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3 results on '"aac (6′)-Ie aph (2″)"'

1. Phenotypic and genotypic characterization of glycopeptide, aminoglycoside and macrolide resistance among clinical isolates of Enterococcus faecalis: a multicenter based study

Author

Mehrdad Zalipour, Bahram Nasr Esfahani, and Seyed Asghar Havaei

Subjects
Enterococcus faecalis, Antibiotic resistance, vanA, ermB, aac (6′)-Ie aph (2″), Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Objectives Enterococcus faecalis as part of the normal floras of human gastrointestinal and genitourinary tracts are an important cause of nosocomial infections. The present study aimed to investigate the prevalence of genes encoding antimicrobial resistance and genetic relatedness of clinical isolates of E. faecalis among Iranian hospitalized patients. Results Antibiotic susceptibility testing results indicated that 53 (22.8%) out of 232 E. faecalis isolates were vancomycin resistant (MIC ≥ 256 μg/ml). All of the 53 vancomycin-resistant E. faecalis isolates carried the vanA and ermB genes; whereas aac (6′)-Ie aph (2″), msrA, and ermA gene were found in 96.2%, 30.2% and 3.8% of vancomycin-resistant isolates, respectively. ERIC-PCR typing revealed that 53 vancomycin-resistant isolates were classified into 14 ERIC types. In our results, the high level of resistance to gentamicin, erythromycin and vancomycin in enterococci isolates were mainly related to the presence of aac (6′)-Ie aph (2″), ermB and vanA genes, respectively. Meanwhile, ERIC-PCR analysis demonstrated that most of the evaluated isolates have a close genetic relatedness.

Published
2019
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3. Phenotypic and genotypic characterization of glycopeptide, aminoglycoside and macrolide resistance among clinical isolates of Enterococcus faecalis: a multicenter based study

Author

Bahram Nasr Esfahani, Seyed Asghar Havaei, and Mehrdad Zalipour

Subjects
0301 basic medicine, Male, Antibiotic resistance, lcsh:Medicine, Iran, 0302 clinical medicine, Drug Resistance, Multiple, Bacterial, Genotype, Enterococcus faecalis, 030212 general & internal medicine, lcsh:QH301-705.5, Cross Infection, biology, Aminoglycoside, General Medicine, Anti-Bacterial Agents, Bacterial Typing Techniques, Erythromycin, Research Note, Phenotype, Vancomycin, Gentamicin, Female, medicine.drug, Microbial Sensitivity Tests, General Biochemistry, Genetics and Molecular Biology, vanA, Microbiology, 03 medical and health sciences, medicine, Humans, Typing, lcsh:Science (General), Gram-Positive Bacterial Infections, lcsh:R, aac (6′)-Ie aph (2″), ermB, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, 030104 developmental biology, Cross-Sectional Studies, lcsh:Biology (General), Genes, Bacterial, Gentamicins, lcsh:Q1-390
Abstract

Objectives Enterococcus faecalis as part of the normal floras of human gastrointestinal and genitourinary tracts are an important cause of nosocomial infections. The present study aimed to investigate the prevalence of genes encoding antimicrobial resistance and genetic relatedness of clinical isolates of E. faecalis among Iranian hospitalized patients. Results Antibiotic susceptibility testing results indicated that 53 (22.8%) out of 232 E. faecalis isolates were vancomycin resistant (MIC ≥ 256 μg/ml). All of the 53 vancomycin-resistant E. faecalis isolates carried the vanA and ermB genes; whereas aac (6′)-Ie aph (2″), msrA, and ermA gene were found in 96.2%, 30.2% and 3.8% of vancomycin-resistant isolates, respectively. ERIC-PCR typing revealed that 53 vancomycin-resistant isolates were classified into 14 ERIC types. In our results, the high level of resistance to gentamicin, erythromycin and vancomycin in enterococci isolates were mainly related to the presence of aac (6′)-Ie aph (2″), ermB and vanA genes, respectively. Meanwhile, ERIC-PCR analysis demonstrated that most of the evaluated isolates have a close genetic relatedness.

Published
2019

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