Innovación (MICIN). España, Spanish State Research Agency (AEI), Gobierno Vasco, European Research Council (ERC), National Aeronautics and Space Administration, Rodríguez Manfredi, J. A., Torre Juárez, M. de la, Sánchez Lavega, A., Hueso, R., Martínez, G., Lemmon, M. T., Newman, C. E., Munguira, A., Hieta, M., Tamppari, L. K., Espejo Meana, Servando Carlos, Zurita, S., Universidad de Sevilla. Departamento de Electrónica y Electromagnetismo, Ministerio de Economía y Competitividad (MINECO). España, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Ministerio de Ciencia e Innovación (MICIN). España, Spanish State Research Agency (AEI), Gobierno Vasco, European Research Council (ERC), National Aeronautics and Space Administration, Rodríguez Manfredi, J. A., Torre Juárez, M. de la, Sánchez Lavega, A., Hueso, R., Martínez, G., Lemmon, M. T., Newman, C. E., Munguira, A., Hieta, M., Tamppari, L. K., Espejo Meana, Servando Carlos, and Zurita, S.

Abstract

NASA’s Perseverance rover’s Mars Environmental Dynamics Analyzer is collecting data at Jezero crater, characterizing the physical processes in the lowest layer of the Martian atmosphere. Here we present measurements from the instrument’s first 250 sols of operation, revealing a spatially and temporally variable meteorology at Jezero. We find that temperature measurements at four heights capture the response of the atmospheric surface layer to multiple phenomena. We observe the transition from a stable night-time thermal inversion to a daytime, highly turbulent convective regime, with large vertical thermal gradients. Measurement of multiple daily optical depths suggests aerosol concentrations are higher in the morning than in the afternoon. Measured wind patterns are driven mainly by local topography, with a small contribution from regional winds. Daily and seasonal variability of relative humidity shows a complex hydrologic cycle. These observations suggest that changes in some local surface properties, such as surface albedo and thermal inertia, play an influential role. On a larger scale, surface pressure measurements show typical signatures of gravity waves and baroclinic eddies in a part of the seasonal cycle previously characterized as low wave activity. These observations, both combined and simultaneous, unveil the diversity of processes driving change on today’s Martian surface at Jezero crater.

