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1. Robust association of the LPAlocus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment

Author

Donnelly, Louise A., Zuydam, Natalie R. van, Zhou, Kaixin, Tavendale, Roger, Carr, Fiona, Zee, Anke H. Maitland-van der, Leusink, Maarten, de Boer, Anthonius, Doevendans, Pieter A., Asselbergs, Folkert W., Morris, Andrew D., Pearson, Ewan R., Klungel, Olaf H., Doney, Alex S.F., and Palmer, Colin N.A.

Abstract

The LPAsingle-nucleotide polymorphism rs10455872 has been associated with low-density lipoprotein cholesterol (LDLc) lowering response to statins in several randomized control trials (RCTs) and is a known coronary artery disease (CAD) marker. However, it is unclear what residual risk of CAD this marker may have during statin treatment.

Published
2013
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