Published
2023

9. The diverse meteorology of Jezero crater over the first 250 sols of Perseverance on Mars

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Instituto Nacional de Técnica Aeroespacial (España), European Commission, National Aeronautics and Space Administration (US), NASA Jet Propulsion Laboratory, California Institute of Technology, Rodriguez-Manfredi, J. A. [0000-0003-0461-9815], Torre Juarez, Manuel de la [0000-0003-1393-5297], Sánchez-Lavega, A. [0000-0001-7234-7634], Hueso, R. [0000-0003-0169-123X], Martinez, G. [0000-0001-5885-236X], Lemmon, M. T. [0000-0002-4504-5136], Newman, C. E. [0000-0001-9990-8817], Munguira, A. [0000-0002-1677-6327], Jaakonaho, I. [0000-0001-7343-5556], Viudez-Moreiras, D. [0000-0001-8442-3788], Ramos, M. Ángeles [0000-0003-3648-6818], Saiz-Lopez, A. [0000-0002-0060-1581], Lepinette, A. [0000-0002-5213-3521], Sullivan, R. J. [0000-0003-4191-598X], Apestigue, V. [0000-0002-4349-8019], Río Gaztelurrutia, Teresa del [0000-0001-8552-226X], Murdoch, N. [0000-0002-9701-4075], Arruego, I. [0000-0001-9705-9743], Banfield, D. [0000-0003-2664-0164], Brown, A. J. [0000-0002-9352-6989], Ceballos, J. [0000-0002-6727-1062], Dominguez-Pumar, M. [0000-0001-5439-7953], Espejo, S. [0000-0003-2609-2663], Fischer, E. [0000-0002-2098-5295], Guzewich, S. D. [0000-0003-1149-7385], Makinen, T. [0000-0001-9489-8154], Martin, C. [0000-0002-8898-4061], Molina, A. [0000-0002-5038-2022], Mora-Sotomayor, L. [0000-0002-8209-1190], Navarro, S. [0000-0001-8606-7799], Perez-Grande, I. [0000-0002-7145-2835], Romero, C. [0000-0001-5442-2581], Rodríguez-Manfredi, José Antonio, Torre Juarez, Manuel de la, Sánchez-Lavega, A., Hueso, R., Martínez, G., Lemmon, M. T., Newman, C. E., Munguira, A., Hieta, M., Tamppari, L. K., Polkko, J., Toledo, D., Sebastian, E., Smith, M. D., Jaakonaho, I., Genzer, M., Vicente-Retortillo, A. de, Viúdez-Moreiras, Daniel, Ramos, M. Ángeles, Saiz-Lopez, A., Lepinette, A., Wolff, M., Sullivan, R. J., Gómez-Elvira, Javier, Apestigue, V., Conrad, P. G., Río Gaztelurrutia, Teresa del, Murdoch, N., Arruego, I., Banfield, D., Boland, J., Brown, A. J., Ceballos, J., Dominguez-Pumar, M., Espejo, S., Fairén, A. G., Ferrandiz, R., Fischer, E., García-Villadangos, Miriam, Gimenez, S., Gomez-Gomez, F., Guzewich, S. D., Harri, A. M., Jimenez, J. J., Jimenez, V., Makinen, T., Marin, M., Martín, C., Martin-Soler, J., Molina, A., Mora-Sotomayor, L., Navarro, S., Peinado, V., Pérez-Grande, I., Pla-Garcia, J., Postigo, M., Prieto-Ballesteros, Olga, Rafkin, Scot C. R., Richardson, M. I., Romeral, J., Romero, C., Savijärvi, H., Schofield, J. T., Torres, J., Urqui, R., Zurita, S., Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Instituto Nacional de Técnica Aeroespacial (España), European Commission, National Aeronautics and Space Administration (US), NASA Jet Propulsion Laboratory, California Institute of Technology, Rodriguez-Manfredi, J. A. [0000-0003-0461-9815], Torre Juarez, Manuel de la [0000-0003-1393-5297], Sánchez-Lavega, A. [0000-0001-7234-7634], Hueso, R. [0000-0003-0169-123X], Martinez, G. [0000-0001-5885-236X], Lemmon, M. T. [0000-0002-4504-5136], Newman, C. E. [0000-0001-9990-8817], Munguira, A. [0000-0002-1677-6327], Jaakonaho, I. [0000-0001-7343-5556], Viudez-Moreiras, D. [0000-0001-8442-3788], Ramos, M. Ángeles [0000-0003-3648-6818], Saiz-Lopez, A. [0000-0002-0060-1581], Lepinette, A. [0000-0002-5213-3521], Sullivan, R. J. [0000-0003-4191-598X], Apestigue, V. [0000-0002-4349-8019], Río Gaztelurrutia, Teresa del [0000-0001-8552-226X], Murdoch, N. [0000-0002-9701-4075], Arruego, I. [0000-0001-9705-9743], Banfield, D. [0000-0003-2664-0164], Brown, A. J. [0000-0002-9352-6989], Ceballos, J. [0000-0002-6727-1062], Dominguez-Pumar, M. [0000-0001-5439-7953], Espejo, S. [0000-0003-2609-2663], Fischer, E. [0000-0002-2098-5295], Guzewich, S. D. [0000-0003-1149-7385], Makinen, T. [0000-0001-9489-8154], Martin, C. [0000-0002-8898-4061], Molina, A. [0000-0002-5038-2022], Mora-Sotomayor, L. [0000-0002-8209-1190], Navarro, S. [0000-0001-8606-7799], Perez-Grande, I. [0000-0002-7145-2835], Romero, C. [0000-0001-5442-2581], Rodríguez-Manfredi, José Antonio, Torre Juarez, Manuel de la, Sánchez-Lavega, A., Hueso, R., Martínez, G., Lemmon, M. T., Newman, C. E., Munguira, A., Hieta, M., Tamppari, L. K., Polkko, J., Toledo, D., Sebastian, E., Smith, M. D., Jaakonaho, I., Genzer, M., Vicente-Retortillo, A. de, Viúdez-Moreiras, Daniel, Ramos, M. Ángeles, Saiz-Lopez, A., Lepinette, A., Wolff, M., Sullivan, R. J., Gómez-Elvira, Javier, Apestigue, V., Conrad, P. G., Río Gaztelurrutia, Teresa del, Murdoch, N., Arruego, I., Banfield, D., Boland, J., Brown, A. J., Ceballos, J., Dominguez-Pumar, M., Espejo, S., Fairén, A. G., Ferrandiz, R., Fischer, E., García-Villadangos, Miriam, Gimenez, S., Gomez-Gomez, F., Guzewich, S. D., Harri, A. M., Jimenez, J. J., Jimenez, V., Makinen, T., Marin, M., Martín, C., Martin-Soler, J., Molina, A., Mora-Sotomayor, L., Navarro, S., Peinado, V., Pérez-Grande, I., Pla-Garcia, J., Postigo, M., Prieto-Ballesteros, Olga, Rafkin, Scot C. R., Richardson, M. I., Romeral, J., Romero, C., Savijärvi, H., Schofield, J. T., Torres, J., Urqui, R., and Zurita, S.

Abstract

NASA’s Perseverance rover’s Mars Environmental Dynamics Analyzer is collecting data at Jezero crater, characterizing the physical processes in the lowest layer of the Martian atmosphere. Here we present measurements from the instrument’s first 250 sols of operation, revealing a spatially and temporally variable meteorology at Jezero. We find that temperature measurements at four heights capture the response of the atmospheric surface layer to multiple phenomena. We observe the transition from a stable night-time thermal inversion to a daytime, highly turbulent convective regime, with large vertical thermal gradients. Measurement of multiple daily optical depths suggests aerosol concentrations are higher in the morning than in the afternoon. Measured wind patterns are driven mainly by local topography, with a small contribution from regional winds. Daily and seasonal variability of relative humidity shows a complex hydrologic cycle. These observations suggest that changes in some local surface properties, such as surface albedo and thermal inertia, play an influential role. On a larger scale, surface pressure measurements show typical signatures of gravity waves and baroclinic eddies in a part of the seasonal cycle previously characterized as low wave activity. These observations, both combined and simultaneous, unveil the diversity of processes driving change on today’s Martian surface at Jezero crater.

Published
2023

11. PB1971: FREQUENCY AND CHARACTERISTICS OF DEL(6Q) IN PATIENTS WITH MULTIPLE MYELOMA FROM LATIN-AMERICAN COUNTRIES. A REAL-WORLD STUDY

Author

Stella, F., primary, Leone, P., additional, Pedrazzini, E., additional, Galvano, C., additional, Zurita, S., additional, Coccé, M., additional, Gallego, M., additional, Schultz, N., additional, Alfonso, G., additional, Canelos Moreno, J., additional, Noboa, A., additional, Huamán Garaicoa, F., additional, Paz y Miño, C., additional, Ziembar, M., additional, Ochoa, P., additional, Duarte, P., additional, Quatrin, M., additional, Colombi Martínez, F., additional, Fernández, D., additional, Cugliari, S., additional, Uturbey, F., additional, Peña, C., additional, and Slavutsky, I., additional

Published
2022
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12. Packing theory derived from phyllotaxis and products of linear forms. N

Author

Zurita, S. E. Graiff, Kane, B., and Oishi-Tomiyasu, R.

Subjects
Mathematics - Number Theory, FOS: Mathematics, 52C15, 52C17 (primary), 11J70, 11J06, 35Q92 (secondary), Number Theory (math.NT)
Abstract

\textit{Parastichies} are spiral patterns observed in plants and numerical patterns generated using golden angle method. We generalize this method by using Markoff theory and the theory of product of linear forms, to obtain a theory for packing of Riemannian manifolds of general dimensions $n$ with a locally diagonalizable metric, including the Euclidean spaces. For example, packings in a plane with logarithmic spirals and in a ball %(3D analogue of the Vogel spiral) are newly obtained. Using this method, we prove that it is possible to generate almost uniformly distributed point sets on any real analytic Riemannian surfaces. The packing density is bounded below by approximately 0.7.

Published
2021
Full Text
View/download PDF

13. The Mars Environmental Dynamics Analyzer, MEDA. A Suite of Environmental Sensors for the Mars 2020 Mission

Author

Rodríguez-Manfredi, José Antonio, Torre Juárez, Manuel de la, Alonso, A., Apéstigue, V., Arruego, I., Atienza, T., Banfield, D., Boland, J., Carrera, M. A., Castañer, L., Ceballos, J., Chen-Chen, H., Cobos, A., Conrad, P.G., Cordoba, E., Río-Gaztelurrutia, T. del, Vicente-Retortillo, A. de, Domínguez-Pumar, M., Espejo, S., Gómez-Elvira, Javier, Gómez, F., Fairen, A.G., Fernández-Palma, A., Ferrándiz, R., Ferri, F., Fischer, E., García-Manchado, A., García-Villadangos, M., Genzer, M., Giménez, S., Guzewich, Scott D., Harri, A.M., Hernández, C.D., Hieta, M., Hueso, R., Jaakonaho, I., Jiménez, J.J., Jiménez, V., Larman, A., Leiter, R., Lepinette, A., Lemmon, M.T., López, G., Madsen, S.N., Mäkinen, T., Marín, M., Martín-Soler, J., Martínez, G., Molina, A., Mora-Sotomayor, L., Moreno-Álvarez, J.F., Navarro, S., Ortega, C., Parrondo, M.C., Peinado, V., Peña, A., Pérez-Grande, I., Pérez-Hoyos, S., Pla-García, J., Postigo, M., Prieto-Ballesteros, Olga, Ramos, M., Romeral, J., Romero, C., Saiz-Lopez, A., Sánchez-Lavega, A., Sard, I., Sebastian, E., Toledo, D., Torrero, F., Torres, J., Urquí, R., Velasco, T., Viúdez-Moreiras, D., Zurita, S., Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Instituto Nacional de Técnica Aeroespacial (España), Eusko Jaurlaritza, and National Aeronautics and Space Administration (US)

Abstract

86 pags., 49 figs., 24 tabs. NASA’s Mars 2020 (M2020) rover mission includes a suite of sensors to monitor current environmental conditions near the surface of Mars and to constrain bulk aerosol properties from changes in atmospheric radiation at the surface. The Mars Environmental Dynamics Analyzer (MEDA) consists of a set of meteorological sensors including wind sensor, a barometer, a relative humidity sensor, a set of 5 thermocouples to measure atmospheric temperature at ∼1.5 m and ∼0.5 m above the surface, a set of thermopiles to characterize the thermal IR brightness temperatures of the surface and the lower atmosphere. MEDA adds a radiation and dust sensor to monitor the optical atmospheric properties that can be used to infer bulk aerosol physical properties such as particle size distribution, non-sphericity, and concentration. The MEDA package and its scientific purpose are described in this document as well as how it responded to the calibration tests and how it helps prepare for the human exploration of Mars. A comparison is also presented to previous environmental monitoring payloads landed on Mars on the Viking, Pathfinder, Phoenix, MSL, and InSight spacecraft. This work has been funded by the Spanish Ministry of Economy and Competitiveness, through the projects No. ESP2014-54256-C4-1-R (also -2-R, -3-R and -4-R) and AYA2015-65041-P; Ministry of Science, Innovation and Universities, projects No. ESP2016-79612-C3-1-R (also -2-R and -3-R), ESP2016-80320-C2-1-R, RTI2018-098728-B-C31 (also -C32 and -C33) and RTI2018-099825-B-C31; Instituto Nacional de Técnica Aeroespacial; Ministry of Science and Innovation’s Centre for the Development of Industrial Technology; Grupos Gobierno Vasco IT1366-19; and European Research Council Consolidator Grant no 818602. The US co-authors performed their work under sponsorship from NASA’s Mars 2020 project, from the Game Changing Development program within the Space Technology Mission Directorate and from the Human Exploration and Operations Directorate.

Published
2021

14. The Mars Environmental Dynamics Analyzer, MEDA. A Suite of Environmental Sensors for the Mars 2020 Mission

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Instituto Nacional de Técnica Aeroespacial (España), Centro para el Desarrollo Tecnológico Industrial (España), Eusko Jaurlaritza, European Research Council, Rodríguez Manfredi, José Antonio, Torre Juárez, M. de la, Alonso, A., Apéstigue, V., Arruego, I., Atienza, T., Banfield, D., Boland, J., Carrera, M. A., Castañer, L., Ceballos-Cáceres, J., Chen-Chen, H, Cobos, A., Conrad, P.G., Cordoba, E., Río Gaztelurrutia, Teresa del, de Vicente Retortillo, A., Domínguez-Pumar, M., Díaz-Espejo, Antonio, González Fairén, Alberto, Fernández-Palma, A., Ferrándiz, Ricardo, Ferri, F., Fischer, E., García-Manchado, A., García-Villadangos, Miriam, Genzer, M., Giménez, S., Gómez-Elvira, Javier, Gómez, Felipe, Guzewich, Scott D., Harri, A-M, Hernández, C.D., Hieta, M., Hueso, R., Jaakonaho, I., Jiménez, J. J., Jiménez, V., Larman, A., Leiter, R., Lepinette, Alain, Lemmon, M.T., López, G, Madsen, S.N., Mäkinen, T., Marín, M., Martín Soler, Javier, Martínez, G., Molina-Jurado, Antonio, Mora Sotomayor, Luis, Moreno-Álvarez, J. F., Navarro, Sara, Newman, C E, Ortega, C., Parrondo, M.C., Peinado, Verónica, Peña, A., Pérez-Grande, I., Pérez-Hoyos, S., Pla-García, Jorge, Polkko, J., Postigo Cacho, Marina, Prieto-Ballesteros, Olga, Rafkin, Scot C. R., Ramos, M. Ángeles, Richardson, M. I., Romeral Planelló, Julio J., Romero, C, Runyon, K D, Saiz-Lopez, A., Sánchez-Lavega, A., Sard, I., Schofield, J. T., Sebastián-Martínez, Eduardo, Smith, M D, Sullivan, R J, Tamppari, L K, Thompson, A D, Toledo, D, Torrero, F, Torres-Redondo, Josefina, Urquí, R., Velasco, T., Viúdez-Moreiras, Daniel, Zurita, S., Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Instituto Nacional de Técnica Aeroespacial (España), Centro para el Desarrollo Tecnológico Industrial (España), Eusko Jaurlaritza, European Research Council, Rodríguez Manfredi, José Antonio, Torre Juárez, M. de la, Alonso, A., Apéstigue, V., Arruego, I., Atienza, T., Banfield, D., Boland, J., Carrera, M. A., Castañer, L., Ceballos-Cáceres, J., Chen-Chen, H, Cobos, A., Conrad, P.G., Cordoba, E., Río Gaztelurrutia, Teresa del, de Vicente Retortillo, A., Domínguez-Pumar, M., Díaz-Espejo, Antonio, González Fairén, Alberto, Fernández-Palma, A., Ferrándiz, Ricardo, Ferri, F., Fischer, E., García-Manchado, A., García-Villadangos, Miriam, Genzer, M., Giménez, S., Gómez-Elvira, Javier, Gómez, Felipe, Guzewich, Scott D., Harri, A-M, Hernández, C.D., Hieta, M., Hueso, R., Jaakonaho, I., Jiménez, J. J., Jiménez, V., Larman, A., Leiter, R., Lepinette, Alain, Lemmon, M.T., López, G, Madsen, S.N., Mäkinen, T., Marín, M., Martín Soler, Javier, Martínez, G., Molina-Jurado, Antonio, Mora Sotomayor, Luis, Moreno-Álvarez, J. F., Navarro, Sara, Newman, C E, Ortega, C., Parrondo, M.C., Peinado, Verónica, Peña, A., Pérez-Grande, I., Pérez-Hoyos, S., Pla-García, Jorge, Polkko, J., Postigo Cacho, Marina, Prieto-Ballesteros, Olga, Rafkin, Scot C. R., Ramos, M. Ángeles, Richardson, M. I., Romeral Planelló, Julio J., Romero, C, Runyon, K D, Saiz-Lopez, A., Sánchez-Lavega, A., Sard, I., Schofield, J. T., Sebastián-Martínez, Eduardo, Smith, M D, Sullivan, R J, Tamppari, L K, Thompson, A D, Toledo, D, Torrero, F, Torres-Redondo, Josefina, Urquí, R., Velasco, T., Viúdez-Moreiras, Daniel, and Zurita, S.

Abstract

NASA's Mars 2020 (M2020) rover mission includes a suite of sensors to monitor current environmental conditions near the surface of Mars and to constrain bulk aerosol properties from changes in atmospheric radiation at the surface. The Mars Environmental Dynamics Analyzer (MEDA) consists of a set of meteorological sensors including wind sensor, a barometer, a relative humidity sensor, a set of 5 thermocouples to measure atmospheric temperature at ∼1.5 m and ∼0.5 m above the surface, a set of thermopiles to characterize the thermal IR brightness temperatures of the surface and the lower atmosphere. MEDA adds a radiation and dust sensor to monitor the optical atmospheric properties that can be used to infer bulk aerosol physical properties such as particle size distribution, non-sphericity, and concentration. The MEDA package and its scientific purpose are described in this document as well as how it responded to the calibration tests and how it helps prepare for the human exploration of Mars. A comparison is also presented to previous environmental monitoring payloads landed on Mars on the Viking, Pathfinder, Phoenix, MSL, and InSight spacecraft.

Published
2021

15. Autotests en vente libre, vraiment utiles ? [Selft-test kits on the high street, really useful ?]

Author

Zurita, S., Senn, N., and Pedrazzini, B.

Subjects
Attitude of Health Personnel, Diagnostic Tests, Routine/standards, Humans, Physicians, Self Care/methods, Self Care/standards, Switzerland
Abstract

Today, there are more and more self-test kits available on the high street. With a few exceptions (HIV, FIT), it is currently unclear whether they are effective, neither beneficial for the consumer, nor useful for the Swiss healthcare system. Is there a favorable impact for the health system? This article tries to help doctors find their way among the many self-test available, providing them a reading grid and recommendations for their patients.

Published
2020

19. Aborto por Leptospira en una yegua en Salta, Argentina

Author

MICHELOUD, Juan, MARTÍNEZ, M, ZURITA, S, GRUNE, S, ROMERO, G, and BRIHUEGA, B

Abstract

La leptospirosis en equinos es generalmente asintomática, aunque existen regiones donde la enfermedad constituye un problema. Aquí se describe un caso de aborto en yegua debido a la infección por este agente. Se efectuó la necropsia completa de un feto a término donde se colectaron muestras para inmunofluorescencia directa (IFD), histopatología y microbiología. Además, se efectuó un estudio serológico de la tropilla y se evaluó seroconversión en la yegua abortada. El feto evidenció hepatomegalia, esplenomegalia e ictericia. Microscópicamente se apreció hepatitis mononuclear con disociación de los hepatocitos, esplenitis aguda y glomérulo-nefritis. Aunque el microrganismo no pudo ser aislado, la enfermedad se confirmó por la seroconversión observada en la yegua abortada, y debido a la identificación del agente mediante IFD en la impronta renal. Este caso demuestra la presencia del agente localmente y evidencia que la enfermedad puede ser un problema para la producción ecuestre. Leptospirosis in horses is usually asymptomatic, although there are regions where the disease is a problem. Here, a case of abortion caused by the agent in a mare is described. Full autopsy of a fetus at term was performed; samples for direct immunofluorescence (DIF), histopathology and microbiology were collected. Additionally, a serological study of the herd was conducted, as well as seroconversion in the aborted mare. The fetus evidenced hepatomegaly, splenomegaly and jaundice. Microscopically, mononuclear hepatitis with hepatocyte dissociation, acute splenitis and glomerulonephritis, were appreciated. Although the microorganism couldn’t be quite properly, the disease was confirmed by the seroconversion present in the aborted mare. Another factor was the identification of the agent through the renal imprint DIF. This case demonstrates the presence of the agent mentioned locally, and evidences that the disease can represent a problem to the equestrian industry.

Published
2016
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20. Results 2007 - 2014 program of external quality assessment for mycological diagnosis of filaments

Author

Zurita, S. R., Navarro, F. A., and Urcia, F.

Subjects
Micosis, Hongos, Técnicas de Laboratorio Clínico
Abstract

Artículo online El propósito de este trabajo es presentar los resultados 2007 al 2014 del PEEC para el diagnóstico micológico de género y especie de los principales filamentos implicados en micosis superficial, subcutánea y oportunista. La metodología empleada para la tipificación de los filamentos involucra el conocimiento de sus características taxonómicas microscópicas, bioquímicas y/o fisiológicas de cada una de las especies. El Programa de Evaluación Externa de Calidad (PEEC) para el diagnóstico micológico evalúa periódicamente la capacidad de los profesionales de las instituciones participantes para tipificar algunas especies fúngicas relacionadas en la producción de las micosis humanas.

Published
2015

21. Nuevos casos de paracoccidioidomicosis

Author

Casquero, J, Demarini, J, Castillo, M, Candella, J, and Zurita, S

Subjects
Immunodiffusion, lcsh:R5-920, Inmunodifusión, lcsh:R, lcsh:Medicine, Dimorfismo, TBC-Paracoccidioides brasiliensis, TBC Paracoccidioides brasiliensis, Paracoccidioidomicosis, Infección, Paracoccidioidomycosis, Infection, Dimorfism, lcsh:Medicine (General)
Abstract

La paracoccidioidomicosis es causada por el hongo Paracoccidioides brasiliensis. Esta infección es crónica y usualmente asintomática en niños. La distribución geográfica está limitada a Centroamérica y América del Sur. En el presente estudio se describen las características clínicas y epidemiológicas de 06 casos confirmados de paracoccidioidomicosis por el Instituto Nacional de Salud. Se observó la presencia del hongo por examen directo y cultivo en muestras de biopsias, absceso, y aspirado de ganglio. Las pruebas de inmunodifusión fueron realizadas en muestras de sangre provenientes de 04 pacientes. Todos los pacientes proceden de zonas tropicales o semitropicales (Tingo María, Oxapampa, Pucallpa y Chanchamayo) que tienen una precipitación media anual de 1500 mm/año, humedad relativa del 82%, temperatura anual de 28°C - 30°C y altura inferior a 1814 m.s.n.m. Las principales características sintomatológicas encontradas incluyen aumento del tamaño de ganglios y tuberculosis pulmonar. P. brasiliensis fue aislado en 2/6 pacientes y en 4/6 de los casos se observó la presencia de anticuerpos precipitantes por inmunodifusión. Se concluye que el 83% de los pacientes presentaron linfoadenopatias y el laboratorio permite confirmar el diagnóstico. Paracoccidioidomycosis caused by Paracoccidioides brasiliensis is a chronic infection usually asymptomatic in children. Its geographic distribution is limited to Central and South America. We reported on the clinical and epidemiological characteristics from 06 confirmed cases of paracoccidioidomycosis in the Instituto Nacional de Salud. The fungus was observed by under direct microscopic examination and/or cultures of samples from biopsy or aspirate of glands. Immunodiffusion test were performed in blood samples from 04 cases. All patients came from tropical and semi-tropical areas of the country (Tingo María, Oxapampa, Pucallpa and Chanchamayo) where the rain fall annual average is 1500 mm/year, the relative humidity 82% and the annual temperature is between 28°C and 30°C. All the places are bellow 1814 m. sea level. The main symptomatology found included increase of size of glands and pulmonar tuberculosis. P. brasiliensis was isolated in 2/6 patients and in 4/6 specific antibodies were detected by immunodiffusion test. We concluded that 83% of patients were limphoadenopaties. Laboratory test permit confirmed diagnosis.

Published
2013

24. Accuracy and inter-observer agreement of the ProcoreTM 25 gauge needle for endoscopic ultrasound-guided tissue core biopsy.

Author

Rindi, Guido, Attili, F, Petrone, G., Abdulkader, I, Correale, L, Inzani, Frediano, Iglesias Garcia, J, Hassan, Cesare, Dominguez Muñoz, Je, Costamagna, Guido, Larghi, Alberto Leonardo, Andrade Zurita, S, Rindi, Guido (ORCID:0000-0003-2996-4404), Costamagna, Guido (ORCID:0000-0002-8100-2731), Larghi, Alberto, Rindi, Guido, Attili, F, Petrone, G., Abdulkader, I, Correale, L, Inzani, Frediano, Iglesias Garcia, J, Hassan, Cesare, Dominguez Muñoz, Je, Costamagna, Guido, Larghi, Alberto Leonardo, Andrade Zurita, S, Rindi, Guido (ORCID:0000-0003-2996-4404), Costamagna, Guido (ORCID:0000-0002-8100-2731), and Larghi, Alberto

Abstract

Accuracy and inter-observer agreement of the ProcoreTM 25 gauge needle for endoscopic ultrasound-guided tissue core biopsy.

Published
2015

25. OC.05.6 CLINICAL CHARACTERISTICS AND OUTCOMES OF POEM ACCORDING TO ACHALASIA MANOMETRIC PATTERN. DO THE OUTCOMES OF TREATMENT DEPEND ON MANOMETRIC SUBTYPE?

Author

Guido Costamagna, P. Familiari, V. Perri, Rosario Landi, Zurita S. Andrade, A. Tringali, Giovanni Gigante, Ivo Boškoski, Anna Calì, and Federico Barbaro

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Achalasia, medicine.disease, business
Published
2016
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28. Philips: Information System national reference laboratory network of public health

Author

Vargas, J. and Zurita, S.

Subjects
Sistemas de Salud, Sistemas de Información en Laboratorio Clínico, Servicios Laboratoriales de Salud Publica
Abstract

El INS, en colaboración con el Departamento de Defensa de los Estados Unidos, a través de la Dirección de Vigilancia Global de las Infecciones Emergentes (DoD - GEIS), viene ejecutando en el Perú el proyecto piloto "Sistema de Información de la Red Nacional de Laboratorios de Referencia en Salud Pública", que tiene como soporte el programa de cómputo Public Health Laboratory System (PHLIS). El proyecto piloto incluye a los departamentos de San Martín y Ayacucho, así como a las Direcciones de Salud de Lima Ciudad, Lima Sur y Lima Este.

Published
2001

29. Zapoteco de Santa Catarina Quioquitani

Author

Marlett, Stephen A., Ward, Michael, Zurita S., Emiliano, Marlett, Stephen A., Ward, Michael, and Zurita S., Emiliano

Abstract

http://www.sil.org/resources/archives/2090

Published
2008

37. Estratigrafía del Plioceno de la Mesopotamia Argentina

Author

Brunetto, Ernesto, Zucol, Alejandro Fabián, Schmidt, Gabriela Ines, Noriega, Jorge Ignacio, Patterer, Noelia Isabel, Brea, Mariana, Franco, María Jimena, Nasif, N., Chiesa, J., Zurita, A., and Zurita, S.

Subjects
PALEOBOTÁNICA, purl.org/becyt/ford/1 [https], purl.org/becyt/ford/1.5 [https], PALEONTOLOGÍA DE VERTEBRADOS, PLIOCENO, MESOPOTAMIA ARGENTINA, LITOESTRATIGRAFÍA
Abstract

A partir de las interpretaciones paleontológicas, estratigráficas y estructurales recientes, se considera como registro del Plioceno del Noreste de Argentina a la Formación Puerto General Alvear aflorante en la faja occidental de la Provincia de Entre Ríos y la Formación San Salvador, enterrada en el subsuelo próximo a la superficie o expuesta en canteras o a lo largo de la faja centro-este de Entre Ríos. Datos bioestratigráficos basados en asociaciones faunísticas de vertebrados y datos magneto estratigráficos sugieren una edad Plioceno-Pleistoceno inferior para la Formación Puerto General Alvear. La Formación San Salvador puede ser ubicada dentro del mismo lapso temporal sobre la base de su posición estratigráfica relativa y su correlación lateral. El análisis integrado sugiere que la Formación Puerto General Alvear se depositó en un ambiente de humedales cálidos principalmente bajo climas semiáridos, y condiciones oscilantes muy húmedas. La información paleobotánica y sedimentológica sugiere que la Formación San Salvador se depositó en ambientes fluviales, bajo climas cálidos y húmedos. Fil: Brunetto, Ernesto. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina Fil: Zucol, Alejandro Fabián. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina Fil: Schmidt, Gabriela Ines. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina Fil: Noriega, Jorge Ignacio. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina Fil: Patterer, Noelia Isabel. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina Fil: Brea, Mariana. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina Fil: Franco, María Jimena. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina

Published
2019

38. Optimization of Hypothermic Protocols for Neurocognitive Preservation in Aortic Arch Surgery: A Literature Review.

Author

Llerena-Velastegui J, Velastegui-Zurita S, Zumbana-Podaneva K, Mejia-Mora M, Jesus ACFS, and Coelho PM

Abstract

Shifts from deep to moderate hypothermic circulatory arrest (HCA) in aortic arch surgery necessitate an examination of their differential impacts on neurocognitive functions, especially structured verbal memory, given its significance for patient recovery and quality of life. This study evaluates and synthesizes evidence on the effects of deep (≤20.0 °C), low-moderate (20.1-24.0 °C), and high-moderate (24.1-28.0 °C) hypothermic temperatures on structured verbal memory preservation and overall cognitive health in patients undergoing aortic arch surgery. We evaluated the latest literature from major medical databases such as PubMed and Scopus, focusing on research from 2020 to 2024, to gather comprehensive insights into the current landscape of temperature management during HCA. This comparative analysis highlights the viability of moderate hypothermia (20.1-28.0 °C), supported by recent trials and observational studies, as a method to achieve comparable neuroprotection with fewer complications than traditional deep hypothermia. Notably, low-moderate and high-moderate temperatures have been shown to support substantial survival rates, with impacts on structured verbal memory preservation that necessitate careful selection based on individual surgical risks and patient profiles. The findings advocate for a nuanced approach to selecting hypothermic protocols in aortic arch surgeries, emphasizing the importance of tailoring temperature management to optimize neurocognitive outcomes and patient recovery. This study fills a critical gap in the literature by providing evidence-based recommendations for temperature ranges during HCA, calling for ongoing updates to clinical guidelines and further research to refine these recommendations. The implications of temperature on survival rates, complications, and success rates underpin the necessity for evolving cardiopulmonary bypass techniques and cerebral perfusion strategies to enhance patient outcomes in complex cardiovascular procedures.

Published
2024
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39. Intrinsic Motivation and Institutional Limitations: Key Implementation Determinants of Psychological First Aid Training.

Author

Rojas-Andrade R, Aranguren Zurita S, Prosser Bravo G, and Vargas B

Subjects
Humans, Chile, Female, Male, Adult, Surveys and Questionnaires, Middle Aged, Self Efficacy, Health Personnel psychology, Health Personnel education, First Aid, Motivation
Abstract

Psychological first aid (PFA) trainings are conducted to train frontline care workers in practical and emotional support to people who have been recently affected by stressful events. The aim of this study was to describe the determinants of the implementation behavior of a PFA training strategy in Chile and to provide theoretical information on the factors that influence trainers' self-efficacy. For this purpose, the Determinants of Implementation Behavior Questionnaire, administered online to a sample of 117 PFA trainers throughout Chile, was used. The results indicate that the main facilitators for implementation originate in the intrinsic motivation of the trainers, while the barriers are mainly found in the limited institutional opportunities offered by the context. Evidence was also found on the effect of motivation and context on trainer self-efficacy. PFA trainers may need to invest a lot of psychological resources to overcome the barriers encountered during implementation., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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40. Advances and challenges in the diagnosis and management of left ventricular noncompaction in adults: A literature review.

Author

Llerena-Velastegui J, Velastegui-Zurita S, Santander-Fuentes C, Dominguez-Gavilanes D, Roa-Guerra A, Jesus ACFS, Coelho PM, Carrasco-Perez P, Calderon-Lopez C, and Benitez-Gutierrez D

Subjects
Humans, Adult, Disease Management, Isolated Noncompaction of the Ventricular Myocardium diagnosis, Isolated Noncompaction of the Ventricular Myocardium therapy, Isolated Noncompaction of the Ventricular Myocardium physiopathology
Abstract

In the realm of cardiovascular health, isolated left ventricular noncompaction (LVNC) stands out for its distinct morphological features and the clinical challenges it presents, particularly in adults. This literature review explores the intricacies of LVNC, aiming to unravel its epidemiological spread, diagnostic hurdles, and therapeutic strategies. Despite technological advancements in cardiac imaging that have improved the recognition of LVNC, a significant gap persists alongside a fragmented understanding of its pathogenesis. The studies scrutinized reveal a broad spectrum of prevalence rates influenced by diverse diagnostic tools and demographic variables. This variation underscores the complexity of accurately identifying LVNC and the resultant implications for clinical management. The review succinctly addresses the need for precise guidelines to navigate the diagnosis of LVNC and outlines the imperative for tailored clinical management approaches that cater to the wide array of patient presentations, from asymptomatic cases to those with severe cardiac dysfunction. By highlighting the critical gaps in current literature-namely the absence of standardized diagnostic criteria and a comprehensive pathogenic model-the review sets the stage for future research directions. These endeavors are essential for enhancing diagnostic accuracy, refining management protocols, and ultimately improving patient outcomes in this complex subset of cardiomyopathy, thus contributing significantly to the advancement of cardiovascular medicine., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2024
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41. Comparative Efficacy of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in the Treatment of Ischemic Heart Disease: A Systematic Review and Meta-Analysis of Recent Randomized Controlled Trials.

Author

Llerena-Velastegui J, Zumbana-Podaneva K, Velastegui-Zurita S, Mejia-Mora M, Perez-Tomassetti J, Cabrera-Cruz A, Haro-Arteaga P, de Jesus ACFS, Coelho PM, and Sanahuja-Montiel C

Abstract

Background: Ischemic heart disease (IHD) is a major global health issue and a leading cause of death. This study compares the effectiveness of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in the management of IHD, focusing on their impact on revascularization, myocardial infarction (MI), and post-procedural stroke. This study aimed to evaluate and compare the effectiveness of PCI and CABG in treating IHD based on an exhaustive literature review of the past 5 years, emphasizing recent advancements and outcomes in IHD management., Methods: A comprehensive literature review analyzed 32 randomized controlled trials (RCTs) retrieved from databases such as PubMed, Cochrane Library, and Google Scholar. The study specifically assessed the incidences of revascularization, stroke, and MI in patients treated with either PCI or CABG. The comparison between CABG and PCI exclusively focused on lesions with a SYNTAX score exceeding 32., Results: Our findings highlight CABG's significant efficacy over PCI in reducing revascularization and MI. The aggregated Mantel-Haenszel (M-H) value for revascularization was 1.85 (95% confidence interval (CI): 1.65 - 2.07), signifying CABG's advantage. Additionally, CABG demonstrated superior performance in diminishing MI occurrences (M-H = 2.71, 95% CI: 1.13 - 6.53). In contrast, PCI was more effective in reducing stroke (M-H = 0.80, 95% CI: 0.60 - 1.10)., Conclusion: The study confirms CABG's superiority in reducing revascularization and MI in IHD patients, highlighting PCI's effectiveness in reducing stroke risk. These findings underscore the importance of personalized treatment strategies in IHD management and emphasize the need for ongoing research and evidence-based guidelines to aid in treatment selection for IHD patients., Competing Interests: The authors declare no conflict of interest to ensure the impartiality of the review., (Copyright 2024, Llerena-Velastegui et al.)

Published
2024
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45. [Selft-test kits on the high street, really useful ?]

Author

Zurita S, Senn N, and Pedrazzini B

Subjects
Humans, Self Care standards, Switzerland, Attitude of Health Personnel, Diagnostic Tests, Routine standards, Physicians, Self Care methods
Abstract

Today, there are more and more self-test kits available on the high street. With a few exceptions (HIV, FIT), it is currently unclear whether they are effective, neither beneficial for the consumer, nor useful for the Swiss healthcare system. Is there a favorable impact for the health system? This article tries to help doctors find their way among the many self-test available, providing them a reading grid and recommendations for their patients., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.

Published
2020

47. Analysis of drug resistance mutations in whole blood DNA from HIV-1 infected patients by single genome and ultradeep sequencing analysis.

Author

Sotillo A, Sierra O, Martínez-Prats L, Gutiérrez F, Zurita S, Pulido F, Rubio R, and Delgado R

Subjects
Anti-HIV Agents pharmacology, Anti-HIV Agents therapeutic use, DNA Mutational Analysis, DNA, Viral blood, Genome, Viral, HIV Infections drug therapy, HIV-1 immunology, High-Throughput Nucleotide Sequencing, Humans, Mutation, Proviruses immunology, Virus Integration, CD4-Positive T-Lymphocytes virology, DNA, Viral genetics, Drug Resistance, Viral genetics, HIV Infections blood, HIV-1 drug effects, HIV-1 genetics, Proviruses genetics
Abstract

In HIV-1 infected patients blood CD4 + T lymphocytes could be a valuable target to analyse drug resistance mutations (DRM) selected over the course of the infection. However, detection of viral resistance mutations in cellular DNA by standard genotype resistance techniques (SGRT) is suboptimal. Whole blood DNA (wbDNA) from 12 HIV-1 infected patients on ART was studied by Single Genome Sequencing (SGS) and 8 of them also by Ultradeep pyrosequencing (UDP). Results were compared with contemporary and historical DRM detected in plasma by SGRT during follow up. All the contemporary DRM detected in plasma from the viremic patients were detected by SGS and UDP (20 from 7 patients and 4 from 5 patients respectively). Out of the 67 historical DRM detected in plasma and no longer present at the time of testing, 38 (57%) were detected by SGS in 12 patients and 27 out of 46 (59%) by UDP in 8 patients. Additional DRM never reported in plasma by SGRT were detected by SGS (12 from 8 patients) and UDP (10 from 8 patients). Analysis of wbDNA from HIV-1 infected patients by SGS and UDP provides proof of concept of the value of blood DNA to investigate current and archived DRM in HIV-1 infected patients on ART., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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48. Accuracy and inter-observer agreement of the Procore™ 25 gauge needle for endoscopic ultrasound-guided tissue core biopsy.

Author

Attili F, Petrone G, Abdulkader I, Correale L, Inzani F, Iglesias-Garcia J, Hassan C, Andrade Zurita S, Rindi G, Dominguez-Muñoz JE, Costamagna G, and Larghi A

Subjects
Aged, Aged, 80 and over, Bile Duct Neoplasms pathology, Biopsy, Large-Core Needle, Carcinoma, Endometrioid pathology, Carcinoma, Hepatocellular pathology, Carcinoma, Pancreatic Ductal pathology, Endoscopic Ultrasound-Guided Fine Needle Aspiration, Female, Humans, Liver Neoplasms pathology, Male, Middle Aged, Observer Variation, Pancreatic Neoplasms pathology, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Stomach Neoplasms pathology, Tumor Burden, Carcinoma pathology, Digestive System Neoplasms pathology, Lung Neoplasms pathology, Lymph Nodes pathology, Neuroectodermal Tumors, Primitive, Peripheral pathology
Abstract

Background: Scanty data on the performance of the new 25-gauge Procore™ biopsy needle are available., Methods: Consecutive patients who underwent endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) using the 25G Procore™ were retrospectively retrieved. All samples were independently reviewed by 3 pathologists for the following: histological, cytological or no specimen, neoplasia, diagnostic or non-diagnostic. Diagnostic accuracy and inter-rater concordance among pathologists were calculated., Results: 94 patients underwent EUS-FNB of 101 sites (69 solid masses, 25 lymph nodes, 5 wall thickening). Forty-one biopsies (40.5%) were classified as histological samples by at least two pathologists, 29 as cytological (28.7%), 31 had no sample (30.7%). Good and almost perfect agreements among pathologists in defining cytological vs. histological samples (k 0.82; 95% CI: 0.74-0.90), diagnostic vs. non-diagnostic (k 0.95; 95% CI: 0.85-1.00) and neoplastic vs. non-neoplastic (k 0.94; 95% CI: 0.83-1.00). According to consensus rating, 61 cases were diagnostic samples (60.4%). Histological samples were more likely to lead to a correct diagnosis (OR, 4.1; 95% P=0.027), while neoplastic lesions were less likely to be correctly classified than benign (OR, 0.11; P=0.04)., Conclusions: EUS-FNB with the Procore™ 25G needle provided samples for histological examination in only 40% of the cases, with 31% of inadequate specimens, despite excellent results in term of inter-observer variability., (Copyright © 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)

Published
2015
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